Transport of drugs from blood vessels to tumour tissue

Bevacizumab plus Irinotecan, Fluorouracil, and Leucovorin for Metastatic Colorectal Cancer

Hurwitz, H., Fehrenbacher, L., Novotny, W., Cartwright, T., Hainsworth, J., Heim, W., Berlin, J., Baron, A., Griffing, S., Holmgren, E., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa032691 · Cited by 10,968

Tumor angiogenesis: therapeutic implications

Sherwood, L. M., Parris, E. E., & Folkman, J. (1971) · New England Journal of Medicine · doi:10.1056/nejm197111182852108 · Cited by 10,187

Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review

Maeda, H., Wu, J., Sawa, T., Matsumura, Y., & Hori, K. (2000) · Journal of Controlled Release · doi:10.1016/s0168-3659(99)00248-5 · Cited by 6,565

Normalization of Tumor Vasculature: An Emerging Concept in Antiangiogenic Therapy

Jain, R. K. (2005) · Science · doi:10.1126/science.1104819 · Cited by 5,527

Tumor Cells Secrete a Vascular Permeability Factor That Promotes Accumulation of Ascites Fluid

Senger, D. R., Galli, S. J., Dvořàk, A. M., Perruzzi, C. A., Harvey, V. S., & Dvorak, H. F. (1983) · Science · doi:10.1126/science.6823562 · Cited by 3,969

Targeting multidrug resistance in cancer

Szakács, G., Paterson, J. K., Ludwig, J. A., Booth-Genthe, C., & Gottesman, M. M. (2006) · Nature Reviews Drug Discovery · doi:10.1038/nrd1984 · Cited by 3,609

Targeting hypoxia in cancer therapy

Wilson, W. R., & Hay, M. P. (2011) · Nature Reviews Cancer · doi:10.1038/nrc3064 · Cited by 3,172

Inhibition of Hedgehog signaling enhances delivery of chemotherapy in a mouse model of pancreatic cancer

Olive, K. P., Jacobetz, M. A., Davidson, C. J., Gopinathan, A., McIntyre, D., Honess, D., Madhu, B., Goldgraben, M. A., Caldwell, M. E., Allard, D., et al. (2009) · Science · doi:10.1126/science.1171362 · Cited by 3,170

Cancer nanotechnology: The impact of passive and active targeting in the era of modern cancer biology

Bertrand, N., Wu, J., Xu, X., Kamaly, N., & Farokhzad, O. C. (2013) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2013.11.009 · Cited by 2,925

Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues.

Thiebaut, F., Tsuruo, T., Hamada, H., Gottesman, M., Pastan, I., & Willingham, M. (1987) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.84.21.7735 · Cited by 2,823

Drug penetration in solid tumours

Minchinton, A. I., & Tannock, I. F. (2006) · Nature reviews. Cancer · doi:10.1038/nrc1893 · Cited by 2,805

The blood-brain barrier: Bottleneck in brain drug development

Pardridge, W. M. (2005) · NeuroRX · doi:10.1602/neurorx.2.1.3 · Cited by 2,798

Transplacental Carcinogenesis by Stilbestrol

Folkman, J. (1971) · New England Journal of Medicine · doi:10.1056/nejm197108122850711 · Cited by 2,640

Hypoxia in cancer: significance and impact on clinical outcome

Vaupel, P., & Mayer, A. (2007) · Cancer and Metastasis Reviews · doi:10.1007/s10555-007-9055-1 · Cited by 2,240

The Histological Structure of Some Human Lung Cancers and the Possible Implications for Radiotherapy

Thomlinson, R. H., & Gray, L. H. (1955) · British Journal of Cancer · doi:10.1038/bjc.1955.55 · Cited by 2,228

Enzymatic targeting of the stroma ablates physical barriers to treatment of pancreatic ductal adenocarcinoma

Provenzano, P. P., Cuevas, C., Chang, A. E., Goel, V. K., Von Hoff, D. D., & Hingorani, S. R. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.01.007 · Cited by 2,195

Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer

Willett, C. G., Boucher, Y., di Tomaso, E., Duda, D. G., Munn, L. L., Tong, R. T., Chung, D. C., Sahani, D. V., Kalva, S. P., Kozin, S. V., et al. (2004) · Nature Medicine · doi:10.1038/nm988 · Cited by 1,985

Role of PDGF-B and PDGFR-β in recruitment of vascular smooth muscle cells and pericytes during embryonic blood vessel formation in the mouse

Hellström, M., Kalén, M., Lindahl, P., Abramsson, A., & Betsholtz, C. (1999) · Development · doi:10.1242/dev.126.14.3047 · Cited by 1,734

Vascular permeability in a human tumor xenograft: molecular size dependence and cutoff size.

Yuan, F., Dellian, M., Fukumura, D., Leunig, M., Berk, D. A., Torchilin, V. P., & Jain, R. K. (1995) · PubMed · Cited by 1,706

Interstitial pH and pO2 gradients in solid tumors in vivo: High-resolution measurements reveal a lack of correlation

Helmlinger, G., Yuan, F., Dellian, M., & Jain, R. K. (1997) · Nature Medicine · doi:10.1038/nm0297-177 · Cited by 1,651

Antiangiogenesis Strategies Revisited: From Starving Tumors to Alleviating Hypoxia

Jain, R. K. (2014) · Cancer Cell · doi:10.1016/j.ccell.2014.10.006 · Cited by 1,589

Challenges and Key Considerations of the Enhanced Permeability and Retention Effect for Nanomedicine Drug Delivery in Oncology

Prabhakar, U., Maeda, H., Jain, R. K., Sevick-Muraca, E. M., Zamboni, W. C., Farokhzad, O. C., Barry, S. T., Gabizón, A., Grodzinski, P. A., & Blakey, D. C. (2013) · Cancer Research · doi:10.1158/0008-5472.can-12-4561 · Cited by 1,493

Transport of molecules in the tumor interstitium: a review.

Jain, R. K. (1987) · PubMed · Cited by 1,357

Normalizing Tumor Microenvironment to Treat Cancer: Bench to Bedside to Biomarkers

Jain, R. K. (2013) · Journal of Clinical Oncology · doi:10.1200/jco.2012.46.3653 · Cited by 1,248

Vascular Normalization by Vascular Endothelial Growth Factor Receptor 2 Blockade Induces a Pressure Gradient Across the Vasculature and Improves Drug Penetration in Tumors

Tong, R. T., Boucher, Y., Kozin, S. V., Winkler, F., Hicklin, D. J., & Jain, R. K. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-0074 · Cited by 1,189

Kinetics of vascular normalization by VEGFR2 blockade governs brain tumor response to radiation

Winkler, F., Kozin, S. V., Tong, R. T., Chae, S.-S., Booth, M. F., Garkavtsev, I., Xu, L., Hicklin, D. J., Fukumura, D., di Tomaso, E., et al. (2004) · Cancer Cell · doi:10.1016/j.ccr.2004.10.011 · Cited by 1,170

Holland-Frei Cancer Medicine

(2016) · Wiley eBooks · doi:10.1002/9781119000822 · Cited by 1,154

Hyaluronan impairs vascular function and drug delivery in a mouse model of pancreatic cancer

Jacobetz, M. A., Chan, D. S., Neesse, A., Bapiro, T. E., Cook, N., Frese, K. K., Feig, C., Nakagawa, T., Caldwell, M. E., Zecchini, H. I., et al. (2013) · Gut · doi:10.1136/gutjnl-2012-302529 · Cited by 1,120

Normalization of tumour blood vessels improves the delivery of nanomedicines in a size-dependent manner

Chauhan, V. P., Stylianopoulos, T., Martin, J. D., Popović, Z., Chen, O., Kamoun, W. S., Bawendi, M. G., Fukumura, D., & Jain, R. K. (2012) · Nature Nanotechnology · doi:10.1038/nnano.2012.45 · Cited by 1,101

Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy response

Dewhirst, M. W., Cao, Y., & Moeller, B. (2008) · Nature Reviews Cancer · doi:10.1038/nrc2397 · Cited by 1,022

Design of Liposomes for Enhanced Local Release of Drugs by Hyperthermia

Yatvin, M. B., Weinstein, J. N., Dennis, W. H., & Blumenthal, R. P. (1978) · Science · doi:10.1126/science.364652 · Cited by 959

Causes, consequences, and remedies for growth-induced solid stress in murine and human tumors

Stylianopoulos, T., Martin, J. D., Chauhan, V. P., Jain, S. R., Diop-Frimpong, B., Bardeesy, N., Smith, B. L., Ferrone, C. R., Hornicek, F. J., Boucher, Y., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1213353109 · Cited by 943

Tumor Vascular Permeability, Accumulation, and Penetration of Macromolecular Drug Carriers

Dreher, M. R., Liu, W., Michelich, C. R., Dewhirst, M. W., Yuan, F., & Chilkoti, A. (2006) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djj070 · Cited by 911

Microvascular permeability and interstitial penetration of sterically stabilized (stealth) liposomes in a human tumor xenograft.

Yuan, F., Leunig, M., Huang, S. K., Berk, D. A., Papahadjopoulos, D., & Jain, R. K. (1994) · PubMed · Cited by 908

Transport of fluid and macromolecules in tumors. I. Role of interstitial pressure and convection

Baxter, L. T., & Jain, R. K. (1989) · Microvascular Research · doi:10.1016/0026-2862(89)90074-5 · Cited by 899

Transport of molecules across tumor vasculature

Jain, R. K. (1987) · Cancer and Metastasis Reviews · doi:10.1007/bf00047468 · Cited by 869

Strategies for advancing cancer nanomedicine

Chauhan, V. P., & Jain, R. K. (2013) · Nature Materials · doi:10.1038/nmat3792 · Cited by 821

Relationship of octanol/water partition coefficient and molecular weight to rat brain capillary permeability

Levin, V. A. (1980) · Journal of Medicinal Chemistry · doi:10.1021/jm00180a022 · Cited by 817

A new temperature-sensitive liposome for use with mild hyperthermia: characterization and testing in a human tumor xenograft model.

Needham, D., Anyarambhatla, G., Kong, G., & Dewhirst, M. W. (2000) · PubMed · Cited by 746

Losartan inhibits collagen I synthesis and improves the distribution and efficacy of nanotherapeutics in tumors

Diop-Frimpong, B., Chauhan, V. P., Krane, S., Boucher, Y., & Jain, R. K. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1018892108 · Cited by 733

Time-dependent vascular regression and permeability changes in established human tumor xenografts induced by an anti-vascular endothelial growth factor/vascular permeability factor antibody

Yuan, F., Chen, Y., Dellian, M., Safabakhsh, N., Ferrara, N., & Jain, R. K. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.25.14765 · Cited by 719

Hyperthermia enables tumor-specific nanoparticle delivery: effect of particle size.

Kong, G., Braun, R. D., & Dewhirst, M. W. (2000) · PubMed · Cited by 630

Effect of local hyperthermia on blood flow and microenvironment: a review.

Song, C. W. (1984) · PubMed · Cited by 628

Delivery of Molecular and Nanoscale Medicine to Tumors: Transport Barriers and Strategies

Chauhan, V. P., Stylianopoulos, T., Boucher, Y., & Jain, R. K. (2011) · Annual Review of Chemical and Biomolecular Engineering · doi:10.1146/annurev-chembioeng-061010-114300 · Cited by 597

Antibody-Maytansinoid Conjugates Are Activated in Targeted Cancer Cells by Lysosomal Degradation and Linker-Dependent Intracellular Processing

Erickson, H. K., Park, P. U., Widdison, W. C., Kovtun, Y., Garrett, L. M., Hoffman, K. L., Lutz, R. J., Goldmacher, V. S., & Blättler, W. A. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-4489 · Cited by 586

Self-assembling chimeric polypeptide–doxorubicin conjugate nanoparticles that abolish tumours after a single injection

MacKay, J. A., Chen, M., McDaniel, J. R., Liu, W., Simnick, A. J., & Chilkoti, A. (2009) · Nature Materials · doi:10.1038/nmat2569 · Cited by 582

Endothelial and nonendothelial sources of PDGF-B regulate pericyte recruitment and influence vascular pattern formation in tumors

Abramsson, A., Lindblom, P., & Betsholtz, C. (2003) · Journal of Clinical Investigation · doi:10.1172/jci18549 · Cited by 578

An Introduction to Cardiovascular Physiology

(1991) · Elsevier eBooks · doi:10.1016/c2013-0-06523-1 · Cited by 558

Site-Specific Antibody–Drug Conjugates: The Nexus of Bioorthogonal Chemistry, Protein Engineering, and Drug Development

Agarwal, P., & Bertozzi, C. (2014) · Bioconjugate chemistry · doi:10.1021/bc5004982 · Cited by 534

Antibody-drug conjugates—an emerging class of cancer treatment

Diamantis, N., & Banerji, U. (2016) · British Journal of Cancer · doi:10.1038/bjc.2015.435 · Cited by 526

Efficacy of liposomes and hyperthermia in a human tumor xenograft model: importance of triggered drug release.

Kong, G., Anyarambhatla, G., Petros, W. P., Braun, R. D., Colvin, O. M., Needham, D., & Dewhirst, M. W. (2000) · PubMed · Cited by 505

Microvascular architecture in a mammary carcinoma: branching patterns and vessel dimensions.

Less, J. R., Skalak, T. C., Sevick, E., & Jain, R. K. (1991) · PubMed · Cited by 501

The distribution of the anticancer drug Doxorubicin in relation to blood vessels in solid tumors

Primeau, A. J., Rendon, A., Hedley, D., Lilge, L., & Tannock, I. F. (2005) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-05-1664 · Cited by 499

Antibody–drug conjugates: current status and future directions

Perez, H. L., Cardarelli, P. M., Deshpande, S. V., Gangwar, S., Schroeder, G. M., Vite, G. D., & Borzilleri, R. M. (2013) · Drug Discovery Today · doi:10.1016/j.drudis.2013.11.004 · Cited by 486

Endothelial and nonendothelial sources of PDGF-B regulate pericyte recruitment and influence vascular pattern formation in tumors

Abramsson, A., Lindblom, P., & Betsholtz, C. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200318549 · Cited by 479

Overcoming Limitations in Nanoparticle Drug Delivery: Triggered, Intravascular Release to Improve Drug Penetration into Tumors

Manzoor, A. A., Lindner, L. H., Landon, C. D., Park, J. Y., Simnick, A. J., Dreher, M. R., Das, S. K., Hanna, G., Park, W., Chilkoti, A., et al. (2012) · Cancer Research · doi:10.1158/0008-5472.can-12-1683 · Cited by 459

Inhibition of platelet-derived growth factor receptors reduces interstitial hypertension and increases transcapillary transport in tumors.

Pietras, K., Östman, A., SJÖQUIST, M., Buchdunger, E., Reed, R. K., Heldin, C., & Rubin, K. (2001) · PubMed · Cited by 449

Bevacizumab-Induced Transient Remodeling of the Vasculature in Neuroblastoma Xenografts Results in Improved Delivery and Efficacy of Systemically Administered Chemotherapy

Dickson, P. V., Hamner, J. B., Sims, T. L., Fraga, C. H., Ng, C. Y., Rajasekeran, S., Hagedorn, N. L., McCarville, M. B., Stewart, C. F., & Davidoff, A. M. (2007) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-07-0278 · Cited by 445

Tumour‐associated macrophages act as a slow‐release reservoir of nano‐therapeutic Pt(IV) pro‐drug

Miller, M. A., Zheng, Y.-R., Gadde, S., Pfirschke, C., Zope, H., Engblom, C., Kohler, R. H., Iwamoto, Y., Yang, K. S., Askevold, B., et al. (2015) · Nature Communications · doi:10.1038/ncomms9692 · Cited by 441

Tie2 Expression and Phosphorylation in Angiogenic and Quiescent Adult Tissues

Wong, A. L., Haroon, Z. A., Werner, S., Dewhirst, M. W., Greenberg, C. S., & Peters, K. G. (1997) · Circulation Research · doi:10.1161/01.res.81.4.567 · Cited by 417

Direct measurement of interstitial convection and diffusion of albumin in normal and neoplastic tissues by fluorescence photobleaching.

Chary, S. R., & Jain, R. K. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.14.5385 · Cited by 412

Diffusion and convection in normal and neoplastic tissues.

Swabb, E. A., Wei, J., & Gullino, P. M. (1974) · PubMed · Cited by 399

64Cu-MM-302 Positron Emission Tomography Quantifies Variability of Enhanced Permeability and Retention of Nanoparticles in Relation to Treatment Response in Patients with Metastatic Breast Cancer

Lee, H., Shields, A. F., Siegel, B. A., Miller, K. D., Krop, I. E., Ma, C. X., LoRusso, P. M., Münster, P. N., Campbell, K., Gaddy, D. F., et al. (2017) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-16-3193 · Cited by 397

Clinical Radiation Oncology

Gunderson, L. L., Tepper, J. E., & Bogart, J. A. (2016) · Elsevier eBooks · doi:10.1016/c2013-0-00648-2 · Cited by 381

Increased microvascular permeability contributes to preferential accumulation of Stealth liposomes in tumor tissue.

Wu, N. Z., Da, D., Rudoll, T. L., Needham, D., Whorton, A. R., & Dewhirst, M. W. (1993) · PubMed · Cited by 364

Liposomes and Local Hyperthermia: Selective Delivery of Methotrexate to Heated Tumors

Weinstein, J. N., Magin, R. L., Yatvin, M. B., & Zaharko, D. S. (1979) · Science · doi:10.1126/science.432641 · Cited by 363

Hyperthermia-triggered drug delivery from temperature-sensitive liposomes using MRI-guided high intensity focused ultrasound

Grüll, H., & Langereis, S. (2012) · Journal of Controlled Release · doi:10.1016/j.jconrel.2012.04.041 · Cited by 361

Fluctuations in red cell flux in tumor microvessels can lead to transient hypoxia and reoxygenation in tumor parenchyma.

Kimura, H., Braun, R. D., Ong, E. T., Hsu, R., Secomb, T. W., Papahadjopoulos, D., Hong, K., & Dewhirst, M. W. (1996) · PubMed · Cited by 358

Predicting therapeutic nanomedicine efficacy using a companion magnetic resonance imaging nanoparticle

Miller, M. A., Gadde, S., Pfirschke, C., Engblom, C., Sprachman, M. M., Köhler, R. H., Yang, K. S., Laughney, A. M., Wojtkiewicz, G. R., Kamaly, N., et al. (2015) · Science Translational Medicine · doi:10.1126/scitranslmed.aac6522 · Cited by 349

Untitled work

(1999) · PubMed · Cited by 348

Phase Ib Study of PEGylated Recombinant Human Hyaluronidase and Gemcitabine in Patients with Advanced Pancreatic Cancer

Hingorani, S. R., Harris, W. P., Beck, J. T., Berdov, B. A., Wagner, S. A., Pshevlotsky, E. M., Tjulandin, S., Gladkov, O. A., Holcombe, R. F., Korn, R. L., et al. (2016) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-15-2010 · Cited by 339

TGF-β blockade improves the distribution and efficacy of therapeutics in breast carcinoma by normalizing the tumor stroma

Liu, J., Liao, S., Diop-Frimpong, B., Chen, W., Goel, S., Naxerova, K., Ancukiewicz, M., Boucher, Y., Jain, R. K., & Xu, L. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1117610109 · Cited by 332

Modulation of murine breast tumor vascularity, hypoxia and chemotherapeutic response by exercise

Betof, A. S., Lascola, C. D., Weitzel, D., Landon, C., Scarbrough, P. M., Devi, G. R., Palmer, G., Jones, L. W., & Dewhirst, M. W. (2015) · JNCI: Journal of the National Cancer Institute · doi:10.1093/jnci/djv040 · Cited by 309

Differential response of normal and tumor microcirculation to hyperthermia.

Dudar, T. E., & Jain, R. K. (1984) · PubMed · Cited by 307

Increased Survival of Glioblastoma Patients Who Respond to Antiangiogenic Therapy with Elevated Blood Perfusion

Sorensen, A. G., Emblem, K. E., Polaskova, P., Jennings, D. L., Kim, H., Ancukiewicz, M., Wang, M., Wen, P. Y., Ivy, P. S., Batchelor, T. T., et al. (2011) · Cancer Research · doi:10.1158/0008-5472.can-11-2464 · Cited by 298

Enzymatic Depletion of Tumor Hyaluronan Induces Antitumor Responses in Preclinical Animal Models

Thompson, C. B., Shepard, H. M., O'Connor, P. M., Kadhim, S., Jiang, P., Osgood, R. J., Bookbinder, L. H., Li, X., Sugarman, B. J., Connor, R. J., et al. (2010) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-10-0470 · Cited by 298

Gap Junctions in the Control of Vascular Function

Figueroa, X. F., & Duling, B. R. (2008) · Antioxidants and Redox Signaling · doi:10.1089/ars.2008.2117 · Cited by 297

Design considerations for nanotherapeutics in oncology

Stylianopoulos, T., & Jain, R. K. (2015) · Nanomedicine Nanotechnology Biology and Medicine · doi:10.1016/j.nano.2015.07.015 · Cited by 293

The first metazoa living in permanently anoxic conditions

Danovaro, R., Dell’Anno, A., Pusceddu, A., Gambi, C., Heiner, I., & Kristensen, R. M. (2010) · BMC Biology · doi:10.1186/1741-7007-8-30 · Cited by 291

An injectable nanoparticle generator enhances delivery of cancer therapeutics

Xu, R., Zhang, G., Mai, J., Deng, X., Segura-Ibarra, V., Wu, S., Shen, J., Liu, H., Hu, Z., Chen, L., et al. (2016) · Nature Biotechnology · doi:10.1038/nbt.3506 · Cited by 278

Review Hyperthermia and liposomes

Kong, M.-Q. (1999) · International Journal of Hyperthermia · doi:10.1080/026567399285558 · Cited by 277

Noninvasive optical imaging of apoptosis by caspase-targeted activity-based probes

Edgington‐Mitchell, L. E., Berger, A. B., Blum, G., Albrow, V. E., Paulick, M. G., Lineberry, N. B., & Bogyo, M. S. (2009) · Nature Medicine · doi:10.1038/nm.1938 · Cited by 276

Structural adaptation and stability of microvascular networks: theory and simulations

Pries, A. R., Secomb, T. W., & Gaehtgens, P. A. L. (1998) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1998.275.2.h349 · Cited by 276

Delivery of molecular and cellular medicine to solid tumors

Jain, R. K. (1997) · Advanced Drug Delivery Reviews · doi:10.1016/s0169-409x(97)00027-6 · Cited by 274

Magnetic Resonance Imaging of Temperature-Sensitive Liposome Release: Drug Dose Painting and Antitumor Effects

Ponce, A. M., Viglianti, B. L., Yu, D., Yarmolenko, P., Michelich, C. R., Woo, J., Bally, M. B., & Dewhirst, M. W. (2007) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djk005 · Cited by 273

Thermosensitive liposomes: Extravasation and release of contents in tumor microvascular networks

Gaber, M. H., Wu, N. Z., Hong, K., Huang, S. K., Dewhirst, M. W., & Papahadjopoulos, D. (1996) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/s0360-3016(96)00389-6 · Cited by 271

Image-guided drug delivery with magnetic resonance guided high intensity focused ultrasound and temperature sensitive liposomes in a rabbit Vx2 tumor model

Ranjan, A., Jacobs, G. C., Woods, D. L., Negussie, A. H., Partanen, A., Yarmolenko, P. S., Gacchina, C. E., Sharma, K. V., Frenkel, V., Wood, B. J., et al. (2012) · Journal of Controlled Release · doi:10.1016/j.jconrel.2011.12.011 · Cited by 267

The shunt problem: control of functional shunting in normal and tumour vasculature

Pries, A. R., Höpfner, M., le Noble, F. A. C., Dewhirst, M. W., & Secomb, T. W. (2010) · Nature reviews. Cancer · doi:10.1038/nrc2895 · Cited by 264

Delivery of Molecular and Cellular Medicine to Solid Tumors

Jain, R. K. (1997) · Microcirculation · doi:10.3109/10739689709148314 · Cited by 260

INTRODUCTION TO CARDIOVASCULAR PHYSIOLOGY

Mulroney, S. E., & Myers, A. K. (2009) · Elsevier eBooks · doi:10.1016/b978-1-4160-4196-2.50017-4 · Cited by 259

Inhibition of tumor angiogenesis using a soluble receptor establishes a role for Tie2 in pathologic vascular growth.

Lin, P., Polverini, P. J., Dewhirst, M. W., Shan, S., Rao, P. S., & Peters, K. G. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119740 · Cited by 252

Temporal changes of lysosome and phagosome pH during phagolysosome formation in macrophages: studies by fluorescence spectroscopy.

Geisow, M. J., Hart, P. D., & Young, M. R. (1981) · The Journal of Cell Biology · doi:10.1083/jcb.89.3.645 · Cited by 248

Relationships between Cycling Hypoxia, HIF-1, Angiogenesis and Oxidative Stress

Dewhirst, M. W. (2009) · Radiation Research · doi:10.1667/rr1926.1 · Cited by 228

Compression of Pancreatic Tumor Blood Vessels by Hyaluronan Is Caused by Solid Stress and Not Interstitial Fluid Pressure

Chauhan, V. P., Boucher, Y., Ferrone, C. R., Roberge, S., Martin, J. D., Stylianopoulos, T., Bardeesy, N. M., DePinho, R. A., Padera, T. P., Munn, L. L., et al. (2014) · Cancer Cell · doi:10.1016/j.ccr.2014.06.003 · Cited by 210

Analysis of oxygen transport to tumor tissue by microvascular networks

Secomb, T. W., Hsu, R., Dewhirst, M. W., Klitzman, B. M., & Gross, J. F. (1993) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/0360-3016(93)90070-c · Cited by 204

Tumor vessel normalization after aerobic exercise enhances chemotherapeutic efficacy

Schadler, K. L., Thomas, N. J., Galie, P. A., Bhang, D. H., Roby, K. C., Addai, P., Till, J. E., Sturgeon, K., Zaslavsky, A., Chen, C. S., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.11748 · Cited by 199

In vivo monitoring of tissue pharmacokinetics of liposome/drug using MRI: Illustration of targeted delivery

Viglianti, B. L., Abraham, S. A., Michelich, C. R., Yarmolenko, P., MacFall, J. R., Bally, M. B., & Dewhirst, M. W. (2004) · Magnetic Resonance in Medicine · doi:10.1002/mrm.20074 · Cited by 192

Thrombospondin‐1 inhibits VEGF levels in the ovary directly by binding and internalization via the low density lipoprotein receptor‐related protein‐1 (LRP‐1)

Greenaway, J. B., Lawler, J., Moorehead, R. A., BORNSTEIN, P. K., LaMarre, J., & Petrik, J. (2006) · Journal of Cellular Physiology · doi:10.1002/jcp.20904 · Cited by 187

Quantification of longitudinal tissue pO2 gradients in window chamber tumours: impact on tumour hypoxia

Dewhirst, M. W., Ong, E. T., Braun, R. D., Smith, B., Klitzman, B. M., Evans, S. M., & Wilson, D. F. (1999) · British Journal of Cancer · doi:10.1038/sj.bjc.6690273 · Cited by 187

Transport properties of pancreatic cancer describe gemcitabine delivery and response

Koay, E. J., Truty, M. J., Cristini, V., Thomas, R. M., Chen, R., Chatterjee, D., Kang, Y., Bhosale, P. R., Tamm, E. P., Crane, C. H., et al. (2014) · Journal of Clinical Investigation · doi:10.1172/jci73455 · Cited by 184

Scaling rules for diffusive drug delivery in tumor and normal tissues

Baish, J. W., Stylianopoulos, T., Lanning, R. M., Kamoun, W. S., Fukumura, D., Munn, L. L., & Jain, R. K. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1018154108 · Cited by 182

Discovery of an enzyme and substrate selective inhibitor of ADAM10 using an exosite-binding glycosylated substrate

Madoux, F., Dreymüller, D., Pettiloud, J.-P., Santos, R. G., Becker‐Pauly, C., Ludwig, A., Fields, G. B., Bannister, T. D., Spicer, T., Čudić, M., et al. (2016) · Scientific Reports · doi:10.1038/s41598-016-0013-4 · Cited by 181

What brings pericytes to tumor vessels?

Jain, R. K., & Booth, M. F. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200320087 · Cited by 178

Geometric resistance to blood flow in solid tumors perfused ex vivo: effects of tumor size and perfusion pressure.

Sevick, E., & Jain, R. K. (1989) · PubMed · Cited by 175

Intratumor partitioning and texture analysis of dynamic contrast‐enhanced (DCE)‐MRI identifies relevant tumor subregions to predict pathological response of breast cancer to neoadjuvant chemotherapy

Wu, J., Gong, G., Cui, Y., & Li, R. (2016) · Journal of Magnetic Resonance Imaging · doi:10.1002/jmri.25279 · Cited by 165

Effect of aerobic exercise on tumor physiology in an animal model of human breast cancer

Jones, L. W., Viglianti, B. L., Tashjian, J. A., Kothadia, S. M., Keir, S. T., Freedland, S. J., Potter, M. Q., Moon, E. J., Schroeder, T., Herndon, J. E., et al. (2009) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00424.2009 · Cited by 156

Exercise modulation of the host-tumor interaction in an orthotopic model of murine prostate cancer

Jones, L. W., Antonelli, J. A., Masko, E. M., Broadwater, G., Lascola, C. D., Fels, D. R., Dewhirst, M. W., Dyck, J. R. B., Nagendran, J., Flores, C., et al. (2012) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01575.2011 · Cited by 154

Morphologic and hemodynamic comparison of tumor and healing normal tissue microvasculature

Dewhirst, M. W., Tso, C. Y., Oliver, R., Gustafson, C. S., Secomb, T. W., & Gross, J. F. (1989) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/0360-3016(89)90375-1 · Cited by 153

Use of Three-Dimensional Tissue Cultures to Model Extravascular Transport and Predict In Vivo Activity of Hypoxia-Targeted Anticancer Drugs

Hicks, K. O., Pruijn, F. B., Secomb, T. W., Hay, M. P., Hsu, R., Brown, J. M., Denny, W. A., Dewhirst, M. W., & Wilson, W. R. (2006) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djj306 · Cited by 153

Comparative effects of thermosensitive doxorubicin-containing liposomes and hyperthermia in human and murine tumours

Yarmolenko, P., Zhao, Y., Landon, C. D., Spasojević, I., Yuan, F., Needham, D., Viglianti, B. L., & Dewhirst, M. W. (2010) · International Journal of Hyperthermia · doi:10.3109/02656731003789284 · Cited by 150

Microvascular blood flow: evidence indicating a cubic dependence on arteriolar diameter

MAYROVITZ, H. N., & Roy, J. (1983) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.1983.245.6.h1031 · Cited by 149

Tumor-Associated Hyaluronan Limits Efficacy of Monoclonal Antibody Therapy

Singha, N. C., Nekoroski, T., Zhao, C., Symons, R. C., Jiang, P., Frost, G. I., Huang, Z., & Shepard, H. M. (2014) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-14-0580 · Cited by 145

What brings pericytes to tumor vessels?

Jain, R. K., & Booth, M. F. (2003) · Journal of Clinical Investigation · doi:10.1172/jci20087 · Cited by 143

Viscous resistance to blood flow in solid tumors: effect of hematocrit on intratumor blood viscosity.

Sevick, E., & Jain, R. K. (1989) · PubMed · Cited by 134

Temperature-dependent changes in physiologic parameters of spontaneous canine soft tissue sarcomas after combined radiotherapy and hyperthermia treatment

Vujašković, Ž., Poulson, J. M., Gaskin, A. A., Thrall, D. Ε., Page, R. L., Charles, H. C., MacFall, J. R., Brizel, D. M., Meyer, R. E., Prescott, D. M., et al. (2000) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/s0360-3016(99)00362-4 · Cited by 134

Therapeutically engineered induced neural stem cells are tumour-homing and inhibit progression of glioblastoma

Bagó, J. R., Alfonso-Pecchio, A. R., Okolie, O., Dumitru, R., Rinkenbaugh, A. L., Baldwin, A. S., Miller, C. R., Magness, S. T., & Hingtgen, S. (2016) · Nature Communications · doi:10.1038/ncomms10593 · Cited by 129

Tumor Priming Enhances Delivery and Efficacy of Nanomedicines

Lü, D., Wientjes, M. G., Lu, Z., & Au, J. L. ‐. (2007) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.107.121632 · Cited by 127

Bevacizumab-Induced Normalization of Blood Vessels in Tumors Hampers Antibody Uptake

Arjaans, M., Munnink, T. H. O., Oosting, S. F., van Scheltinga, A. G. T. T., Gietema, J. A., Garbacik, E. T., Timmer‐Bosscha, H., Hooge, M. N. L., Schroder, C. P., & de Vries, E. G. E. (2013) · Cancer Research · doi:10.1158/0008-5472.can-12-3518 · Cited by 124

Effects of Vascular-Endothelial Protein Tyrosine Phosphatase Inhibition on Breast Cancer Vasculature and Metastatic Progression

Goel, S., Gupta, N., Walcott, B. P., Snuderl, M., Kesler, C. T., Kirkpatrick, N. D., Heishi, T., Huang, Y., Martin, J. D., Ager, E., et al. (2013) · JNCI: Journal of the National Cancer Institute · doi:10.1093/jnci/djt164 · Cited by 117

Transforming growth factor-beta signaling and tumor angiogenesis

Pardali, E. (2009) · Frontiers in bioscience · doi:10.2741/3573 · Cited by 117

The structure of the vascular network of tumors

Ribatti, D., Nico, B., Enrico Crivellato, B., & Vacca, A. (2006) · Cancer Letters · doi:10.1016/j.canlet.2006.06.007 · Cited by 117

Gold Nanoparticle–Mediated Targeted Delivery of Recombinant Human Endostatin Normalizes Tumour Vasculature and Improves Cancer Therapy

Li, W., Zhao, X., Du, B., Li, X., Liu, S., Yang, X., Ding, H., Yang, W., Pan, F., Wu, X., et al. (2016) · Scientific Reports · doi:10.1038/srep30619 · Cited by 116

Biodistribution of cisplatin revealed by imaging mass cytometry identifies extensive collagen binding in tumor and normal tissues

Chang, Q., Ornatsky, O., Siddiqui, I. F. S., Straus, R., Baranov, V. I., & Hedley, D. W. (2016) · Scientific Reports · doi:10.1038/srep36641 · Cited by 116

Tumour Hypoxia: The Picture Has Changed in the 1990s

Brown, J., & Giaccia, A. J. (1994) · International Journal of Radiation Biology · doi:10.1080/09553009414550131 · Cited by 114

Two phase I dose-escalation/pharmacokinetics studies of low temperature liposomal doxorubicin (LTLD) and mild local hyperthermia in heavily pretreated patients with local regionally recurrent breast cancer

Zagar, T. M., Vujašković, Ž., Formenti, S. C., Rugo, H. S., Muggia, F. M., O'Connor, B. M., Myerson, R. J., Stauffer, P. R., Hsu, I.-C. J., Diederich, C. J., et al. (2014) · International Journal of Hyperthermia · doi:10.3109/02656736.2014.936049 · Cited by 111

Blood flow in normal tissues and tumors during hyperthermia.

Song, C. W., Rhee, J. G., & Levitt, S. H. (1980) · PubMed · Cited by 110

Perivascular Oxygen Tensions in a Transplantable Mammary Tumor Growing in a Dorsal Flap Window Chamber

Dewhirst, M. W., Ong, E. T., Klitzman, B. M., Secomb, T. W., Vinuya, R. Z., Dodge, R. K., Brizel, D. M., & Gross, J. F. (1992) · Radiation Research · doi:10.2307/3578274 · Cited by 109

Effect of Pazopanib on Tumor Microenvironment and Liposome Delivery

Tailor, T. D., Hanna, G., Yarmolenko, P., Dreher, M. R., Warner, A. B., Nixon, A. B., Spasojević, I., & Dewhirst, M. W. (2010) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-09-0856 · Cited by 106

Lyso-Thermosensitive Liposomal Doxorubicin: An Adjuvant to Increase The Cure Rate of Radiofrequency Ablation in Liver Cancer

Poon, R. T. P., & Borys, N. (2011) · Future Oncology · doi:10.2217/fon.11.73 · Cited by 100

Determination of local oxygen consumption rates in tumors.

Dewhirst, M. W., Secomb, T. W., Ong, E. T., Hsu, R., & Gross, J. F. (1994) · PubMed · Cited by 99

A Mechanistic Tumor Penetration Model to Guide Antibody Drug Conjugate Design

Vasalou, C., Helmlinger, G., & Gomes, B. (2015) · PLOS ONE · doi:10.1371/journal.pone.0118977 · Cited by 98

Available volume fraction of macromolecules in the extravascular space of a fibrosarcoma: implications for drug delivery.

Krol, A., Maresca, J., Dewhirst, M. W., & Yuan, F. (1999) · PubMed · Cited by 97

Hyperthermia increases accumulation of technetium-99m-labeled liposomes in feline sarcomas.

Matteucci, M. L., Anyarambhatla, G., Rosner, G. L., Azuma, C., Fisher, P. E., Dewhirst, M. W., Needham, D., & Thrall, D. Ε. (2000) · PubMed · Cited by 96

Capillary-wall collagen as a biophysical marker of nanotherapeutic permeability into the tumor microenvironment

Yokoi, K., Kojic, M., Milosevic, M., Tanei, T., Ferrari, M., & Ziemys, A. (2014) · Cancer Research · doi:10.1158/0008-5472.can-13-3494 · Cited by 95

Enhancement of Paclitaxel Delivery to Solid Tumors by Apoptosis-Inducing Pretreatment: Effect of Treatment Schedule

Jang, S. H., Wientjes, M. G., & Au, J. L. ‐. (2001) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)38848-2 · Cited by 93

Prospective Early Response Imaging Biomarker for Neoadjuvant Breast Cancer Chemotherapy

Lee, K. C., Moffat, B. A., Schott, A. F., Layman, R. M., Ellingworth, S., Juliar, R., Khan, A. P., Helvie, M. A., Meyer, C. R., Chenevert, T. L., et al. (2007) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-06-1888 · Cited by 90

PDGF-D Improves Drug Delivery and Efficacy via Vascular Normalization, But Promotes Lymphatic Metastasis by Activating CXCR4 in Breast Cancer

Liu, J., Liao, S., Huang, Y., Samuel, R., Shi, T., Naxerova, K., Huang, P., Kamoun, W. S., Jain, R. K., Fukumura, D., et al. (2011) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-10-2456 · Cited by 86

A Theoretical Model for Intraperitoneal Delivery of Cisplatin and the Effect of Hyperthermia on Drug Penetration Distance

El-Kareh, A. W., & Secomb, T. W. (2004) · Neoplasia · doi:10.1593/neo.03205 · Cited by 85

Determination of Cellular Processing Rates for a Trastuzumab-Maytansinoid Antibody-Drug Conjugate (ADC) Highlights Key Parameters for ADC Design

Maass, K. F., Kulkarni, C., Betts, A. M., & Wittrup, K. D. (2016) · The AAPS Journal · doi:10.1208/s12248-016-9892-3 · Cited by 85

In depth study on thermosensitive liposomes: Optimizing formulations for tumor specific therapy and in vitro to in vivo relations

Lokerse, W. J. M., Kneepkens, E., ten Hagen, T. L. M., Eggermont, A. M. M., Grüll, H., & Koning, G. A. (2015) · Biomaterials · doi:10.1016/j.biomaterials.2015.12.023 · Cited by 83

Direct Assessment of Drug Penetration into Tissue Using a Novel Application of Three-Dimensional Cell Culture

Kyle, A. H., Huxham, L. A., Chiam, A. S. J., Sim, D. H., & Minchinton, A. I. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-1099 · Cited by 82

Dual role of hexadecylphosphocholine (miltefosine) in thermosensitive liposomes: Active ingredient and mediator of drug release

Lindner, L. H., Hossann, M., Vogeser, M., Teichert, N., Wachholz, K., Eibl, H., Hiddemann, W., & Issels, R. D. (2007) · Journal of Controlled Release · doi:10.1016/j.jconrel.2007.10.009 · Cited by 80

Measurement of capillary filtration coefficient in a solid tumor.

Sevick, E., & Jain, R. K. (1991) · PubMed · Cited by 79

Enhanced delivery of a monoclonal antibody F(ab')2 fragment to subcutaneous human glioma xenografts using local hyperthermia.

Cope, D. A., Dewhirst, M. W., Friedman, H. S., Bigner, D. D., & Zalutsky, M. R. (1990) · PubMed · Cited by 78

Heat-activated thermosensitive liposomal cisplatin (HTLC) results in effective growth delay of cervical carcinoma in mice

Dou, Y. N., Zheng, J., Foltz, W. D., Weersink, R., Chaudary, N., Jaffray, D. A., & Allen, C. J. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.01.009 · Cited by 78

Treatment with Imatinib in NSCLC is associated with decrease of phosphorylated PDGFR-β and VEGF expression, decrease in interstitial fluid pressure and improvement of oxygenation

Vlahovic, G., Rabbani, Z. N., Herndon, J. E., Dewhirst, M. W., & Vujaskovic, Z. (2006) · British Journal of Cancer · doi:10.1038/sj.bjc.6603366 · Cited by 77

Spectral imaging facilitates visualization and measurements of unstable and abnormal microvascular oxygen transport in tumors

Sorg, B. S., Hardee, M. E., Agarwal, N., Moeller, B. J., & Dewhirst, M. W. (2008) · Journal of Biomedical Optics · doi:10.1117/1.2837439 · Cited by 75

Flow characteristics of hepatic tumors at color Doppler sonography: correlation with arteriographic findings.

Numata, K., Tanaka, K., Mitsui, K., Morimoto, M., Inoue, S., & Yonezawa, H. (1993) · American Journal of Roentgenology · doi:10.2214/ajr.160.3.8381573 · Cited by 69

Comparative intracellular uptake of adriamycin and 4'-deoxydoxorubicin by nonsmall cell lung tumor cells in culture and its relationship to cell survival

Kerr, D. J., Kerr, A., Freshney, R. I., & Kaye, S. B. (1986) · Biochemical Pharmacology · doi:10.1016/0006-2952(86)90195-4 · Cited by 68

Mechanistic patient-specific predictive correlation of tumor drug response with microenvironment and perfusion measurements

Pascal, J. A., Bearer, E. L., Wang, Z., Koay, E. J., Curley, S. A., & Vittorio Cristini, C. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1300619110 · Cited by 65

Treatment with imatinib improves drug delivery and efficacy in NSCLC xenografts

Vlahovic, G., Ponce, A. M., Rabbani, Z. N., Salahuddin, F. K., Zgonjanin, L., Spasojević, I., Vujaskovic, Z., & Dewhirst, M. W. (2007) · British Journal of Cancer · doi:10.1038/sj.bjc.6603941 · Cited by 64

Tumor priming using metronomic chemotherapy with neovasculature-targeted, nanoparticulate paclitaxel

Luan, X., Guan, Y., Lovell, J. F., Zhao, M., Lu, Q., Liu, Y., Liu, H.-J., Gao, Y., Dong, X., Yang, S., et al. (2016) · Biomaterials · doi:10.1016/j.biomaterials.2016.04.008 · Cited by 63

Cyclophosphamide-Mediated Tumor Priming for Enhanced Delivery and Antitumor Activity of HER2-Targeted Liposomal Doxorubicin (MM-302)

Geretti, E., Leonard, S. C., Dumont, N., Lee, H., Zheng, J., Souza, R. D., Gaddy, D. F., Espelin, C. W., Jaffray, D. A., Moyo, V. M., et al. (2015) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-15-0314 · Cited by 62

Rational Design of “Heat Seeking” Drug Loaded Polypeptide Nanoparticles That Thermally Target Solid Tumors

McDaniel, J. R., MacEwan, S. R., Li, X., Radford, D. C., Landon, C. D., Dewhirst, M. W., & Chilkoti, A. (2014) · Nano Letters · doi:10.1021/nl5009376 · Cited by 62

An optical and microPET assessment of thermally-sensitive liposome biodistribution in the Met-1 tumor model: Importance of formulation

Paoli, E. E., Kruse, D. E., Seo, J. W., Zhang, H., Kheirolomoom, A., Watson, K. D., Chiu, P., Stahlberg, H., & Ferrara, K. W. (2009) · Journal of Controlled Release · doi:10.1016/j.jconrel.2009.12.010 · Cited by 61

The effect of flunarizine on erythrocyte suspension viscosity under conditions of extreme hypoxia, low pH, and lactate treatment

Kavanagh, B. D., Coffey, B. E., Needham, D., Hochmuth, R. M., & Dewhirst, M. W. (1993) · British Journal of Cancer · doi:10.1038/bjc.1993.134 · Cited by 55

Actively targeting solid tumours with thermoresponsive drug delivery systems that respond to mild hyperthermia

McDaniel, J. R., Dewhirst, M. W., & Chilkoti, A. (2013) · International Journal of Hyperthermia · doi:10.3109/02656736.2013.819999 · Cited by 55

Formulation and optimization of idarubicin thermosensitive liposomes provides ultrafast triggered release at mild hyperthermia and improves tumor response

Lu, T., Lokerse, W. J. M., Seynhaeve, A. L. B., Koning, G. A., & ten Hagen, T. L. M. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.10.056 · Cited by 53

Available Space and Extracellular Transport of Macromolecules: Effects of Pore Size and Connectedness

Yuan, F., Krol, A., & Tong, S. (2001) · Annals of Biomedical Engineering · doi:10.1114/1.1424915 · Cited by 51

A pilot study of the effects of mild systemic heating on human head and neck tumour xenografts: Analysis of tumour perfusion, interstitial fluid pressure, hypoxia and efficacy of radiation therapy

Winslow, T. B., Eranki, A., Ullas, S., Singh, A. K., Repasky, E. A., & Sen, A. (2015) · International Journal of Hyperthermia · doi:10.3109/02656736.2015.1037800 · Cited by 50

Theoretical Models for Drug Delivery to Solid Tumors

El-Kareh, A. W., & Secomb, T. W. (1997) · Critical Reviews in Biomedical Engineering · doi:10.1615/critrevbiomedeng.v25.i6.20 · Cited by 45

Drug delivery to the brain using thermosensitive liposome and local hyperthermia

Kakinuma, K., Tanaka, R., Takahashi, H. E., Sekihara, Y., Watanabe, M., & Kuroki, M. (1996) · International Journal of Hyperthermia · doi:10.3109/02656739609023698 · Cited by 45

Exploiting the promiscuity of imatinib

Lee, S. J., & Wang, J. Y. J. (2009) · Journal of Biology · doi:10.1186/jbiol134 · Cited by 45

Surrogate MRI markers for hyperthermia-induced release of doxorubicin from thermosensitive liposomes in tumors

Peller, M., Willerding, L., Limmer, S., Hossann, M., Dietrich, O., Ingrisch, M., Sroka, R. C., & Lindner, L. H. (2016) · Journal of Controlled Release · doi:10.1016/j.jconrel.2016.06.035 · Cited by 43

Patterns of vasculature in two pairs of related fibrosarcomas in the rat and their relation to tumour responses to single large doses of radiation

Falk, P. (1978) · European Journal of Cancer (1965) · doi:10.1016/0014-2964(78)90187-1 · Cited by 41

Hyperthermic modulation of radiolabelled antibody uptake in a human glioma xenograft and normal tissues

Schuster, J. M., Zalutsky, M. R., Noska, M. A., Dodge, R. K., Friedman, H. S., Bigner, D. D., & Dewhirst, M. W. (1995) · International Journal of Hyperthermia · doi:10.3109/02656739509004948 · Cited by 41

Prediction of Tumour Tissue Diffusion Coefficients of Hypoxia-Activated Prodrugs from Physicochemical Parameters

Pruijn, F. B., Patel, K., Hay, M. P., Wilson, W. R., & Hicks, K. O. (2008) · Australian Journal of Chemistry · doi:10.1071/ch08240 · Cited by 38

Fever-range whole body hyperthermia increases the number of perfused tumor blood vessels and therapeutic efficacy of liposomally encapsulated doxorubicin

Xu, Y., Choi, J. C., Hylander, B. L., Sen, A., Evans, S. S., Kraybill, W. G., & Repasky, E. A. (2007) · International Journal of Hyperthermia · doi:10.1080/02656730701666112 · Cited by 34

Vascularity of primary and metastatic renal cell carcinoma specimens

Aziz, S. A., Sznol, J. A., Adeniran, A., Colberg, J. W., Camp, R. L., & Kluger, H. M. (2013) · Journal of Translational Medicine · doi:10.1186/1479-5876-11-15 · Cited by 34

Selecting the embryo with the highest implantation potential using a data mining based prediction model

Chen, F., Neubourg, D. D., Debrock, S., Peeraer, K., D’Hooghe, T. M., & Spiessens, C. (2016) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-016-0145-1 · Cited by 29

Predicting diffusive transport of cationic liposomes in 3-dimensional tumor spheroids

Wientjes, M. G., Yeung, B. Z., Lu, Z., Wientjes, M. G., & Au, J. L. ‐. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.06.050 · Cited by 27

Tumor priming by Apo2L/TRAIL reduces interstitial fluid pressure and enhances efficacy of liposomal gemcitabine in a patient derived xenograft tumor model

Hylander, B. L., Sen, A., Beachy, S. H., Pitoniak, R., Ullas, S., Gibbs, J. F., Qiu, J., Prey, J. D., Fetterly, G. J., & Repasky, E. A. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.08.047 · Cited by 25

SKLB1002, a novel inhibitor of VEGF receptor 2 signaling, induces vascular normalization to improve systemically administered chemotherapy efficacy

Shen, G., Li, Y., Du, T., Shi, G., Dai, L., Chen, X., Zheng, R., Li, W., Su, X., Zhang, S., et al. (2012) · Neoplasma · doi:10.4149/neo_2012_062 · Cited by 25

Hyperthermia-mediated targeted delivery of thermosensitive liposome-encapsulated melphalan in murine tumors.

Chelvi, T. P., Jain, S. K., & Ralhan, R. (1995) · PubMed · Cited by 23

Systemic anti-tumour effects of local thermally sensitive liposome therapy

Viglianti, B. L., Dewhirst, M. W., Boruta, R. J., Park, J. Y., Landon, C. D., Fontanella, A. N., Guo, J., Manzoor, A. A., Hofmann, C. L., & Palmer, G. M. (2014) · International Journal of Hyperthermia · doi:10.3109/02656736.2014.944587 · Cited by 22

Implications of Increase in Vascular Permeability in Tumors by VEGF: A Commentary on the Pioneering Work of Harold Dvorak

Dewhirst, M. W., & Ashcraft, K. A. (2016) · Cancer Research · doi:10.1158/0008-5472.can-16-1292 · Cited by 22

Phase Ib/II randomized, open-label study of doxorubicin and cyclophosphamide with or without low-dose, short-course sunitinib in the pre-operative treatment of breast cancer

Wong, A. L. A., Sundar, R., Wang, T., Ng, T.-C., Zhang, B., Tan, S., Soh, I., Pang, A. S. L., Tan, C., Ow, S. G. W., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.11596 · Cited by 21

Effects of the Calcium Channel Blocker Flunarizine on the Hemodynamics and Oxygenation of Tumor Microvasculature

Dewhirst, M. W., Ong, E. T., Madwed, D., Klitzman, B. M., Secomb, T. W., Brizel, D. M., Bonaventura, J., Rosner, G. L., Kavanagh, B. D., Edwards, J., et al. (1992) · Radiation Research · doi:10.2307/3578334 · Cited by 20

Effects of cell damage and glycosaminoglycan degradation on available extravascular space of different dextrans in a rat fibrosarcoma

Krol, A., Dewhirst, M. W., & Yuan, F. (2003) · International Journal of Hyperthermia · doi:10.1080/02656730210166519 · Cited by 19

The role of payload hydrophobicity in nanotherapeutic pharmacokinetics.

Norvaisas, P., & Ziemys, A. (2014) · Journal of Pharmacy and Science · doi:10.1002/jps.23996 · Cited by 19

Local 42°C Hyperthermia Improves Vascular Conductance of the R3230Ac Rat Mammary Adenocarcinoma during Sodium Nitroprusside Infusion

Meyer, R. E., Braun, R. D., Rosner, G., & Dewhirst, M. W. (2000) · Radiation Research · doi:10.1667/0033-7587(2000)154[0196:lchivc]2.0.co;2 · Cited by 18

Improvement of intratumor microdistribution of PEGylated liposome via tumor priming by metronomic S-1 dosing

Doi, Y., Lila, A. S. A., Matsumoto, H., Okada, T., Shimizu, T., & Ishida, T. (2016) · International Journal of Nanomedicine · doi:10.2147/ijn.s119069 · Cited by 15

Enhanced tumour perfusion following treatment with water-filtered IR-A radiation to the thorax in a patient with head and neck cancer

Rich, L. J., Winslow, T. B., Alberico, R. A., Repasky, E. A., Seshadri, M., & Singh, A. K. (2016) · International Journal of Hyperthermia · doi:10.3109/02656736.2016.1167259 · Cited by 11

Hyperthermia

Dewhirst, M. W., Stauffer, P. R., Das, S. K., Craciunescu, O. I., & Vujašković, Ž. (2015) · Elsevier eBooks · doi:10.1016/b978-0-323-24098-7.00021-6 · Cited by 9

Cytoreductive Chemotherapy Improves the Biodistribution of Antibodies Directed against Tumor Necrosis in Murine Solid Tumor Models

Jang, J. K., Khawli, L. A., Park, R. J.-H., Wu, B. W., Li, Z., Canter, D., Conti, P. S., & Epstein, A. L. (2013) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-13-0383 · Cited by 8

Optical-resolution photoacoustic microscopy of the metabolic rate of oxygen in a mouse renal tumor model

Yeh, C., Hu, S., Liang, J., Li, L. S., Soetikno, B. T., Lu, Z. H., Sohn, R. E., Maslov, K., Arbeit, J. M., & Wang, L. V. (2015) · Proceedings of SPIE, the International Society for Optical Engineering/Proceedings of SPIE · doi:10.1117/12.2082948 · Cited by 5

Chronic effects of an anti-angiogenic thrombospondin-1 mimetic peptide, ABT-898, on female mouse reproductive outcomes

Edwards, A. K., Olariu, I., Nakamura, D. S., Ahn, S. H., & Tayade, C. (2016) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-016-0192-7 · Cited by 3

Arteriovenous Shunting in Renal Pelvic Tumors

Forman, W. H., Green, J., & OBERHEU, V. (1975) · Southern Medical Journal · doi:10.1097/00007611-197508000-00013 · Cited by 2

RED CEREBRAL VEINS: A REPORT ON ARTERIOVENOUS SHUNTS IN TUMORS AND CEREBRAL SCARS.

潤二, 中., & 湯田, 智. (1965) · PubMed · doi:10.3171/jns.1965.22.4.0315

Therapeutic Targeting of the Tumor Microenvironment

Bejarano, L., Jordão, M. J. C., & Joyce, J. A. (2021) · Cancer Discovery · doi:10.1158/2159-8290.cd-20-1808 · Cited by 1,718

Tumor targeting via EPR: Strategies to enhance patient responses

Golombek, S. K., May, J.-N., Theek, B., Appold, L., Drude, N., Kiessling, F., & Lammers, T. (2018) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2018.07.007 · Cited by 1,262

Extracellular Matrix in the Tumor Microenvironment and Its Impact on Cancer Therapy

Henke, E., Nandigama, R., & Ergün, S. (2020) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2019.00160 · Cited by 1,142

Reengineering the Physical Microenvironment of Tumors to Improve Drug Delivery and Efficacy: From Mathematical Modeling to Bench to Bedside

Stylianopoulos, T., Munn, L. L., & Jain, R. K. (2018) · Trends in cancer · doi:10.1016/j.trecan.2018.02.005 · Cited by 589

Therapeutic targeting of the hypoxic tumour microenvironment

Singleton, D. C., Macann, A., & Wilson, W. R. (2021) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-021-00539-4 · Cited by 507

Drug Delivery and Transport to Solid Tumors

Jang, S. H., Wientjes, M. G., Lü, D., & Au, J. L. ‐. (2003) · Pharmaceutical Research · doi:10.1023/a:1025785505977 · Cited by 491

Understanding the effects of the tumor vasculature on effective drug transport

Wijeratne, N. S., & Hoo, K. A. (2007) · Proceedings of the ... American Control Conference/Proceedings of the American Control Conference · doi:10.1109/acc.2007.4282584

Understanding the role of the tumour vasculature in the transport of drugs to solid cancer tumours

Wijeratne, N. S., & Hoo, K. A. (2007) · Cell Proliferation · doi:10.1111/j.1365-2184.2007.00436.x · Cited by 12

Investigating the Effect of Tumor Microvascular Architecture on Drug Transport and Distribution

Alamer, M., & Xu, X. Y. (2018) · Proceedings of the World Congress on Electrical Engineering and Computer Systems and Science · doi:10.11159/icbes18.115

Extravascular transport in normal and tumor tissues

Jain, R. K., Gerlowski, L. E., & Cilento, E. V. (1986) · Critical Reviews in Oncology/Hematology · doi:10.1016/s1040-8428(86)80023-3 · Cited by 98