Cited by 95Cancer, Hypoxia, and MetabolismAngiogenesis and VEGF in CancerHepatocellular Carcinoma Treatment and Prognosis

Progress toward Overcoming Hypoxia-Induced Resistance to Solid Tumor Therapy

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Reginato, Mauricio, Karakashev, Sergey·2015·Cancer Management and Research

Abstract

Hypoxic tumors are associated with poor clinical outcome for multiple types of human cancer. This may be due, in part, to hypoxic cancer cells being resistant to anticancer therapy, including radiation therapy, chemotherapy, and targeted therapy. Hypoxia inducible factor 1, a major regulator of cellular response to hypoxia, regulates the expression of genes that are involved in multiple aspects of cancer biology, including cell survival, proliferation, metabolism, invasion, and angiogenesis. Here, we review multiple pathways regulated by hypoxia/hypoxia inducible factor 1 in cancer cells and discuss the latest advancements in overcoming hypoxia-mediated tumor resistance.

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Authors
Reginato, M., & Karakashev, S.
Affiliations
Drexel University (US)
Corresponding author
Reginato, Mauricio
Venue
Cancer Management and Research
Published
2015-08
Volume
7
Pages
253
ISSN
1179-1322 (ISSN-L)
OpenAlex
W1695753507
Cited by
95
References
134
Citations by year
2026: 1 · 2025: 7 · 2024: 8 · 2023: 2 · 2022: 8 · 2021: 15 · 2020: 16 · 2019: 7 · 2018: 13 · 2017: 6 · 2016: 12
FWCI
1.01
Type
journal article
Language
en
Open access
Locations
  • Cancer Management and Research (publishedVersion, cc-by-nc)
  • PubMed Central (publishedVersion, cc-by-nc)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (acceptedVersion)
  • Dove Medical Press (Taylor and Francis Group) (submittedVersion, cc-by-nc)
Funders
  • National Institutes of Health
  • National Cancer Institute (R01CA155413)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
  • Health Sciences › Medicine › Hepatology › Hepatocellular Carcinoma Treatment and Prognosis
Keywords
tumor hypoxia, HIF-1, drug resistance, solid tumors, radioresistance (biology), chemoresistance, targeted therapy resistance, angiogenesis, cancer metabolism, tumor invasion, gene expression regulation

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