Cited by 2,222Cancer Cells and MetastasisCellular Mechanics and InteractionsLymphatic System and Diseases

The DOI matches its Crossref record; 78 of the 78 references it cites were found in a registry or an index.

High Interstitial Fluid Pressure - an Obstacle in Cancer Therapy

Heldin, Carl-Henrik, Rubin, Kristofer, Pietras, Kristian, Östman, Arne·2004·Nature reviews. Cancer

Open this paper in CoChat — free account

Abstract

Many solid tumours show an increased interstitial fluid pressure (IFP), which forms a barrier to transcapillary transport. This barrier is an obstacle in tumour treatment, as it results in inefficient uptake of therapeutic agents. There are a number of factors that contribute to increased IFP in the tumour, such as vessel abnormalities, fibrosis and contraction of the interstitial matrix. Lowering the tumour IFP with specific signal-transduction antagonists might be a useful approach to improving anticancer drug efficacy.

Integrity signals

Registry

Crossref · 10.1038/nrc1456

Cites

78 of 78 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Vascular permeability factor/vascular endothelial growth factor, microvascular hyperpermeability, and angiogenesis.
Dvorak, H. F., Brown, L. F., Detmar, M. J., & Dvořàk, A. M. (1995) · Europe PMC (PubMed Central) · Cited by 3,100
Pericyte Loss and Microaneurysm Formation in PDGF-B-Deficient Mice
Lindahl, P., Johansson, B. R., Levéen, P., & Betsholtz, C. (1997) · Science · doi:10.1126/science.277.5323.242 · Cited by 2,226
Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer
Willett, C. G., Boucher, Y., di Tomaso, E., Duda, D. G., Munn, L. L., Tong, R. T., Chung, D. C., Sahani, D. V., Kalva, S. P., Kozin, S. V., et al. (2004) · Nature Medicine · doi:10.1038/nm988 · Cited by 1,985
The myofibroblast in wound healing and fibrocontractive diseases
Gabbiani, G. (2003) · The Journal of Pathology · doi:10.1002/path.1427 · Cited by 1,630
Transport of molecules in the tumor interstitium: a review.
Jain, R. K. (1987) · PubMed · Cited by 1,357
Angiopoietin-1 protects the adult vasculature against plasma leakage
Thurston, G., Rudge, J. S., Ioffe, E., Zhou, H., Ross, L. H., Croll, S. D., Glazer, N. L., Holash, J. A., McDonald, D. M., & Yancopoulos, G. D. (2000) · Nature Medicine · doi:10.1038/74725 · Cited by 1,314
Vascular Normalization by Vascular Endothelial Growth Factor Receptor 2 Blockade Induces a Pressure Gradient Across the Vasculature and Improves Drug Penetration in Tumors
Tong, R. T., Boucher, Y., Kozin, S. V., Winkler, F., Hicklin, D. J., & Jain, R. K. (2004) · Cancer Research · doi:10.1158/0008-5472.can-04-0074 · Cited by 1,189
Barriers to Drug Delivery in Solid Tumors
Jain, R. K. (1994) · Scientific American · doi:10.1038/scientificamerican0794-58 · Cited by 1,074
Abnormalities in Pericytes on Blood Vessels and Endothelial Sprouts in Tumors
Morikawa, S., Bałuk, P., Kaidoh, T., Haskell, A., Jain, R. K., & McDonald, D. M. (2002) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64920-6 · Cited by 987
Lymphatic Metastasis in the Absence of Functional Intratumor Lymphatics
Padera, T. P., Kadambi, A., di Tomaso, E., Carreira, C. M., Brown, E. B., Boucher, Y., Choi, N. C., Mathisen, D. J., Wain, J. R., Mark, E. J., et al. (2002) · Science · doi:10.1126/science.1071420 · Cited by 982

Show all 78 references

Research works printed but not linked: 1

Kristensen, C. A. et al. Reduction of interstitial fluid pressure after TNF-α treatment of three human melanoma xenografts. Br. J. Cancer 74, 533–536 (1996). · DOI

Sorted by citations

Items 801–900 of 1,003

PEGPH20, a PEGylated human hyaluronidase, induces radiosensitization by reoxygenation in pancreatic cancer xenografts. A molecular imaging study
Seki, T., Saida, Y., Kishimoto, S., Lee, J., Otowa, Y., Yamamoto, K., Chandramouli, G. V. R., Devasahayam, N., Mitchell, J. B., Krishna, M. C., et al. (2022) · Neoplasia · doi:10.1016/j.neo.2022.100793 · Cited by 44
Nitric Oxide‐Based Nanomedicines for Conquering TME Fortress: Say “NO” to Insufficient Tumor Treatment
Xiang, Y., Chen, Q., Nan, Y., Liu, M., Xiao, Z., Yang, Y., Zhang, J., Ying, X., Long, X., Wang, S., et al. (2023) · Advanced Functional Materials · doi:10.1002/adfm.202312092 · Cited by 44
Augmentation of the EPR effect by mild hyperthermia to improve nanoparticle delivery to the tumor
Aloss, K., & Hamar, P. (2024) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2024.189109 · Cited by 49
Radiocurability Is Associated with Interstitial Fluid Pressure in Human Tumor Xenografts
Rofstad, E. K., Gaustad, J., Brurberg, K. G., Mathiesen, B. S., Galappathi, K., & Simonsen, T. G. (2009) · Neoplasia · doi:10.1593/neo.91152 · Cited by 44
Hypoxic stress and cancer: imaging the axis of evil in tumor metastasis
Avni, R., Cohen, B., & Neeman, M. (2011) · NMR in Biomedicine · doi:10.1002/nbm.1632 · Cited by 45
Extra- and intra-cellular fate of nanocarriers under dynamic interactions with biology
Seo, S.-J., Chen, M., Wang, H., Kang, M. S., Leong, K. W., & Kim, H. (2017) · Nano Today · doi:10.1016/j.nantod.2017.04.011 · Cited by 48
Harnessing Tumor Microenvironment for Nanoparticle‐Mediated Radiotherapy
Zhu, S., Gu, Z., & Zhao, Y. (2018) · Advanced Therapeutics · doi:10.1002/adtp.201800050 · Cited by 44
Recent advances in tumor microenvironment associated therapeutic strategies and evaluation models
Haider, T., Sandha, K. K., Soni, V., & Gupta, P. N. (2020) · Materials Science and Engineering C · doi:10.1016/j.msec.2020.111229 · Cited by 44
Engineering Intelligent Nanosystems for Enhanced Medical Imaging
van Moolenbroek, G. T., Patiño, T., Llop, J., & Sánchez, S. (2020) · Advanced Intelligent Systems · doi:10.1002/aisy.202000087 · Cited by 46
Cancer Acidity and Hypertonicity Contribute to Dysfunction of Tumor-Associated Dendritic Cells: Potential Impact on Antigen Cross-Presentation Machinery
Burgdorf, S., Porubský, Š., Marx, A., & Popović, Z. V. (2020) · Cancers · doi:10.3390/cancers12092403 · Cited by 48
Recent Advances of Nanotechnology-Facilitated Bacteria-Based Drug and Gene Delivery Systems for Cancer Treatment
Zhu, C., Ji, Z., Ma, J., Ding, Z., Shen, J., & Wang, Q. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13070940 · Cited by 44
Strategies for active tumor targeting-an update
Vyas, D., Patel, M. N., & Wairkar, S. (2021) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2021.174512 · Cited by 46
Sequential Intra‐Intercellular Nanoparticle Delivery System for Deep Tumor Penetration
Ju, C., Mo, R., Xue, J., Zhang, L., Zhao, Z., Xue, L., Ping, Q. N., & Zhang, C. (2014) · Angewandte Chemie · doi:10.1002/ange.201311227 · Cited by 44
Emerging platinum(IV) prodrug nanotherapeutics: A new epoch for platinum-based cancer therapy
Zheng, S., Li, G., Shi, J., Liu, X., Li, M., He, Z., Tian, C., & Kamei, K. (2023) · Journal of Controlled Release · doi:10.1016/j.jconrel.2023.08.035 · Cited by 42
Protein-based nanoparticles for therapeutic nucleic acid delivery
Eweje, F., Walsh, M. L., Ahmad, K., Ibrahim, V., Alrefai, A., Chen, J., & Chaikof, E. L. (2024) · Biomaterials · doi:10.1016/j.biomaterials.2023.122464 · Cited by 46
Pharmacokinetics in cancer chemotherapy
Garattini, S. K. (2006) · European Journal of Cancer · doi:10.1016/j.ejca.2006.10.015 · Cited by 43
The Effect of Molecular Weight, PK, and Valency on Tumor Biodistribution and Efficacy of Antibody-Based Drugs
Muchekehu, R., Liu, D., Horn, M., Campbell, L. A., Rosario, J. D., Bacica, M., Moskowitz, H., Osothprarop, T., Dirksen, A., Doppalapudi, V. R., et al. (2013) · Translational Oncology · doi:10.1593/tlo.13409 · Cited by 43
Effects of Sorafenib on Intra-Tumoral Interstitial Fluid Pressure and Circulating Biomarkers in Patients with Refractory Sarcomas (NCI Protocol 6948)
Raut, C. P., Boucher, Y., Duda, D. G., Morgan, J. A., Quek, R. H. H., Ancukiewicz, M., Lahdenranta, J., Eder, J. P., Demetri, G. D., & Jain, R. K. (2012) · PLoS ONE · doi:10.1371/journal.pone.0026331 · Cited by 44
Predicting IGF-1R Therapy Response in Bone Sarcomas: Immuno-SPECT Imaging with Radiolabeled R1507
Fleuren, E. D. G., Versleijen‐Jonkers, Y. M. H., van de Luijtgaarden, A. C. M., Molkenboer‐Kuenen, J. D. M., Heskamp, S., Roeffen, M. H. S., van Laarhoven, H. W. M., Houghton, P. J., Oyen, W. J. G., Boerman, O. C., et al. (2011) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-11-1488 · Cited by 43
The Acinar Cage: Basement Membranes Determine Molecule Exchange and Mechanical Stability of Human Breast Cell Acini
Gaiko-Shcherbak, A., Fabris, G., Dreissen, G., Merkel, R., Hoffmann, B., & Noetzel, E. (2015) · PLoS ONE · doi:10.1371/journal.pone.0145174 · Cited by 43
Heterocellular 3D scaffolds as biomimetic to recapitulate the tumor microenvironment of peritoneal metastases in vitro and in vivo
Jaeghere, E. A. D., Vlieghere, E. D., Hoorick, J. V., Vlierberghe, S. V., Wagemans, G., Pieters, L., Melsens, E., Praet, M. M., Dorpe, J. V., Boone, M., et al. (2017) · Biomaterials · doi:10.1016/j.biomaterials.2017.12.017 · Cited by 42
Microfluidics in Malignant Glioma Research and Precision Medicine
Logun, M. T., Zhao, W., Mao, L., & Karumbaiah, L. (2018) · Advanced Biosystems · doi:10.1002/adbi.201700221 · Cited by 46
Ultrasound contrast agent microbubbles with ultrahigh loading capacity of camptothecin and floxuridine for enhancing tumor accumulation and combined chemotherapeutic efficacy
Liang, X., Xu, Y., Gao, C., Zhou, Y., Zhang, N., & Dai, Z. (2018) · NPG Asia Materials · doi:10.1038/s41427-018-0066-x · Cited by 43
Multifunctional lipid-coated calcium phosphate nanoplatforms for complete inhibition of large triple negative breast cancer via targeted combined therapy
Tang, J., Li, B., Howard, C. B., Mahler, S. M., Thurecht, K. J., Wu, Y., Huang, L., & Xu, Z. P. (2019) · Biomaterials · doi:10.1016/j.biomaterials.2019.119232 · Cited by 43
Organic Nanocarriers for Delivery and Targeting of Therapeutic Agents for Cancer Treatment
Peng, Y., Bariwal, J. B., Kumar, V., Tan, C., & Mahato, R. I. (2020) · Advanced Therapeutics · doi:10.1002/adtp.201900136 · Cited by 44
Paracrine and cell autonomous signalling in pancreatic cancer progression and metastasis
Thomas, S. K., Lee, J., & Beatty, G. L. (2020) · EBioMedicine · doi:10.1016/j.ebiom.2020.102662 · Cited by 46
Hydrogels to engineer tumor microenvironments in vitro
Fernando, K., Kwang, L. G., Lim, J. T. C., & Fong, E. L. S. (2021) · Biomaterials Science · doi:10.1039/d0bm01943g · Cited by 44
Remodeling of Tumor Immune Microenvironment by Oncolytic Viruses
Zhang, B., Wang, X., & Cheng, P. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2020.561372 · Cited by 44
Ultrasound-enhanced drug dispersion through solid tumours and its possible role in aiding ultrasound-targeted cancer chemotherapy
Nomikou, N., Li, Y. S., & McHale, A. P. (2009) · Cancer Letters · doi:10.1016/j.canlet.2009.06.028 · Cited by 43
Metal-coordinated nanodrugs based on natural products for cancer theranostics
Liu, S., Xu, X., Ye, J., Wang, J., Wang, Q., Liu, Z., Xu, J., & Fu, Y. (2022) · Chemical Engineering Journal · doi:10.1016/j.cej.2022.140892 · Cited by 42
Deciphering mechanical cues in the microenvironment: from non-malignant settings to tumor progression
Zhu, Y., Chen, J., Chen, C., Tang, R., Xu, J., Shi, S., & Yu, X. (2025) · Biomarker Research · doi:10.1186/s40364-025-00727-9 · Cited by 45
Oroxylin A regulates glucose metabolism in response to hypoxic stress with the involvement of Hypoxia‐inducible factor‐1 in human hepatoma HepG2 cells
Dai, Q., Yin, Q., Wei, L., Zhou, Y., Qiao, C., Guo, Y., Wang, X., Ma, S., & Lu, N. (2015) · Molecular Carcinogenesis · doi:10.1002/mc.22369 · Cited by 43
Characterization of solid focal pancreatic lesions using endoscopic ultrasonography with real-time elastography
Havre, R. F., Ødegaard, S., Gilja, O. H., & Nesje, L. B. (2014) · Scandinavian Journal of Gastroenterology · doi:10.3109/00365521.2014.905627 · Cited by 42
Nanoparticles Containing Anti-inflammatory Agents as Chemotherapy Adjuvants: Optimization and In Vitro Characterization
Lü, X., Howard, M. D., Mazik, M., Eldridge, J. A., Rinehart, J. J., Jay, M., & Leggas, M. L. (2008) · The AAPS Journal · doi:10.1208/s12248-008-9013-z · Cited by 42
Targeted gene delivery to glioblastoma using a C-end rule RGERPPR peptide-functionalised polyethylenimine complex
Wang, J., Yang, L., Xie, C., Lu, W., Yan, Z., Gao, J., Xie, Z., Zhang, X., & Liu, M. (2013) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2013.10.017 · Cited by 42
Accumulation and distribution of doxorubicin in tumour spheroids: the influence of acidity and expression of P-glycoprotein
Mellor, H. R., & Callaghan, R. (2011) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-011-1598-8 · Cited by 43
Tumor-penetrating peptide fused to a pro-apoptotic peptide facilitates effective gastric cancer therapy
Huang, Y., Li, X., Sha, H., Zhang, L., Bian, X., Han, X., & Liu, B. (2017) · Oncology Reports · doi:10.3892/or.2017.5440 · Cited by 42
Tumor Cell-Specific Nuclear Targeting of Functionalized Graphene Quantum Dots In Vivo
Yao, C., Tu, Y., Ding, L., Li, C., Wang, J., Fang, H., Huang, Y., Zhang, K., Lu, Q., Wu, M., et al. (2017) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.7b00466 · Cited by 42
Revealing elasticity of largely deformed cells flowing along confining microchannels
Hu, S., Wang, R., Tsang, C. M., Tsao, S. W., Sun, D. B., & Lam, R. H. W. (2018) · RSC Advances · doi:10.1039/c7ra10750a · Cited by 41
Reduction-active polymeric prodrug micelles based on α-cyclodextrin polyrotaxanes for triggered drug release and enhanced cancer therapy
Bai, S., Hou, M., Shi, X., Chen, J., Ma, X., Gao, Y.-E., Wang, Y., Xue, P., Kang, Y., & Xu, Z. (2018) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2018.03.097 · Cited by 42
Patient-Specific Characterization of Breast Cancer Hemodynamics Using Image-Guided Computational Fluid Dynamics
Wu, C., Hormuth, D. A., Oliver, T., Pineda, F., Lorenzo, G., Karczmar, G. S., Moser, R., & Yankeelov, T. E. (2020) · IEEE Transactions on Medical Imaging · doi:10.1109/tmi.2020.2975375 · Cited by 43
In-vitro tumor microenvironment models containing physical and biological barriers for modelling multidrug resistance mechanisms and multidrug delivery strategies
Rahmanian, M., Seyfoori, A., Ghasemi, M., Shamsi, M., Kolahchi, A. R., Modarres, H. P., Sanati‐Nezhad, A., & Majidzadeh‐A, K. (2021) · Journal of Controlled Release · doi:10.1016/j.jconrel.2021.04.024 · Cited by 42
Nanoparticle-Based Therapies for Turning Cold Tumors Hot: How to Treat an Immunosuppressive Tumor Microenvironment
Giustarini, G., Pavesi, A., & Adriani, G. (2021) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2021.689245 · Cited by 42
Volumetric compression develops noise-driven single-cell heterogeneity
Zhao, X., Hu, J., Li, Y., & Guo, M. (2021) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2110550118 · Cited by 43
Primary and metastatic peritoneal surface malignancies
(2021) · Nature Reviews Disease Primers · doi:10.1038/s41572-021-00331-9 · Cited by 42
Endothelial nanoparticle binding kinetics are matrix and size dependent
Doiron, A. L., Clark, B. R., & Rinker, K. D. (2011) · Biotechnology and Bioengineering · doi:10.1002/bit.23253 · Cited by 42
Improving delivery of antineoplastic agents with anti‐vascular endothelial growth factor therapy
Yang, A. D., Bauer, T. W., Camp, E. R., Somcio, R., Liu, W., Fan, F., & Ellis, L. M. (2005) · Cancer · doi:10.1002/cncr.20942 · Cited by 42
Regulation of Tumor Invasion by the Physical Microenvironment: Lessons from Breast and Brain Cancer
Beeghly, G. F., Amofa, K. Y., Fischbach, C., & Kumar, S. (2022) · Annual Review of Biomedical Engineering · doi:10.1146/annurev-bioeng-110220-115419 · Cited by 43
Nanodrug removes physical barrier to promote T-cell infiltration for enhanced cancer immunotherapy
Xiao, Z., Tan, Y., Cai, Y., Huang, J., Wang, X., Li, B., Lin, L., Wang, Y., Shuai, X., & Zhu, K. (2023) · Journal of Controlled Release · doi:10.1016/j.jconrel.2023.02.029 · Cited by 42
Targeted polymer-drug conjugates: Current progress and future perspective
Xu, H., Ma, H., Yang, P., Zhang, X., Wu, X., Yin, W., Wang, H., & Xu, D. (2015) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2015.10.001 · Cited by 41
NANOMEDICINE: will it offer possibilities to overcome multiple drug resistance in cancer?
Friberg, S. G., & Nyström, A. M. (2016) · Journal of Nanobiotechnology · doi:10.1186/s12951-016-0172-2 · Cited by 43
Evaluating Nanoparticles in Preclinical Research Using Microfluidic Systems
Zhu, D., Long, Q., Xu, Y., & Xing, J. (2019) · Micromachines · doi:10.3390/mi10060414 · Cited by 41
Tumor self-responsive upconversion nanomedicines for theranostic applications
Xu, J., Gulzar, A., Yang, D., Gai, S., He, F., & Yang, P. (2019) · Nanoscale · doi:10.1039/c9nr06450h · Cited by 41
Combination Radioimmunotherapy Strategies for Solid Tumors
Zaheer, J., Kim, H., Lee, Y., Kim, J. S., & Lim, S. M. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20225579 · Cited by 41
tLyP-1 Peptide Functionalized Human H Chain Ferritin for Targeted Delivery of Paclitaxel
Ma, Y., Li, R., Dong, Y., You, C., Huang, S., Li, X., Wang, F., & Zhang, Y. (2021) · International Journal of Nanomedicine · doi:10.2147/ijn.s289005 · Cited by 41
Local delivery to malignant brain tumors: potential biomaterial-based therapeutic/adjuvant strategies
Alghamdi, M. A., Gumbleton, M., & Newland, B. (2021) · Biomaterials Science · doi:10.1039/d1bm00896j · Cited by 45
A mathematical model for understanding nanoparticle biodistribution after intratumoral injection in cancer tumors
Mahesh, N., Singh, N., & Talukdar, P. (2021) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2021.103048 · Cited by 41
Importance and Considerations of Antibody Engineering in Antibody-Drug Conjugates Development from a Clinical Pharmacologist’s Perspective
Lucas, A. T., Moody, A., Schorzman, A. N., & Zamboni, W. C. (2021) · Antibodies · doi:10.3390/antib10030030 · Cited by 40
Emerging nanomedicines strategies focused on tumor microenvironment against cancer recurrence and metastasis
Feng, Y., Liao, Z., Zhang, H., Xie, X., You, F., Liao, X., Wu, C., Zhang, W., Yang, H., & Liu, Y. (2022) · Chemical Engineering Journal · doi:10.1016/j.cej.2022.139506 · Cited by 41
Opportunities for nanomaterials in enzyme therapy
Torres‐Herrero, B., Armenia, I., Ortiz, C., de la Fuente, J. M., Betancor, L., & Grazú, V. (2024) · Journal of Controlled Release · doi:10.1016/j.jconrel.2024.06.035 · Cited by 40
Interstitial fluid—A reflection of the tumor cell microenvironment and secretome
Haslene‐Hox, H., Tenstad, O., & Wiig, H. (2013) · Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics · doi:10.1016/j.bbapap.2013.01.028 · Cited by 41
Peptide-Mediated Liposomal Drug Delivery System Targeting Tumor Blood Vessels in Anticancer Therapy
Wu, H., & Chang, D.-K. (2010) · Journal of Oncology · doi:10.1155/2010/723798 · Cited by 40
Two-dimensional closed-form model for temperature in living tissues for hyperthermia treatments
Dutta, J., & Kundu, B. (2017) · Journal of Thermal Biology · doi:10.1016/j.jtherbio.2017.10.012 · Cited by 40
Collateral Damage Intended—Cancer-Associated Fibroblasts and Vasculature Are Potential Targets in Cancer Therapy
Cavaco, A. C. M., Rezaei, M., Niland, S., & Eble, J. A. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18112355 · Cited by 40
Tissue‐Penetrating, Hypoxia‐Responsive Echogenic Polymersomes For Drug Delivery To Solid Tumors
Kulkarni, P., Haldar, M. K., Karandish, F., Confeld, M. I., Hossain, R., Borowicz, P. P. P., Gange, K. N., Xia, L., Sarkar, K., & Mallik, S. (2018) · Chemistry - A European Journal · doi:10.1002/chem.201802229 · Cited by 42
NIR light triggered size variable “remote-controlled cluster bomb” for deep penetration and tumor therapy
Cao, W., He, Y., Zhu, R., He, Y., Hao, Z., Zhao, Q., He, H., Wang, S., Li, C., & Gao, D. (2019) · Chemical Engineering Journal · doi:10.1016/j.cej.2019.122080 · Cited by 40
Homing Peptides for Cancer Therapy
Lingasamy, P., & Teesalu, T. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-58174-9_2 · Cited by 42
Therapeutic antibodies – natural and pathological barriers and strategies to overcome them
Ojaimi, Y. A., Blin, T., Lamamy, J., Gracia, M., Pitiot, A., Denevault‐Sabourin, C., Joubert, N., Pouget, J., Gouilleux‐Gruart, V., Heuzé‐Vourc'h, N., et al. (2021) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2021.108022 · Cited by 43
A CFH peptide-decorated liposomal oxymatrine inactivates cancer-associated fibroblasts of hepatocellular carcinoma through epithelial–mesenchymal transition reversion
Guo, J. X., Zeng, H., Shi, X., Han, T., Liu, Y., Liu, Y., Liu, C., Qu, D., & Chen, Y. (2022) · Journal of Nanobiotechnology · doi:10.1186/s12951-022-01311-1 · Cited by 40
Zone‐specific remodeling of tumor blood vessels affects tumor growth
Derya Tilki, A., Kilic, N., Sevinc, S., Zywietz, F., Stief, C. G., & Ergün, S. (2007) · Cancer · doi:10.1002/cncr.23024 · Cited by 40
Receptor tyrosine kinase inhibitors in thyroid cancer
Castellone, M. D., Carlomagno, F., Salvatore, G., & Santoro, M. (2008) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2008.09.012 · Cited by 40
Tumor-associated neutrophils: orchestrating cancer pathobiology and therapeutic resistance
Bui, T. M., Yalom, L. K., & Sumagin, R. (2021) · Expert Opinion on Therapeutic Targets · doi:10.1080/14728222.2021.1954162 · Cited by 42
Development of the Peritoneal Metastasis: A Review of Back-Grounds, Mechanisms, Treatments and Prospects
Ren, K., Xie, X., Min, T., Sun, T., Wang, H., Zhang, Y., Dang, C., & Zhang, H. (2022) · Journal of Clinical Medicine · doi:10.3390/jcm12010103 · Cited by 39
Translational nanorobotics breaking through biological membranes
Ressnerova, A., Heger, Z., & Pumera, M. (2025) · Chemical Society Reviews · doi:10.1039/d4cs00483c · Cited by 39
Targeting delivery and deep penetration using multistage nanoparticles for triple-negative breast cancer
Ruan, S., Zhang, L., Chen, J., Cao, T., Yang, Y., Liu, Y., He, Q., Gao, F., & Gao, H. (2015) · RSC Advances · doi:10.1039/c5ra12436k · Cited by 39
Intelligent Design of Multifunctional lipid-coated Nanoparticle Platforms for Cancer Therapy
Ramishetti, S., & Huang, L. (2012) · Therapeutic Delivery · doi:10.4155/tde.12.127 · Cited by 39
A contact line pinning based microfluidic platform for modelling physiological flows
Tung, C.-K., Krupa, O., Apaydin, E., Liou, J., Diaz-Santana, A., Kim, B. J., & Wu, M. (2013) · Lab on a Chip · doi:10.1039/c3lc50489a · Cited by 38
A combination of low-dose bevacizumab and imatinib enhances vascular normalisation without inducing extracellular matrix deposition
Schiffmann, L. M., Brunold, M., Liwschitz, M., Goede, V., Loges, S., Wroblewski, M., Quaas, A., Alakus, H., Stippel, D. L., Bruns, C. J., et al. (2017) · British Journal of Cancer · doi:10.1038/bjc.2017.13 · Cited by 40
A non-equilibrium thermodynamic model for tumor extracellular matrix with enzymatic degradation
Xue, S.-L., Li, B., Feng, X., & Gao, H. (2017) · Journal of the Mechanics and Physics of Solids · doi:10.1016/j.jmps.2017.04.002 · Cited by 39
A Cascade‐Targeting Nanocapsule for Enhanced Photothermal Tumor Therapy with Aid of Autophagy Inhibition
Wu, X., Wu, Y., Wang, Z., Liu, L., Sun, C., Chen, Y., & Wang, C. (2018) · Advanced Healthcare Materials · doi:10.1002/adhm.201800121 · Cited by 38
Stromal cells in breast cancer as a potential therapeutic target
Dykes, S. S., Hughes, V. S., Wiggins, J. M., Fasanya, H. O., Tanaka, M., & Siemann, D. W. (2018) · Oncotarget · doi:10.18632/oncotarget.25245 · Cited by 41
Liposomal Irinotecan for Treatment of Colorectal Cancer in a Preclinical Model
Huang, J.-R., Lee, M., Li, W., & Wu, H.-C. (2019) · Cancers · doi:10.3390/cancers11030281 · Cited by 39
Biodegradable iron-coordinated hollow polydopamine nanospheres for dihydroartemisinin delivery and selectively enhanced therapy in tumor cells
Dong, L., Wang, C., Zhen, W., Jia, X., An, S., Xu, Z., Zhang, W., & Jiang, X. (2019) · Journal of Materials Chemistry B · doi:10.1039/c9tb01397k · Cited by 38
Injectable corilagin/low molecular weight chitosan/PLGA-PEG-PLGA thermosensitive hydrogels for localized cancer therapy and promoting drug infiltration by modulation of tumor microenvironment
Jin, X., Fu, Q., Gu, Z., Zhang, Z., & Lv, H. (2020) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2020.119772 · Cited by 39
Radiation sensitization of tumor cells induced by shear stress: The roles of integrins and FAK
Luo, C., Wu, C., & Ch'ang, H.-J. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2014.06.007 · Cited by 39
Multiple administration of PEG-coated liposomal oxaliplatin enhances its therapeutic efficacy: A possible mechanism and the potential for clinical application
Lila, A. S. A., Eldin, N. E., Ichihara, M., Ishida, T., & Kiwada, H. (2012) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2012.08.030 · Cited by 39
Clostridial Spores for Cancer Therapy: Targeting Solid Tumour Microenvironment
Umer, B. A., Good, D. M., Anné, J., Duan, W., & Wei, M. Q. (2012) · Journal of Toxicology · doi:10.1155/2012/862764 · Cited by 39
Inducing Optimal Antitumor Immune Response through Coadministering iRGD with Pirarubicin Loaded Nanostructured Lipid Carriers for Breast Cancer Therapy
Deng, C., Jia, M., Wei, G., Tan, T., Fu, Y. S., Gao, H., Sun, X., Zhang, Q., Gong, T., & Zhang, Z. (2016) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.6b00932 · Cited by 39
Fibrinolytic Enzyme Cotherapy Improves Tumor Perfusion and Therapeutic Efficacy of Anticancer Nanomedicine
Kirtane, A. R., Sadhukha, T., Kim, H., Khanna, V., Koniar, B., & Panyam, J. (2017) · Cancer Research · doi:10.1158/0008-5472.can-16-1646 · Cited by 38
Mechanical regulation of the early stages of angiogenesis
Barrasa-Ramos, S., Dessalles, C. A., Hautefeuille, M., & Barakat, A. I. (2022) · Journal of The Royal Society Interface · doi:10.1098/rsif.2022.0360 · Cited by 43
Trends in smart drug delivery systems for targeting cancer cells
Kandula, S., Singh, P. K., Kaur, G. A., & Tiwari, A. (2023) · Materials Science and Engineering B · doi:10.1016/j.mseb.2023.116816 · Cited by 38
Cancer Metastasis‐on‐a‐Chip for Modeling Metastatic Cascade and Drug Screening
Brooks, A., Zhang, Y., Chen, J., & Zhao, C. (2024) · Advanced Healthcare Materials · doi:10.1002/adhm.202302436 · Cited by 41
Bio-nanomaterials: Promising anticancer properties and treatment strategies
Elemike, E. E., Onunkwo, I. C., Ughumiakpor, O., Alawuru, F., Mukoro, A., Ishom, P., Obarakpor, F., Hossain, I., & Aziza, A. E. (2025) · Nano TransMed · doi:10.1016/j.ntm.2025.100076 · Cited by 42
Combination therapy in cancer: effects of angiogenesis inhibitors on drug pharmacokinetics and pharmacodynamics
Nerini, I. F., Cesca, M., Bizzaro, F., & Giavazzi, R. (2016) · 癌症：英文版 · doi:10.1186/s40880-016-0123-1 · Cited by 38
Tumour tissue transport after intraperitoneal anticancer drug delivery
Carlier, C., Mathys, A., Jaeghere, E. A. D., Steuperaert, M., Wever, O. D., & Ceelen, W. P. (2017) · International Journal of Hyperthermia · doi:10.1080/02656736.2017.1312563 · Cited by 39
Preclinical three‐dimensional colorectal cancer model: The next generation of in vitro drug efficacy evaluation
Sensi, F., D’Angelo, E., DaRonco, S., Molinaro, R., & Agostini, M. (2018) · Journal of Cellular Physiology · doi:10.1002/jcp.26812 · Cited by 40
PD-L1 microSPECT/CT Imaging for Longitudinal Monitoring of PD-L1 Expression in Syngeneic and Humanized Mouse Models for Cancer
Heskamp, S., Wierstra, P. J., Molkenboer‐Kuenen, J. D. M., Sandker, G. W., Thordardottir, S., Cany, J., Olive, D., Bussink, J., Boerman, O. C., Dolstra, H., et al. (2018) · Cancer Immunology Research · doi:10.1158/2326-6066.cir-18-0280 · Cited by 38
Force-Directed “Mechanointeractome” of Talin–Integrin
Chakraborty, S., Banerjee, S., Raina, M., & Haldar, S. (2019) · Biochemistry · doi:10.1021/acs.biochem.9b00442 · Cited by 38
An approach for vascular tumor growth based on a hybrid embedded/homogenized treatment of the vasculature within a multiphase porous medium model
Kremheller, J., Vuong, A., Schrefler, B. A., & Wall, W. A. (2019) · International Journal for Numerical Methods in Biomedical Engineering · doi:10.1002/cnm.3253 · Cited by 38
Lysophosphatidic Acid: Promoter of Cancer Progression and of Tumor Microenvironment Development. A Promising Target for Anticancer Therapies?
Aiello, S., & Casiraghi, F. (2021) · Cells · doi:10.3390/cells10061390 · Cited by 39

Authors: Heldin, C.-H., Rubin, K., Pietras, K., & Östman, A.
Affiliations: Ludwig Cancer Research (SE)
Uppsala University (SE)
University of California, San Francisco (US)
Karolinska Institutet (SE)
Corresponding author: Heldin, Carl-Henrik
ORCID: Heldin, Carl-Henrik
Rubin, Kristofer
Pietras, Kristian
Östman, Arne
Venue: Nature reviews. Cancer
Publisher: Springer Science and Business Media LLC
Published: 2004-10
Volume: 4
Issue: 10
Pages: 806-813
ISSN: 1474-175X (ISSN-L)
1474-1768
DOI: 10.1038/nrc1456
OpenAlex: W2028156849
Cited by: 2,222
References: 78
Citations by year: 2026: 121 · 2025: 110 · 2024: 118 · 2023: 119 · 2022: 163 · 2021: 158 · 2020: 158 · 2019: 123 · 2018: 123 · 2017: 135 · 2016: 133 · 2015: 110 · 2014: 117 · 2013: 124 · 2012: 87
FWCI: 3.19
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Cancer (publishedVersion)
PubMed (publishedVersion)
Funders: Cancerfonden
Topics: Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
Health Sciences › Medicine › Oncology › Lymphatic System and Diseases
Keywords: interstitial fluid pressure, solid tumors, tumor microenvironment, tumor fibrosis, anticancer drug delivery, tumor hypoxia
MeSH terms: Alprostadil, Animals, Antineoplastic Agents, Biological Transport, Bradykinin, Humans, Hyaluronoglucosaminidase, Hydrostatic Pressure, Neoplasms, Niacinamide, Platelet-Derived Growth Factor, Tumor Necrosis Factor-alpha, Signal Transduction, Transforming Growth Factor beta, Vascular Endothelial Growth Factor A, Extracellular Fluid, Mice

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

High Interstitial Fluid Pressure - an Obstacle in Cancer Therapy

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks