The DOI matches its Crossref record; 43 of the 44 references it cites were found in a registry or an index.
A census of human cancer genes
Open accessOverview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Focusing on cancer census genes [28], we observed such complex expression patterns for 26 of the current 513 cancer census genes (Additional file 1: Table S2).”
From Comparison of RNA-seq and microarray-based models for clinical endpoint prediction (2015) · cites this paper as [28]
In the citing paper
“We noted that many of the boundaries of cancer driver genes were altered in specific histological subtypes (Fig. 3a, Supplementary Table 2).”
From Disruption of chromatin folding domains by somatic genomic rearrangements in human cancer (2020) · cites this paper as [29]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
The Pfam Protein Families Database
Bateman, A. G. (2002) · Nucleic Acids Research · doi:10.1093/nar/30.1.276 · Cited by 14,075
Li, J., Yen, C., Liaw, D., Podsypanina, K., Bose, S., Wang, S. I., Puc, J., Miliaresis, C., Rodgers, L., McCombie, R., et al. (1997) · Science · doi:10.1126/science.275.5308.1943 · Cited by 4,785
Gain-of-Function Mutations of c- kit in Human Gastrointestinal Stromal Tumors
Hirota, S., Isozaki, K., Moriyama, Y., Hashimoto, K., Nishida, T., Ishiguro, S., Kawano, K., Hanada, M., Kurata, A., Takeda, M., et al. (1998) · Science · doi:10.1126/science.279.5350.577 · Cited by 4,487
The human mutator gene homolog MSH2 and its association with hereditary nonpolyposis colon cancer
Fishel, R. A., Lescoe, M. K., Rao, M. R. S., Copeland, N. G., Jenkins, N. A., Garber, J. E., Kane, M., & Kolodner, R. D. (1993) · Cell · doi:10.1016/0092-8674(93)90546-3 · Cited by 2,884
A Single Ataxia Telangiectasia Gene with a Product Similar to PI-3 Kinase
Savitsky, K., Bar-Shira, A., Gilad, S., Rotman, G., Ziv, Y., Vanagaite, L., Tagle, D. A., Smith, S., Uziel, T., Sfez, S., et al. (1995) · Science · doi:10.1126/science.7792600 · Cited by 2,785
A cell cycle regulator potentially involved in genesis of many tumor types
Kamb, A., Gruis, N. A., Weaver-Feldhaus, J., Liu, Q., Harshman, K., Tavtigian, S. V., Stockert, E., Day, R. S., Johnson, B. E., & Skolnick, M. H. (1994) · Science · doi:10.1126/science.8153634 · Cited by 2,751
PDGFRA Activating Mutations in Gastrointestinal Stromal Tumors
Heinrich, M. C., Corless, C. L., Duensing, A. U., McGreevey, L. S., Chen, C.-J., Joseph, N. E., Singer, S., Griffith, D., Haley, A., Town, A., et al. (2003) · Science · doi:10.1126/science.1079666 · Cited by 2,297
Mutations of a mutS homolog in hereditary nonpolyposis colorectal cancer
Leach, F. S., Nicolaides, N. C., Papadopoulos, N., Liu, B., Jen, J., Parsons, R. E., Peltomäki, P., Sistonen, P., Aaltonen, L. A., Nyström, M., et al. (1993) · Cell · doi:10.1016/0092-8674(93)90330-s · Cited by 2,271
Merlo, A., Herman, J. G., Mao, L., Lee, D. J., Gabrielson, E. W., Burger, P. C., Baylin, S. B., & Sidransky, D. (1995) · Nature Medicine · doi:10.1038/nm0795-686 · Cited by 1,992
A serine/threonine kinase gene defective in Peutz–Jeghers syndrome
Hemminki, A., Markie, D., Tomlinson, I. P. M., Avizienyte, E., Roth, S., Loukola, A., Bignell, G. R., Warren, W., Aminoff, M., Höglund, P., et al. (1998) · Nature · doi:10.1038/34432 · Cited by 1,680
Self-citation
Cited by
Sorted by citations
Items 501–600 of 1,007
Subramanian, S., Thayanithy, V., West, R. B., Lee, C., Beck, A. H., Zhu, S., Downs-Kelly, E. P., Montgomery, K. D., Goldblum, J. R., Hogendoorn, P. C. W., et al. (2009) · The Journal of Pathology · doi:10.1002/path.2633 · Cited by 120
Exon identity crisis: disease-causing mutations that disrupt the splicing code
Sterne-Weiler, T., & Sanford, J. R. (2014) · Genome biology · doi:10.1186/gb4150 · Cited by 123
Clonal evolution mechanisms in NT5C2 mutant-relapsed acute lymphoblastic leukaemia
Tzoneva, G., Dieck, C. L., Oshima, K., Ambesi‐Impiombato, A., Sánchez-Martín, M., Madubata, C. J., Khiabanian, H., Yu, J., Waanders, E., Iacobucci, I., et al. (2018) · Nature · doi:10.1038/nature25186 · Cited by 117
Zheng, C., Li, L., Haak, M., Brors, B., Frank, O., Giehl, M., Fabarius, A. C., Schatz, M. C., Weisser, A., Lorentz, C., et al. (2006) · Leukemia · doi:10.1038/sj.leu.2404227 · Cited by 117
To die or grow: Parkinson's disease and cancer
WEST, A., DAWSON, V, & DAWSON, T. (2005) · Trends in Neurosciences · doi:10.1016/j.tins.2005.05.002 · Cited by 117
Molecular Characterization of the Pediatric Preclinical Testing Panel
Neale, G. A. M., Su, X., Morton, C. L., Phelps, D. A., Gorlick, R. G., Lock, R. B., Reynolds, C. P., Maris, J. M., Friedman, H. S., Dome, J. S., et al. (2008) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-07-5090 · Cited by 117
DEGAS: De Novo Discovery of Dysregulated Pathways in Human Diseases
Ulitsky, I., Krishnamurthy, A., Karp, R. M., & Ron Shamir, A. (2010) · PLoS ONE · doi:10.1371/journal.pone.0013367 · Cited by 116
In silico identification of oncogenic potential of fyn-related kinase in hepatocellular carcinoma
Chen, J., Hung, W.-S., Chan, H.-H., Tsai, S., & Sun, H. S. (2012) · Bioinformatics · doi:10.1093/bioinformatics/bts715 · Cited by 116
PTEN opposes negative selection and enables oncogenic transformation of pre-B cells
Shojaee, S., Chan, L. N., Buchner, M., Cazzaniga, V., Cosgun, K. N., Geng, H., Qiu, Y. H., Minden, M. D.-V., Ernst, T., Hochhaus, A., et al. (2016) · Nature Medicine · doi:10.1038/nm.4062 · Cited by 118
Bayesian inference of negative and positive selection in human cancers
Weghorn, D., & Sunyaev, S. R. (2017) · Nature Genetics · doi:10.1038/ng.3987 · Cited by 120
Giacomini, C. P., Sun, S., Varma, S., Shain, A. H., Giacomini, M. M., Balagtas, J. M. S., Sweeney, R. T., Lai, E., Fitz, C. D. V., Forster, A. D., et al. (2013) · PLoS Genetics · doi:10.1371/journal.pgen.1003464 · Cited by 117
The tandem duplicator phenotype as a distinct genomic configuration in cancer
Menghi, F., Inaki, K., Woo, X., Kumar, P., Grzȩda, K. R., Malhotra, A., Yadav, V. K., Kim, H., Márquez, E. J., Ucar, D., et al. (2016) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1520010113 · Cited by 119
Wang, C., Yin, R. H., Dai, J., Gu, Y., Cui, S., Ma, H., Zhang, Z., Huang, J., Qin, N., Jiang, T., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-04492-2 · Cited by 115
Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases
Buljan, M., Ciuffa, R., van Drogen, A., Vichalkovski, A., Mehnert, M., Rosenberger, G., Lee, S., Varjosalo, M. T., Pernas, L. E., Spegg, V., et al. (2020) · Molecular Cell · doi:10.1016/j.molcel.2020.07.001 · Cited by 118
Allele-Specific Amplification in Cancer Revealed by SNP Array Analysis
LaFramboise, T., Weir, B. A., Zhao, X., Beroukhim, R., Li, C., Harrington, D. P., Sellers, W. R., & Meyerson, M. M. (2005) · PLoS Computational Biology · doi:10.1371/journal.pcbi.0010065 · Cited by 117
Inverse cancer comorbidity: a serendipitous opportunity to gain insight into CNS disorders
Tabarés‐Seisdedos, R., & Rubenstein, J. L. R. (2013) · Nature reviews. Neuroscience · doi:10.1038/nrn3464 · Cited by 118
Asmann, Y. W., Hossain, A., Necela, B. M., Middha, S., Kalari, K. R., Sun, Z., Chai, H. S., Williamson, D. W., Radisky, D. C., Schroth, G. P., et al. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkr362 · Cited by 114
Guo, W.-F., Zhang, S., Liu, L., Liu, F., Shi, Q., Zhang, L., Tang, Y. Z., Zeng, T., & Chen, L. (2018) · Bioinformatics · doi:10.1093/bioinformatics/bty006 · Cited by 114
Paulson, V., Chandler, G. L., Rakheja, D., Galindo, R. L., Wilson, K., Amatruda, J. F., & Cameron, S. (2011) · Genes Chromosomes and Cancer · doi:10.1002/gcc.20864 · Cited by 114
Better prediction by use of co‐data: adaptive group‐regularized ridge regression
van de Wiel, M. A., Lien, T. G., Verlaat, W., van Wieringen, W. N., & Wilting, S. M. (2015) · Statistics in Medicine · doi:10.1002/sim.6732 · Cited by 116
Loss of heterozygosity: what is it good for?
Ryland, G. L., Doyle, M., Goode, D. L., Boyle, S. E., Choong, D. Y. H., Rowley, S. M., Li, J., Australian Ovarian Cancer Study Group, Bowtell, D. D. L., Tothill, R. W., et al. (2015) · BMC Medical Genomics · doi:10.1186/s12920-015-0123-z · Cited by 121
Giehl, M., Fabarius, A. C., Frank, O., Hochhaus, A., Hafner, M., Hehlmann, R., & Seifarth, W. (2005) · Leukemia · doi:10.1038/sj.leu.2403779 · Cited by 114
Ramakrishna, M., Williams, L. H., Boyle, S. E., Bearfoot, J. L., Sridhar, A., Speed, T. P., Gorringe, K. L., & Campbell, I. (2010) · PLoS ONE · doi:10.1371/journal.pone.0009983 · Cited by 112
Improving Breast Cancer Survival Analysis through Competition-Based Multidimensional Modeling
Bilal, E., Dutkowski, J., Guinney, J., Jang, I. S., Logsdon, B. A., Pandey, G. S., Sauerwine, B., Shimoni, Y., Vollan, H. K. M., Mecham, B. H., et al. (2013) · PLoS Computational Biology · doi:10.1371/journal.pcbi.1003047 · Cited by 113
Genetic Heterogeneity in Therapy-Naïve Synchronous Primary Breast Cancers and Their Metastases
Ng, C. K. Y., Bidard, F., Piscuoglio, S., Geyer, F. C., Lim, R. S., de Bruijn, I., Shen, R., Pareja, F. G., Berman, S., Wang, L., et al. (2017) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-16-3115 · Cited by 112
Genomic and transcriptomic heterogeneity in metaplastic carcinomas of the breast
Piscuoglio, S., Ng, C. K. Y., Geyer, F. C., Burke, K. A., Cowell, C. F., Martelotto, L. G., Natrajan, R., Popova, T. G., Maher, C. A., Lim, R. S., et al. (2017) · npj Breast Cancer · doi:10.1038/s41523-017-0048-0 · Cited by 111
Lanzós, A., Carlevaro-Fita, J., Mularoni, L., Reverter, F., Palumbo, E., Guigó, R., & Johnson, R. (2017) · Scientific Reports · doi:10.1038/srep41544 · Cited by 111
Germline variant burden in cancer genes correlates with age at diagnosis and somatic mutation burden
Qing, T., Mohsen, H., Marczyk, M., Ye, Y., O’Meara, T. A., Zhao, H., Townsend, J. P., Gerstein, M., Hatzis, C., Kluger, Y., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-16293-7 · Cited by 112
The translational challenges of precision oncology
Pich, O., Bailey, C., Watkins, T. B. K., Zaccaria, S., Jamal‐Hanjani, M., & Swanton, C. (2022) · Cancer Cell · doi:10.1016/j.ccell.2022.04.002 · Cited by 116
Soung, Y. H., Lee, J. W., Kim, S. Y., Sung, Y. J., Park, W. S., Nam, S. W., Kim, S. H., Lee, J. Y., Yoo, N. J., & Lee, S. H. (2004) · Oncogene · doi:10.1038/sj.onc.1208244 · Cited by 111
Identification of genes with a correlation between copy number and expression in gastric cancer
Cheng, L., Wang, P., Yang, S., Yang, Y., Zhang, Q., Zhang, W., Gao, H., Gao, H., & Zhang, Q. (2012) · BMC Medical Genomics · doi:10.1186/1755-8794-5-14 · Cited by 110
Large-Scale Functional Organization of Long-Range Chromatin Interaction Networks
Sandhu, K. S., Li, G., Poh, H. M., Quek, Y. L. K., Sia, Y. Y., Peh, S. Q., Mulawadi, F. H., Lim, J., Šikić, M., Menghi, F., et al. (2012) · Cell Reports · doi:10.1016/j.celrep.2012.09.022 · Cited by 113
Role of let-7 family microRNA in breast cancer
Thammaiah, C. K., & Jayaram, S. (2016) · Non-coding RNA Research · doi:10.1016/j.ncrna.2016.10.003 · Cited by 113
LEDGF/p75 interacts with mRNA splicing factors and targets HIV-1 integration to highly spliced genes
Singh, P. K., Plumb, M. R., Ferris, A. L., Iben, J. R., Wu, X., Fadel, H. J., Luke, B. T., Esnault, C., Poeschla, E. M., Hughes, S. H., et al. (2015) · Genes & Development · doi:10.1101/gad.267609.115 · Cited by 109
Bodian, D. L., McCutcheon, J. N., Kothiyal, P., Huddleston, K., Iyer, R. K., Vockley, J. G., & Niederhuber, J. E. (2014) · PLoS ONE · doi:10.1371/journal.pone.0094554 · Cited by 110
Suzuki, A., Makinoshima, H., Wakaguri, H., Esumi, H., Sugano, S., Kohno, T., Tsuchihara, K., & Suzuki, Y. (2014) · Nucleic Acids Research · doi:10.1093/nar/gku885 · Cited by 109
Hartmann, S., Martín-Subero, J. I., Gesk, S., Husken, J., Giefing, M., Nagel, I., Riemke, J., Chott, A., Klapper, W., Parrens, M., et al. (2008) · Haematologica · doi:10.3324/haematol.12875 · Cited by 109
Tothill, R. W., Li, J., Mileshkin, L., Doig, K., Siganakis, T., Cowin, P. A., FELLOWES, A. P., Semple, T. J., Fox, S. B., Byron, K. A., et al. (2013) · The Journal of Pathology · doi:10.1002/path.4251 · Cited by 108
Smad phosphoisoform signaling specificity: the right place at the right time
Matsuzaki, K. (2011) · Carcinogenesis · doi:10.1093/carcin/bgr172 · Cited by 114
GLIS Rearrangement is a Genomic Hallmark of Hyalinizing Trabecular Tumor of the Thyroid Gland
Nikiforova, M. N., Nikitski, A. V., Panebianco, F., Kaya, C., Yip, L., Williams, M. D., Chiosea, S. I., Seethala, R. R., Roy, S., Condello, V., et al. (2019) · Thyroid · doi:10.1089/thy.2018.0791 · Cited by 108
GLO1 —A novel amplified gene in human cancer
Santarius, T., Bignell, G. R., Greenman, C., Widaa, S., Chen, L., Mahoney, C., Butler, A. P., Edkins, S., Waris, S., Thornalley, P. J., et al. (2010) · Genes Chromosomes and Cancer · doi:10.1002/gcc.20784 · Cited by 107
Self-citationCharacterization of the Drugged Human Genome
Lauss, M., Kriegner, A., Vierlinger, K., & Noehammer, C. (2007) · Pharmacogenomics · doi:10.2217/14622416.8.8.1063 · Cited by 108
A Bioinformatics Workflow for Variant Peptide Detection in Shotgun Proteomics
Li, J., Su, Z., Ma, Z., Slebos, R. J. C., Halvey, P. J., Tabb, D. L., Liebler, D. C., Pao, W. J., & Zhang, B. (2011) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m110.006536 · Cited by 107
Dominating Biological Networks
Milenković, T., Memišević, V., Bonato, A., & Pržulj, N. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023016 · Cited by 107
Somatic mutations of theERBB4kinase domain in human cancers
Soung, Y. H., Lee, J. W., Kim, S. Y., Wang, Y. P., Jo, K. H., Moon, S. W., Park, W. S., Nam, S. W., Lee, J. Y., Yoo, N. J., et al. (2005) · International Journal of Cancer · doi:10.1002/ijc.21507 · Cited by 107
Targeting tumor suppressor genes for cancer therapy
Liu, Y., Hu, X., Han, C., Wang, L., Zhang, X., He, X., & Lu, X. (2015) · BioEssays · doi:10.1002/bies.201500093 · Cited by 112
APOBEC3 genes: retroviral restriction factors to cancer drivers
Henderson, S. R., & Fenton, T. R. (2015) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2015.02.007 · Cited by 107
Our changing view of the genomic landscape of cancer
Bell, D. W. (2009) · The Journal of Pathology · doi:10.1002/path.2645 · Cited by 109
Kirouac, D. C., Du, J. Y., Lahdenranta, J., Overland, R. P., Yarar, D., Paragas, V. B., Pace, E. A., McDonagh, C. F., Nielsen, U. B., & Onsum, M. D. (2013) · Science Signaling · doi:10.1126/scisignal.2004008 · Cited by 107
Cheng, F., Jia, P., Wang, Q., & Zhao, Z. (2014) · Oncotarget · doi:10.18632/oncotarget.1984 · Cited by 105
Pan-cancer analysis of homozygous deletions in primary tumours uncovers rare tumour suppressors
Cheng, J., Demeulemeester, J., Wedge, D. C., Vollan, H. K. M., Pitt, J. J., Russnes, H. G., Pandey, B. P., Nilsen, G., Nord, S., Bignell, G. R., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-01355-0 · Cited by 106
Self-citationThe LL-100 panel: 100 cell lines for blood cancer studies
Quentmeier, H., Pommerenke, C., Dirks, W. G., Eberth, S., Koeppel, M., MacLeod, R. A. F., Nagel, S., Steube, K. G., Uphoff, C. C., & Drexler, H. G. (2019) · Scientific Reports · doi:10.1038/s41598-019-44491-x · Cited by 114
Korbel, J. O., Kim, P. M., Chen, X., Urban, A. E., Weissman, S. M., Snyder, M. P., & Gerstein, M. (2008) · Current Opinion in Structural Biology · doi:10.1016/j.sbi.2008.02.005 · Cited by 110
Novel aspects of oxidative stress-associated carcinogenesis
Toyokuni, S. (2006) · Antioxidants & Redox Signaling · doi:10.1089/ars.2006.8.1373 · Cited by 104
An, Ö., Dall’Olio, G. M., Mourikis, T. P., & Ciccarelli, F. D. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv1123 · Cited by 106
A comprehensive network and pathway analysis of candidate genes in major depressive disorder
Jia, P., Kao, C.-F., Kuo, P., & Zhao, Z. (2011) · BMC Systems Biology · doi:10.1186/1752-0509-5-s3-s12 · Cited by 104
Systematic analysis of somatic mutations impacting gene expression in 12 tumour types
Ding, J., McConechy, M. K., Horlings, H. M., Ha, G., Chan, F. C., Funnell, T., Mullaly, S. C., Reimand, J., Bashashati, A., Bader, G. D., et al. (2015) · Nature Communications · doi:10.1038/ncomms9554 · Cited by 108
Harbst, K., Lauss, M., Cirenajwis, H., Isaksson, K., Rosengren, F., Törngren, T., Kvist, A., Johansson, M. C., Vallon‐Christersson, J., Baldetorp, B., et al. (2016) · Cancer Research · doi:10.1158/0008-5472.can-15-3476 · Cited by 108
Regulation of epidermal growth factor receptor signalling by inducible feedback inhibitors
Segatto, O., Anastasi, S., & Alemà, S. (2011) · Journal of Cell Science · doi:10.1242/jcs.083303 · Cited by 103
Large-Scale Profiling of Kinase Dependencies in Cancer Cell Lines
Campbell, J., Ryan, C. J., Brough, R., Bajrami, I., Pemberton, H. N., Chong, I. Y.-S., Costa-Cabral, S., Frankum, J. R., Gulati, A., Holme, H., et al. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.02.023 · Cited by 104
Tan, O., Shrestha, R. N., Cunich, M. M., & SCHOFIELD, D. J. (2017) · Clinical Genetics · doi:10.1111/cge.13199 · Cited by 106
The Temporal Order of Genetic and Pathway Alterations in Tumorigenesis
Gerstung, M., Eriksson, N., Lin, J., Vogelstein, B., & Beerenwinkel, N. (2011) · PLoS ONE · doi:10.1371/journal.pone.0027136 · Cited by 103
Unraveling the clonal hierarchy of somatic genomic aberrations
Prandi, D., Baca, S. C., Romanel, A., Barbieri, C. E., Mosquera, J., Fontugne, J., Beltran, H., Sboner, A., Garraway, L. A., Rubin, M. A., et al. (2014) · Genome biology · doi:10.1186/s13059-014-0439-6 · Cited by 102
Genome-wide mutational spectra analysis reveals significant cancer-specific heterogeneity
Tan, H., Bao, J., & Zhou, X. (2015) · Scientific Reports · doi:10.1038/srep12566 · Cited by 106
Cancer driver mutations in protein kinase genes
Torkamani, A., Verkhivker, G. M., & Schork, N. J. (2008) · Cancer Letters · doi:10.1016/j.canlet.2008.11.008 · Cited by 102
Thomas, R. J., Seiser, E., Motsinger‐Reif, A. A., Borst, L. B., Valli, V. E., Kelley, K. L., Suter, S. E., Argyle, D. J., Burgess, K. E., Bell, J. S., et al. (2011) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.3109/10428194.2011.559802 · Cited by 102
Venkatesan, R. N., Treuting, P. M., Fuller, E. D., Goldsby, R. E., Norwood, T. H., Gooley, T. A., Ladiges, W., Preston, B. D., & Loeb, L. A. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.00002-07 · Cited by 102
Oncofuse: a computational framework for the prediction of the oncogenic potential of gene fusions
Shugay, M., de Mendíbil, I. O., Vizmanos, J. L., & Novo, F. J. (2013) · Bioinformatics · doi:10.1093/bioinformatics/btt445 · Cited by 101
Identification of diverse target RNAs that are functionally regulated by human Pumilio proteins
Bohn, J. A., Etten, J. L. V., Schagat, T. L., Bowman, B. M., McEachin, R. C., Freddolino, L., & Goldstrohm, A. C. (2017) · Nucleic Acids Research · doi:10.1093/nar/gkx1120 · Cited by 104
Piñeiro-Yáñez, E., Reboiro‐Jato, M., Goméz-López, G., Perales-Patón, J., Troulé, K., Rodrı́guez, J. M., Tejero, H., Shimamura, T., Lopez-Casas, P. P., Carretero, J., et al. (2018) · Genome Medicine · doi:10.1186/s13073-018-0546-1 · Cited by 104
A cloud-based workflow to quantify transcript-expression levels in public cancer compendia
Tatlow, P., & Piccolo, S. (2016) · Scientific Reports · doi:10.1038/srep39259 · Cited by 101
Sidders, B. S., Zhang, P., Goodwin, K., O’Connor, G., Russell, D. L., Borodovsky, A., Armenia, J., McEwen, R. K., Linghu, B., Bendell, J. C., et al. (2020) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-19-2183 · Cited by 104
Prediction of Cancer Driver Mutations in Protein Kinases
Torkamani, A., & Schork, N. J. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-5283 · Cited by 102
Role for Amplification and Expression of Glypican-5 in Rhabdomyosarcoma
Williamson, D., Selfe, J., Gordon, T., Lu, Y., Pritchard‐Jones, K., Murai, K., Jones, P. H., Workman, P., & SHIPLEY, J. M. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-1650 · Cited by 101
L1 retrotransposons, cancer stem cells and oncogenesis
Carreira, P. E., Richardson, S. R., & Faulkner, G. J. (2013) · FEBS Journal · doi:10.1111/febs.12601 · Cited by 100
Intercellular competition and the inevitability of multicellular aging
Nelson, P., & Masel, J. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1618854114 · Cited by 103
Interpreting pathways to discover cancer driver genes with Moonlight
Colaprico, A., Olsen, C., Bailey, M. H., Odom, G., Terkelsen, T., Silva, T. C., Olsen, A. V., Cantini, L., Zinovyev, A. Y., Barillot, E., et al. (2020) · Nature Communications · doi:10.1038/s41467-019-13803-0 · Cited by 101
Genome-wide analysis of somatic noncoding mutation patterns in cancer
Dietlein, F., Wang, A. B., Fagre, C. R., Tang, A., Besselink, N. J. M., Cuppen, E. P. J. G., Li, C., Sunyaev, S. R., Neal, J. T., & Allen, E. M. V. (2022) · Science · doi:10.1126/science.abg5601 · Cited by 103
A comparative study of cancer proteins in the human protein-protein interaction network
Sun, J., & Zhao, Z. (2010) · BMC Genomics · doi:10.1186/1471-2164-11-s3-s5 · Cited by 103
DNA bar coding and pyrosequencing to analyze adverse events in therapeutic gene transfer
Wang, G. P., Garrigue, A., Ciuffi, A., Ronen, K., Leipzig, J. N., Berry, C. C., Lagresle‐Peyrou, C., Benjelloun, F., Hacein‐Bey‐Abina, S., Fischer, A., et al. (2008) · Nucleic Acids Research · doi:10.1093/nar/gkn125 · Cited by 104
Quantification of random genomic mutations
Bielas, J. H., & Loeb, L. A. (2005) · Nature Methods · doi:10.1038/nmeth751 · Cited by 99
Juškevičius, D., Lorber, T., Gsponer, J. R., Perrina, V., Ruiz, C. F., Stenner, F., Dirnhofer, S., & Tzankov, A. (2016) · Leukemia · doi:10.1038/leu.2016.135 · Cited by 99
Functional variomics and network perturbation: connecting genotype to phenotype in cancer
Yi, S. S., Lin, S., Li, Y., Zhao, W., Mills, G. B., & Sahni, N. (2017) · Nature Reviews Genetics · doi:10.1038/nrg.2017.8 · Cited by 105
Frank, M. H., Wilson, B. J., Gold, J. S., & Frank, N. Y. (2021) · Gastroenterology · doi:10.1053/j.gastro.2020.12.080 · Cited by 102
Selecting causal genes from genome-wide association studies via functionally coherent subnetworks
Taşan, M., Musso, G. A., Hao, T., Vidal, M., MacRae, C. A., & Roth, F. P. (2014) · Nature Methods · doi:10.1038/nmeth.3215 · Cited by 102
Clinical Actionability Enhanced through Deep Targeted Sequencing of Solid Tumors
Chen, K., Meric‐Bernstam, F., Zhao, H., Zhang, Q. C., Ezzeddine, N., Tang, L.-Y., Qi, Y., Mao, Y., Chen, T., Chong, Z., et al. (2015) · Clinical Chemistry · doi:10.1373/clinchem.2014.231100 · Cited by 97
BioXpress: an integrated RNA-seq-derived gene expression database for pan-cancer analysis
Wan, Q., Dingerdissen, H., Fan, Y., Gulzar, N., Pan, Y., Wu, T.-J., Cheng, Y., Zhang, H., & Mazumder, R. (2015) · Database · doi:10.1093/database/bav019 · Cited by 99
DriverDBv2: a database for human cancer driver gene research
Chung, I., Chen, C., Su, S.-C., Li, C., Wu, K., Wang, H., & Cheng, W. (2015) · Nucleic Acids Research · doi:10.1093/nar/gkv1314 · Cited by 97
Protein Kinase CK2: Intricate Relationships within Regulatory Cellular Networks
de Villavicencio-Díaz, T. N., Rabalski, A. J., & Litchfield, D. W. (2017) · Pharmaceuticals · doi:10.3390/ph10010027 · Cited by 97
Bard-Chapeau, E. A., Jeyakani, J., Kok, C. H., Müller, J., Chua, B. Q., Gunaratne, J., Batagov, A. O., Jenjaroenpun, P., Kuznetsov, V. A., Wei, C., et al. (2012) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1119229109 · Cited by 97
Systematic screening reveals a role for BRCA1 in the response to transcription-associated DNA damagePreprint
Hill, S. J., Rolland, T., Adelmant, G., Xia, X., Owen, M., Dricot, A., Zack, T. I., Sahni, N., Jacob, Y., Hao, T., et al. (2014) · Genes & Development · doi:10.1101/gad.241620.114 · Cited by 102
Krassowski, M., Paczkowska, M., Cullion, K., Huang, T., Dzneladze, I., Ouellette, B. F. F., Yamada, J. T., Fradet‐Turcotte, A., & Reimand, J. (2017) · Nucleic Acids Research · doi:10.1093/nar/gkx973 · Cited by 98
Retrotransposon insertions can initiate colorectal cancer and are associated with poor survival
Cajuso, T., Sulo, P., Tanskanen, T. J., Katainen, R., Taira, A., Hänninen, U. A., Kondelin, J., Forsström, L. M., Välimäki, N., Aavikko, M., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-11770-0 · Cited by 96
Zhu, H., Uusküla-Reimand, L., Isaev, K., Wadi, L., Alizada, A., Shuai, S., Huang, V., Aduluso-Nwaobasi, D., Paczkowska, M., Abd-Rabbo, D., et al. (2020) · Molecular Cell · doi:10.1016/j.molcel.2019.12.027 · Cited by 100
Oncogenomics and the development of new cancer therapies
Strausberg, R. L., Simpson, A. J. G., Old, L. J., & Riggins, G. J. (2004) · Nature · doi:10.1038/nature02627 · Cited by 96
González-Pérez, A., Deu-Pons, J., & López-Bigas, N. (2012) · Genome Medicine · doi:10.1186/gm390 · Cited by 98
Epidemiology, Etiology, and Prevention of Prostate Cancer
Abouassaly, R., Thompson, I. M., Platz, E. A., & Klein, E. A. (2012) · Elsevier eBooks · doi:10.1016/b978-1-4160-6911-9.00095-5 · Cited by 96
Yost, S. E., Smith, E. N., Schwab, R. B., Bao, L., Jung, H., Wang, X., Voest, E. E., Pierce, J. P., Messer, K. S., Parker, B. A., et al. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks299 · Cited by 95
Milenković, T., Memišević, V., Ganesan, A. K., & Pržulj, N. (2009) · Journal of The Royal Society Interface · doi:10.1098/rsif.2009.0192 · Cited by 95
Molecular pathway identification using biological network-regularized logistic models
Zhang, W., Wan, Y., Allen, G. I., Pang, K., Anderson, M. L., & Liu, Z. (2013) · BMC Genomics · doi:10.1186/1471-2164-14-s8-s7 · Cited by 95
Metadata
- Authors
- Futreal, P. A., Coin, L., Marshall, M., Down, T., Hubbard, T., Wooster, R., Rahman, N., & Stratton, M. R.
- Affiliations
- Wellcome Sanger Institute (GB)
- Institute of Cancer Research (GB)
- Corresponding author
- Stratton, Michael R.
- Venue
- Nature Reviews Cancer
- Published
- 2004-03
- Volume
- 4
- Issue
- 3
- Pages
- 177-183
- ISSN
- 1474-175X (ISSN-L)
- 1474-1768
- PMC
- PMC2665285
- OpenAlex
- W2102140136
- Cited by
- 3,184
- References
- 44
- Citations by year
- 2026: 13 · 2025: 51 · 2024: 71 · 2023: 134 · 2022: 109 · 2021: 143 · 2020: 166 · 2019: 204 · 2018: 237 · 2017: 190 · 2016: 191 · 2015: 228 · 2014: 201 · 2013: 208 · 2012: 164
- FWCI
- 7.35
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Cancer (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Research Portal (King's College London) (submittedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer Genomics and Diagnostics
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genomics and Rare Diseases
- Keywords
- cancer genes, oncogenes, tumor suppressor, oncogenic mutations, mutation frequency, human genome, protein domains, cancer classification
- MeSH terms
- Genes, Humans, Mutation, Neoplasms, Oncogenes, Genome, Human
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review