Targeting PI3K signalling in cancer: opportunities, challenges and limitations

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

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Activating Mutations in the Epidermal Growth Factor Receptor Underlying Responsiveness of Non–Small-Cell Lung Cancer to Gefitinib

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EGFR Mutations in Lung Cancer: Correlation with Clinical Response to Gefitinib Therapy

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Comprehensive genomic characterization defines human glioblastoma genes and core pathways

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Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex

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The phosphoinositide 3-kinase pathway

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PTEN , a Putative Protein Tyrosine Phosphatase Gene Mutated in Human Brain, Breast, and Prostate Cancer

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MET Amplification Leads to Gefitinib Resistance in Lung Cancer by Activating ERBB3 Signaling

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Aberrant low expression of p85α in stromal fibroblasts promotes breast cancer cell metastasis through exosome-mediated paracrine Wnt10b

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The regulation of cancer cell death and metabolism by extracellular matrix attachment

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NOX4 promotes non-small cell lung cancer cell proliferation and metastasis through positive feedback regulation of PI3K/Akt signaling

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Emerging roles of PDGF-D signaling pathway in tumor development and progression

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Stathmin Overexpression Identifies High-Risk Patients and Lymph Node Metastasis in Endometrial Cancer

Trovik, J., Wik, E., Stefansson, I. M., Marcickiewicz, J., Tingulstad, S., Staff, A. C., Njølstad, T. S., MoMaTec Study Group, Vandenput, I., Amant, F. C., et al. (2011) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-10-2412 · Cited by 121

Maintenance of adenomatous polyposis coli ( APC )-mutant colorectal cancer is dependent on Wnt/β-catenin signaling

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Suppression of SPIN1 ‐mediated PI3K –Akt pathway by miR ‐489 increases chemosensitivity in breast cancer

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Genetic alterations in Krebs cycle and its impact on cancer pathogenesis

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The role of PI3K/Akt in human herpesvirus infection: From the bench to the bedside

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A kt‐ and E rk‐mediated regulation of proliferation and differentiation during PDGFR β‐induced MSC self‐renewal

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The role of PI3K/AKT-related PIP5K1α and the discovery of its selective inhibitor for treatment of advanced prostate cancer

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Four MicroRNAs Promote Prostate Cell Proliferation with Regulation of PTEN and Its Downstream Signals In Vitro

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Correlating Phosphatidylinositol 3-Kinase Inhibitor Efficacy with Signaling Pathway Status: In silico and Biological Evaluations

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Structural insights into NHEJ: Building up an integrated picture of the dynamic DSB repair super complex, one component and interaction at a time

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Emerging Role of mTOR in the Response to Cancer Therapeutics

Ilagan, E., & Manning, B. D. (2016) · Trends in cancer · doi:10.1016/j.trecan.2016.03.008 · Cited by 118

Merkel Cell Polyomavirus and Merkel Cell Carcinoma

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Eukaryotic translation initiation factors as promising targets in cancer therapy

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Prostate cancer stem cells: deciphering the origins and pathways involved in prostate tumorigenesis and aggression

Rybak, A. P., Bristow, R. G., & Kapoor, A. (2014) · Oncotarget · doi:10.18632/oncotarget.2953 · Cited by 122

The regulatory roles of phosphatases in cancer

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Triple‑negative breast cancer: A run‑through of features, classification and current therapies (Review)

Manjunath, M., & Choudhary, B. (2021) · Oncology Letters · doi:10.3892/ol.2021.12773 · Cited by 123

Preclinical Rationale for PI3K/Akt/mTOR Pathway Inhibitors as Therapy for Epidermal Growth Factor Receptor Inhibitor-Resistant Non–Small-Cell Lung Cancer

Gadgeel, S. M., & Wozniak, A. J. (2013) · Clinical Lung Cancer · doi:10.1016/j.cllc.2012.12.001 · Cited by 116

Kras as a key oncogene and therapeutic target in pancreatic cancer

Collins, M. A., & di Magliano, M. P. (2014) · Frontiers in Physiology · doi:10.3389/fphys.2013.00407 · Cited by 114

Mouse models of human PIK3CA-related brain overgrowth have acutely treatable epilepsy

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Tumor Dormancy and Interplay with Hypoxic Tumor Microenvironment

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The role of PI3k/AKT signaling pathway in attenuating liver fibrosis: a comprehensive review

Shamsan, E., Almezgagi, M., Gamah, M., Khan, N., Qasem, A., Chuanchuan, L., & Haining, F. (2024) · Frontiers in Medicine · doi:10.3389/fmed.2024.1389329 · Cited by 134

Small-Molecule Inhibitors of the Pi3K Signaling Network

McNamara, C. R., & Degterev, A. (2011) · Future Medicinal Chemistry · doi:10.4155/fmc.11.12 · Cited by 117

Causes and consequences of nuclear envelope alterations in tumour progression

Bell, E. S., & Lammerding, J. (2016) · European Journal of Cell Biology · doi:10.1016/j.ejcb.2016.06.007 · Cited by 115

Mechanisms of Resistance to PI3K Inhibitors in Cancer: Adaptive Responses, Drug Tolerance and Cellular Plasticity

Wright, S. C. E., Vasilevski, N., Serra, V., Rodon, J. A., & Eichhorn, P. J. A. (2021) · Cancers · doi:10.3390/cancers13071538 · Cited by 116

Autophagic pathways as new targets for cancer drug development

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Delphinidin Reduces Cell Proliferation and Induces Apoptosis of Non-Small-Cell Lung Cancer Cells by Targeting EGFR/VEGFR2 Signaling Pathways

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Novel therapeutic strategies for multiple myeloma

Mimura, N., Hideshima, T., & Anderson, K. C. (2015) · Experimental Hematology · doi:10.1016/j.exphem.2015.04.010 · Cited by 110

Pressing the right buttons: signaling in lymphangiogenesis

Coso, S., Bovay, E., & Petrova, T. V. (2014) · Blood · doi:10.1182/blood-2013-12-297317 · Cited by 109

Ellagic acid prevents rat colon carcinogenesis induced by 1, 2 dimethyl hydrazine through inhibition of AKT-phosphoinositide-3 kinase pathway

Umesalma, S., & Sudhandiran, G. (2011) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2011.03.036 · Cited by 114

The Molecular Pathogenesis of Head and Neck Cancer

Klein, J. D., & Grandis, J. R. (2010) · Cancer Biology & Therapy · doi:10.4161/cbt.9.1.10905 · Cited by 110

Comprehensive genomic profiles of metastatic and relapsed salivary gland carcinomas are associated with tumor type and reveal new routes to targeted therapies

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Targeting the PI3K/Akt/mTOR pathway in estrogen-receptor positive HER2 negative advanced breast cancer

du Rusquec, P., Blonz, C., Frenel, J., & Campone, M. (2020) · Therapeutic Advances in Medical Oncology · doi:10.1177/1758835920940939 · Cited by 109

Mast cell homeostasis and the JAK–STAT pathway

Morales, J. K., Falanga, Y. T., Depcrynski, A., Fernando, J. F. A., & Ryan, J. J. (2010) · Genes and Immunity · doi:10.1038/gene.2010.35 · Cited by 110

Noncanonical TGF-β Signaling During Mammary Tumorigenesis

Parvani, J. G., Taylor, M. A., & Schiemann, W. P. (2011) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1007/s10911-011-9207-3 · Cited by 112

Targeting Multiple Kinase Pathways: A Change In Paradigm

Gossage, L., & Eisen, T. G. (2010) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-09-3182 · Cited by 112

Muscarinic Receptor Agonists and Antagonists: Effects on Cancer

Spindel, E. R. (2011) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-23274-9_19 · Cited by 109

Impact of Concurrent PIK3CA Mutations on Response to EGFR Tyrosine Kinase Inhibition in EGFR-Mutant Lung Cancers and on Prognosis in Oncogene-Driven Lung Adenocarcinomas

Eng, J., Woo, K. M., Sima, C. S., Plodkowski, A., Hellmann, M. D., Chaft, J. E., Kris, M. G., Arcila, M. E., Ladanyi, M., & Drilon, A. (2015) · Journal of Thoracic Oncology · doi:10.1097/jto.0000000000000671 · Cited by 107

Unraveling the molecular genetics of head and neck cancer through genome-wide approaches

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Prognostic Significance of MTOR Pathway Component Expression in Neuroendocrine Tumors

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Recent Approaches to Chemical Discovery and Development Against Malaria and the Neglected Tropical Diseases Human African Trypanosomiasis and Schistosomiasis

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Asiatic acid attenuates CCl 4 -induced liver fibrosis in rats by regulating the PI3K/AKT/mTOR and Bcl-2/Bax signaling pathways

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Reciprocal regulation of cellular mechanics and metabolism

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PI3K/Akt/mTOR signaling in medullary thyroid cancer: a promising molecular target for cancer therapy

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Transient PI3K Inhibition Induces Apoptosis and Overcomes HGF-Mediated Resistance to EGFR-TKIs in EGFR Mutant Lung Cancer

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Molecular Promiscuity of Plant Polyphenols in the Management of Age-Related Diseases: Far Beyond Their Antioxidant Properties

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mTORC1 inhibition restricts inflammation-associated gastrointestinal tumorigenesis in mice

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Our changing view of the genomic landscape of cancer

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Hodgkin lymphoma: 2016 update on diagnosis, risk‐stratification, and management

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Lipid raft involvement in signal transduction in cancer cell survival, cell death and metastasis

Li, B., Qin, Y., Yu, X., Xu, X., & Yu, W. (2021) · Cell Proliferation · doi:10.1111/cpr.13167 · Cited by 107

AKT Signaling Pathway in the Nucleus Accumbens Mediates Excessive Alcohol Drinking Behaviors

Neasta, J., Hamida, S. B., Yowell, Q. V., Carnicella, S., & Dorit Ron, A. (2011) · Biological Psychiatry · doi:10.1016/j.biopsych.2011.03.019 · Cited by 111

MAPK pathway activation and the origins of pediatric low‐grade astrocytomas

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Nuclear factor of activated T cells in cancer development and treatment

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Genomic dissection of the epidermal growth factor receptor (EGFR)/PI3K pathway reveals frequent deletion of the EGFR phosphatase PTPRS in head and neck cancers

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Phosphatidylinositol 3-kinase pathway activation in breast cancer brain metastases

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Targeting the PI3K/Akt/mTOR Pathway for Breast Cancer Therapy

Cidado, J. R., & Park, B. H. (2012) · Journal of Mammary Gland Biology and Neoplasia · doi:10.1007/s10911-012-9264-2 · Cited by 106

Mesenchymal stem cell transformation and sarcoma genesis

Xiao, W., Mohseny, A. B., Hogendoorn, P. C. W., & Cleton-Jansen, A. (2013) · Clinical Sarcoma Research · doi:10.1186/2045-3329-3-10 · Cited by 104

Taming the dragon: genomic biomarkers to individualize the treatment of cancer

Majewski, I. J., & Bernards, R. (2011) · Nature Medicine · doi:10.1038/nm.2311 · Cited by 101

Betulinic acid and the pharmacological effects of tumor suppression

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New liver cancer biomarkers: PI3K/AKT/mTOR pathway members and eukaryotic translation initiation factors

Golob‐Schwarzl, N., Krassnig, S., Toeglhofer, A. M., Park, Y. N., Gogg-Kamerer, M., Vierlinger, K., Schroeder, F., Rhee, H., Schicho, R., Fickert, P., et al. (2017) · European Journal of Cancer · doi:10.1016/j.ejca.2017.06.003 · Cited by 102

Small-Molecule Kinase Inhibitors for the Treatment of Nononcologic Diseases

Xie, Z., Yang, X., Duan, Y., Han, J., & Liao, C. (2021) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.0c01511 · Cited by 102

Somatic MAP3K3 and PIK3CA mutations in sporadic cerebral and spinal cord cavernous malformations

Hong, T., Xiao, X., Ren, J. C., Cui, B., Zong, Y., Zou, J., Kou, Z., Nan, J., Meng, G., Zeng, G., et al. (2021) · Brain · doi:10.1093/brain/awab117 · Cited by 102

Phylogenomics of phosphoinositide lipid kinases: perspectives on the evolution of second messenger signaling and drug discovery

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MicroRNA-mediated downregulation of mTOR/FGFR3 controls tumor growth induced by Src-related oncogenic pathways

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HIV-1 Tat Promotes Kaposi’s Sarcoma-Associated Herpesvirus (KSHV) vIL-6-Induced Angiogenesis and Tumorigenesis by Regulating PI3K/PTEN/AKT/GSK-3β Signaling Pathway

Zhou, F., Xue, M., Qin, D., Zhu, X., Wang, C., Zhu, J., Hao, T., Cheng, L., Chen, X., Bai, Z., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0053145 · Cited by 103

DUBs, the regulation of cell identity and disease

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O-GlcNAc regulation of autophagy and α-synuclein homeostasis; implications for Parkinson’s disease

Wani, W. Y., Ouyang, X., Benavides, G. A., Redmann, M., Cofield, S. S., Shacka, J. J., Chatham, J. C., Darley-Usmar, V. M., & Zhang, J. (2017) · Molecular Brain · doi:10.1186/s13041-017-0311-1 · Cited by 105

The long noncoding RNA SNHG1 promotes tumor growth through regulating transcription of both local and distal genes

Sun, Y., Wei, G., Luo, H., Wu, W., Skogerbø, G., Luo, J., & Chen, R. (2017) · Oncogene · doi:10.1038/onc.2017.286 · Cited by 101

mTOR Inhibitors Alone and in Combination with JAK2 Inhibitors Effectively Inhibit Cells of Myeloproliferative Neoplasms

Bogani, C., Bartalucci, N., Martinelli, S., Tozzi, L., Guglielmelli, P., Bosi, A., Vannucchi, A. M., & Mieloproliferative, A. I. P. L. R. S. C. A. G. I. M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0054826 · Cited by 103

Targeting PI3K/Akt signaling in prostate cancer therapy

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Iatrogenic endometriosis harbors somatic cancer-driver mutations

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Targeting PI3K/Akt represses Hypoxia inducible factor-1α activation and sensitizes Rhabdomyosarcoma and Ewing’s sarcoma cells for apoptosis

Eren, M. K., Boylu, T., & Tabor, V. (2013) · Cancer Cell International · doi:10.1186/1475-2867-13-36 · Cited by 99

Alpelisib administration reduced lymphatic malformations in a mouse model and in patients

Delestre, F., Venot, Q., Bayard, C., Fraissenon, A., Ladraa, S., Hoguin, C., Chapelle, C., Yamaguchi, J., Cassaca, R., Zerbib, L., et al. (2021) · Science Translational Medicine · doi:10.1126/scitranslmed.abg0809 · Cited by 99

P21-activated kinase 1 stimulates colon cancer cell growth and migration/invasion via ERK- and AKT-dependent pathways

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Inhibition of AKT1 signaling promotes invasion and metastasis of non-small cell lung cancer cells with K-RAS or EGFR mutations

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Differing Roles of Hyaluronan Molecular Weight on Cancer Cell Behavior and Chemotherapy Resistance

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RGD functionalized chitosan nanoparticle mediated targeted delivery of raloxifene selectively suppresses angiogenesis and tumor growth in breast cancer

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Cell-to-Cell Variability in PI3K Protein Level Regulates PI3K-AKT Pathway Activity in Cell Populations

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Inhibition of the PI3K/AKT-NF-κB Pathway With Curcumin Enhanced Radiation-Induced Apoptosis in Human Burkitt’s Lymphoma

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[6]-Shogaol inhibits growth and induces apoptosis of non-small cell lung cancer cells by directly regulating Akt1/2

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