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Transport of drugs from blood vessels to tumour tissue
Open accessAbstract
The effectiveness of anticancer drugs in treating a solid tumour is dependent on delivery of the drug to virtually all cancer cells in the tumour. The distribution of drug in tumour tissue depends on the plasma pharmacokinetics, the structure and function of the tumour vasculature and the transport properties of the drug as it moves through microvessel walls and in the extravascular tissue. The aim of this Review is to provide a broad, balanced perspective on the current understanding of drug transport to tumour cells and on the progress in developing methods to enhance drug delivery. First, the fundamental processes of solute transport in blood and tissue by convection and diffusion are reviewed, including the dependence of penetration distance from vessels into tissue on solute binding or uptake in tissue. The effects of the abnormal characteristics of tumour vasculature and extravascular tissue on these transport properties are then discussed. Finally, methods for overcoming limitations in drug transport and thereby achieving improved therapeutic results are surveyed.
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“Hypoxia occurs in the majority of solid tumors due to a poor vascular oxygen supply that is not sufficient to meet the needs of rapidly proliferating cancer cells.”
From Hypoxia signaling in cancer: Implications for therapeutic interventions (2023) · cites this paper as [4]
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Metadata
- Authors
- Dewhirst, M. W., & Secomb, T. W.
- Affiliations
- Duke Medical Center (US)
- University of Arizona (US)
- Corresponding author
- Dewhirst, Mark W.
- Venue
- Nature Reviews Cancer
- Published
- 2017-12
- Volume
- 17
- Issue
- 12
- Pages
- 738-750
- ISSN
- 1474-175X (ISSN-L)
- 1474-1768
- PMC
- PMC6371795
- OpenAlex
- W2767780867
- Cited by
- 749
- References
- 188
- Citations by year
- 2026: 63 · 2025: 98 · 2024: 91 · 2023: 87 · 2022: 108 · 2021: 97 · 2020: 104 · 2019: 62 · 2018: 38 · 2017: 1
- FWCI
- 4.06
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Cancer (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health
- National Heart, Lung, and Blood Institute (R01HL034555)
- National Cancer Institute (R01CA040355)
- Topics
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
- Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
- Keywords
- tumor vasculature, drug transport, solute transport, convection and diffusion, penetration depth, plasma pharmacokinetics, tumor microenvironment, tissue absorption
- MeSH terms
- Antineoplastic Agents, Biological Transport, Blood Vessels, Humans, Neoplasms, Drug Delivery Systems
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