Cited by 3,957Cancer-related Molecular PathwaysMicrotubule and mitosis dynamicsPI3K/AKT/mTOR signaling in cancer

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Cell cycle, CDKs and cancer: a changing paradigm

Malumbres, Marcos, Barbacid, Mariano·2009·Nature Reviews Cancer

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Abstract

Tumour-associated cell cycle defects are often mediated by alterations in cyclin-dependent kinase (CDK) activity. Misregulated CDKs induce unscheduled proliferation as well as genomic and chromosomal instability. According to current models, mammalian CDKs are essential for driving each cell cycle phase, so therapeutic strategies that block CDK activity are unlikely to selectively target tumour cells. However, recent genetic evidence has revealed that, whereas CDK1 is required for the cell cycle, interphase CDKs are only essential for proliferation of specialized cells. Emerging evidence suggests that tumour cells may also require specific interphase CDKs for proliferation. Thus, selective CDK inhibition may provide therapeutic benefit against certain human neoplasias.

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RETRACTED: shRNA Knockdown of Bmi-1 Reveals a Critical Role for p21-Rb Pathway in NSC Self-Renewal during Development
Fasano, C. A., Dimos, J. T., Ivanova, N. B., Lowry, N. A., Lemischka, I. R., & Temple, S. (2007) · Cell stem cell · doi:10.1016/j.stem.2007.04.001 · Cited by 308
Retracted
Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy
Farmer, H., McCabe, N., Lord, C. J., Tutt, A. N. J., Johnson, D. A., Richardson, T. B., Santarosa, M., Dillon, K. J., Hickson, I., Knights, C., et al. (2005) · Nature · doi:10.1038/nature03445 · Cited by 6,683
Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a
Serrano, M., Lin, A. W., McCurrach, M. E., Beach, D., & Lowe, S. W. (1997) · Cell · doi:10.1016/s0092-8674(00)81902-9 · Cited by 5,218
p53, guardian of the genome
Lane, D. P. (1992) · Nature · doi:10.1038/358015a0 · Cited by 5,138
Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours
Donehower, L. A., Harvey, M., Slagle, B. L., McArthur, M. J., Montgomery, C. A., Butel, J. S., & Bradley, A. (1992) · Nature · doi:10.1038/356215a0 · Cited by 4,649
p21 is a universal inhibitor of cyclin kinases
Xiong, Y., Hannon, G., Zhang, H., Casso, D., Kobayashi, R., & Beach, D. (1993) · Nature · doi:10.1038/366701a0 · Cited by 3,691
A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4.
Serrano, M., Hannon, G. J., & Beach, D. (1993) · Nature · doi:10.1038/366704a0 · Cited by 3,650
Patterns of somatic mutation in human cancer genomes
Greenman, C. D., Stephens, P., Smith, R., Dalgliesh, G. L., Hunter, C., Bignell, G. R., Davies, H. R., Teague, J. W., Butler, A. P., Stevens, C., et al. (2007) · Nature · doi:10.1038/nature05610 · Cited by 3,143
A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia
Kastan, M. B., Zhan, Q., El-Deiry, W. S., Carrier, F., Jacks, T., Walsh, W. V., Plunkett, B. S., Vogelstein, B., & Fornace, A. J. (1992) · Cell · doi:10.1016/0092-8674(92)90593-2 · Cited by 3,047
Cell-cycle checkpoints and cancer
Kastan, M. B., & Bartek, J. (2004) · Nature · doi:10.1038/nature03097 · Cited by 2,836

Show all 178 references

Research works printed but not linked: 1

Hanks, S. et al. Constitutional aneuploidy and cancer predisposition caused by biallelic mutations in BUB1B. Nature Genet. 36, 1159–1161 (2004). · DOI

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Wang, L., Feng, J., Chen, X., Guo, W., Du, Y., Wang, Y., Zang, W., Zhang, S., & Zhao, G. (2014) · Cancer Cell International · doi:10.1186/s12935-014-0071-2 · Cited by 55
“Meanwhile, Previous studies had established that Cyclin D1 plays a crucial role in the progression of cell cycle from G1 to S phase and the down-regulation of Cyclin D1 would lead to cell cycle arrest at G1 [32].”
Result
Seliciclib in malignancies
Aldoss, I. T., Tashi, T., & Ganti, A. K. (2009) · Expert Opinion on Investigational Drugs · doi:10.1517/13543780903418445 · Cited by 55
“Aberrancy in the CDK system propagates uncontrolled growth as well as genomic and chromosomal instability [6].”
Background
Molecular insight into the regulation and function of MCAK
Ritter, A., Kreis, N., Louwen, F., Wordeman, L. G., & Yuan, J. (2016) · Critical Reviews in Biochemistry and Molecular Biology · doi:10.1080/10409238.2016.1178705 · Cited by 59
“…multiple kinases like Aurora A/B, Cdk1, p21-activated kinase 1 (PAK1) and Plk1 are very often deregulated in cancer cells (Kumar et al., 2006; Malumbres & Barbacid, 2009; Strebhardt & Ullrich, 2006; Takeshita et al., 2013; Xu et al., 2013) leading to perturbations in the proper regulation of…”
Background
Molecular Regulation of the Spindle Assembly Checkpoint by Kinases and Phosphatases
Manic, G., Corradi, F., Sistigu, A., Siteni, S., & Vitale, I. (2016) · International review of cytology · doi:10.1016/bs.ircmb.2016.08.004 · Cited by 59
Wnt/Tcf1 pathway restricts embryonic stem cell cycle through activation of the Ink4/Arf locus
Jaime-Soguero, A. D., Aulicino, F., Ertaylan, G., Griego, A., Cerrato, A., Tallam, A., del Sol, A., Cosma, M. P., & Lluís, F. (2017) · PLoS Genetics · doi:10.1371/journal.pgen.1006682 · Cited by 58
“Therefore, the Ink4/Arf locus controls the two main cell cycle inhibitors and tumor suppressor pathways [26,27].”
Background
Levan promotes antiproliferative and pro-apoptotic effects in MCF-7 breast cancer cells mediated by oxidative stress
de Queiroz, E. A. I. F., Fortes, Z. B., da Cunha, M. A. A., Sarılmışer, H. K., Dekker, A. D. M. B., Öner, E. T., Dekker, R. F. H., & Khaper, N. (2017) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2017.04.035 · Cited by 55
Cyclin E Deregulation and Genomic Instability
Teixeira, L. K., & Reed, S. I. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-981-10-6955-0_22 · Cited by 55
Network Pharmacology‐Based Approach to Investigate the Mechanisms of Hedyotis diffusa Willd. in the Treatment of Gastric Cancer
Liu, X., Wu, J., Zhang, D., Wang, K., Duan, X., Meng, Z., & Zhang, X. (2018) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2018/7802639 · Cited by 55
“It is well known that CDKs require binding of cyclins to stimulate cell cycle progression [79, 80], and either continuous proliferation or irregular reentry into cell cycle often occurs due to frequent dysregulation of certain cyclin/CDK complexes caused by tumor-related mutations [81].”
Malignant canine mammary epithelial cells shed exosomes containing differentially expressed microRNA that regulate oncogenic networks
Fish, E. J., Irizarry, K. J. L., DeInnocentes, P., Ellis, C., Prasad, N., Moss, A. G., & Bird, R. (2018) · BMC Cancer · doi:10.1186/s12885-018-4750-6 · Cited by 55
Venous thromboembolism risk in patients with hormone receptor-positive HER2-negative metastatic breast cancer treated with combined CDK 4/6 inhibitors plus endocrine therapy versus endocrine therapy alone: a systematic review and meta-analysis of randomized controlled trials
Thein, K. Z., Htut, T. W., Ball, S., Swarup, S., Sultan, A., & Oo, T. H. (2020) · Breast Cancer Research and Treatment · doi:10.1007/s10549-020-05783-3 · Cited by 56
“Cell cycle dysregulation has a crucial role in carcinogenesis through induction of proliferative potential and genomic instability in cancer cells [3].”
Background
A highly potent CDK4/6 inhibitor was rationally designed to overcome blood brain barrier in gliobastoma therapy
Yin, L., Li, H., Liu, W., Yao, Z., Cheng, Z., Zhang, H., & Zou, H. (2018) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2017.12.003 · Cited by 54
MicroRNA‑424 serves an anti‑oncogenic role by targeting cyclin‑dependent kinase�1 in breast cancer cells
Xie, D., Song, H., Wu, T., Li, D., Hua, K., Xu, H., Zhao, B., Wu, C., Hu, J., Ji, C., et al. (2018) · Oncology Reports · doi:10.3892/or.2018.6741 · Cited by 54
“Aberrant activation of CDKs may enhance tumor proliferation and chromosomal instability; therefore, they were focuses for the development of anticancer drug (25).”
Background
The CCR5 antagonist maraviroc causes remission of pancreatic cancer liver metastasis in nude rats based on cell cycle inhibition and apoptosis induction
Huang, H., Zepp, M., Georges, R. B., Jarahian, M., Kazemi, M., Eyol, E., & Berger, M. R. (2020) · Cancer Letters · doi:10.1016/j.canlet.2020.01.009 · Cited by 54
Cellular senescence or stemness: hypoxia flips the coin
Otero-Albiol, D., & Carnero, A. (2021) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-021-02035-0 · Cited by 56
Evidence for cancer stem cells contributing to the pathogenesis of ovarian cancer
Michael, D. C. (2010) · Frontiers in bioscience · doi:10.2741/3693 · Cited by 54
“The originally perturbed tumor cells are often more susceptible to further genetic hits due to inherent genomic/chromosomal instability (21) and progressively lose their responsiveness to normal growth regulatory signals (22), resulting in (epi)genetic changes that drive tumor progression.”
Background
HPIP is upregulated in colorectal cancer and regulates colorectal cancer cell proliferation, apoptosis and invasion
Feng, Y., Xu, X., Zhang, Y., Ding, J., Wang, Y., Zhang, X., Wu, Z. B., Kang, L., Liang, Y., Zhou, L., et al. (2015) · Scientific Reports · doi:10.1038/srep09429 · Cited by 54
Release from quiescence stimulates the expression of human NEIL3 under the control of the Ras dependent ERK–MAP kinase pathway
Neurauter, C. G., Luna, L., & Bjørås, M. (2012) · DNA repair · doi:10.1016/j.dnarep.2012.01.007 · Cited by 54
Role and therapeutic potential of CDK12 in human cancers
Chilà, R., Guffanti, F., & Damia, G. L. M. (2016) · Cancer Treatment Reviews · doi:10.1016/j.ctrv.2016.09.003 · Cited by 53
Updating the research on the chemopreventive and therapeutic role of the peptide lunasin
Hsieh, C., Martínez‐Villaluenga, C., de Lumen, B. O., & Hernández‐Ledesma, B. (2017) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.8719 · Cited by 54
Codelivery of sorafenib and GPC3 siRNA with PEI-modified liposomes for hepatoma therapy
Sun, W., Wang, Y., Cai, M., Lin, L., Chen, X., Cao, Z., Zhu, K., & Shuai, X. (2017) · Biomaterials Science · doi:10.1039/c7bm00866j · Cited by 55
SNHG16 as the miRNA let‐7b‐5p sponge facilitates the G2/M and epithelial‐mesenchymal transition by regulating CDC25B and HMGA2 expression in hepatocellular carcinoma
Li, S.-G., Peng, F., Ning, Y., Jiang, P., Peng, J., Ding, X., Zhang, J., Jiang, T., & Xiang, S. (2019) · Journal of Cellular Biochemistry · doi:10.1002/jcb.29477 · Cited by 54
“Cell cycle dysregulation leads to uncontrolled cell proliferation, which has been acknowledged as a common feature of human cancers.(22,23) It is very important to investigate whether SNHG16 was involved in cell cycle regulation.”
Background
LINC00346 Acts as a Competing Endogenous RNA Regulating Development of Hepatocellular Carcinoma via Modulating CDK1/CCNB1 Axis
Jin, J., Xu, H., Li, W., Xu, X., Liu, H., & Feng, W. (2020) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2020.00054 · Cited by 54
“Only CDK1 in the CDK family can promote cell cycle independently (Santamaría et al., 2007; Malumbres and Barbacid, 2009).”
Background
Retracted
Current Therapeutic Progress of CDK4/6 Inhibitors in Breast Cancer
Wu, Y., Zhang, Y., Pi, H., & Sheng, Y. (2020) · Cancer Management and Research · doi:10.2147/cmar.s250632 · Cited by 56
Human amniotic mesenchymal stem cells to promote/suppress cancer: two sides of the same coin
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Liu, S., Yang, Y., Jiang, S., Xu, H., Tang, N., Lobo, A. J., Zhang, R., Liu, S., Yu, T., & Xin, H. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.00022 · Cited by 53
“Cyclin-dependent kinase 1 (CDK1) is a protein that regulates the cell cycle, which belongs to a serine/threonine kinase family (Malumbres and Barbacid, 2009); previous studies have proved that CDK1 acted as a key regulator for cell cycle (Yang et al.”
Background
Latent periodic process inference from single-cell RNA-seq data
Liang, S., Wang, F., Han, J., & Chen, K. (2020) · Nature Communications · doi:10.1038/s41467-020-15295-9 · Cited by 58
Transcriptomic profile induced in bone marrow mesenchymal stromal cells after interaction with multiple myeloma cells: implications in myeloma progression and myeloma bone disease
García-Gómez, A., Rivas, J. D. L., Ocio, E. M., Dı́az-Rodrı́guez, E., Montero, J. C., Martín, M., Blanco, J. F., Sanchez-Guijo, F. M., Pandiella, A., Miguel, J. F. S., et al. (2014) · Oncotarget · doi:10.18632/oncotarget.2058 · Cited by 55
MicroRNA-490-3p inhibits proliferation of A549 lung cancer cells by targeting CCND1
Gu, H., Yang, T., Fu, S., Chen, X., Guo, L., & Ni, Y. (2014) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2014.01.020 · Cited by 53
The transcription factor DEC1 (BHLHE40/STRA13/SHARP-2) is negatively associated with TNM stage in non-small-cell lung cancer and inhibits the proliferation through cyclin D1 in A549 and BE1 cells
Liu, Y., Wang, L., Lin, X., Wang, J., Yu, J., Miao, Y., & Wang, E. (2013) · Tumor Biology · doi:10.1007/s13277-013-0697-z · Cited by 53
MicroRNA and signaling pathways in gastric cancer
Zhang, Z., Li, Z., Li, Y., & Zang, A. (2014) · Cancer Gene Therapy · doi:10.1038/cgt.2014.37 · Cited by 54
Suppression of Src/ERK and GSK-3/β-catenin signaling by pinosylvin inhibits the growth of human colorectal cancer cells
Park, E., Chung, H., Park, H. J., Kim, G. D., Ahn, Y., & Lee, S. K. (2013) · Food and Chemical Toxicology · doi:10.1016/j.fct.2013.01.007 · Cited by 53
Integrated Analysis of Copy Number Variation and Genome-Wide Expression Profiling in Colorectal Cancer Tissues
Hassan, N. Z. A., Mokhtar, N. M., Sin, T. K., Rose, I. M., Sagap, I., Harun, R., & Jamal, R. (2014) · PLoS ONE · doi:10.1371/journal.pone.0092553 · Cited by 53
“The loss of cell cycle checkpoint control promotes genetic instability, which leads to uncontrolled cell proliferation and could promote cancer development [46].”
Background
Shogaols at proapoptotic concentrations induce G2/M arrest and aberrant mitotic cell death associated with tubulin aggregation
Gan, F.-F., Nagle, A. A., Ang, X., Ho, O. H., Tan, S.-H., Yang, H., Chui, W., & Chew, E. (2011) · APOPTOSIS · doi:10.1007/s10495-011-0611-3 · Cited by 55
“The cdk1/cyclin B complex is a crucial checkpoint for entry of cells from G2 to M phase, whereas the spindle assembly checkpoint functions between metaphase and anaphase [25, 26 ].”
Background
New frontiers in the treatment of liposarcoma, a therapeutically resistant malignant cohort
Hoffman, A., Lazar, A. J., Pollock, R. E., & Lev, D. C. (2010) · Drug Resistance Updates · doi:10.1016/j.drup.2010.11.001 · Cited by 52
Free-Energy-Based Methods for Binding Profile Determination in a Congeneric Series of CDK2 Inhibitors
Fidelak, J., Juraszek, J., Branduardi, D., Bianciotto, M., & Gervasio, F. L. (2010) · The Journal of Physical Chemistry B · doi:10.1021/jp911689r · Cited by 55
Inhibition of KIF22 suppresses cancer cell proliferation by delaying mitotic exit through upregulating CDC25C expression
Yu, Y., Wang, X., Sun, L., Wang, Y.-L., Wan, Y. F., Li, X., & Feng, Y.-M. (2014) · Carcinogenesis · doi:10.1093/carcin/bgu065 · Cited by 53
“The cell cycle progression is dependent on the activity of complexes of CDK with respective cyclin partners (29).”
Background
Cell-specific Kaiso (ZBTB33) Regulation of Cell Cycle through Cyclin D1 and Cyclin E1
Pozner, A., Terooatea, T. W., & Buck‐Koehntop, B. A. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m116.746370 · Cited by 54
“Dysregulated expression of G1-phase cyclins has been correlated with the genesis of a large proportion of human malignancies (52).”
Background
Structure-based discovery of cyclin-dependent protein kinase inhibitors
Martin, M. P., Endicott, J., & Noble, M. E. M. (2017) · Essays in Biochemistry · doi:10.1042/ebc20170040 · Cited by 53
Hematological adverse effects in breast cancer patients treated with cyclin-dependent kinase 4 and 6 inhibitors: a systematic review and meta-analysis
Kassem, L. M. H., Shohdy, K. S., Lasheen, S., Abdel-Rahman, O. M., & Bachelot, T. (2017) · Breast Cancer · doi:10.1007/s12282-017-0818-4 · Cited by 53
Chrysosplenol d, a Flavonol from Artemisia annua, Induces ERK1/2-Mediated Apoptosis in Triple Negative Human Breast Cancer Cells
Lang, S. J., Schmiech, M., Häfner, S., Paetz, C., Werner, K., Gaafary, M. E., Schmidt, C. Q., Syrovets, T., & Simmet, T. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21114090 · Cited by 53
“Uncontrolled proliferation caused by deregulated cell cycle control mechanisms is a common feature of neoplasia and many cancers are reported to be selectively vulnerable to the inhibition of cell cycle regulatory proteins [22,23].”
Background

Authors: Malumbres, M., & Barbacid, M.
Affiliations: Spanish National Cancer Research Centre (ES)
ORCID: Malumbres, Marcos
Barbacid, Mariano
Venue: Nature Reviews Cancer
Publisher: Springer Science and Business Media LLC
Published: 2009-03
Volume: 9
Issue: 3
Pages: 153-166
ISSN: 1474-175X (ISSN-L)
1474-1768
DOI: 10.1038/nrc2602
OpenAlex: W2046024621
Cited by: 3,957
References: 178
Citations by year: 2026: 191 · 2025: 241 · 2024: 266 · 2023: 277 · 2022: 297 · 2021: 318 · 2020: 272 · 2019: 222 · 2018: 237 · 2017: 260 · 2016: 195 · 2015: 228 · 2014: 218 · 2013: 206 · 2012: 186
FWCI: 15.80
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Cancer (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Microtubule and mitosis dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
Keywords: cyclin-dependent kinases, CDK1, cell cycle, tumor cell proliferation, genomic instability, chromosomal instability, cyclin-dependent kinase inhibitors, selective cancer therapy
MeSH terms: Animals, Cell Cycle, Chromosome Aberrations, DNA Damage, Humans, Mitosis, Neoplasms, Neoplastic Stem Cells, Cyclins, Cyclin-Dependent Kinases, Cyclin E, Chromosomal Instability, Protein Kinase Inhibitors, Cell Proliferation, Cyclin D

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Cell cycle, CDKs and cancer: a changing paradigm

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