Cell cycle, CDKs and cancer: a changing paradigm

Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

Farmer, H., McCabe, N., Lord, C. J., Tutt, A. N. J., Johnson, D. A., Richardson, T. B., Santarosa, M., Dillon, K. J., Hickson, I., Knights, C., et al. (2005) · Nature · doi:10.1038/nature03445 · Cited by 6,683

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

Serrano, M., Lin, A. W., McCurrach, M. E., Beach, D., & Lowe, S. W. (1997) · Cell · doi:10.1016/s0092-8674(00)81902-9 · Cited by 5,218

p53, guardian of the genome

Lane, D. P. (1992) · Nature · doi:10.1038/358015a0 · Cited by 5,138

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

Donehower, L. A., Harvey, M., Slagle, B. L., McArthur, M. J., Montgomery, C. A., Butel, J. S., & Bradley, A. (1992) · Nature · doi:10.1038/356215a0 · Cited by 4,649

p21 is a universal inhibitor of cyclin kinases

Xiong, Y., Hannon, G., Zhang, H., Casso, D., Kobayashi, R., & Beach, D. (1993) · Nature · doi:10.1038/366701a0 · Cited by 3,691

A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4.

Serrano, M., Hannon, G. J., & Beach, D. (1993) · Nature · doi:10.1038/366704a0 · Cited by 3,650

Patterns of somatic mutation in human cancer genomes

Greenman, C. D., Stephens, P., Smith, R., Dalgliesh, G. L., Hunter, C., Bignell, G. R., Davies, H. R., Teague, J. W., Butler, A. P., Stevens, C., et al. (2007) · Nature · doi:10.1038/nature05610 · Cited by 3,143

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

Kastan, M. B., Zhan, Q., El-Deiry, W. S., Carrier, F., Jacks, T., Walsh, W. V., Plunkett, B. S., Vogelstein, B., & Fornace, A. J. (1992) · Cell · doi:10.1016/0092-8674(92)90593-2 · Cited by 3,047

Cell-cycle checkpoints and cancer

Kastan, M. B., & Bartek, J. (2004) · Nature · doi:10.1038/nature03097 · Cited by 2,836

DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis

Bartkova, J., Hořejší, Z., Koed, K., Krämer, A., Tort, F., Zieger, K., Guldberg, P., Sehested, M., Nesland, J. M., Lukas, C., et al. (2005) · Nature · doi:10.1038/nature03482 · Cited by 2,688

The spindle-assembly checkpoint in space and time

Musacchio, A., & Salmon, E. D. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2163 · Cited by 2,227

p27, a novel inhibitor of G1 cyclin-Cdk protein kinase activity, is related to p21.

Toyoshima, H., & Hunter, T. (1994) · Cell · doi:10.1016/0092-8674(94)90573-8 · Cited by 2,208

BRAFE600-associated senescence-like cell cycle arrest of human naevi

Michaloglou, C., Vredeveld, L. C. W., Soengas, M. S., Denoyelle, C., Kuilman, T., van der Horst, C. M. A. M., Majoor, D. M., Shay, J. W., Mooi, W. J., & Peeper, D. S. (2005) · Nature · doi:10.1038/nature03890 · Cited by 2,160

Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals

Polyák, K., Lee, M.-H., Erdjument‐Bromage, H., Koff, A., Roberts, J. M., Tempst, P., & Massagué, J. (1994) · Cell · doi:10.1016/0092-8674(94)90572-x · Cited by 2,118

Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions

Gorgoulis, V. G., Vassiliou, L.-V. F., Karakaidos, P., Zacharatos, P., Kotsinas, A., Liloglou, T., Venere, M., DiTullio, R. A., Kastrinakis, N. G., Levy, B., et al. (2005) · Nature · doi:10.1038/nature03485 · Cited by 2,009

Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis

Chen, Z., Trotman, L. C., Shaffer, D., Lin, H.-K., Dotan, Z. A., Niki, M., Koutcher, J. A., Scher, H. I., Ludwig, T., Gerald, W., et al. (2005) · Nature · doi:10.1038/nature03918 · Cited by 1,993

Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints

Bartkova, J., Rezaei, N., Liontos, M., Karakaidos, P., Kletsas, D., Issaeva, N., Vassiliou, L.-V. F., Kolettas, E., Niforou, K., Zoumpourlis, V. C., et al. (2006) · Nature · doi:10.1038/nature05268 · Cited by 1,986

p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-beta and contact inhibition to cell cycle arrest.Preprint

Polyak, K., Kato, J., Solomon, M., Sherr, C., Massagué, J., Roberts, J., & Koff, A. (1994) · Genes & Development · doi:10.1101/gad.8.1.9 · Cited by 1,949

An Oncogene-Induced DNA Damage Model for Cancer Development

Halazonetis, T. D., Gorgoulis, V. G., & Bartek, J. (2008) · Science · doi:10.1126/science.1140735 · Cited by 1,851

Wild-type p53 is a cell cycle checkpoint determinant following irradiation.

Kuerbitz, S. J., Plunkett, B., Walsh, W., & Kastan, M. B. (1992) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.89.16.7491 · Cited by 1,837

Oncogene-induced senescence is a DNA damage response triggered by DNA hyper-replication

Di Micco, R., Fumagalli, M., Cicalese, A., Piccinin, S., Gasparini, P., Luise, C., Schurra, C., Garre’, M., Giovanni Nuciforo, P., Bensimon, A., et al. (2006) · Nature · doi:10.1038/nature05327 · Cited by 1,821

ATR: an essential regulator of genome integrity

Cimprich, K. A., & Cortez, D. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2450 · Cited by 1,798

Genetic Control of the Cell Division Cycle in Yeast

Hartwell, L. H., Culotti, J. G., Pringle, J. R., & Reid, B. J. (1974) · Science · doi:10.1126/science.183.4120.46 · Cited by 1,567

Cyclin: A protein specified by maternal mRNA in sea urchin eggs that is destroyed at each cleavage division

Evans, T., Rosenthal, E. T., Youngblom, J., Distel, D. L., & Hunt, T. (1983) · Cell · doi:10.1016/0092-8674(83)90420-8 · Cited by 1,516

To cycle or not to cycle: a critical decision in cancer

Malumbres, M., & Barbacid, M. (2001) · Nature reviews. Cancer · doi:10.1038/35106065 · Cited by 1,510

Mutations of mitotic checkpoint genes in human cancers

Cahill, D. P., Lengauer, C., Yu, J., Riggins, G. J., Willson, J. K. V., Markowitz, S. D., Kinzler, K. W., & Vogelstein, B. (1998) · Nature · doi:10.1038/32688 · Cited by 1,490

Senescence in premalignant tumours

Collado, M., Gil, J., Efeyan, A., Guerra, C., Schuhmacher, A. J., Barradas, M., Benguría, A., Zaballos, A., Flores, J. M., Barbacid, M., et al. (2005) · Nature · doi:10.1038/436642a · Cited by 1,482

Ubiquitin ligases: cell-cycle control and cancer

Nakayama, K. I., & Nakayama, K. (2006) · Nature reviews. Cancer · doi:10.1038/nrc1881 · Cited by 1,450

Hematopoietic Stem Cell Quiescence Maintained by p21 cip1/waf1

Cheng, T., Rodrigues, N., Shen, H., Yang, Y.-G., Dombkowski, D., Sykes, M., & Scadden, D. T. (2000) · Science · doi:10.1126/science.287.5459.1804 · Cited by 1,339

Mammalian cyclin-dependent kinases

Malumbres, M., & Barbacid, M. (2005) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2005.09.005 · Cited by 1,333

The anaphase promoting complex/cyclosome: a machine designed to destroy

Peters, J.-M. (2006) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1988 · Cited by 1,315

G1 cell-cycle control and cancer

Massagué, J. (2004) · Nature · doi:10.1038/nature03094 · Cited by 1,251

Oncogene-induced senescence as an initial barrier in lymphoma development

Braig, M., Lee, S., Loddenkemper, C., Rudolph, C., Peters, A. H. F. M., Schlegelberger, B., Stein, H., Dörken, B., Jenuwein, T., & Schmitt, C. A. (2005) · Nature · doi:10.1038/nature03841 · Cited by 1,220

On the road to cancer: aneuploidy and the mitotic checkpoint

Kops, G. J. P. L., Weaver, B. A. A., & Cleveland, D. W. (2005) · Nature reviews. Cancer · doi:10.1038/nrc1714 · Cited by 1,201

A signature of chromosomal instability inferred from gene expression profiles predicts clinical outcome in multiple human cancers

Carter, S. L., Eklund, A. C., Kohane, I. S., Harris, L. N., & Szállási, Z. (2006) · Nature Genetics · doi:10.1038/ng1861 · Cited by 1,199

Colony-stimulating factor 1 regulates novel cyclins during the G1 phase of the cell cycle

Matsushime, H., Roussel, M. F., Ashmun, R. A., & Sherr, C. J. (1991) · Cell · doi:10.1016/0092-8674(91)90101-4 · Cited by 1,169

Complementation used to clone a human homologue of the fission yeast cell cycle control gene cdc2

Lee, M. G., & Nurse, P. (1987) · Nature · doi:10.1038/327031a0 · Cited by 1,137

Stem-cell ageing modified by the cyclin-dependent kinase inhibitor p16INK4a

Janzen, V., Forkert, R., Fleming, H. E., Saito, Y., Waring, M. T., Dombkowski, D. M., Cheng, T., DePinho, R. A., Sharpless, N. E., & Scadden, D. T. (2006) · Nature · doi:10.1038/nature05159 · Cited by 1,106

Single-strand break repair and genetic disease

Caldecott, K. W. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2380 · Cited by 1,097

Cdk1 is sufficient to drive the mammalian cell cycle

Santamarı́a, D., Barrière, C., Cerqueira, A., Hunt, S. L., Tardy, C., Newton, K., Cáceres, J. F., Dubus, P. R., Malumbres, M., & Barbacid, M. (2007) · Nature · doi:10.1038/nature06046 · Cited by 1,096

Distinct Roles for Cyclin-Dependent Kinases in Cell Cycle Control

van den Heuvel, S., & Harlow, E. (1993) · Science · doi:10.1126/science.8266103 · Cited by 1,092

Functional Inactivation of the Retinoblastoma Protein Requires Sequential Modification by at Least Two Distinct Cyclin-cdk Complexes

Lundberg, A. S., & Weinberg, R. A. (1998) · Molecular and Cellular Biology · doi:10.1128/mcb.18.2.753 · Cited by 1,077

Cdk phosphorylation triggers sequential intramolecular interactions that progressively block Rb functions as cells move through G1

Harbour, J. W., Luo, R. X., Santi, A. D., Postigo, A. A., & Dean, D. C. (1999) · Cell · doi:10.1016/s0092-8674(00)81519-6 · Cited by 1,057

Cyclin-Dependent Kinase Pathways As Targets for Cancer Treatment

Shapiro, G. I. (2006) · Journal of Clinical Oncology · doi:10.1200/jco.2005.03.7689 · Cited by 1,036

Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal carcinomas

Loda, M. F., Cukor, B., Tam, S. W., Lavin, P. T., Fiorentinc, M., Draetta, G. F., Jessup, J. M., & Pagano, M. (1997) · Nature Medicine · doi:10.1038/nm0297-231 · Cited by 1,031

p16INK4a induces an age-dependent decline in islet regenerative potential

Krishnamurthy, J., Ramsey, M. R., Ligon, K. L., Torrice, C., Koh, A., Bonner-Weir, S., & Sharpless, N. E. (2006) · Nature · doi:10.1038/nature05092 · Cited by 1,003

The retinoblastoma protein is phosphorylated during specific phases of the cell cycle

Buchkovich, K., Duffy, L. A., & Harlow, E. (1989) · Cell · doi:10.1016/0092-8674(89)90508-4 · Cited by 995

D-type cyclins

Sherr, C. J. (1995) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(00)89005-2 · Cited by 980

Increasing p16INK4a expression decreases forebrain progenitors and neurogenesis during ageing

Molofsky, A. V., Slutsky, S. G., Joseph, N. M., He, S., Pardal, R., Krishnamurthy, J., Sharpless, N. E., & Morrison, S. J. (2006) · Nature · doi:10.1038/nature05091 · Cited by 972

p57KIP2, a structurally distinct member of the p21CIP1 Cdk inhibitor family, is a candidate tumor suppressor gene.Preprint

Matsuoka, S., Edwards, M. C., Bai, C., Parker, S., Zhang, P., Baldini, A., Harper, J. W., & Elledge, S. J. (1995) · Genes & Development · doi:10.1101/gad.9.6.650 · Cited by 952

Phosphorylation of the retinoblastoma gene product is modulated during the cell cycle and cellular differentiation

Chen, P.-L., Scully, P., Shew, J.-Y., Wang, J. Y. J., & Lee, W.-H. (1989) · Cell · doi:10.1016/0092-8674(89)90517-5 · Cited by 952

Specific protection against breast cancers by cyclin D1 ablation

Yu, Q., Geng, Y., & Sicinski, P. (2001) · Nature · doi:10.1038/35082500 · Cited by 934

Regulation of the specific DNA binding function of p53

Hupp, T. R., Meek, D. W., Midgley, C., & Lane, D. P. (1992) · Cell · doi:10.1016/0092-8674(92)90562-q · Cited by 916

Ataxia-telangiectasia: from a rare disorder to a paradigm for cell signalling and cancer

Lavin, M. F. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2514 · Cited by 901

Identification and properties of an atypical catalytic subunit (p34PSK-J3/Cdk4) for mammalian D type G1 cyclins

Matsushime, H., Ewen, M. E., Strom, D. K., Kato, J.-Y., Hanks, S. K., Roussel, M. F., & Sherr, C. J. (1992) · Cell · doi:10.1016/0092-8674(92)90360-o · Cited by 897

The product of the retinoblastoma susceptibility gene has properties of a cell cycle regulatory element

DeCaprio, J. A., Ludlow, J. W., Lynch, D., Furukawa, Y., Griffin, J., Piwnica-Worms, H., Huang, C.-M., & Livingston, D. M. (1989) · Cell · doi:10.1016/0092-8674(89)90507-2 · Cited by 897

Cloning of p57KIP2, a cyclin-dependent kinase inhibitor with unique domain structure and tissue distribution.Preprint

Lee, M., Reynisdóttir, I., & Massagué, J. (1995) · Genes & Development · doi:10.1101/gad.9.6.639 · Cited by 889

Genetic control of cell size at cell division in yeast

Nurse, P. (1975) · Nature · doi:10.1038/256547a0 · Cited by 868

Targeting polo-like kinase 1 for cancer therapy

Strebhardt, K., & Ullrich, A. (2006) · Nature reviews. Cancer · doi:10.1038/nrc1841 · Cited by 849

Genome instability: a mechanistic view of its causes and consequences

Aguilera, A., & Gómez‐González, B. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2268 · Cited by 830

Decreased levels of the cell-cycle inhibitor p27Kip1 protein: Prognostic implications in primary breast cancer

Catzavelos, C., Bhattacharya, N., Ung, Y., Wilson, J. A., Roncari, L., Sandhu, C., Shaw, P. H., Yeger, H., Morava‐Protzner, I., Kapusta, L. R., et al. (1997) · Nature Medicine · doi:10.1038/nm0297-227 · Cited by 824

Isolation of three novel human cyclins by rescue of G1 cyclin (cln) function in yeast

Lew, D. J., Dulić, V., & Reed, S. I. (1991) · Cell · doi:10.1016/0092-8674(91)90042-w · Cited by 820

Zur Frage der Entstehung maligner Tumoren

Boveri, T. (1914) · Cited by 801

Cyclin-dependent kinase 2 is essential for meiosis but not for mitotic cell division in mice

Ortega, S., Priéto, I., Odajima, J., Martín, A. L., Dubus, P. R., Sotillo, R., Barbero, J. L., Malumbres, M., & Barbacid, M. (2003) · Nature Genetics · doi:10.1038/ng1232 · Cited by 798

Mammalian cells cycle without the D-type cyclin-dependent kinases Cdk4 and Cdk6

Malumbres, M., Sotillo, R., Santamarı́a, D., Galán, J., Cerezo, A., Ortega, S., Dubus, P., & Barbacid, M. (2004) · Cell · doi:10.1016/j.cell.2004.08.002 · Cited by 793

Cyclin D-dependent kinases, INK4 inhibitors and cancer

Ortega, S., Malumbres, M., & Barbacid, M. (2002) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/s0304-419x(02)00037-9 · Cited by 790

Checking on DNA damage in S phase

Bartek, J., Lukas, C., & Lukas, J. (2004) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1493 · Cited by 758

BubR1 insufficiency causes early onset of aging-associated phenotypes and infertility in mice

Baker, D. J., Jeganathan, K. B., Cameron, J. D., Thompson, M., Juneja, S., Kopecka, A., Kumar, R., Jenkins, R. B., de Groen, P. C., Roche, P., et al. (2004) · Nature Genetics · doi:10.1038/ng1382 · Cited by 731

Aneuploidy Acts Both Oncogenically and as a Tumor Suppressor

Weaver, B. A. A., Silk, A. D., Montagna, C., Verdier-Pinard, P., & Cleveland, D. W. (2007) · Cancer Cell · doi:10.1016/j.ccr.2006.12.003 · Cited by 729

MAD2 haplo-insufficiency causes premature anaphase and chromosome instability in mammalian cells

Michel, L. S., Liberal, V., Chatterjee, A., Kirchwegger, R., Pasche, B., Gerald, W. L., Dobles, M., Sorger, P. K., Murty, V. V. V. S., & Benezra, R. (2001) · Nature · doi:10.1038/35053094 · Cited by 725

Cyclic AMP-induced G1 phase arrest mediated by an inhibitor (p27Kip1) of cyclin-dependent kinase 4 activation

Kato, J., Matsuoka, M., Polyák, K., Massagué, J., & Sherr, C. J. (1994) · Cell · doi:10.1016/0092-8674(94)90257-7 · Cited by 720

Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function.Preprint

Guan, K., Jenkins, C. W., Li, Y., Nichols, M. A., Wu, X., O'Keefe, C., Matera, A. G., & Xiong, Y. (1994) · Genes & Development · doi:10.1101/gad.8.24.2939 · Cited by 707

Loss of Cdk4 expression causes insulin-deficient diabetes and Cdk4 activation results in β-islet cell hyperplasia

Rane, S. G., Dubus, P., Mettus, R. V., Galbreath, E. J., Boden, G., Reddy, E. P., & Barbacid, M. (1999) · Nature Genetics · doi:10.1038/8751 · Cited by 700

CDK8 is a colorectal cancer oncogene that regulates β-catenin activity

Firestein, R., Bass, A. J., Kim, S. Y., Dunn, I. F., Silver, S. J., Guney, I., Freed, E., Ligon, A. H., Vena, N., Ogino, S., et al. (2008) · Nature · doi:10.1038/nature07179 · Cited by 692

Human D-type cyclin

Xiong, Y., Connolly, T., Futcher, B., & Beach, D. (1991) · Cell · doi:10.1016/0092-8674(91)90100-d · Cited by 687

Aurora-kinase inhibitors as anticancer agents

Keen, N., & Taylor, S. S. (2004) · Nature reviews. Cancer · doi:10.1038/nrc1502 · Cited by 680

Cdk2 Knockout Mice Are Viable

Berthet, C., Aleem, E. A., Coppola, V., Tessarollo, L., & Kaldis, P. (2003) · Current Biology · doi:10.1016/j.cub.2003.09.024 · Cited by 665

Cyclin E Ablation in the Mouse

Geng, Y., Yu, Q., Sicińska, E., Das, M., Schneider, J. E., Bhattacharya, S., Rideout, W. M., Bronson, R. T., Gardner, H., & Siciński, P. (2003) · Cell · doi:10.1016/s0092-8674(03)00645-7 · Cited by 663

Mouse development and cell proliferation in the absence of D-cyclins

Kozar, K., Ciemerych, M. A., Rebel, V. I., Shigematsu, H., Zagozdzon, A., Sicinska, E., Geng, Y., Yu, Q., Bhattacharya, S., Bronson, R. T., et al. (2004) · Cell · doi:10.1016/j.cell.2004.07.025 · Cited by 647

Constitutional aneuploidy and cancer predisposition caused by biallelic mutations in BUB1B

Hanks, S., Coleman, K., Reid, S., Plaja, A., Firth, H., Fitzpatrick, D., Kidd, A., Méhes, K., Nash, R., Robin, N. H., et al. (2004) · Nature Genetics · doi:10.1038/ng1449 · Cited by 627

Mad2 Overexpression Promotes Aneuploidy and Tumorigenesis in Mice

Sotillo, R., Hernando, E., Díaz-Rodríguez, E., Teruya-Feldstein, J., Cordón-Cardo, C., Lowe, S. W., & Benezra, R. (2007) · Cancer Cell · doi:10.1016/j.ccr.2006.10.019 · Cited by 612

Cyclin-dependent kinases and cell-cycle transitions: does one fit all?

Hochegger, H., Takeda, S., & Hunt, T. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2510 · Cited by 599

Identification of a Human Mitotic Checkpoint Gene: hsMAD2

Li, Y., & Benezra, R. (1996) · Science · doi:10.1126/science.274.5285.246 · Cited by 597

Wild-type p53 activates transcription in vitro

Farmer, G., Bargonetti, J., Zhu, H., Friedman, P., Prywes, R., & Prives, C. (1992) · Nature · doi:10.1038/358083a0 · Cited by 579

Genetic Control of the Cell-Division Cycle in Yeast, I. Detection of Mutants

Hartwell, L. H., Culotti, J. G., & Reid, B. J. (1970) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.66.2.352 · Cited by 576

CDK targets Sae2 to control DNA-end resection and homologous recombination

Huertas, P., Cortés‐Ledesma, F., Sartori, A. A., Aguilera, A., & Jackson, S. P. (2008) · Nature · doi:10.1038/nature07215 · Cited by 509

Subunit rearrangement of the cyclin-dependent kinases is associated with cellular transformation.Preprint

Xiong, Y., Zhang, H., & Beach, D. (1993) · Genes & Development · doi:10.1101/gad.7.8.1572 · Cited by 507

Multiple levels of cyclin specificity in cell-cycle control

Bloom, J., & Cross, F. R. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2105 · Cited by 504

Polo on the Rise—from Mitotic Entry to Cytokinesis with Plk1

Petronczki, M. P., Lénárt, P., & Peters, J. (2008) · Developmental Cell · doi:10.1016/j.devcel.2008.04.014 · Cited by 503

Imbalance between pSmad3 and Notch induces CDK inhibitors in old muscle stem cells

Carlson, M. E., Hsu, M., & Conboy, I. M. (2008) · Nature · doi:10.1038/nature07034 · Cited by 498

CDK-dependent phosphorylation of BRCA2 as a regulatory mechanism for recombinational repair

Esashi, F., Christ, N., Gannon, J., Liu, Y., Hunt, T., Jasin, M., & West, S. C. (2005) · Nature · doi:10.1038/nature03404 · Cited by 473

Proliferation of cancer cells despite CDK2 inhibition

Tetsu, O., & McCormick, F. P. (2003) · Cancer Cell · doi:10.1016/s1535-6108(03)00053-9 · Cited by 472

p21 loss compromises the relative quiescence of forebrain stem cell proliferation leading to exhaustion of their proliferation capacity

Kippin, T. E., Martens, D. J., & van der Kooy, D. (2005) · Genes & Development · doi:10.1101/gad.1272305 · Cited by 442

Requirement for CDK4 kinase function in breast cancer

Yu, Q., Sicinska, E., Geng, Y., Ahnström, M., Zagozdzon, A., Kong, Y., Gardner, H., Kiyokawa, H., Harris, L. N., Stål, O., et al. (2006) · Cancer Cell · doi:10.1016/j.ccr.2005.12.012 · Cited by 429

Cdkn1a deletion improves stem cell function and lifespan of mice with dysfunctional telomeres without accelerating cancer formation

Choudhury, A. R., Ju, Z., Djojosubroto, M. W., Schienke, A., Lechel, A., Schaetzlein, S., Jiang, H., Stepczynska, A., Wang, C., Buer, J., et al. (2007) · Nature Genetics · doi:10.1038/ng1937 · Cited by 426

NFATc1 Balances Quiescence and Proliferation of Skin Stem Cells

Horsley, V., Aliprantis, A. O., Polak, L., Glimcher, L. H., & Fuchs, E. (2008) · Cell · doi:10.1016/j.cell.2007.11.047 · Cited by 424

Targeted Disruption of CDK4 Delays Cell Cycle Entry with Enhanced p27 Kip1 Activity

Tsutsui, T., Hesabi, B., Moons, D. S., Pandolfi, P. P., Hansel, K. S., Koff, A., & Kiyokawa, H. (1999) · Molecular and Cellular Biology · doi:10.1128/mcb.19.10.7011 · Cited by 395

Cdc2–cyclin E complexes regulate the G1/S phase transition

Aleem, E. A., Kiyokawa, H., & Kaldis, P. (2005) · Nature Cell Biology · doi:10.1038/ncb1284 · Cited by 383

Finishing mitosis, one step at a time

Sullivan, M., & Morgan, D. O. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2276 · Cited by 375

Secrets of a double agent: CDK7 in cell-cycle control and transcription

Fisher, R. P. (2005) · Journal of Cell Science · doi:10.1242/jcs.02718 · Cited by 371

Genomic stability and tumour suppression by the APC/C cofactor Cdh1

García-Higuera, I., Manchado, E., Dubus, P. R., Cañamero, M., Méndez, J., Moreno, S., & Malumbres, M. (2008) · Nature Cell Biology · doi:10.1038/ncb1742 · Cited by 357

Zur Frage der Entstehung maligner Tumoren

Ribbert, H., & Bally, W. (1914) · Die Naturwissenschaften · doi:10.1007/bf01497322 · Cited by 342

Cell cycle kinases in cancer

Malumbres, M., & Barbacid, M. (2007) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2006.12.008 · Cited by 338

Rescue of Cyclin D1 Deficiency by Knockin Cyclin E

Geng, Y., Whoriskey, W. J., Park, M. Y., Bronson, R. T., Medema, R. H., Li, T., Weinberg, R. A., & Siciński, P. (1999) · Cell · doi:10.1016/s0092-8674(00)80788-6 · Cited by 336

Cyclin D1-dependent kinase activity in murine development and mammary tumorigenesis

Landis, M. W., Pawlyk, B. S., Li, T., Sicinski, P., & Hinds, P. W. (2006) · Cancer Cell · doi:10.1016/j.ccr.2005.12.019 · Cited by 329

Cyclin C/Cdk3 Promotes Rb-Dependent G0 Exit

Ren, S., & Rollins, B. J. (2004) · Cell · doi:10.1016/s0092-8674(04)00300-9 · Cited by 326

Regulation of the cell cycle by the cdk2 protein kinase in cultured human fibroblasts.

Pagano, M., Pepperkok, R., Lukáš, J., Baldin, V., Ansorge, W., Bártek, J., & Draetta, G. F. (1993) · The Journal of Cell Biology · doi:10.1083/jcb.121.1.101 · Cited by 322

Oncogenes and tumour suppressors take on centrosomes

Fukasawa, K. (2007) · Nature reviews. Cancer · doi:10.1038/nrc2249 · Cited by 320

E2F1 represses β-catenin transcription and is antagonized by both pRB and CDK8

Morris, E. J., Ji, J., Yang, F., Stefano, L. D., Herr, A., Moon, N. S., Kwon, E. J., Haigis, K. M., Näär, A. M., & Dyson, N. J. (2008) · Nature · doi:10.1038/nature07310 · Cited by 306

CHK2 kinase: cancer susceptibility and cancer therapy – two sides of the same coin?

Antoni, L., Sodha, N., Collins, I., & Garrett, M. D. (2007) · Nature reviews. Cancer · doi:10.1038/nrc2251 · Cited by 296

Slippage of Mitotic Arrest and Enhanced Tumor Development in Mice with BubR1 Haploinsufficiency

Dai, W. H., Wang, Q., Liu, T., Swamy, M. V., Fang, Y., Xie, S., Mahmood, R., Yang, Y., Xu, M., & Rao, C. V. (2004) · Cancer Research · doi:10.1158/0008-5472.can-03-3119 · Cited by 291

Cyclin B2-null mice develop normally and are fertile whereas cyclin B1-null mice die in utero

Brandeis, M., Rosewell, I. R., Carrington, M., Crompton, T., Jacobs, M. A., Kirk, J. A., Gannon, J., & Hunt, T. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.8.4344 · Cited by 290

Delayed early embryonic lethality following disruption of the murine cyclin A2 gene

Murphy, M., Stinnakre, M., Sénamaud‐Beaufort, C., Winston, N. J., Sweeney, C., Kubelka, M., Carrington, M., Bréchot, C., & Sobczak‐Thépot, J. (1997) · Nature Genetics · doi:10.1038/ng0197-83 · Cited by 279

Requirements for Cdk7 in the Assembly of Cdk1/Cyclin B and Activation of Cdk2 Revealed by Chemical Genetics in Human Cells

Larochelle, S., Merrick, K. A., Terret, M., Wohlbold, L., Barboza, N. M., Zhang, C., Shokat, K. M., Jallepalli, P. V., & Fisher, R. P. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.02.003 · Cited by 272

In vivo self-renewing divisions of haematopoietic stem cells are increased in the absence of the early G1-phase inhibitor, p18INK4C

Yuan, Y., Shen, H., Franklin, D. S., Scadden, D. T., & Cheng, T. (2004) · Nature Cell Biology · doi:10.1038/ncb1126 · Cited by 269

Cyclins E1 and E2 are required for endoreplication in placental trophoblast giant cells

Parisi, T., Beck, A. R., Rougier, N., McNeil, T., Lucian, L., Werb, Z., & Amati, B. B. (2003) · The EMBO Journal · doi:10.1093/emboj/cdg482 · Cited by 269

CDK inhibitors in cancer therapy: what is next?

Malumbres, M., Pevarello, P., Barbacid, M., & Bischoff, J. R. (2007) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2007.10.012 · Cited by 240

Identification of CDK10 as an Important Determinant of Resistance to Endocrine Therapy for Breast Cancer

Iorns, E. J., Turner, N. C., Elliott, R. J. R., Syed, N., Garrone, O., Gasco, M., Tutt, A. N. J., Crook, T., Lord, C. J., & Ashworth, A. (2008) · Cancer Cell · doi:10.1016/j.ccr.2008.01.001 · Cited by 230

Bub1 mediates cell death in response to chromosome missegregation and acts to suppress spontaneous tumorigenesis

Jeganathan, K. B., Malureanu, L. A., Baker, D. J., Abraham, S. C., & van Deursen, J. M. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200706015 · Cited by 226

Cdk2 is dispensable for cell cycle inhibition and tumor suppression mediated by p27Kip1 and p21Cip1

Martín, A., Odajima, J., Hunt, S. L., Dubus, P. R., Ortega, S., Malumbres, M., & Barbacid, M. (2005) · Cancer Cell · doi:10.1016/j.ccr.2005.05.006 · Cited by 223

A census of mitotic cancer genes: new insights into tumor cell biology and cancer therapy

de Castro, I. P., de Cárcer, G., & Malumbres, M. (2006) · Carcinogenesis · doi:10.1093/carcin/bgm019 · Cited by 222

14-3-3σ controls mitotic translation to facilitate cytokinesis

Wilker, E., van Vugt, M. A. T. M., Artim, S. C., Huang, P. H., Petersen, C. P., Reinhardt, H. C., Feng, Y., Sharp, P. A., Sonenberg, N., White, F. M., et al. (2007) · Nature · doi:10.1038/nature05584 · Cited by 217

Wide spectrum of tumors in knock‐in mice carrying a Cdk4 protein insensitive to INK4 inhibitors

Sotillo, R., Dubus, P., Martn, J., de la Cueva, E., Ortega, S., Malumbres, M., & Barbacid, M. (2001) · The EMBO Journal · doi:10.1093/emboj/20.23.6637 · Cited by 208

Discovery of an oncogenic activity in p27 Kip1 that causes stem cell expansion and a multiple tumor phenotypePreprint

Besson, A., Hwang, H. C., Cicero, S. A., Donovan, S. L., Gurian-West, M., Johnson, D. A., Clurman, B. E., Dyer, M. A., & Roberts, J. M. (2007) · Genes & Development · doi:10.1101/gad.1556607 · Cited by 208

Aneuploidy: Instigator and Inhibitor of Tumorigenesis

Weaver, B. A. A., & Cleveland, D. W. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-2266 · Cited by 199

The reversibility of mitotic exit in vertebrate cells

Potapova, T., Daum, J. R., Pittman, B. D., Hudson, J. R., Jones, T. N., Satinover, D. L., Stukenberg, P. T., & Gorbsky, G. J. (2006) · Nature · doi:10.1038/nature04652 · Cited by 190

Role of CDK/cyclin complexes in transcription and RNA splicing

Loyer, P., Trembley, J. H., Katona, R. L., Kidd, V. J., & Lahti, J. M. (2005) · Cellular Signalling · doi:10.1016/j.cellsig.2005.02.005 · Cited by 189

Kinase-independent function of cyclin E

Geng, Y., Lee, Y.-M., Welcker, M., Swanger, J., Zagozdzon, A., Winer, J. D., Roberts, J. M., Kaldis, P., Clurman, B. E., & Sicinski, P. (2007) · Molecular Cell · doi:10.1016/j.molcel.2006.11.029 · Cited by 187

Cdc20 and Cks Direct the Spindle Checkpoint-Independent Destruction of Cyclin A

Wolthuis, R. M. F., Clay-Farrace, L., van Zon, W., Yekezare, M., Koop, L., Ogink, J., Medema, R. H., & Pines, J. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.02.027 · Cited by 177

An essential role for Cdk1 in S phase control is revealed via chemical genetics in vertebrate cells

Hochegger, H., Dejsuphong, D., Sonoda, E., Saberi, A., Rajendra, E., Kirk, J. A., Hunt, T., & Takeda, S. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200702034 · Cited by 170

Germ Line Transmission of the Cdk4R24C Mutation Facilitates Tumorigenesis and Escape from Cellular Senescence

Rane, S. G., Cosenza, S. C., Mettus, R. V., & Reddy, E. P. (2002) · Molecular and Cellular Biology · doi:10.1128/mcb.22.2.644-656.2002 · Cited by 167

Invasive melanoma in Cdk4-targeted mice

Sotillo, R., García, J. F., Ortega, S., Martín‐Broto, J., Dubus, P. R., Barbacid, M., & Malumbres, M. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.241338598 · Cited by 164

Early mitotic degradation of Nek2A depends on Cdc20-independent interaction with the APC/C

Hayes, M. J., Kimata, Y., Wattam, S. L., Lindon, C., Mao, G., Yamano, H., & Fry, A. M. (2006) · Nature Cell Biology · doi:10.1038/ncb1410 · Cited by 160

Pho85, a multifunctional cyclin‐dependent protein kinase in budding yeast

Huang, D., Friesen, H., & Andrews, B. (2007) · Molecular Microbiology · doi:10.1111/j.1365-2958.2007.05914.x · Cited by 158

The adaptor protein of the anaphase promoting complex Cdh1 is essential in maintaining replicative lifespan and in learning and memory

Li, M., Shin, Y.-H., Hou, L., Huang, X., Wei, Z., Klann, E., & Zhang, P. (2008) · Nature Cell Biology · doi:10.1038/ncb1768 · Cited by 156

Cell cycle in mouse development

Ciemerych, M. A., & Siciński, P. (2005) · Oncogene · doi:10.1038/sj.onc.1208608 · Cited by 154

Combined Loss of Cdk2 and Cdk4 Results in Embryonic Lethality and Rb Hypophosphorylation

Berthet, C., Klarmann, K. D., Hilton, M. B., Suh, H. C., Keller, J. R., Kiyokawa, H., & Kaldis, P. (2006) · Developmental Cell · doi:10.1016/j.devcel.2006.03.004 · Cited by 152

Identification and Characterization of the CDK12/Cyclin L1 Complex Involved in Alternative Splicing Regulation

Chen, H.-H., Wang, Y.-C., & Fann, M. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.26.7.2736-2745.2006 · Cited by 144

Cdk-counteracting phosphatases unlock mitotic exit

Queralt, E., & Uhlmann, F. (2008) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2008.09.003 · Cited by 143

Bub1 Maintains Centromeric Cohesion by Activation of the Spindle Checkpoint

Perera, D., Tilston, V., Hopwood, J. A., Barchi, M., Boot-Handford, R., & Taylor, S. S. (2007) · Developmental Cell · doi:10.1016/j.devcel.2007.08.008 · Cited by 143

Checkpoint-apoptosis uncoupling in human and mouse embryonic stem cells: a source of karyotpic instability

Mantel, C., Guo, Y., Lee, M. R., Kim, M.-K., Han, M., Shibayama, H., Fukuda, S., Yöder, M. C., Pelus, L. M., Kim, K.-S., et al. (2007) · Blood · doi:10.1182/blood-2006-10-054247 · Cited by 136

The PITSLRE/CDK11p58 protein kinase promotes centrosome maturation and bipolar spindle formation

Petretti, C., Savoian, M. S., Montembault, É., Glover, D. M., Prigent, C., & Giet, R. (2006) · EMBO Reports · doi:10.1038/sj.embor.7400639 · Cited by 134

ras-Induced hyperplasia occurs with mutation of p53, but activated ras and myc together can induce carcinoma without p53 mutation

Lü, X., Park, S. H., Thompson, T. C., & Lane, D. P. (1992) · Cell · doi:10.1016/0092-8674(92)90541-j · Cited by 132

Polo and Aurora kinases — lessons derived from chemical biology

Taylor, S. S., & Peters, J. (2008) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2007.11.008 · Cited by 131

Hematopoietic stem cell exhaustion impacted by p18INK4C and p21Cip1/Waf1 in opposite manners

Yu, H., Yuan, Y., Shen, H., & Cheng, T. (2006) · Blood · doi:10.1182/blood-2005-02-0685 · Cited by 127

Cdk5 phosphorylates Cdh1 and modulates cyclin B1 stability in excitotoxicity

Maestre, C., Delgado‐Esteban, M., Sánchez, J. C. G., Bolaños, J. P., & Almeida, Á. (2008) · The EMBO Journal · doi:10.1038/emboj.2008.195 · Cited by 126

Mice thrive without Cdk4 and Cdk2

Barrière, C., Santamarı́a, D., Cerqueira, A., Galán, J., Martín, A. L., Ortega, S., Malumbres, M., Dubus, P. R., & Barbacid, M. (2007) · Molecular Oncology · doi:10.1016/j.molonc.2007.03.001 · Cited by 125

Genetic rescue of Cdk4 null mice restores pancreatic β-cell proliferation but not homeostatic cell number

Martín, J., Hunt, S. L., Dubus, P., Sotillo, R., Néhmé-Pélluard, F., Magnuson, M. A., Parlow, A. F., Malumbres, M., Ortega, S., & Barbacid, M. (2003) · Oncogene · doi:10.1038/sj.onc.1206506 · Cited by 122

The ubiquitin ligase APCCdh1 is required to maintain genome integrity in primary human cells

Engelbert, D., Schnerch, D., Baumgarten, A., & Wäsch, R. (2007) · Oncogene · doi:10.1038/sj.onc.1210703 · Cited by 115

Nuclear localization of Cdk5 is a key determinant in the postmitotic state of neurons

Zhang, J., Cicero, S. A., Wang, L., Romito-DiGiacomo, R. R., Yang, Y., & Herrup, K. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0711355105 · Cited by 113

Negative cell-cycle regulators cooperatively control self-renewal and differentiation of haematopoietic stem cells

Walkley, C. R., Fero, M. L., Chien, W., Purton, L. E., & McArthur, G. A. (2005) · Nature Cell Biology · doi:10.1038/ncb1214 · Cited by 112

Cyclin-dependent kinase 2 is dispensable for normal centrosome duplication but required for oncogene-induced centrosome overduplication

Duensing, A. U., Liu, Y., Tseng, M., Malumbres, M., Barbacid, M., & Duensing, S. M. (2005) · Oncogene · doi:10.1038/sj.onc.1209310 · Cited by 107

A premature-termination mutation in the Mus musculus cyclin-dependent kinase 3 gene

Ye, X., Zhu, C., & Harper, J. W. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.4.1682 · Cited by 105

Cyclin-Dependent Kinase 4 Expression Is Essential for Neu-Induced Breast Tumorigenesis

Reddy, H. K. D. L., Mettus, R. V., Rane, S. G., Graña, X., Litvin, J., & Reddy, E. P. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-2639 · Cited by 105

p21 Cip1 restricts neuronal proliferation in the subgranular zone of the dentate gyrus of the hippocampus

Pechnick, R. N., Zonis, S., Wawrowsky, K., Pourmorady, J., & Chesnokova, V. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0711030105 · Cited by 103

Lack of Cyclin-Dependent Kinase 4 Inhibits c- myc Tumorigenic Activities in Epithelial Tissues

de Marval, P. L. M., Macias, E., Rounbehler, R. J., Siciński, P., Kiyokawa, H., Johnson, D. G., Conti, C. J., & Rodríguez‐Puebla, M. L. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.17.7538-7547.2004 · Cited by 100

Characterization of the abnormal pancreatic development, reduced growth and infertility in Cdk4 mutant mice

Mettus, R. V., & Rane, S. G. (2003) · Oncogene · doi:10.1038/sj.onc.1206888 · Cited by 97

CDK11p58 is required for the maintenance of sister chromatid cohesion

Hu, D., Valentine, M. B., Kidd, V. J., & Lahti, J. M. (2007) · Journal of Cell Science · doi:10.1242/jcs.007963 · Cited by 96

Is Cyclin D1-CDK4 kinase a bona fide cancer target?

Malumbres, M., & Barbacid, M. (2006) · Cancer Cell · doi:10.1016/j.ccr.2005.12.026 · Cited by 96

Cdk2 is critical for proliferation and self-renewal of neural progenitor cells in the adult subventricular zone

Jablonska, B., Aguirre, A. A., Vandenbosch, R., Belachew, S. M., Berthet, C., Kaldis, P., & Gallo, V. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200702031 · Cited by 92

Cdk11 is a RanGTP-dependent microtubule stabilization factor that regulates spindle assembly rate

Yokoyama, H., Gruß, O. J., Rybina, S., Caudron‐Herger, M., Schelder, M., Wilm, M. S., Mattaj, I. W., & Karsenti, E. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200706189 · Cited by 89

Control of G2 delay by the RAD9 gene of Saccharomyces cerevisiae

Weinert, T. A., & Hartwell, L. H. (1989) · Journal of Cell Science · doi:10.1242/jcs.1989.supplement_12.12 · Cited by 87

Failure To Proliferate and Mitotic Arrest of CDK11p110/p58-Null Mutant Mice at the Blastocyst Stage of Embryonic Cell Development

Li, T., Inoue, A., Lahti, J. M., & Kidd, V. J. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.8.3188-3197.2004 · Cited by 86

CDK13/CDC2L5 interacts with L-type cyclins and regulates alternative splicing

Chen, H.-H., Wong, Y., Genevière, A., & Fann, M. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.01.049 · Cited by 83

Genetic substitution of Cdk1 by Cdk2 leads to embryonic lethality and loss of meiotic function of Cdk2

Ande, S., Berthet, C., Lopez-Molina, J., Coppola, V., Tessarollo, L., & Kaldis, P. (2008) · Development · doi:10.1242/dev.024919 · Cited by 79

Cdk4 Is Indispensable for Postnatal Proliferation of the Anterior Pituitary

Jirawatnotai, S., Aziyu, A., Osmundson, E. C., Moons, D. S., Zou, X., Kineman, R. D., & Kiyokawa, H. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m409080200 · Cited by 76

CDK activation by non-cyclin proteins

Nebreda, Á. R. (2006) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2006.01.001 · Cited by 75

Pituitary Hypoplasia and Lactotroph Dysfunction in Mice Deficient for Cyclin-Dependent Kinase-4

Moons, D. S., Jirawatnotai, S., Parlow, A. F., Gibori, G., Kineman, R. D., & Kiyokawa, H. (2002) · Endocrinology · doi:10.1210/endo.143.8.8956 · Cited by 71

Dual role of CDKs in DNA repair: To be, or not to be

Yata, K., & Esashi, F. (2008) · DNA repair · doi:10.1016/j.dnarep.2008.09.002 · Cited by 62

Emerging cancer therapeutic opportunities by inhibiting mitotic kinases

de Castro, I. P., de Cárcer, G., Montoya, G., & Malumbres, M. (2008) · Current Opinion in Pharmacology · doi:10.1016/j.coph.2008.06.013 · Cited by 58

Roles of cyclins A and E in induction of centrosome amplification in p53-compromised cells

Hanashiro, K., Kanai, M., Geng, Y., Siciński, P., & Fukasawa, K. (2008) · Oncogene · doi:10.1038/onc.2008.161 · Cited by 55

Cooperation between Cdk4 and p27kip1 in Tumor Development: A Preclinical Model to Evaluate Cell Cycle Inhibitors with Therapeutic Activity

Sotillo, R., Renner, O., Dubus, P. R., Ruı́z-Cabello, J., Martín‐Caballero, J., Barbacid, M., Carnero, A., & Malumbres, M. (2005) · Cancer Research · doi:10.1158/0008-5472.can-04-4195 · Cited by 53

p18 Ink4c Collaborates with Men1 to Constrain Lung Stem Cell Expansion and Suppress Non–Small-Cell Lung Cancers

Pei, X., Bai, F., Smith, M. D., & Xiong, Y. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-4517 · Cited by 45

Loss of the tumor suppressor p15Ink4b enhances myeloid progenitor formation from common myeloid progenitors

Rosu‐Myles, M., Taylor, B. J., & Wolff, L. (2007) · Experimental Hematology · doi:10.1016/j.exphem.2006.11.005 · Cited by 35

Haploinsufficiency of the cdc2l gene contributes to skin cancer development in mice

Chandramouli, A., Shi, J., Feng, Y., Holubec, H., Shañas, R., Bhattacharyya, A. K., Zheng, W., & Nelson, M. A. (2007) · Carcinogenesis · doi:10.1093/carcin/bgm066 · Cited by 25

The wages of CIN

Yuen, K. W. Y., & Desai, A. B. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200801030 · Cited by 15

Synchronicity: policing multiple aspects of gene expression by Ctk1: Figure 1.Preprint

Hampsey, M., & Kinzy, T. G. (2007) · Genes & Development · doi:10.1101/gad.1564807 · Cited by 6

p21 in cancer: Intricate networks and multiple activities

Abbas, T., & Dutta, A. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2657 · Cited by 2,712

Monitoring Drug Target Engagement in Cells and Tissues Using the Cellular Thermal Shift Assay

Molina, D. M., Jafari, R., Ignatushchenko, M., Seki, T., Larsson, E. A., Dan, C., Sreekumar, L., Cao, Y., & Nordlund, P. (2013) · Science · doi:10.1126/science.1233606 · Cited by 2,261

Programmed Cell Death in Animal Development and Disease

Fuchs, Y., & Steller, H. (2011) · Cell · doi:10.1016/j.cell.2011.10.033 · Cited by 1,915

The cyclin-dependent kinase 4/6 inhibitor palbociclib in combination with letrozole versus letrozole alone as first-line treatment of oestrogen receptor-positive, HER2-negative, advanced breast cancer (PALOMA-1/TRIO-18): a randomised phase 2 study

Finn, R. S., Crown, J. P., Lang, I., Boer, K., Bondarenko, I. M., Kulyk, S. O., Ettl, J., Patel, R., Pinter, T., Schmidt, M., et al. (2015) · The Lancet Oncology · doi:10.1016/s1470-2045(14)71159-3 · Cited by 1,900

Cell cycle proteins as promising targets in cancer therapy

Otto, T., & Siciński, P. (2017) · Nature reviews. Cancer · doi:10.1038/nrc.2016.138 · Cited by 1,931

Investigative progress of relation of CDKs and cancer

Shu-you, Z. (2009) · China Medical Engineering

Cyclins and related kinases in cancer cells.

Malumbres, M. (2007) · PubMed · Cited by 40

Updating the Mammalian Cell Cycle: The Role of Interphase Cdks in Tissue Homeostasis and Cancer

Barbacid, M. (2010) · Research and perspectives in Alzheimer's disease · doi:10.1007/978-3-642-16602-0_1

Cyclins and CDKS in development and cancer: lessons from genetically modified mice

Santamarı́a, D. (2006) · Frontiers in bioscience · doi:10.2741/1871 · Cited by 164

Cyclin Dependent Kinase as Significant Target for Cancer Treatment

Singh, S. K., Tripathi, S. K., Dessalew, N., & Singh, P. C. (2012) · Current Cancer Therapy Reviews · doi:10.2174/157339412802653164 · Cited by 11