The DOI matches its Crossref record; 122 of the 122 references it cites were found in a registry or an index.
RAS oncogenes: the first 30 years
Abstract
From the pioneering work with acute transforming retroviruses to the current post-genomic era, RAS genes have always been at the leading edge of signal transduction and molecular oncology. Yet, a complete understanding of RAS function and dysfunction - mainly in human cancer - is still to come. The knowledge that has accumulated since their discovery 30 years ago has, however, been remarkable, and should pave the way for not only solving the outstanding issues regarding RAS biology, but also for developing efficacious drugs that could have a significant impact on cancer treatment.
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“On the other hand, the KRAS proteins are featureless. They have a nearly spherical structure that lacks a deep hydrophobic pocket and has no obvious binding site [20].”
From Targeting KRAS mutant cancers: from druggable therapy to drug resistance (2022) · cites this paper as [20]
Citations
Cites
1 retracted
The Human c- ras 1 H Oncogene: a Mutation in Normal and Neoplastic Tissue from the Same Patient
Muschel, R. J., Khoury, G., Lebowitz, P., Koller, R. P., & Dhar, R. (1983) · Science · doi:10.1126/science.6337398 · Cited by 18
RetractedMutations of the BRAF gene in human cancer
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Targeting RAS signalling pathways in cancer therapy
Downward, J. (2003) · Nature reviews. Cancer · doi:10.1038/nrc969 · Cited by 3,354
Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes
Land, H., Parada, L. F., & Weinberg, R. A. (1983) · Nature · doi:10.1038/304596a0 · Cited by 2,804
Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes
Almoguera, C., Shibata, D. K., Forrester, K., Wj, M., Arnheim, N., & Perucho, M. (1988) · Cell · doi:10.1016/0092-8674(88)90571-5 · Cited by 2,122
Phosphatidylinositol-3-OH kinase direct target of Ras
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Mammalian Ras interacts directly with the serine/threonine kinase raf
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Analysis of lung tumor initiation and progression using conditional expression of oncogenic K-rasPreprint
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M3NetFlow: A multi-scale multi-hop graph AI model for integrative multi-omic data analysis
Zhang, H., Goedegebuure, S. P., Ding, L., DeNardo, D., Fields, R. C., Province, M., Chen, Y., Payne, P., & Li, F. (2025) · iScience · doi:10.1016/j.isci.2025.111920 · Cited by 12
Abbas, N., Mourad, M., Smaily, H., Al Mahmasani, L., & Shamseddine, A. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27073265 · Cited by 4
“These proteins play significant roles in EGFR-related signaling pathways [87,88].”
Metadata
- Authors
- Malumbres, M., & Barbacid, M.
- Affiliations
- Spanish National Cancer Research Centre (ES)
- Corresponding author
- Malumbres, Marcos
- Barbacid, Mariano
- Venue
- Nature Reviews Cancer
- Published
- 2003-06-01
- Volume
- 3
- Issue
- 6
- Pages
- 459-465
- ISSN
- 1474-175X (ISSN-L)
- 1474-1768
- OpenAlex
- W2083695927
- Cited by
- 1,902
- References
- 122
- Citations by year
- 2026: 39 · 2025: 77 · 2024: 94 · 2023: 84 · 2022: 89 · 2021: 78 · 2020: 68 · 2019: 74 · 2018: 80 · 2017: 99 · 2016: 91 · 2015: 98 · 2014: 117 · 2013: 120 · 2012: 104
- FWCI
- 3.49
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nature reviews. Cancer (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Tyrosine Phosphatases
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Melanoma and MAPK Pathways
- Keywords
- oncogenic Ras, signal transduction, molecular oncology, RAS inhibitors, cancer therapy
- MeSH terms
- Animals, Humans, Genes, ras, Biomedical Research, History, 20th Century, History, 21st Century
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