RAS oncogenes: the first 30 years

Malumbres, Marcos, Barbacid, Mariano·2003·Nature Reviews Cancer

DOI 10.1038/nrc1097

Cited by (1,002)

Items 401–500 of 1,002

Activated Mutant NRasQ61K Drives Aberrant Melanocyte Signaling, Survival, and Invasiveness via a Rac1-Dependent Mechanism
Ang Li, Yafeng Ma, Meng Jin, Susan M. Mason, Richard L. Mort, Karen Blyth, Lionel Larue, Owen James Sansom, Laura M. Machesky · 2012 · Journal of Investigative Dermatology
Common cardiovascular medications in cancer therapeutics
Christos Vaklavas, Yiannis S. Chatzizisis, Apostolia Maria Tsimberidou · 2011 · Pharmacology & Therapeutics
Phosphorylation at Ser-181 of Oncogenic KRAS Is Required for Tumor Growth
Carles Barceló, Noelia Paco, Mireia Morell, Blanca Alvarez-Moya, Neus Bota‐Rabassedas, Montserrat Jaumot, Felip Vilardell, Gabriel Capellá, Neus Agell · 2013 · Cancer Research
Thyroid C-Cell Biology and Oncogenic Transformation
Gilbert J. Cote, Elizabeth Gardner Grubbs, Marie-Claude C. Hofmann · 2015 · Recent results in cancer research/Recent Results in Cancer Research
Targeting KRAS Mutant in Non-Small Cell Lung Cancer: Novel Insights Into Therapeutic Strategies
Anne-Laure Désage, Camille Léonce, Aurélie Swalduz, Sandra Ortiz‐Cuaran · 2022 · Frontiers in Oncology
Targeting Oncogenic BRAF in Human Cancer
Christine A. Pratilas, Feng Xing, David B. Solit · 2010 · Current topics in microbiology and immunology
MEK inhibitors as a chemotherapeutic intervention in multiple myeloma
Christopher Chang-Yew Leow, Steve Gerondakis, A. Spencer · 2013 · Blood Cancer Journal
Molecular genetic analysis of ovarian serous cystadenomas
Eric J Cheng, Robert J. Kurman, Menglin Wang, Robert J. Oldt, Brant G. Wang, David Monty Berman, Ie‐Ming Shih · 2004 · Laboratory Investigation
Properties of FDA-approved small molecule phosphatidylinositol 3-kinase inhibitors prescribed for the treatment of malignancies
Robert Jr. Roskoski · 2021 · Pharmacological Research
K-ras/PI3K-Akt Signaling Is Essential for Zebrafish Hematopoiesis and Angiogenesis
Lihui Liu, Shizhen Zhu, Zhiyuan Gong, Boon Chuan Low · 2008 · PLoS ONE
Mutated K‐rasAsp12 promotes tumourigenesis in ApcMin mice more in the large than the small intestines, with synergistic effects between K‐ras and Wnt pathways
Feijun Luo, David G. Brooks, Hongtao Ye, Rifat Hamoudi, George Poulogiannis, Charles E. Patek, Douglas J. Winton, Mark Johan Arends · 2009 · International Journal of Experimental Pathology
The dominant role of G12C over other KRAS mutation types in the negative prediction of efficacy of epidermal growth factor receptor tyrosine kinase inhibitors in non–small cell lung cancer
Ondřej Fiala, Miloš Pešek, Jindřich Fínek, Lucie Benešová, Barbora Belšánová, Marek Minárik · 2013 · Cancer Genetics
Hydrolysis of Guanosine Triphosphate (GTP) by the Ras·GAP Protein Complex: Reaction Mechanism and Kinetic Scheme
Maria G. Khrenova, Bella L. Grigorenko, Anatoly B. Kolomeisky, Alexander V. Nemukhin · 2015 · The Journal of Physical Chemistry B
KRAS induces lung tumorigenesis through microRNAs modulation
Lei Shi, Justin D. Middleton, Young-Jun Jeon, Peter Magee, Dario Veneziano, Alessandro Laganà, Hui Sun Leong, Sudhakar Sahoo, Matteo Fassan, Richard Booton et al. · 2018 · Cell Death and Disease
RAS/MAPK pathway hyperactivation determines poor prognosis in undifferentiated pleomorphic sarcomas
Serrano, César, Romagosa, Cleofé, Hernández‐Losa, Javier, Simonetti, Sara, Valverde, Claudia, Moliné, Teresa, Somoza, Rosa, Pérez, Manuel, Vélez, Roberto, Vergés, Ramona et al. · 2016 · Cancer
Non-melanoma skin cancer in mouse and man
Michael Schwarz, Peter Münzel, Albert Braeuning · 2012 · Archives of Toxicology
Lack of evidence for KRAS oncogenic mutations in triple-negative breast cancer
Alfonso Sánchez‐Muñoz, Elena Gallego, Vanessa de Luque, Luis Gustavo Perez‐Rivas, Luís Vicioso, Nuria Ribelles, José Lozano, Emilio Alba · 2010 · BMC Cancer
Mutant N-RAS Protects Colorectal Cancer Cells from Stress-Induced Apoptosis and Contributes to Cancer Development and Progression
Yufang Wang, Sérgia Velho, Efsevia Vakiani, Shouyong Peng, Adam Joel Bass, Gerald C. Chu, Jessica J. Gierut, James M. Bugni, Channing J. Der, Mark R. Philips et al. · 2012 · Cancer Discovery
The biological complexity of colorectal cancer: insights into biomarkers for early detection and personalized care
Marina De Rosa, Daniela Rega, Valeria Costabile, Francesca Duraturo, Antonello Niglio, Paola Izzo, Ugo Pace, Paolo Delrio · 2016 · Therapeutic Advances in Gastroenterology
The Dual Roles of MYC in Genomic Instability and Cancer Chemoresistance
Alpana Kumari, Watson P. Folk, Daitoku Sakamuro · 2017 · Genes
Leukemia in Cardio-facio-cutaneous (CFC) Syndrome: A Patient With a Germline Mutation in BRAF Proto-oncogene
Yoshio Makita, Yoko Narumi, Makoto Yoshida, Tetsuya Niihori, Shigeo Kure, Kenji Fujieda, Yoichi Matsubara, Yoko Aoki · 2007 · Journal of Pediatric Hematology/Oncology
Inactivation of Capicua in adult mice causes T-cell lymphoblastic lymphoma
Lucía Simón-Carrasco, Osvaldo Graña‐Castro, Marina Salmón, Harrys K.C. Jacob, Alejandro Gutiérrez, Gerardo Jiménez, Matthias Drosten, Mariano Barbacid · 2017 · Genes & Development
The Ins and Outs of RAS Effector Complexes
Christina Kiel, David Matallanas, Walter Kölch · 2021 · Biomolecules
RAS, FLT3, and C-KIT mutations in immunophenotyped canine leukemias
Suzanne Usher, Alan David Radford, Elizabeth J. Villiers, Laura Blackwood · 2008 · Experimental Hematology
Autoregulatory effects of serotonin on proliferation and signaling pathways in lung and small intestine neuroendocrine tumor cell lines
Ignat A. Drozdov, Mark S. Kidd, Björn Inge Gustafsson, Bernhard Svejda, Richard A. Joseph, Roswitha Pfragner, Irvin Mark Modlin · 2009 · Cancer
The N-Terminal Domain of ERK1 Accounts for the Functional Differences with ERK2
Matilde Marchi, Angela D'Antoni, Ivan Formentini, Riccardo Parra, Riccardo Brambilla, Gian Michele Ratto, Mario Costa · 2008 · PLoS ONE
The Yeast Saccharomyces cerevisiae as a Model for Understanding RAS Proteins and their Role in Human Tumorigenesis
Giulia Cazzanelli, Flávia Dayana Silva Pereira, Sara Alves, Rita Francisco, Luı́sa Azevedo, Patrícia Dias Carvalho, Ana F. Almeida, Manuela Côrte‐Real, María José Oliveira, Cândida Lucas et al. · 2018 · Cells
A synergic approach to enhance long-term culture and manipulation of MiaPaCa-2 pancreatic cancer spheroids
Marta Cavo, Donatella Delle Cave, Eliana D’Amone, Giuseppe Gigli, Enza Lonardo, Loretta L. del Mercato · 2020 · Scientific Reports
Impact of oncogenic K-RASon YB-1 phosphorylation induced by ionizing radiation
Mahmoud Toulany, Tim-Andre Schickfluß, Wolfgang Eicheler, Rainer Kehlbach, Birgit Schittek, H. Peter Rodemann · 2011 · Breast Cancer Research
Biochemical and molecular characterization of the novel BRAFV599Ins mutation detected in a classic papillary thyroid carcinoma
S Moretti, Antonio Macchiarulo, Valentina De Falco, Nicola Avenia, Flavia Barbi, Claudio Carta, Antonio Cavaliere, Rosa Marina Melillo, L Passeri, Fausto Santeusanio et al. · 2006 · Oncogene
CpG island promoter hypermethylation of the Ras-effector gene NORE1A occurs in the context of a wild-type K-ras in lung cancer
Manuel Irimia, Mario F. Fraga, Montse Sánchez‐Céspedes, Manel Esteller · 2004 · Oncogene
Identification of RASSF8 as a candidate lung tumor suppressor gene
Felicia Stefania Falvella, Giacomo Manenti, M Spinola, Carmen Pignatiello, B Conti, Ugo Pastorino, Tommaso Antonio Dragani · 2006 · Oncogene
Targeting BRAFV600E in thyroid carcinoma: therapeutic implications
Constantine S. Mitsiades, Joseph M. Negri, Ciaran J. McMullan, Douglas W. McMillin, Elias Sozopoulos, Galinos Fanourakis, Gerassimos E. Voutsinas, Sofia Tseleni‐Balafouta, Vassiliki Poulaki, David B. Batt et al. · 2007 · Molecular Cancer Therapeutics
Investigating human cancer etiology by DNA lesion footprinting and mutagenicity analysis
Ahmad Besarati Nia · 2005 · Carcinogenesis
Ras-induced ROS upregulation affecting cell proliferation is connected with cell type-specific alterations of HSF1/SESN3/p21Cip1/WAF1pathways
Maria A. Zamkova, Н. В. Хромова, Boris P. Kopnin, Pavel Kopnin · 2013 · Cell Cycle
miR-29c-3p promotes senescence of human mesenchymal stem cells by targeting CNOT6 through p53–p21 and p16–pRB pathways
Jin Shang, Yuan Yao, Xin Fan, Lei Shangguan, Jie Li, Huan Liu, Yue Zhou · 2016 · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
Classification of gene signatures for their information value and functional redundancy
Laura Cantini, Laurence Calzone, Loredana Martignetti, Mattias Rydenfelt, Nils Blüthgen, Emmanuel Barillot, Andrei Y. Zinovyev · 2017 · npj Systems Biology and Applications
KRAS: A Druggable Target in Colon Cancer Patients
Francesca Negri, Lorena Bottarelli, Gian Luigi de’Angelis, Letizia Gnetti · 2022 · International Journal of Molecular Sciences
KRAS Testing: A Tool for the Implementation of Personalized Medicine
Rodney E. Shackelford, Nicholas A. Whitling, Patricia Moody McNab, S. Japa, Domenico Coppola · 2012 · Genes & Cancer
Spermatinamine, the first natural product inhibitor of isoprenylcysteine carboxyl methyltransferase, a new cancer target
Malcolm S. Buchanan, Anthony Richard Carroll, Gregory A. Fechner, Anthony Boyle, Moana M. Simpson, Rama Addepalli, Vicky M. Avery, John N. A. Hooper, Nancy Su, Huawei Chen et al. · 2007 · Bioorganic & Medicinal Chemistry Letters
NORE1A is a Ras senescence effector that controls the apoptotic/senescent balance of p53 via HIPK2
Howard Donninger, Diego Francesco Calvisi, Thibaut Barnoud, Jennifer Clark, Marianne Schmidt, Michele D. Vos, Geoffrey J. Clark · 2015 · The Journal of Cell Biology
Epigenetic regulation of the ras effector/tumour suppressor RASSF2 in breast and lung cancer
Wendy N. Cooper, RE Dickinson, Ashraf Dallol, Григорьева Эльвира Витальевна, Tatiana V. Pavlova, Luke B. Hesson, Ivan Bièche, Massimo Broggini, Eamonn Richard Maher, Eugene R. Zabarovsky et al. · 2007 · Oncogene
Single-Molecule Microscopy Reveals Membrane Microdomain Organization of Cells in a Living Vertebrate
Marcel J. M. Schaaf, Wiepke J. A. Koopmans, Tobias Meckel, John van Noort, Ewa B. Snaar-Jagalska, Thomas S. Schmidt, Herman P. Spaink · 2009 · Biophysical Journal
Inhibition of Wee1, AKT, and CDK4 Underlies the Efficacy of the HSP90 Inhibitor XL888 in an In Vivo Model of NRAS -Mutant Melanoma
Hans Eirik Haarberg, Kim H.T. Paraiso, Elizabeth R. Wood, Vito W. Rebecca, Vernon K. Sondak, John M. Koomen, Keiran S.M. Smalley · 2013 · Molecular Cancer Therapeutics
MiRNA-143 mediates the proliferative signaling pathway of FSH and regulates estradiol production
Li Zhang, XiaoXin Zhang, Xuejing Zhang, Yu Lu, Lei Li, Sheng Cui · 2017 · Journal of Endocrinology
Characterization of distinct types of KRAS mutation and its impact on first‑line platinum‑based chemotherapy in Chinese patients with advanced non‑small cell lung cancer
Yijun Jia, Tao Jiang, Xuefei Li, Chao Zhao, Limin Zhang, Sha Zhao, Xiaozhen Liu, Meng Qiao, Jiawei Luo, Jinpeng Shi et al. · 2017 · Oncology Letters
Toll-like Receptor 9 Agonist IMO Cooperates with Cetuximab in K - Ras Mutant Colorectal and Pancreatic Cancers
Rosa, Roberta, Melisi, Davide, Damiano, Vincenzo, Bianco, Roberto, Garofalo, Sonia, Gelardi, Teresa, Agrawal, Sudhir, Di Nicolantonio, Federica, Scarpa, Aldo, Bardelli, Alberto et al. · 2011 · Clinical Cancer Research
Targeting KRAS Mutant Lung Cancer Cells with siRNA-Loaded Bovine Serum Albumin Nanoparticles
Mehta, Aditi, Dalle Vedove, Elena, Isert, Lorenz, Merkel, Olivia M. · 2019 · Pharmaceutical Research
A novel chemical screening strategy in zebrafish identifies common pathways in embryogenesis and rhabdomyosarcoma development
Xiuning Le, Emily K. Pugach, Simone Hettmer, Narie Yoo Storer, Jianing Liu, Airon A. Wills, Antony DiBiase, Eleanor Y. Chen, Myron S. Ignatius, Kenneth D. Poss et al. · 2013 · Development
Krüppel-like factor 5 is a crucial mediator of intestinal tumorigenesis in mice harboring combined Apc Min and KRASV 12mutations
Mandayam O. Nandan, Amr M. Ghaleb, Beth B. McConnell, Nilesh V. Patel, Sylvie Robine, Vincent W. Yang · 2010 · Molecular Cancer
Targeting mutant NRAS signaling pathways in melanoma
Ha Linh Vu, Andrew E. Aplin · 2016 · Pharmacological Research
Pre-Clinical and Clinical Applications of Small Interfering RNAs (siRNA) and Co-Delivery Systems for Pancreatic Cancer Therapy
Sepideh Mirzaei, Mohammad Hossein Gholami, Hui Li Ang, Farid Hashemi, Ali Zarrabi, Amirhossein Zabolian, Kiavash Hushmandi, Masoud Delfi, Haroon Zaman Khan, Milad Ashrafizadeh et al. · 2021 · Cells
Characterization of a novel oncogenic K-ras mutation in colon cancer
Kiwamu Akagi, Ryosuke Uchibori, Kensei Yamaguchi, Keiko Kurosawa, Yoichiro Tanaka, Tomoko Kozu · 2006 · Biochemical and Biophysical Research Communications
Inhibition of breast cancer growth and invasion by single-minded 2s
Hyeongil Kwak, Tiffany P. Gustafson, Richard P. Metz, Brian Laffin, Pepper S. Schedin, Weston W. Porter · 2006 · Carcinogenesis
A KSR/CNK complex mediated by HYP, a novel SAM domain-containing protein, regulates RAS-dependent RAF activation in Drosophila
Mélanie Douziech, Malha Sahmi, Gino Laberge, Marc Therrien · 2006 · Genes & Development
Contribution of pks+ Escherichia coli (E. coli) to Colon Carcinogenesis
Mohammad Sadeghi, Denis Mestivier, Iradj Sobhani · 2024 · Microorganisms
Mutational analysis of NOTCH1, 2, 3 and 4 genes in common solid cancers and acute leukemias
Sung Hak Lee, Eun Goo Jeong, Nam Jin Yoo, Sug Hyung Lee · 2007 · Apmis
PAF-Mediated MAPK Signaling Hyperactivation via LAMTOR3 Induces Pancreatic Tumorigenesis
Sohee Jun, Sunhye Lee, Han-Cheon Kim, Christopher Ng, Andrea M. Schneider, Hong Long Ji, Haoqiang Ying, Huamin Wang, Ronald Anthony DePinho, Jae‐Il Park · 2013 · Cell Reports
Aging: gene silencing or gene activation?
Stanislaw Rajmund Burzynski · 2004 · Medical Hypotheses
Synthetic Lethality in Cancer Therapeutics
Roderick L. Beijersbergen, Lodewyk F.A. Wessels, René Bernards · 2016 · Annual Review of Cancer Biology
K-Ras and its inhibitors towards personalized cancer treatment: Pharmacological and structural perspectives
Vivek Asati, Debarshi Kar Mahapatra, Sanjay Kumar Bharti · 2016 · European Journal of Medicinal Chemistry
Cellular and metabolic engineering of oleaginous yeast Yarrowia lipolytica for bioconversion of hydrophobic substrates into high‐value products
Ya‐Hue Valerie Soong, Na Liu, Seongkyu Yoon, Carl Lawton, Dongming Xie · 2019 · Engineering in Life Sciences
Wild-Type NRas and KRas Perform Distinct Functions during Transformation
Poppy P. Fotiadou, Chiaki Takahashi, Hasan N. Rajabi, Mark E. Ewen · 2007 · Molecular and Cellular Biology
Farnesyl Transferase Inhibitor (R115777)–Induced Inhibition of STAT3(Tyr705) Phosphorylation in Human Pancreatic Cancer Cell Lines Require Extracellular Signal-Regulated Kinases
Kolaparthi Venkatasubbarao, Ahsan Choudary, James W. Freeman · 2005 · Cancer Research
G12V and G12A KRAS mutations are associated with poor outcome in patients with metastatic colorectal cancer treated with bevacizumab
Fiala, Ondrej, Buchler, Tomas, Mohelnikova-Duchonova, Beatrice, Melichar, Bohuslav, Matejka, Vit Martin, Holubec, Lubos, Kulhankova, Jana, Bortlicek, Zbynek, Bartouskova, Marie, Liska, Vaclav et al. · 2016 · Tumor Biology
Impairment of mitochondrial respiration in mouse fibroblasts byoncogenic H-RASQ61L
Dianer Yang, Man-Tzu Wang, Yong Tang, Yakun Chen, Hongmei Jiang, Torrie T. Jones, Krishna Rao, Gregory J. Brewer, Keshav Kumar Singh, Daotai Nie · 2010 · Cancer Biology & Therapy
Contributions of KRAS and RAL in Non–Small-Cell Lung Cancer Growth and Progression
Sunny Guin, Yuanbin Ru, Murry W. Wynes, Rangnath Mishra, Xian Jun David Lu, Charles R. Owens, Anna E. Barón, Vihas T. Vasu, Fred R. Hirsch, Jeffrey A. Kern et al. · 2013 · Journal of Thoracic Oncology
PAQR3 Plays a Suppressive Role in the Tumorigenesis of Colorectal Cancers
Xiaohui Wang, Xuefeng Li, Fengjuan Fan, S. Jiao, Lianshui Wang, Lu Zhu, Yi Pan, Guohao Wu, Zhi Ling, Jing Fang et al. · 2012 · Carcinogenesis
Golgi-associated RhoBTB3 targets Cyclin E for ubiquitylation and promotes cell cycle progression
Albert Lu, Suzanne R. Pfeffer · 2013 · The Journal of Cell Biology
Ras, an Actor on Many Stages: Posttranslational Modifications, Localization, and Site-Specified Events
Imanol Arozarena, Fernando Calvo, Piero Crespo · 2011 · Genes & Cancer
RETRACTED: Interaction of KRAS G-quadruplex with natural polyphenols: A spectroscopic analysis with molecular modeling
Rudradip Pattanayak, Pijush Basak, Srikanta Sen, Maitree Bhattacharyya · 2016 · International Journal of Biological Macromolecules · Retracted
Evolution of RAS Mutational Status in Liquid Biopsies During First-Line Chemotherapy for Metastatic Colorectal Cancer
Susanne Klein‐Scory, Ingo Wahner, Marina Maslova, Yosef Al‐Sewaidi, Michael Pohl, Thomas Mika, Swetlana Ladigan, Roland Schroers, Alexander Baraniskin · 2020 · Frontiers in Oncology
p38γ Mitogen-Activated Protein Kinase Integrates Signaling Crosstalk between Ras and Estrogen Receptor to Increase Breast Cancer Invasion
Xiao-Mei Qi, Jun Tang, Mathew Loesch, Nicole M. Pohl, Serhan Alkan, Guan Chen · 2006 · Cancer Research
Immortalization and malignant transformation of Eukaryotic cells
Aleksei A. Stepanenko, VADIM M. KAVSAN · 2012 · Cytology and Genetics
Inhibition and Termination of Physiological Responses by GTPase Activating Proteins
Erzsébet Ligeti, Stefan Welti, Klaus Scheffzek · 2012 · Physiological Reviews
RAS Mutations Affect Tumor Necrosis Factor–Induced Apoptosis in Colon Carcinoma Cells via ERK-Modulatory Negative and Positive Feedback Circuits Along with Non-ERK Pathway Effects
Pamela K. Kreeger, Roli Mandhana, Shannon K. Hughes, Kevin M. Haigis, Douglas A. Lauffenburger · 2009 · Cancer Research
G4 DNA in ras genes and its potential in cancer therapy
Susanna Cogoi, Luigi Emilio Xodo · 2016 · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms
Comparison of the Conformations of KRAS Isoforms, K-Ras4A and K-Ras4B, Points to Similarities and Significant Differences
Mayukh Chakrabarti, Hyunbum Jang, Ruth Nussinov · 2016 · The Journal of Physical Chemistry B
Mutation spectra of RAS gene family in colorectal cancer
Yu-Yao Chang, Pei-Ching Lin, Hung‐Hsin Lin, Jen-Kou Lin, Wei-Shone Chen, Jeng‐Kai Jiang, Shung-Haur Yang, Wen-Yih Liang, Shih‐Ching Chang · 2016 · The American Journal of Surgery
Recent Advances in Basic Research for Brain Arteriovenous Malformation
Leandro Barbosa Do Prado, Chul Ju Han, Suk Paul Oh, Hua Su · 2019 · International Journal of Molecular Sciences
Ischemia-Induced K- ras Mutations in Human Colorectal Cancer Cells: Role of Microenvironmental Regulation of MSH2 Expression
Siranoush Shahrzad, Lindsay Quayle, Courtney Stone, Claire Plumb, Senji Shirasawa, Janusz W. Rak, Brenda Lynn Coomber · 2005 · Cancer Research
Behavioral Methods for the Study of the Ras–ERK Pathway in Memory Formation and Consolidation: Passive Avoidance and Novel Object Recognition Tests
Raffaele d’Isa, Riccardo Brambilla, Stefania Fasano · 2013 · Methods in molecular biology
RSK promotes G2 DNA damage checkpoint silencing and participates in melanoma chemoresistance
Hind Ray, Yves Roméo, Geneviève Lavoie, Paul Déléris, Joseph Tcherkezian, Jacob Anthony Galan, Philippe P. Roux · 2012 · Oncogene
The Role of Conserved Waters in Conformational Transitions of Q61H K-ras
Priyanka Prakash, Abdallah Sayyed–Ahmad, Alemayehu Abebe Gorfe · 2012 · PLoS Computational Biology
Lessons from computer simulations of Ras proteins in solution and in membrane
Priyanka Prakash, Alemayehu Abebe Gorfe · 2013 · Biochimica et Biophysica Acta (BBA) - General Subjects
The Molecular Biology of Soft-Tissue Sarcomas and Current Trends in Therapy
Jorge R. Quesada, Robert John Amato · 2012 · Sarcoma
The molecular basis of chemoradiosensitivity in rectal cancer:implications for personalized therapies
Marian Grade, Hendrik A. Wolff, Jochen Gaedcke, Β. Michael Ghadimi · 2012 · Langenbeck s Archives of Surgery
BRAF Inactivation Drives Aneuploidy by Deregulating CRAF
Tamihiro Kamata, Jahan Hussain, Susan M. Giblett, Robert Hayward, Richard Marais, Catrin A. Pritchard · 2010 · Cancer Research
Autophagy suppresses Ras-driven epithelial tumourigenesis by limiting the accumulation of reactive oxygen species
Jan Manent, S Banerjee, Ricardo De Matos Simoes, Tamara Zoranovic, Constantine S. Mitsiades, Josef Martin Penninger, Kaylene J. Simpson, Patrick Orson Humbert, Helena E. Richardson · 2017 · Oncogene
Prelude to an Anniversary for the RAS Oncogene
Julian Downward · 2006 · Science
A genetic screen for dominant modifiers of a cyclin E hypomorphic mutation identifies novel regulators of S-phase entry in Drosophila
Brumby, Anthony, Secombe, Julie, Horsfield, Julie, Coombe, Michelle, Amin, Nancy, Coates, Deborah, Saint, Robert, Richardson, Helena · 2004 · Genetics
Pharmacological restoration of GTP hydrolysis by mutant RAS
Antonio Cuevas-Navarro, Yasin Pourfarjam, Feng Hu, Diego J. Rodriguez, Alberto Vides, Ben Sang, Shijie Fan, Yehuda Goldgur, Elisa de Stanchina, Piro Lito · 2024 · Nature
Pancreatic cancer gene therapy using an siRNA-functionalized single walled carbon nanotubes (SWNTs) nanoplex
Tommy Anderson, Rui Hu, Chengbin Yang, Ho Sup Yoon, Ken‐Tye Yong · 2014 · Biomaterials Science
Sef Downregulation by Ras Causes MEK1/2 to Become Aberrantly Nuclear Localized Leading to Polyploidy and Neoplastic Transformation
Stéphanie Duhamel, Josée Hébert, Louis Arthur Gaboury, Amélie Bouchard, Ronald Simon, Guido Sauter, Mark Basik, Sylvain Meloche · 2012 · Cancer Research
Aberrant Receptor Signaling and Trafficking as Mechanisms in Oncogenesis
Tor Erik Rusten, Kaisa Haglund, Harald Stenmark · 2007 · Critical Reviews™ in Oncogenesis
Role of Akt Isoforms Controlling Cancer Stem Cell Survival, Phenotype and Self-Renewal
Sergio Rivas-Muñoz, Carla Gómez-Oro, Inés M. Antón, Francisco G. Wandosell · 2018 · Biomedicines
New approaches for modelling cancer mechanisms in the mouse
Kathryn Maddison, Alan Richard Clarke · 2005 · The Journal of Pathology
Protein cysteine thiol nitrosation: maker or marker of reactive nitrogen species-induced nonerythroid cellular signaling?
Lancaster, Jack R. · 2008 · Nitric Oxide
EGFR, the Lazarus target for precision oncology in glioblastoma
Benjamin Lin, Julia K. Ziebro, Erin Smithberger, Kasey Skinner, Eva Zhao, Timothy Francis Cloughesy, Zev A. Binder, Donald M. O’Rourke, David A. Nathanson, Frank B. Furnari et al. · 2022 · Neuro-Oncology
Oncolytic reovirus induces intracellular redistribution of Ras to promote apoptosis and progeny virus release
Katy A. Garant, Maya Shmulevitz, Lingjuan Pan, Rémi Daigle, D-G Ahn, Shashi Ashok Gujar, P W K Lee · 2015 · Oncogene