Cited by 3,957Cancer-related Molecular PathwaysMicrotubule and mitosis dynamicsPI3K/AKT/mTOR signaling in cancer

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Cell cycle, CDKs and cancer: a changing paradigm

Malumbres, Marcos, Barbacid, Mariano·2009·Nature Reviews Cancer

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Abstract

Tumour-associated cell cycle defects are often mediated by alterations in cyclin-dependent kinase (CDK) activity. Misregulated CDKs induce unscheduled proliferation as well as genomic and chromosomal instability. According to current models, mammalian CDKs are essential for driving each cell cycle phase, so therapeutic strategies that block CDK activity are unlikely to selectively target tumour cells. However, recent genetic evidence has revealed that, whereas CDK1 is required for the cell cycle, interphase CDKs are only essential for proliferation of specialized cells. Emerging evidence suggests that tumour cells may also require specific interphase CDKs for proliferation. Thus, selective CDK inhibition may provide therapeutic benefit against certain human neoplasias.

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Background
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CDK1 serves as a potential prognostic biomarker and target for lung cancer
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Influential
Association of Cyclin-Dependent Kinases 4 and 6 Inhibitors With Survival in Patients With Hormone Receptor–Positive Metastatic Breast Cancer
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Inhibiting CDK6 Activity by Quercetin Is an Attractive Strategy for Cancer Therapy
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Down-Regulation of microRNA-26a Promotes Mouse Hepatocyte Proliferation during Liver Regeneration
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Authors: Malumbres, M., & Barbacid, M.
Affiliations: Spanish National Cancer Research Centre (ES)
ORCID: Malumbres, Marcos
Barbacid, Mariano
Venue: Nature Reviews Cancer
Publisher: Springer Science and Business Media LLC
Published: 2009-03
Volume: 9
Issue: 3
Pages: 153-166
ISSN: 1474-175X (ISSN-L)
1474-1768
DOI: 10.1038/nrc2602
OpenAlex: W2046024621
Cited by: 3,957
References: 178
Citations by year: 2026: 191 · 2025: 241 · 2024: 266 · 2023: 277 · 2022: 297 · 2021: 318 · 2020: 272 · 2019: 222 · 2018: 237 · 2017: 260 · 2016: 195 · 2015: 228 · 2014: 218 · 2013: 206 · 2012: 186
FWCI: 15.80
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Cancer (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
Keywords: cyclin-dependent kinases, CDK1, cell cycle, tumor cell proliferation, genomic instability, chromosomal instability, cyclin-dependent kinase inhibitors, selective cancer therapy
MeSH terms: Animals, Cell Cycle, Chromosome Aberrations, DNA Damage, Humans, Mitosis, Neoplasms, Neoplastic Stem Cells, Cyclins, Cyclin-Dependent Kinases, Cyclin E, Chromosomal Instability, Protein Kinase Inhibitors, Cell Proliferation, Cyclin D

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Cell cycle, CDKs and cancer: a changing paradigm

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