Hyaluronan: from extracellular glue to pericellular cue

The hallmarks of cancer

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Prospective identification of tumorigenic breast cancer cells

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New functions for the matrix metalloproteinases in cancer progression

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CD44: From adhesion molecules to signalling regulators

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CD44 is the principal cell surface receptor for hyaluronate

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Putting tumours in context

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Anoikis mechanisms

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Angiogenesis Induced by Degradation Products of Hyaluronic Acid

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Signaling Properties of Hyaluronan Receptors

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Disruption of hyaluronan synthase-2 abrogates normal cardiac morphogenesis and hyaluronan-mediated transformation of epithelium to mesenchyme

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Membrane-Type 1 Matrix Metalloproteinase Cleaves Cd44 and Promotes Cell Migration

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The human tumor cell-derived collagenase stimulatory factor (renamed EMMPRIN) is a member of the immunoglobulin superfamily.

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Localization of matrix metalloproteinase 9 to the cell surface provides a mechanism for CD44-mediated tumor invasionPreprint

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Resolution of Lung Inflammation by CD44

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A lymphocyte molecule implicated in lymph node homing is a member of the cartilage link protein family

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Hyaluronan Synthases

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The deaf and the dumb: the biology of ErbB-2 and ErbB-3

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The six hyaluronidase-like genes in the human and mouse genomes

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Hyaluronan in morphogenesis

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Forkhead Transcription Factors Are Critical Effectors of Cell Death and Cell Cycle Arrest Downstream of PTEN

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Hyaluronan-binding Proteins: Tying Up the Giant

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Landscaping the Cancer Terrain

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CD44 is required for two consecutive steps in HGF/c-Met signalingPreprint

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Hyaluronan-Cell Interactions in Cancer and Vascular Disease

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Hyaluronan in Peritumoral Stroma and Malignant Cells Associates with Breast Cancer Spreading and Predicts Survival

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Formation of Hyaluronan- and Versican-Rich Pericellular Matrix Is Required for Proliferation and Migration of Vascular Smooth Muscle Cells

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Tumor suppressor PTEN: modulator of cell signaling, growth, migration and apoptosis

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Hyaluronan and Homeostasis: A Balancing Act

Tammi, M., Day, A. J., & Turley, E. A. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.r100037200 · Cited by 462

CD44 Interaction with Na+-H+ Exchanger (NHE1) Creates Acidic Microenvironments Leading to Hyaluronidase-2 and Cathepsin B Activation and Breast Tumor Cell Invasion

Bourguignon, L., Singleton, P. A., Diedrich, F., Stern, R., & Gilad, E. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m311838200 · Cited by 423

Hyaluronan Binding by Cell Surface CD44

Lesley, J. (2000) · Journal of Biological Chemistry · doi:10.1074/jbc.m002527200 · Cited by 400

Multicellular resistance: a paradigm for clinical resistance?

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Regulation of MMP-1 and MMP-2 production through CD147/extracellular matrix metalloproteinase inducer interactions.

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EGFR is a transducer of the urokinase receptor initiated signal that is required for in vivo growth of a human carcinoma

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Hyaluronan Binding by Cell Surface CD44

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Identification of a common hyaluronan binding motif in the hyaluronan binding proteins RHAMM, CD44 and link protein.

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The effect of hyaluronate and its oligosaccharides on endothelial cell proliferation and monolayer integrity

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Angiogenic Oligosaccharides of Hyaluronan Induce Multiple Signaling Pathways Affecting Vascular Endothelial Cell Mitogenic and Wound Healing Responses

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Hyaluronate production and removal during corneal development in the chick

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Stimulation of Matrix Metalloproteinase Production by Recombinant Extracellular Matrix Metalloproteinase Inducer from Transfected Chinese Hamster Ovary Cells

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Apoptosis and cancer chemotherapy

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Characterization and Molecular Evolution of a Vertebrate Hyaluronan Synthase Gene Family

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Differential Involvement of the Hyaluronan (HA) Receptors CD44 and Receptor for HA-mediated Motility in Endothelial Cell Function and Angiogenesis

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Hyaluronan Oligosaccharides Inhibit Anchorage-independent Growth of Tumor Cells by Suppressing the Phosphoinositide 3-Kinase/Akt Cell Survival Pathway

Ghatak, S., Misra, S., & Toole, B. P. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m202404200 · Cited by 332

Interaction between CD44 and hyaluronate is directly implicated in the regulation of tumor development.

Bartolazzi, A., Peach, R., Aruffo, A. A., & Stamenkovic, I. (1994) · The Journal of Experimental Medicine · doi:10.1084/jem.180.1.53 · Cited by 331

Heart-valve mesenchyme formation is dependent on hyaluronan-augmented activation of ErbB2–ErbB3 receptors

Camenisch, T. D., Schroeder, J. A., Bradley, J. M., Klewer, S. E., & McDonald, J. A. (2002) · Nature Medicine · doi:10.1038/nm742 · Cited by 330

Tumor cell-associated hyaluronan as an unfavorable prognostic factor in colorectal cancer.

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High levels of stromal hyaluronan predict poor disease outcome in epithelial ovarian cancer.

Anttila, M., Tammi, R., Tammi, M., Syrjänen, K. J., Saarikoski, S., & Kosma, V. (2000) · PubMed · Cited by 327

Combined transcriptome and genome analysis of single micrometastatic cells

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Stromal and Epithelial Expression of Tumor Markers Hyaluronic Acid and HYAL1 Hyaluronidase in Prostate Cancer

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Overproduction of hyaluronan by expression of the hyaluronan synthase Has2 enhances anchorage-independent growth and tumorigenicity.

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Abnormal accumulation of hyaluronan matrix diminishes contact inhibition of cell growth and promotes cell migration

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CD44 directs membrane-type 1 matrix metalloproteinase to lamellipodia by associating with its hemopexin-like domain.

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Selective suppression of CD44 in keratinocytes of mice bearing an antisense CD44 transgene driven by a tissue-specific promoter disrupts hyaluronate metabolism in the skin and impairs keratinocyte proliferation.Preprint

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Tumor-Stroma Interaction: Positive Feedback Regulation of Extracellular Matrix Metalloproteinase Inducer (EMMPRIN) Expression and Matrix Metalloproteinase-Dependent Generation of Soluble EMMPRIN

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Tumorigenic Potential of Extracellular Matrix Metalloproteinase Inducer

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CD44 cleavage induced by a membrane-associated metalloprotease plays a critical role in tumor cell migration

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The role of the CD44 transmembrane and cytoplasmic domains in co-ordinating adhesive and signalling events

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Induction of Apoptosis of Metastatic Mammary Carcinoma Cells In Vivo by Disruption of Tumor Cell Surface CD44 Function

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A novel PKC-regulated mechanism controls CD44–ezrin association and directional cell motility

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Hsp-90-associated oncoproteins: multiple targets of geldanamycin and its analogs

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Hyaluronan-mediated CD44 Interaction with RhoGEF and Rho Kinase Promotes Grb2-associated Binder-1 Phosphorylation and Phosphatidylinositol 3-Kinase Signaling Leading to Cytokine (Macrophage-Colony Stimulating Factor) Production and Breast Tumor Progression

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Hyaluronate and invasiveness of the rabbit V2 carcinoma.

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Hyaluronan and the hyaluronan receptor RHAMM promote focal adhesion turnover and transient tyrosine kinase activity.

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Expression of hyaluronidase by tumor cells induces angiogenesis in vivo.

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Regulation of Multidrug Resistance in Cancer Cells by Hyaluronan

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Hyaluronan Promotes Signaling Interaction between CD44 and the Transforming Growth Factor β Receptor I in Metastatic Breast Tumor Cells

Bourguignon, L., Singleton, P. A., Zhu, H., & Zhou, B. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m204320200 · Cited by 224

Elevated Hyaluronan Production Induces Mesenchymal and Transformed Properties in Epithelial Cells

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Intracellular Localization of Hyaluronan in Proliferating Cells

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Differences in Hyaluronic Acid-mediated Functions and Signaling in Arterial, Microvessel, and Vein-derived Human Endothelial Cells

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Hyaluronan on the surface of tumor cells is correlated with metastatic behavior.

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The Hyaluronan Receptor RHAMM Regulates Extracellular-regulated Kinase

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Interactions between human tumor cells and fibroblasts stimulate hyaluronate synthesis.

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Absence of lymphangiogenesis and intratumoural lymph vessels in human metastatic breast cancer

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RHAMM Is a Centrosomal Protein That Interacts with Dynein and Maintains Spindle Pole Stability

Maxwell, C. A., Keats, J. J., Crainie, M., Sun, X., Yen, T. J., Shibuya, E. K., Hendzel, M. J., Chan, G. K. T., & Pilarski, L. M. (2003) · Molecular Biology of the Cell · doi:10.1091/mbc.e02-07-0377 · Cited by 194

Radiation dose, chemotherapy and risk of osteosarcoma after solid tumours during childhood

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Hyaluronan Promotes CD44v3-Vav2 Interaction with Grb2-p185HER2 and Induces Rac1 and Ras Signaling during Ovarian Tumor Cell Migration and Growth

Bourguignon, L., Zhu, H., Zhou, B. O., Diedrich, F., Singleton, P. A., & Hung, M. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m106759200 · Cited by 188

Application of Angiogenic Oligosaccharides of Hyaluronan Increases Blood Vessel Numbers in Rat Skin

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The intracellular hyaluronan receptor RHAMM/IHABP interacts with microtubules and actin filaments

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Relationship between hyaluronan production and metastatic potential of mouse mammary carcinoma cells.

Itano, N., Sawai, T., Miyaishi, O., & Kimata, K. (1999) · PubMed · Cited by 182

Emmprin (CD147), a cell surface regulator of matrix metalloproteinase production and function

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Inhibition of Phosphorylation of BAD and Raf-1 by Akt Sensitizes Human Ovarian Cancer Cells to Paclitaxel

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Hyaluronan and Angiogenesis

West, D. C., & Kumar, S. (2007) · Novartis Foundation symposium · doi:10.1002/9780470513774.ch12 · Cited by 172

Hyaluronan synthase 3 overexpression promotes the growth of TSU prostate cancer cells.

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EMMPRIN-mediated MMP regulation in tumor and endothelial cells

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High stromal hyaluronan level is associated with poor differentiation and metastasis in prostate cancer

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Overexpression of extracellular matrix metalloproteinase inducer in multidrug resistant cancer cells.

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A Model for the Cytoplasmic Trafficking of Signalling Proteins Involving the hsp90-Binding Immunophilins and p50cdc37

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Proteoglycans

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Emmprin Promotes Anchorage-Independent Growth in Human Mammary Carcinoma Cells by Stimulating Hyaluronan Production

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Hyaluronan (hyaluronic acid) and hyaluronectin in the extracellular matrix of human breast carcinomas: Comparison between invasive and non‐invasive areas

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Hyaluronan expression in gastric cancer cells is associated with local and nodal spread and reduced survival rate

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Degradation of HER2 by ansamycins induces growth arrest and apoptosis in cells with HER2 overexpression via a HER3, phosphatidylinositol 3'-kinase-AKT-dependent pathway.

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Clinical Uses of Hyaluronan

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Hyaluronan in the Tumor Microenvironment

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Altered Hyaluronan Biosynthesis and Cancer Progression: an Immunological Perspective

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Importance of Hyaluronan-CD44 Interactions in Inflammation and Tumorigenesis

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Hyaluronan network: a driving force in cancer progression

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