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Cited by 1,300

The DOI matches its Crossref record; 15 of the 15 references it cites were found in a registry or an index.

The metastatic niche: adapting the foreign soil

Open access
Psaila, Bethan, Lyden, David·2009·Nature Reviews Cancer

Abstract

The 'seed and soil' hypothesis for metastasis sets forth the concept that a conducive microenvironment, or niche, is required for disseminating tumour cells to engraft distant sites. This Opinion presents emerging data that support this concept and outlines the potential mechanism and temporal sequence by which changes occur in tissues distant from the primary tumour. To enable improvements in the prognosis of advanced malignancy, early interventions that target both the disseminating seed and the metastatic soil are likely to be required.

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Crossref · 10.1038/nrc2621

Cites

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Citations

Cites

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Metadata

Authors
Psaila, B., & Lyden, D.
Venue
Nature Reviews Cancer
Published
2009-04
Volume
9
Issue
4
Pages
285-293
ISSN
  • 1474-175X (ISSN-L)
  • 1474-1768
OpenAlex
W2012247886
Cited by
1,300
References
15
FWCI
4.14
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: The metastatic niche: adapting the foreign soil. https://app.cochat.ai/papers/10.1038/nrc2621
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Psaila, B., & Lyden, D. (2009). The metastatic niche: adapting the foreign soil. Nature Reviews Cancer. https://doi.org/10.1038/nrc2621

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.