Cited by 749Nanoparticle-Based Drug DeliveryBarrier Structure and Function StudiesDrug Transport and Resistance Mechanisms

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Transport of drugs from blood vessels to tumour tissue

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Dewhirst, Mark W., Secomb, Timothy W.·2017·Nature Reviews Cancer

DOI 10.1038/nrc.2017.93PMC PMC6371795

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Abstract

The effectiveness of anticancer drugs in treating a solid tumour is dependent on delivery of the drug to virtually all cancer cells in the tumour. The distribution of drug in tumour tissue depends on the plasma pharmacokinetics, the structure and function of the tumour vasculature and the transport properties of the drug as it moves through microvessel walls and in the extravascular tissue. The aim of this Review is to provide a broad, balanced perspective on the current understanding of drug transport to tumour cells and on the progress in developing methods to enhance drug delivery. First, the fundamental processes of solute transport in blood and tissue by convection and diffusion are reviewed, including the dependence of penetration distance from vessels into tissue on solute binding or uptake in tissue. The effects of the abnormal characteristics of tumour vasculature and extravascular tissue on these transport properties are then discussed. Finally, methods for overcoming limitations in drug transport and thereby achieving improved therapeutic results are surveyed.

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Authors: Dewhirst, M. W., & Secomb, T. W.
Affiliations: Duke Medical Center (US)
University of Arizona (US)
Corresponding author: Dewhirst, Mark W.
ORCID: Dewhirst, Mark W.
Secomb, Timothy W.
Venue: Nature Reviews Cancer
Publisher: Springer Science and Business Media LLC
Published: 2017-12
Volume: 17
Issue: 12
Pages: 738-750
ISSN: 1474-175X (ISSN-L)
1474-1768
DOI: 10.1038/nrc.2017.93
PMC: PMC6371795
OpenAlex: W2767780867
Cited by: 749
References: 188
Citations by year: 2026: 63 · 2025: 98 · 2024: 91 · 2023: 87 · 2022: 108 · 2021: 97 · 2020: 104 · 2019: 62 · 2018: 38 · 2017: 1
FWCI: 4.06
Type: journal article
Language: en
Open access: green
europepmc.org
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Cancer (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
National Heart, Lung, and Blood Institute (R01HL034555)
National Cancer Institute (R01CA040355)
Topics: Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Life Sciences › Neuroscience › Neurology › Barrier Structure and Function Studies
Health Sciences › Medicine › Oncology › Drug Transport and Resistance Mechanisms
Keywords: tumor vasculature, drug transport, solute transport, convection and diffusion, penetration depth, plasma pharmacokinetics, tumor microenvironment, tissue absorption
MeSH terms: Antineoplastic Agents, Biological Transport, Blood Vessels, Humans, Neoplasms, Drug Delivery Systems

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