Cell cycle, CDKs and cancer: a changing paradigm

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1. Molecular Pathways: Targeting the Protein Kinase Wee1 in Cancer
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2. Transcriptional landscape of the human cell cycle
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3. Arginine Methylation-Dependent Reader-Writer Interplay Governs Growth Control by E2F-1
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4. Targeting cyclin-dependent kinase 1 (CDK1) but not CDK4/6 or CDK2 is selectively lethal to MYC-dependent human breast cancer cells
   Jian Kang, C. Marcelo Sergio, Robert L. Sutherland, Elizabeth A. Musgrove · 2014 · BMC Cancer
5. Reaction-Based Enumeration, Active Learning, and Free Energy Calculations To Rapidly Explore Synthetically Tractable Chemical Space and Optimize Potency of Cyclin-Dependent Kinase 2 Inhibitors
   Kyle D. Konze, Pieter H. Bos, Markus K. Dahlgren, Karl Leswing, Ivan Tubert‐Brohman, Andrea Bortolato, Braxton Robbason, Robert Abel, Sathesh Bhat · 2019 · Journal of Chemical Information and Modeling
6. Selective inhibition of CDK4/6: A safe and effective strategy for developing anticancer drugs
   Kai Yuan, Xiao Wang, Haojie Dong, Wenjian Min, Haiping Hao, Peng Yang · 2020 · Acta Pharmaceutica Sinica B
7. Phylogenetic analysis of CDK and cyclin proteins in premetazoan lineages
   Lihuan Cao, Fang Chen, Xianmei Yang, Weijin Xu, Jun Xie, Long Yu · 2014 · BMC Evolutionary Biology
8. The Conundrum of Genetic “Drivers” in Benign Conditions
   Shumei Kato, Scott Michael Lippman, Keith T. Flaherty, Razelle Kurzrock · 2016 · JNCI Journal of the National Cancer Institute
9. Division and apoptosis of E2f-deficient retinal progenitors
   Chen, Danian, Pacal, Marek, Wenzel, Pamela, Knoepfler, Paul S., Leone, Gustavo, Bremner, Rod · 2009 · Nature
10. Cdk7: a kinase at the core of transcription and in the crosshairs of cancer drug discovery
    Robert P. Fisher · 2018 · Transcription
11. Ovarian carcinoma CDK12 mutations misregulate expression of DNA repair genes via deficient formation and function of the Cdk12/CycK complex
    Kingsley Mokube Ekumi, Hana Paculová, Tina Lenasi, Vendula Pospíchalová, Christian A. Bösken, Jana Rybaříková, Vı́tězslav Bryja, Matthias Geyer, Dalibor Blažek, Matjaž Barborič · 2015 · Nucleic Acids Research
12. Andrographolide derivatives inhibit guanine nucleotide exchange and abrogate oncogenic Ras function
    Harrison J. Hocker, Kwang-Jin Cho, Chung-Ying K. Chen, Nandini Rambahal, Sreenivasa Rao Sagineedu, Khozirah Shaari, Johnson Stanslas, John F. Hancock, Alemayehu Abebe Gorfe · 2013 · Proceedings of the National Academy of Sciences
13. ICEC0942, an Orally Bioavailable Selective Inhibitor of CDK7 for Cancer Treatment
    Hetal Patel, Manikandan Periyasamy, Georgina P. Sava, Alexander Bondke, Brian W. Slafer, Sebastian H. B. Kroll, Marion Barbazanges, Richard Starkey, Silvia Ottaviani, Alison Harrod et al. · 2018 · Molecular Cancer Therapeutics
14. Fusobacterium nucleatum Caused DNA Damage and Promoted Cell Proliferation by the Ku70 / p53 Pathway in Oral Cancer Cells
    Fengxue Geng, Yunjia Zhang, Ze Lu, Shuwei Zhang, Yaping Pan · 2019 · DNA and Cell Biology
15. Cyclin-Dependent Kinase 6 Is a Chromatin-Bound Cofactor for NF-κB-Dependent Gene Expression
    Handschick, Katja, Beuerlein, Knut, Jurida, Liane, Bartkuhn, Marek, Müller, Helmut, Soelch, Johanna, Weber, Axel, Dittrich-Breiholz, Oliver, Schneider, Heike, Scharfe, Maren et al. · 2014 · Molecular Cell
16. Systematic exploration of different E3 ubiquitin ligases: an approach towards potent and selective CDK6 degraders
    Steinebach, Christian, Ng, Yuen Lam Dora, Sosič, Izidor, Lee, Chih-Shia, Chen, Sirui, Lindner, Stefanie, Vu, Lan Phuong, Bricelj, Aleša, Haschemi, Reza, Monschke, Marius et al. · 2020 · Chemical Science
17. Cyclin-dependent Kinase 1 (CDK1)-mediated Phosphorylation of Enhancer of Zeste 2 (Ezh2) Regulates Its Stability
    Susan C. Wu, Yi Zhang · 2011 · Journal of Biological Chemistry
18. Upregulation of HIF-2α induced by sorafenib contributes to the resistance by activating the TGF-α/EGFR pathway in hepatocellular carcinoma cells
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19. Anticancer Applications and Pharmacological Properties of Piperidine and Piperine: A Comprehensive Review on Molecular Mechanisms and Therapeutic Perspectives
    Sicon Mitra, Uttpal Anand, Niraj Kumar Jha, Mahipal S. Shekhawat, Suchismita Chatterjee Saha, Potshangbam Nongdam, Kannan R. R. Rengasamy, Jarosław Proćków, Abhijit Dey · 2022 · Frontiers in Pharmacology
20. Protein post-translational modifications in the regulation of cancer hallmarks
    Haiying Wang, Liqian Yang, Minghui Liu, Jianyuan Luo · 2022 · Cancer Gene Therapy
21. Cell cycle–related kinase is a direct androgen receptor–regulated gene that drives β-catenin/T cell factor–dependent hepatocarcinogenesis
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22. Icaritin Causes Sustained ERK1/2 Activation and Induces Apoptosis in Human Endometrial Cancer Cells
    Jingshan Tong, Qinghua Zhang, Xin Huang, Xueqi Fu, Shu‐Tao Qi, Yapeng Wang, Yi Hou, Jun Sheng, Qing‐Yuan Sun · 2011 · PLoS ONE
23. Polo-like kinase 1 coordinates biosynthesis during cell cycle progression by directly activating pentose phosphate pathway
    Xiaoyu Ma, Lin Wang, De Huang, Yunyan Li, Dongdong Yang, Tingting Li, Fudong Li, Linchong Sun, Haoran Wei, Kun He et al. · 2017 · Nature Communications
24. A proteome-wide atlas of drug mechanism of action
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25. Cyclin-Dependent Kinase Inhibitors as Anticancer Drugs
    Vladimı́r Kryštof, Stjepan Uldrijan · 2010 · Current Drug Targets
26. P-TEFb regulation of transcription termination factor Xrn2 revealed by a chemical genetic screen for Cdk9 substrates
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27. The chemistry of senescence
    Lozano-Torres, Beatriz, Estepa-Fernández, Alejandra, Rovira, Miguel, Orzáez, Mar, Serrano, Manuel, Martínez-Máñez, Ramón, Sancenón, Félix · 2019 · Nature Reviews Chemistry
28. C-Phycocyanin exerts anti-cancer effects via the MAPK signaling pathway in MDA-MB-231 cells
    Liangqian Jiang, Yujuan Wang, Guoxiang Liu, Huihui Liu, Feng Zhu, Huanhuan Ji, Bing Li · 2018 · Cancer Cell International
29. Glucocorticoids, genes and brain function
    Grzegorz Roman Juszczak, Adrian Mateusz Stankiewicz · 2017 · Progress in Neuro-Psychopharmacology and Biological Psychiatry
30. CDK1 Interacts with Sox2 and Promotes Tumor Initiation in Human Melanoma
    Dinoop Ravindran Menon, Yuchun Luo, John J. Arcaroli, Sucai Liu, Lekha Nair KrishnanKutty, Douglas Grant Osborne, Yang Li, Jenny Mae Samson, Stacey M. Bagby, Aik Choon Tan et al. · 2018 · Cancer Research
31. DANCR Promotes Metastasis and Proliferation in Bladder Cancer Cells by Enhancing IL-11-STAT3 Signaling and CCND1 Expression
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32. Design, Synthesis, Molecular Modeling, Anticancer Studies, and Density Functional Theory Calculations of 4-(1,2,4-Triazol-3-ylsulfanylmethyl)-1,2,3-triazole Derivatives
    Adeeb Al-Sheikh Ali, Daoud J. O. Khan, Arshi Naqvi, Fawzia Faleh Al-blewi, Nadjet Rezki, Mohamed Reda Aouad, Mohamed Hagar · 2020 · ACS Omega
33. Androgen receptor phosphorylation: biological context and functional consequences
    Yulia A Koryakina, Huy Q. Ta, Daniel G. Gioeli · 2014 · Endocrine Related Cancer
34. A Mechanism for Controlled Breakage of Under-replicated Chromosomes during Mitosis
    Heike Duda, Meret Arter, Jiradet Gloggnitzer, Federico Teloni, Philipp Sebastian Wild, Miguel G. Blanco, Matthias Altmeyer, Joao Matos · 2016 · Developmental Cell
35. CDK1 in Breast Cancer: Implications for Theranostic Potential
    Sepideh Izadi, Afshin Nikkhoo, Mohammad Hojjat‐Farsangi, Afshin Namdar, Gholamreza Azizi, Hamed Mohammadi, Mehdi Yousefi, Farhad Jadidi‐Niaragh · 2020 · Anti-Cancer Agents in Medicinal Chemistry
36. Global Changes in the Mammary Epigenome Are Induced by Hormonal Cues and Coordinated by Ezh2
    Bhupinder Pal, Toula Bouras, Wei Shi, François Vaillant, Julie M. Sheridan, Nai Yang Fu, Kelsey A. Breslin, Kun Jiang, Matthew E. Ritchie, Matthew D. Young et al. · 2013 · Cell Reports
37. High expression of CDK1 and BUB1 predicts poor prognosis of pancreatic ductal adenocarcinoma
    Junjie Piao, Lianhua Zhu, Jie Lena Sun, Nan Li, Bing Dong, Yang Yang, Liyan Chen · 2019 · Gene
38. Identification and Characterization of an Irreversible Inhibitor of CDK2
    Elizabeth Anscombe, Elisa Meschini, Regina Mora-Vidal, Mathew P. Martin, David Staunton, Matthis Geitmann, U. Helena Danielson, Will A. Stanley, Lan-Zhen Wang, Tristan D. Reuillon et al. · 2015 · Chemistry & Biology
39. Salinomycin sensitizes cancer cells to the effects of doxorubicin and etoposide treatment by increasing DNA damage and reducing p21 protein
    Ju-Hwa Kim, Min-Ji Chae, Won Ki Kim, Youjin Kim, Han Sung Kang, Hyung Sik Kim, Sungpil Yoon · 2010 · British Journal of Pharmacology
40. Targeting zebrafish and murine pituitary corticotroph tumors with a cyclin-dependent kinase (CDK) inhibitor
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41. Recent developments in cyclin-dependent kinase biochemical and structural studies
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42. Cadmium Promotes Breast Cancer Cell Proliferation by Potentiating the Interaction between ERα and c-Jun
    Christina L. Siewit, Bridget Gengler, Esera Vegas, Rachel Puckett, Maggie C. Louie · 2010 · Molecular Endocrinology
43. Multicellular tumor spheroid models to explore cell cycle checkpoints in 3D
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44. Identification of N,1,4,4-Tetramethyl-8-{[4-(4-methylpiperazin-1-yl)phenyl]amino}-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide (PHA-848125), a Potent, Orally Available Cyclin Dependent Kinase Inhibitor
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45. Substituted 4-(Thiazol-5-yl)-2-(phenylamino)pyrimidines Are Highly Active CDK9 Inhibitors: Synthesis, X-ray Crystal Structures, Structure–Activity Relationship, and Anticancer Activities
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46. Decorin Antagonizes Met Receptor Activity and Down-regulates β-Catenin and Myc Levels
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47. Targeting Cancer with Small-Molecular-Weight Kinase Inhibitors
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48. Emerging therapeutic targets in bladder cancer
    Benedito A. Carneiro, Joshua J. Meeks, Timothy Michael Kuzel, Mariana Scaranti, Sarki Abba Abdulkadir, Francis Joseph Giles · 2014 · Cancer Treatment Reviews
49. Carbon dots based FRET for the detection of DNA damage
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50. Akt activation by Ca2+/calmodulin-dependent protein kinase kinase 2 (CaMKK2) in ovarian cancer cells
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51. CRISPR/Cas9 gene editing: a new approach for overcoming drug resistance in cancer
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52. The DNA Damage Response in Neurons: Die by Apoptosis or Survive in a Senescence-Like State?
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53. ORAI2 Promotes Gastric Cancer Tumorigenicity and Metastasis through PI3K/Akt Signaling and MAPK-Dependent Focal Adhesion Disassembly
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54. Discovery of PF-06873600, a CDK2/4/6 Inhibitor for the Treatment of Cancer
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55. CDK4/6 inhibition induces epithelial cell cycle arrest and ameliorates acute kidney injury
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56. Understanding cell cycle and cell death regulation provides novel weapons against human diseases
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57. Cell Cycle Regulation by the Nutrient-Sensing Mammalian Target of Rapamycin (mTOR) Pathway
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58. CDK1 Phosphorylation of YAP Promotes Mitotic Defects and Cell Motility and Is Essential for Neoplastic Transformation
    Shuping Yang, Lin Zhang, Miao Liu, Rong Chong, Shi‐Jian Ding, Yuanhong Chen, Jixin Dong · 2013 · Cancer Research
59. Discovery of 4-((7H-Pyrrolo[2,3-d]pyrimidin-4-yl)amino)-N-(4-((4-methylpiperazin-1-yl)methyl)phenyl)-1H-pyrazole-3-carboxamide (FN-1501), an FLT3- and CDK-Kinase Inhibitor with Potentially High Efficiency against Acute Myelocytic Leukemia
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60. Combination Therapy Targeting the Chk1 and Wee1 Kinases Shows Therapeutic Efficacy in Neuroblastoma
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61. Cyclin-Dependent Kinase (CDK) Inhibitors: Structure–Activity Relationships and Insights into the CDK-2 Selectivity of 6-Substituted 2-Arylaminopurines
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62. Phase-2 trial of palbociclib in adult patients with recurrent RB1-positive glioblastoma
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63. Regulating neutrophil apoptosis: new players enter the game
    Véronique Witko‐Sarsat, Magali Pederzoli-Ribeil, Emilio Hirsch, Silvano Sozzani, Marco Antonio Cassatella · 2011 · Trends in Immunology
64. SUMO1 modification stabilizes CDK6 protein and drives the cell cycle and glioblastoma progression
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65. Loss of Cdk2 and cyclin A2 impairs cell proliferation and tumorigenesis.
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66. Discovery of AZD4573, a Potent and Selective Inhibitor of CDK9 That Enables Short Duration of Target Engagement for the Treatment of Hematological Malignancies
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67. Selective CDK9 inhibition overcomes TRAIL resistance by concomitant suppression of cFlip and Mcl-1
    Johannes Lemke, Silvia von Karstedt, Muad Y Abd El Hay, Annalisa Conti, Frederick Arce Vargas, Antonella Montinaro, Kerstin Papenfuss, Mona A El-Bahrawy, Henning Walczak · 2013 · Cell Death and Differentiation
68. Ferulic acid inhibits proliferation and promotes apoptosis via blockage of PI3K/Akt pathway in osteosarcoma cell.
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69. Naturally derived indole alkaloids targeting regulated cell death (RCD) for cancer therapy: from molecular mechanisms to potential therapeutic targets
    Rui Qin, Feng-Ming You, Qian Zhao, Xin Xie, Cheng Peng, Gu Zhan, Bo Han · 2022 · Journal of Hematology & Oncology
70. Cyclin K goes with Cdk12 and Cdk13
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71. Cyclin D3 coordinates the cell cycle during differentiation to regulate erythrocyte size and number
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72. Targeting cell cycle regulators in hematologic malignancies
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73. Aloperine induces apoptosis and G2/M cell cycle arrest in hepatocellular carcinoma cells through the PI3K/Akt signaling pathway
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74. High nuclear/cytoplasmic ratio of Cdk1 expression predicts poor prognosis in colorectal cancer patients
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75. Andrographolide and its derivatives: Current achievements and future perspectives
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76. Natural products and derivatives for breast cancer treatment: From drug discovery to molecular mechanism
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77. Hydrogen Sulfide Biology and Its Role in Cancer
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78. Characterization of molecular and cellular functions of the cyclin‐dependent kinase CDK9 using a novel specific inhibitor
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79. The emerging role of APC/CCdh1 in controlling differentiation, genomic stability and tumor suppression
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80. USP7 Is a Master Regulator of Genome Stability
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81. Quantifying CDK inhibitor selectivity in live cells
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82. Overcoming anti-cancer drug resistance via restoration of tumor suppressor gene function
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83. Targeting cyclin-dependent kinase 1 (CDK1) in cancer: molecular docking and dynamic simulations of potential CDK1 inhibitors
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84. Cyclin-dependent kinase inhibitor Dinaciclib (SCH727965) inhibits pancreatic cancer growth and progression in murine xenograft models
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85. Cyclin E Constrains Cdk5 Activity to Regulate Synaptic Plasticity and Memory Formation
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86. Recent Advances in the Medicinal Chemistry of Aurones
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87. Discovery of selective CDK9 degraders with enhancing antiproliferative activity through PROTAC conversion
    Xiaqiu Qiu, Yuan‐Qing Li, Bin Yu, Jie Ren, Huidan Huang, Min Wang, Hong Ding, Zhiyu Li, Jubo Wang, Jinlei Bian · 2020 · European Journal of Medicinal Chemistry
88. Cyclin E1 and RTK/RAS signaling drive CDK inhibitor resistance via activation of E2F and ETS
    Barbie Taylor‐Harding, Paul-Joseph P. Aspuria, Hasmik Agadjanian, Dong‐Joo Cheon, Takako Mizuno, Danielle N. Greenberg, Jenieke R. Allen, Lindsay Spurka, Vincent Anthony Funari, Elizabeth Spiteri et al. · 2014 · Oncotarget
89. Targeted Therapeutic Strategies for Triple-Negative Breast Cancer
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90. M phase phosphorylation of the epigenetic regulator UHRF1 regulates its physical association with the deubiquitylase USP7 and stability
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91. ChIP sequencing of cyclin D1 reveals a transcriptional role in chromosomal instability in mice
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92. Less understood issues: p21Cip1 in mitosis and its therapeutic potential
    Nina‐Naomi Kreis, Frank Louwen, Juping Yuan · 2014 · Oncogene
93. Cantharidin induces G2/M phase arrest and apoptosis in human colorectal cancer colo 205 cells through inhibition of CDK1 activity and caspase-dependent signaling pathways
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94. Molecular mechanisms underpinning sarcomas and implications for current and future therapy
    Victoria Damerell, Michael Sean Pepper, Sharon Prince · 2021 · Signal Transduction and Targeted Therapy
95. Molecular mechanism of palmitic acid and its derivatives in tumor progression
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96. Skp2: A novel potential therapeutic target for prostate cancer
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97. NSun2 Promotes Cell Growth via Elevating Cyclin-Dependent Kinase 1 Translation
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98. Mutant p53 Gains Its Function via c-Myc Activation upon CDK4 Phosphorylation at Serine 249 and Consequent PIN1 Binding
    Peng Liao, Shelya X. Zeng, Xiang Yu Zhou, Tianjian Chen, Fen Zhou, Bo Cao, Ji Hoon Jung, Giannino Del Sal, Shiwen Luo, Hua Lu · 2017 · Molecular Cell
99. Natural products: a hope for glioblastoma patients
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100. Cellular senescence: a double-edged sword in cancer therapy
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