Progress toward Overcoming Hypoxia-Induced Resistance to Solid Tumor Therapy
Open accessAbstract
Hypoxic tumors are associated with poor clinical outcome for multiple types of human cancer. This may be due, in part, to hypoxic cancer cells being resistant to anticancer therapy, including radiation therapy, chemotherapy, and targeted therapy. Hypoxia inducible factor 1, a major regulator of cellular response to hypoxia, regulates the expression of genes that are involved in multiple aspects of cancer biology, including cell survival, proliferation, metabolism, invasion, and angiogenesis. Here, we review multiple pathways regulated by hypoxia/hypoxia inducible factor 1 in cancer cells and discuss the latest advancements in overcoming hypoxia-mediated tumor resistance.
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In experimental models, HIF1/2α can be downregulated by antisense oligos or sh-RNA.
“In experimental models, it was possible to downregulate HIF1/2α by antisense oligos or sh-RNA [83].”
From Hypoxia Signaling in Cancer: From Basics to Clinical Practice (2021) · cites this paper as [83]
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Stimuli‐responsive nanotherapeutics for precision drug delivery and cancer therapy
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Hypoxia Dictates Metabolic Rewiring of Tumors: Implications for Chemoresistance
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Hypoxia Signaling in Cancer: From Basics to Clinical Practice
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- Authors
- Reginato, M., & Karakashev, S.
- Affiliations
- Drexel University (US)
- Corresponding author
- Reginato, Mauricio
- Venue
- Cancer Management and Research
- Publisher
- Informa UK Limited
- Published
- 2015-08
- Volume
- 7
- Pages
- 253
- ISSN
- 1179-1322 (ISSN-L)
- PMC
- PMC4542411
- OpenAlex
- W1695753507
- Cited by
- 95
- References
- 134
- Citations by year
- 2026: 1 · 2025: 7 · 2024: 8 · 2023: 2 · 2022: 8 · 2021: 15 · 2020: 16 · 2019: 7 · 2018: 13 · 2017: 6 · 2016: 12
- FWCI
- 1.01
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Cancer Management and Research (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion, cc-by-nc)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (acceptedVersion)
- Dove Medical Press (Taylor and Francis Group) (submittedVersion, cc-by-nc)
- Funders
- National Institutes of Health
- National Cancer Institute (R01CA155413)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
- Health Sciences › Medicine › Hepatology › Hepatocellular Carcinoma Treatment and Prognosis
- Keywords
- tumor hypoxia, HIF-1, drug resistance, solid tumors, radioresistance (biology), chemoresistance, targeted therapy resistance, angiogenesis, cancer metabolism, tumor invasion, gene expression regulation
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