Cited by 2,222Cancer Cells and MetastasisCellular Mechanics and InteractionsLymphatic System and Diseases

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High Interstitial Fluid Pressure - an Obstacle in Cancer Therapy

Heldin, Carl-Henrik, Rubin, Kristofer, Pietras, Kristian, Östman, Arne·2004·Nature reviews. Cancer

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Abstract

Many solid tumours show an increased interstitial fluid pressure (IFP), which forms a barrier to transcapillary transport. This barrier is an obstacle in tumour treatment, as it results in inefficient uptake of therapeutic agents. There are a number of factors that contribute to increased IFP in the tumour, such as vessel abnormalities, fibrosis and contraction of the interstitial matrix. Lowering the tumour IFP with specific signal-transduction antagonists might be a useful approach to improving anticancer drug efficacy.

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Authors: Heldin, C.-H., Rubin, K., Pietras, K., & Östman, A.
Affiliations: Ludwig Cancer Research (SE)
Uppsala University (SE)
University of California, San Francisco (US)
Karolinska Institutet (SE)
Corresponding author: Heldin, Carl-Henrik
ORCID: Heldin, Carl-Henrik
Rubin, Kristofer
Pietras, Kristian
Östman, Arne
Venue: Nature reviews. Cancer
Publisher: Springer Science and Business Media LLC
Published: 2004-10
Volume: 4
Issue: 10
Pages: 806-813
ISSN: 1474-175X (ISSN-L)
1474-1768
DOI: 10.1038/nrc1456
OpenAlex: W2028156849
Cited by: 2,222
References: 78
Citations by year: 2026: 121 · 2025: 110 · 2024: 118 · 2023: 119 · 2022: 163 · 2021: 158 · 2020: 158 · 2019: 123 · 2018: 123 · 2017: 135 · 2016: 133 · 2015: 110 · 2014: 117 · 2013: 124 · 2012: 87
FWCI: 3.19
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Cancer (publishedVersion)
PubMed (publishedVersion)
Funders: Cancerfonden
Topics: Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
Health Sciences › Medicine › Oncology › Lymphatic System and Diseases
Keywords: interstitial fluid pressure, solid tumors, tumor microenvironment, tumor fibrosis, anticancer drug delivery, tumor hypoxia
MeSH terms: Alprostadil, Animals, Antineoplastic Agents, Biological Transport, Bradykinin, Humans, Hyaluronoglucosaminidase, Hydrostatic Pressure, Neoplasms, Niacinamide, Platelet-Derived Growth Factor, Tumor Necrosis Factor-alpha, Signal Transduction, Transforming Growth Factor beta, Vascular Endothelial Growth Factor A, Extracellular Fluid, Mice

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High Interstitial Fluid Pressure - an Obstacle in Cancer Therapy

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