The regulation of cancer cell death and metabolism by extracellular matrix attachment

On the origin of cancer cells

Warburg, O. (1956) · Science · doi:10.1126/science.123.3191.309 · Cited by 13,425 · see citing works

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

Kim, J., Kundu, M., Viollet, B., & Guan, K.-L. (2011) · Nature Cell Biology · doi:10.1038/ncb2152 · Cited by 7,227 · see citing works

Matrix Metalloproteinases: Regulators of the Tumor Microenvironment

Kessenbrock, K., Plaks, V., & Werb, Z. (2010) · Cell · doi:10.1016/j.cell.2010.03.015 · Cited by 5,151 · see citing works

An Nrf2/Small Maf Heterodimer Mediates the Induction of Phase II Detoxifying Enzyme Genes through Antioxidant Response Elements

Itoh, K., Chiba, T., Takahashi, S., Ishii, T., Igarashi, K., Katoh, Y., Oyake, T., Hayashi, N., Satoh, K., Hatayama, I., et al. (1997) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1997.6943 · Cited by 3,999 · see citing works

Microenvironmental regulation of metastasis

Joyce, J. A., & Pollard, J. W. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2618 · Cited by 3,684 · see citing works

Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

Itoh, K., Wakabayashi, N., Katoh, Y., Ishii, T., Igarashi, K., Engel, J. D., & Yamamoto, M. (1999) · Genes & Development · doi:10.1101/gad.13.1.76 · Cited by 3,634 · see citing works

On Respiratory Impairment in Cancer Cells

Warburg, O. H. (1956) · Science · doi:10.1126/science.124.3215.269 · Cited by 3,472 · see citing works

Disruption of epithelial cell-matrix interactions induces apoptosis

Frisch, S., & Francis, H. (1994) · The Journal of Cell Biology · doi:10.1083/jcb.124.4.619 · Cited by 3,272 · see citing works

Metabolic Reprogramming: A Cancer Hallmark Even Warburg Did Not Anticipate

Ward, P. S., & Thompson, C. B. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.02.014 · Cited by 3,233 · see citing works

Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis.

Yang, J., & Weinberg, R. (2008) · Developmental Cell · doi:10.1016/j.devcel.2008.05.009 · Cited by 3,135 · see citing works

Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury

Degterev, A., Huang, Z., Boyce, M., Li, Y., Jagtap, P., Mizushima, N., Cuny, G. D., Mitchison, T. J., Moskowitz, M. A., & Yuan, J. (2005) · Nature Chemical Biology · doi:10.1038/nchembio711 · Cited by 3,068 · see citing works

The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth

Christofk, H. R., Vander Heiden, M. G., Harris, M. H., Ramanathan, A., Gerszten, R. E., Wei, R., Fleming, M. D., Schreiber, S. L., & Cantley, L. C. (2008) · Nature · doi:10.1038/nature06734 · Cited by 2,820 · see citing works

Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes

Micheau, O., & Tschopp, J. (2003) · Cell · doi:10.1016/s0092-8674(03)00521-x · Cited by 2,738 · see citing works

Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase

Sun, L., Wang, H., Wang, Z., He, S., Chen, S., Liao, D., Wang, L., Yan, J., Liu, W., Lei, X., et al. (2012) · Cell · doi:10.1016/j.cell.2011.11.031 · Cited by 2,698 · see citing works

Targeting PI3K signalling in cancer: opportunities, challenges and limitations

Engelman, J. A. (2009) · Nature Reviews Cancer · doi:10.1038/nrc2664 · Cited by 2,445 · see citing works

Phosphorylation-Driven Assembly of the RIP1-RIP3 Complex Regulates Programmed Necrosis and Virus-Induced Inflammation

Cho, Y., Challa, S., Moquin, D., Genga, R., Ray, T. D., Guildford, M., & Chan, F. K.-M. (2009) · Cell · doi:10.1016/j.cell.2009.05.037 · Cited by 2,435 · see citing works

Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis

DeNicola, G. M., Karreth, F. A., Humpton, T. J., Gopinathan, A., Wei, C., Frese, K., Mangal, D., Yu, K. H., Yeo, C. J., Calhoun, E. S., et al. (2011) · Nature · doi:10.1038/nature10189 · Cited by 2,277 · see citing works

Receptor Interacting Protein Kinase-3 Determines Cellular Necrotic Response to TNF-α

He, S., Wang, L., Miao, L., Wang, T., Du, F., Zhao, L., & Wang, X. (2009) · Cell · doi:10.1016/j.cell.2009.05.021 · Cited by 2,214 · see citing works

mTOR regulation of autophagy

Jung, C. H., Ro, S.-H., Cao, J., Otto, N. M., & Kim, D.-H. (2010) · FEBS Letters · doi:10.1016/j.febslet.2010.01.017 · Cited by 2,090 · see citing works

Identification of RIP1 kinase as a specific cellular target of necrostatins

Degterev, A., Hitomi, J., Germscheid, M., Ch'en, I. L., Korkina, O., Teng, X., Abbott, D., Cuny, G. D., Yuan, C., Wagner, G., et al. (2008) · Nature Chemical Biology · doi:10.1038/nchembio.83 · Cited by 2,059 · see citing works

TIGAR, a p53-Inducible Regulator of Glycolysis and Apoptosis

Bensaad, K., Tsuruta, A., Selak, M. A., Vidal, M. N. C., Nakano, K., Bartrons, R., Gottlieb, E., & Vousden, K. H. (2006) · Cell · doi:10.1016/j.cell.2006.05.036 · Cited by 2,019 · see citing works

Autophagy and Metabolism

Rabinowitz, J. D., & White, E. (2010) · Science · doi:10.1126/science.1193497 · Cited by 1,982 · see citing works

RIP3, an Energy Metabolism Regulator That Switches TNF-Induced Cell Death from Apoptosis to Necrosis

Zhang, D.-W., Shao, J., Lin, J., Zhang, N., Lu, B.-J., Lin, S.-C., Dong, M.-Q., & Han, J. (2009) · Science · doi:10.1126/science.1172308 · Cited by 1,931 · see citing works

AMP-activated protein kinase induces a p53-dependent metabolic checkpoint

Jones, R. G., Plas, D. R., Kubek, S., Buzzai, M., Mu, J., Xu, Y., Birnbaum, M. J., & Thompson, C. B. (2005) · Molecular Cell · doi:10.1016/j.molcel.2005.03.027 · Cited by 1,619 · see citing works

The extracellular matrix as a cell survival factor.

Meredith, J. E., Fazeli, B., & Schwartz, M. A. (1993) · Molecular Biology of the Cell · doi:10.1091/mbc.4.9.953 · Cited by 1,540 · see citing works

TNF-α Induces Two Distinct Caspase-8 Activation Pathways

Wang, L., Du, F., & Wang, X. (2008) · Cell · doi:10.1016/j.cell.2008.03.036 · Cited by 1,352 · see citing works

p53 Target Genes Sestrin1 and Sestrin2 Connect Genotoxic Stress and mTOR Signaling

Budanov, A. V., & Karin, M. (2008) · Cell · doi:10.1016/j.cell.2008.06.028 · Cited by 1,326 · see citing works

Anoikis mechanisms

Frisch, S. M., & Screaton, R. A. (2001) · Current Opinion in Cell Biology · doi:10.1016/s0955-0674(00)00251-9 · Cited by 1,249 · see citing works

Inhibition of Pyruvate Kinase M2 by Reactive Oxygen Species Contributes to Cellular Antioxidant Responses

Anastasiou, D., Poulogiannis, G., Asara, J. M., Boxer, M. B., Jiang, J., Shen, M., Bellinger, G., Sasaki, A. T., Locasale, J. W., Auld, D. S., et al. (2011) · Science · doi:10.1126/science.1211485 · Cited by 1,196 · see citing works

Antioxidant and oncogene rescue of metabolic defects caused by loss of matrix attachment

Schafer, Z. T., Grassian, A. R., Song, L., Jiang, Z., Gerhart-Hines, Z., Irie, H. Y., Gao, S., Puigserver, P., & Brugge, J. S. (2009) · Nature · doi:10.1038/nature08268 · Cited by 1,031 · see citing works

Activation of IKK by TNFα Requires Site-Specific Ubiquitination of RIP1 and Polyubiquitin Binding by NEMO

Ea, C.-K., Deng, L., Xia, Z.-P., Pineda, G., & Chen, Z. J. (2006) · Molecular Cell · doi:10.1016/j.molcel.2006.03.026 · Cited by 998 · see citing works

Identification of a Molecular Signaling Network that Regulates a Cellular Necrotic Cell Death Pathway

Hitomi, J., Christofferson, D. E., Ng, A., Yao, J., Degterev, A., Xavier, R. J., & Yuan, J. (2008) · Cell · doi:10.1016/j.cell.2008.10.044 · Cited by 989 · see citing works

The Mitochondrial Phosphatase PGAM5 Functions at the Convergence Point of Multiple Necrotic Death Pathways

Wang, Z., Jiang, H., Chen, S., Du, F., & Wang, X. (2012) · Cell · doi:10.1016/j.cell.2011.11.030 · Cited by 949 · see citing works

Keap1-null mutation leads to postnatal lethality due to constitutive Nrf2 activation

Wakabayashi, N., Itoh, K., Wakabayashi, J., Motohashi, H., Noda, S., Takahashi, S., Imakado, S., KOTSUJI, T., Otsuka, F., Roop, D. R., et al. (2003) · Nature Genetics · doi:10.1038/ng1248 · Cited by 881 · see citing works

Genetic determinants of cancer metastasis

Nguyen, D. X., & Massagué, J. (2007) · Nature Reviews Genetics · doi:10.1038/nrg2101 · Cited by 796 · see citing works

Tyrosine Phosphorylation Inhibits PKM2 to Promote the Warburg Effect and Tumor Growth

Hitosugi, T., Kang, S., Vander Heiden, M. G., Chung, T.-W., Elf, S., Lythgoe, K., Dong, S., Lonial, S., Wang, X., Chen, G. Z., et al. (2009) · Science Signaling · doi:10.1126/scisignal.2000431 · Cited by 784 · see citing works

The Role of Apoptosis in Creating and Maintaining Luminal Space within Normal and Oncogene-Expressing Mammary Acini

Debnath, J., Mills, K. R., Collins, N. L., Reginato, M. J., Muthuswamy, S. K., & Brugge, J. S. (2002) · Cell · doi:10.1016/s0092-8674(02)01001-2 · Cited by 763 · see citing works

A Nonapoptotic Cell Death Process, Entosis, that Occurs by Cell-in-Cell Invasion

Overholtzer, M., Mailleux, A. A., Mouneimne, G., Normand, G., Schnitt, S. J., King, R. W., Cibas, E. S., & Brugge, J. S. (2007) · Cell · doi:10.1016/j.cell.2007.10.040 · Cited by 748 · see citing works

Anoikis resistance and tumor metastasis

Simpson, C. D., Anyiwe, K., & Schimmer, A. D. (2008) · Cancer Letters · doi:10.1016/j.canlet.2008.05.029 · Cited by 640 · see citing works

Evidence for an Alternative Glycolytic Pathway in Rapidly Proliferating Cells

Heiden, M. G. V., Locasale, J. W., Swanson, K. D., Sharfi, H., Heffron, G. J., Amador‐Noguez, D., Christofk, H. R., Wagner, G., Rabinowitz, J. D., Asara, J. M., et al. (2010) · Science · doi:10.1126/science.1188015 · Cited by 635 · see citing works

Suppression of anoikis and induction of metastasis by the neurotrophic receptor TrkB

Douma, S., van Laar, T., Zevenhoven, J., Meuwissen, R. L. J., van Garderen, E., & Peeper, D. S. (2004) · Nature · doi:10.1038/nature02765 · Cited by 608 · see citing works

Levels of Hypoxia-Inducible Factor-1 During Breast Carcinogenesis

Bos, R., Zhong, H., Hanrahan, C. F., Mommers, E. C. M., Semenza, G. L., Pinedo, H. M., Abeloff, M. D., Simons, J. W., van Diest, P. J., & van der Wall, E. (2001) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/93.4.309 · Cited by 593 · see citing works

Induction of Autophagy during Extracellular Matrix Detachment Promotes Cell Survival

Fung, C., Lock, R., Gao, S., Salas, E., & Debnath, J. (2008) · Molecular Biology of the Cell · doi:10.1091/mbc.e07-10-1092 · Cited by 558 · see citing works

The M1- and M2-type isozymes of rat pyruvate kinase are produced from the same gene by alternative RNA splicing.

Noguchi, T., Inoue, H., & Tanaka, T. (1986) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)67091-7 · Cited by 544 · see citing works

A two-way street: reciprocal regulation of metabolism and signalling

Wellen, K. E., & Thompson, C. B. (2012) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3305 · Cited by 528 · see citing works

Survival of Cancer Cells Is Maintained by EGFR Independent of Its Kinase Activity

Weihua, Z., Tsan, R. Z., Huang, W., Wu, Q., Chiu, C., Fidler, I. J., & Hung, M. (2008) · Cancer Cell · doi:10.1016/j.ccr.2008.03.015 · Cited by 491 · see citing works

Chapter 2 PI3K/PTEN Signaling in Angiogenesis and Tumorigenesis

(2009) · Advances in Cancer Research · doi:10.1016/s0065-230x(09)02002-8 · Cited by 486 · see citing works

Autophagy machinery mediates macroendocytic processing and entotic cell death by targeting single membranes

Florey, O., Kim, S. E., Sandoval, C. P., Haynes, C. M., & Overholtzer, M. (2011) · Nature Cell Biology · doi:10.1038/ncb2363 · Cited by 459 · see citing works

Phosphoinositide signalling in cancer: beyond PI3K and PTEN

Bunney, T. D., & Katan, M. (2010) · Nature Reviews Cancer · doi:10.1038/nrc2842 · Cited by 400 · see citing works

Signaling Kinase AMPK Activates Stress-Promoted Transcription via Histone H2B Phosphorylation

Bungard, D., Fuerth, B. J., Zeng, P.-Y., Faubert, B., Maas, N. L., Viollet, B., Carling, D., Thompson, C. B., Jones, R. G., & Berger, S. L. (2010) · Science · doi:10.1126/science.1191241 · Cited by 372 · see citing works

Modulation of intracellular ROS levels by TIGAR controls autophagy

Bensaad, K., Cheung, E. C., & Vousden, K. H. (2009) · The EMBO Journal · doi:10.1038/emboj.2009.242 · Cited by 361 · see citing works

The molecular determinants of de novo nucleotide biosynthesis in cancer cells

Tong, X., Zhao, F., & Thompson, C. B. (2009) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2009.01.002 · Cited by 351 · see citing works

The PERK/eIF2α/ATF4 module of the UPR in hypoxia resistance and tumor growth

Fels, D. R., & Koumenis, C. (2006) · Cancer Biology & Therapy · doi:10.4161/cbt.5.7.2967 · Cited by 347 · see citing works

New aspects of the Warburg effect in cancer cell biology

Bensinger, S. J., & Christofk, H. R. (2012) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2012.02.003 · Cited by 309 · see citing works

PGAM5 tethers a ternary complex containing Keap1 and Nrf2 to mitochondria

Lo, S.-C., & Hannink, M. (2008) · Experimental Cell Research · doi:10.1016/j.yexcr.2008.02.014 · Cited by 300 · see citing works

Angiopoietin-like 4 Protein Elevates the Prosurvival Intracellular O2−:H2O2 Ratio and Confers Anoikis Resistance to Tumors

Zhu, P., Tan, M., Huang, R.-L., Tan, C. K., Chong, H. C., Pal, M., Lam, C. R. I., Boukamp, P., Pan, J. Y., Tan, S. H., et al. (2011) · Cancer Cell · doi:10.1016/j.ccr.2011.01.018 · Cited by 283 · see citing works

PERK Integrates Autophagy and Oxidative Stress Responses To Promote Survival during Extracellular Matrix Detachment

Avivar‐Valderas, A., Salas, E., Bobrovnikova-Marjon, E. V., Diehl, J. A., Nagi, C. S., Debnath, J., & Aguirre‐Ghiso, J. A. (2011) · Molecular and Cellular Biology · doi:10.1128/mcb.05164-11 · Cited by 280 · see citing works

Modulation of Glucose Metabolism by CD44 Contributes to Antioxidant Status and Drug Resistance in Cancer Cells

Tamada, M., Nagano, O., Tateyama, S., Ohmura, M., Yae, T., Ishimoto, T., Sugihara, E., Onishi, N., Yamamoto, T., Yanagawa, H., et al. (2012) · Cancer Research · doi:10.1158/0008-5472.can-11-3024 · Cited by 275 · see citing works

Hypoxia-Inducible Factor-1α Expression Predicts a Poor Response to Primary Chemoendocrine Therapy and Disease-Free Survival in Primary Human Breast Cancer

Generali, D., Berruti, A., Brizzi, M. P., Campo, L., Bonardi, S., Wigfield, S., Bersiga, A., Allevi, G., Milani, M., Aguggini, S., et al. (2006) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-05-2690 · Cited by 250 · see citing works

TrkA overexpression enhances growth and metastasis of breast cancer cells

Lagadec, C. H., Meignan, S., Adriaenssens, É., Foveau, B., Vanhecke, E., Romon, R., Toillon, R., Oxombre, B., Hondermarck, H., & Bourhis, X. L. (2009) · Oncogene · doi:10.1038/onc.2009.61 · Cited by 238 · see citing works

Glucose Oxidation Modulates Anoikis and Tumor Metastasis

Kamarajugadda, S., Stemboroski, L. N., Cai, Q., Simpson, N. E., Nayak, S., Tan, M., & Lu, J. (2012) · Molecular and Cellular Biology · doi:10.1128/mcb.06248-11 · Cited by 216 · see citing works

Pyruvate Kinase Triggers a Metabolic Feedback Loop that Controls Redox Metabolism in Respiring Cells

Grüning, N., Rinnerthaler, M., Bluemlein, K., Mülleder, M., Wamelink, M. M. C., Lehrach, H., Jakobs, C., Breitenbach, M., & Ralser, M. (2011) · Cell Metabolism · doi:10.1016/j.cmet.2011.06.017 · Cited by 215 · see citing works

The cell biology of cell-in-cell structures

Overholtzer, M., & Brugge, J. S. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2504 · Cited by 202 · see citing works

Altered metabolism in cancer

Locasale, J. W., & Cantley, L. C. (2010) · BMC Biology · doi:10.1186/1741-7007-8-88 · Cited by 199 · see citing works

Erk regulation of pyruvate dehydrogenase flux through PDK4 modulates cell proliferationPreprint

Grassian, A. R., Metallo, C. M., Coloff, J. L., Stephanopoulos, G. N., & Brugge, J. S. (2011) · Genes & Development · doi:10.1101/gad.16771811 · Cited by 178 · see citing works

Nutrient-dependent regulation of autophagy through the target of rapamycin pathway

Chang, Y.-Y., Juhász, G., Goraksha-Hicks, P., Arsham, A. M., Mallin, D. R., Müller, L., & Neufeld, T. P. (2009) · Biochemical Society Transactions · doi:10.1042/bst0370232 · Cited by 173 · see citing works

Learning therapeutic lessons from metastasis suppressor proteins

Smith, S. C., & Theodorescu, D. (2009) · Nature reviews. Cancer · doi:10.1038/nrc2594 · Cited by 170 · see citing works

Extracellular matrix regulation of autophagy

Lock, R., & Debnath, J. (2008) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2008.05.002 · Cited by 160 · see citing works

Bim Regulation of Lumen Formation in Cultured Mammary Epithelial Acini Is Targeted by Oncogenes

Reginato, M. J., Mills, K. R., Becker, E. B. E., Lynch, D. K., Bonni, A., Muthuswamy, S. K., & Brugge, J. S. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.11.4591-4601.2005 · Cited by 147 · see citing works

Functional role and oncogene-regulated expression of the BH3-only factor Bmf in mammary epithelial anoikis and morphogenesis

Schmelzle, T., Mailleux, A., Overholtzer, M., Carroll, J. S., Solimini, N. L., Lightcap, E. S., Veiby, O. P., & Brugge, J. S. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0700115104 · Cited by 145 · see citing works

Life, death and burial: multifaceted impact of autophagy

Galluzzi, L., Morselli, E., Vicencio, J. M., Kepp, O., Joza, N. A., Tajeddine, N., & Kroemer, G. (2008) · Biochemical Society Transactions · doi:10.1042/bst0360786 · Cited by 138 · see citing works

The AMPK stress response pathway mediates anoikis resistance through inhibition of mTOR and suppression of protein synthesis

Ng, T. L., Leprivier, G., Robertson, M. D., Chow, C., Martin, M. J., Laderoute, K. R., Davicioni, E., Triche, T. J., & Sorensen, P. H. B. (2011) · Cell Death and Differentiation · doi:10.1038/cdd.2011.119 · Cited by 135 · see citing works

Rethinking the metastatic cascade as a therapeutic target

Mina, L. A., & Sledge, G. W. (2011) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2011.59 · Cited by 123 · see citing works

Suppression of anoikis by the neurotrophic receptor TrkB in human ovarian cancer

Yu, X., Liu, L., Cai, B., He, Y., & Wan, X. (2008) · Cancer Science · doi:10.1111/j.1349-7006.2007.00722.x · Cited by 121 · see citing works

Pyruvate Kinase

Carbonell, J., Marco, R., Felíu, J. E., & Sols, A. (1973) · European Journal of Biochemistry · doi:10.1111/j.1432-1033.1973.tb02969.x · Cited by 113 · see citing works

Hypoxia-Inducible Factor 1α Mediates Anoikis Resistance via Suppression of α5 Integrin

Rohwer, N., Welzel, M., Daskalow, K., Pfander, D., Wiedenmann, B. J., Detjen, K. M., & Cramer, T. (2008) · Cancer Research · doi:10.1158/0008-5472.can-08-1839 · Cited by 109 · see citing works

Autophagy and cancer: Dynamism of the metabolism of tumor cells and tissues

Tsuchihara, K., Fujii, S., & Esumi, H. (2008) · Cancer Letters · doi:10.1016/j.canlet.2008.09.040 · Cited by 102 · see citing works

Autophagy suppression promotes apoptotic cell death in response to inhibition of the PI3K—mTOR pathway in pancreatic adenocarcinoma

Mirzoeva, O. K., Hann, B. C., Hom, Y. K., Debnath, J., Aftab, D. T., Shokat, K. M., & Korn, W. M. (2011) · Journal of Molecular Medicine · doi:10.1007/s00109-011-0774-y · Cited by 100 · see citing works

Live Free or Die

Horbinski, C., Mojesky, C., & Kyprianou, N. (2010) · American Journal Of Pathology · doi:10.2353/ajpath.2010.091270 · Cited by 94 · see citing works

The Neurotrophic Receptor TrkB in Anoikis Resistance and Metastasis: A Perspective

Geiger, T. R., & Peeper, D. S. (2005) · Cancer Research · doi:10.1158/0008-5472.can-05-0709 · Cited by 79 · see citing works

L- and M2- pyruvate kinase expression in renal cell carcinomas and their metastases

Brinck, U., Fischer, G., EIGENBRODT, E., Oehmke, M. J., & Mazurek, S. (1994) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/bf00193498 · Cited by 77 · see citing works

TrkC plays an essential role in breast tumor growth and metastasis

Jin, W., Kim, G. M., Kim, M. S., Lim, M. H., Yun, C., Jeong, J., Nam, J., & Kim, S. (2010) · Carcinogenesis · doi:10.1093/carcin/bgq180 · Cited by 72 · see citing works

Hypoxia Suppression of Bim and Bmf Blocks Anoikis and Luminal Clearing during Mammary Morphogenesis

Whelan, K. A., Caldwell, S. A., Shahriari, K. S., Jackson, S. R., Franchetti, L. D., Johannes, G. J., & Reginato, M. J. (2010) · Molecular Biology of the Cell · doi:10.1091/mbc.e10-04-0353 · Cited by 70 · see citing works

Expression of pyruvate kinase M 2 in preneoplastic hepatic foci of N -nitrosomorpholine-treated rats

Steinberg, P., Klingelhöffer, A., Schäfer, A., Wüst, G., Weisse, G., Oesch, F., & EIGENBRODT, E. (1999) · Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin · doi:10.1007/s004280050330 · Cited by 60 · see citing works

Functional Characterization of Human Cancer-Derived TRKB Mutations

Geiger, T. R., Song, J., Rosado, A., & Peeper, D. S. (2011) · PLoS ONE · doi:10.1371/journal.pone.0016871 · Cited by 58 · see citing works

Regulation of Pyruvate Kinase M Gene Expression

Yamada, K., & Noguchi, T. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.0228 · Cited by 57 · see citing works

Immunohistological demonstration of the same type of pyruvate kinase isoenzyme (M2-Pk) in tumors of chicken and rat

Reinacher, M., & EIGENBRODT, E. (1981) · Virchows Archiv B Cell Pathology Including Molecular Pathology · doi:10.1007/bf02892557 · Cited by 46 · see citing works

Immunohistological demonstration of pyruvate kinase isoenzyme type L in rat with monoclonal antibodies.

Domingo, M., Einig, C., EIGENBRODT, E., & Reinacher, M. (1992) · Journal of Histochemistry & Cytochemistry · doi:10.1177/40.5.1374093 · Cited by 25 · see citing works

S100A4 protects gastric cancer cells from anoikis through regulation of αv and α5 integrin

Shen, W., Chen, D., Fu, H., Liu, S., Sun, K., & Sun, X. (2011) · Cancer Science · doi:10.1111/j.1349-7006.2011.01915.x · Cited by 20 · see citing works

Immunohistochemical localization of pyruvate kinase isoenzymes in chicken tissues

Reinacher, M., EIGENBRODT, E., Schering, B., & Schöner, W. (1979) · Histochemistry and Cell Biology · doi:10.1007/bf00490095 · Cited by 16 · see citing works

Surviving without oxygen: Hypoxia regulation of mammary morphogenesis and anoikis

Whelan, K. A., & Reginato, M. J. (2011) · Cell Cycle · doi:10.4161/cc.10.14.16532 · Cited by 14 · see citing works

Comparative kinetic behaviour and regulation by fructose-1,6-bisphosphate and ATP of pyruvate kinase from erythrocytes, reticulocytes and bone marrow cells

Rodriguez‐Horche, P., Luque, J., Pérez-Artés, E., Pineda, M., & Pinilla, M. C. F. (1987) · Comparative Biochemistry and Physiology Part B Comparative Biochemistry · doi:10.1016/0305-0491(87)90051-4 · Cited by 9 · see citing works

The Role of Red Cell Aging in the Diagnosis of Glycolytic Enzyme Defects

Staal, G. E. J., & Rijksen, G. (1991) · Advances in experimental medicine and biology · doi:10.1007/978-1-4684-5985-2_22 · Cited by 7 · see citing works

Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018.

Galluzzi, L., Vitale, I., Aaronson, S. A., Abrams, J. M., Adam, D., Agostinis, P., Alnemri, E. S., Altucci, L., Amelio, I., Andrews, D. W., et al. (2018) · Cell Death & Differentiation · doi:10.1038/s41418-017-0012-4 · Cited by 6,680 · see citing works

Activation of apoptosis signalling pathways by reactive oxygen species

Redza-Dutordoir, M., & Averill-Bates, D. A. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2016.09.012 · Cited by 3,731 · see citing works

A Symbiotic View of Life: We Have Never Been Individuals

Gilbert, S. F., Sapp, J., & Tauber, A. I. (2012) · The Quarterly Review of Biology · doi:10.1086/668166 · Cited by 1,208 · see citing works

Anoikis molecular pathways and its role in cancer progression

Paoli, P., Giannoni, E., & Chiarugi, P. (2013) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2013.06.026 · Cited by 1,160 · see citing works

The role of necroptosis in cancer biology and therapy

Gong, Y., Fan, Z., Luo, G., Yang, C., Huang, Q., Fan, K., He, C., Jin, K., Ni, Q., Yu, X., et al. (2019) · Molecular Cancer · doi:10.1186/s12943-019-1029-8 · Cited by 1,048 · see citing works

Apoptosis, autophagy, necroptosis, and cancer metastasis

Su, Z., Yang, Z., Xu, Y., Chen, Y., & Yu, Q. (2015) · Molecular Cancer · doi:10.1186/s12943-015-0321-5 · Cited by 1,039 · see citing works

Cancer Metabolism: Phenotype, Signaling and Therapeutic Targets

Park, J. H., Pyun, W. Y., & Park, H. W. (2020) · Cells · doi:10.3390/cells9102308 · Cited by 558 · see citing works

Interplay between ROS and autophagy in cancer cells, from tumor initiation to cancer therapy

Poillet-Perez, L., Despouy, G., Delage-Mourroux, R., & Boyer-Guittaut, M. (2015) · Redox Biology · doi:10.1016/j.redox.2014.12.003 · Cited by 503 · see citing works

Cancer cell survival during detachment from the ECM: multiple barriers to tumour progression

Buchheit, C. L., Weigel, K. J., & Schafer, Z. T. (2014) · Nature Reviews Cancer · doi:10.1038/nrc3789 · Cited by 367 · see citing works

Mitochondrial Reactive Oxygen Species and Mitophagy: A Complex and Nuanced Relationship

Schofield, J. H., & Schafer, Z. T. (2020) · Antioxidants and Redox Signaling · doi:10.1089/ars.2020.8058 · Cited by 207 · see citing works

Programmed Cell Death, from a Cancer Perspective: An Overview

Mishra, A. P., Salehi, B., Sharifi‐Rad, M., Pezzani, R., Kobarfard, F., Sharifi‐Rad, J., & Nigam, M. (2018) · Molecular Diagnosis & Therapy · doi:10.1007/s40291-018-0329-9 · Cited by 192 · see citing works

Antioxidant Enzymes Mediate Survival of Breast Cancer Cells Deprived of Extracellular Matrix

Davison, C. A., Durbin, S., Thau, M. R., Zellmer, V. R., Chapman, S. E., Diener, J. M., Wathen, C. A., Leevy, W. M., & Schafer, Z. T. (2013) · Cancer Research · doi:10.1158/0008-5472.can-12-2482 · Cited by 124 · see citing works

Tumor stroma and differentiated cancer cells can be originated directly from polyploid giant cancer cells induced by paclitaxel

Zhang, S., Mercado‐Uribe, I., & Liu, J. (2013) · International Journal of Cancer · doi:10.1002/ijc.28319 · Cited by 126 · see citing works

Mitochondrial metabolism-mediated redox regulation in cancer progression

Boese, A. C., & Kang, S. (2021) · Redox Biology · doi:10.1016/j.redox.2021.101870 · Cited by 114 · see citing works

Role of cell surface proteoglycans in cancer immunotherapy

Espinoza‐Sánchez, N. A., & Götte, M. (2019) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2019.07.012 · Cited by 108 · see citing works

The Extracellular Matrix Regulates Granuloma Necrosis in Tuberculosis

Shammari, B. R. A., Shiomi, T., Tezera, L. B., Bielecka, M. K., Workman, V. L., Sathyamoorthy, T., Mauri, F. A., Jayasinghe, S. N., Robertson, B. D., D'Armiento, J. M., et al. (2015) · The Journal of Infectious Diseases · doi:10.1093/infdis/jiv076 · Cited by 101 · see citing works

Protein Kinase A Activation Promotes Cancer Cell Resistance to Glucose Starvation and Anoikis

Palorini, R., Votta, G., Pirola, Y., Vitto, H. D., Palma, S. D., Airoldi, C., Vasso, M., Ricciardiello, F., Lombardi, P. P., Cirulli, C., et al. (2016) · PLoS Genetics · doi:10.1371/journal.pgen.1005931 · Cited by 94 · see citing works

RIPK1-mediated induction of mitophagy compromises the viability of extracellular-matrix-detached cells

Hawk, M. A., Gorsuch, C. L., Fagan, P., Lee, C., Kim, S. E., Hamann, J. C., Mason, J. A., Weigel, K. J., Tsegaye, M. A., Shen, L., et al. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0034-2 · Cited by 94 · see citing works

A biomimetic 3D model of hypoxia-driven cancer progression

Liverani, C., Vita, A. D., Minardi, S., Kang, Y., Mercatali, L., Amadori, D., Bongiovanni, A., Manna, F. L., Ibrahim, T., & Tasciotti, E. (2019) · Scientific Reports · doi:10.1038/s41598-019-48701-4 · Cited by 91 · see citing works

Ripening-induced chemical modifications of papaya pectin inhibit cancer cell proliferation

do Prado, S. B. R., Ferreira, G. F., Harazono, Y., Shiga, T. M., Raz, A., Carpita, N. C., & Fabi, J. P. (2017) · Scientific Reports · doi:10.1038/s41598-017-16709-3 · Cited by 86 · see citing works

Mechanisms of redox metabolism and cancer cell survival during extracellular matrix detachment

Hawk, M. A., & Schafer, Z. T. (2018) · Journal of Biological Chemistry · doi:10.1074/jbc.tm117.000260 · Cited by 80 · see citing works

Dissection of the host-pathogen interaction in human tuberculosis using a bioengineered 3-dimensional model

Tezera, L. B., Bielecka, M. K., Chancellor, A., Reichmann, M. T., Shammari, B. R. A., Brace, P., Batty, A., Tocheva, A., Jogai, S., Marshall, B. G., et al. (2017) · eLife · doi:10.7554/elife.21283 · Cited by 80 · see citing works

Metabolism during ECM Detachment: Achilles Heel of Cancer Cells?

Mason, J. A., Hagel, K. R., Hawk, M. A., & Schafer, Z. T. (2017) · Trends in Cancer · doi:10.1016/j.trecan.2017.04.009 · Cited by 78 · see citing works

Oncogenic Ras differentially regulates metabolism and anoikis in extracellular matrix-detached cells

Mason, J. A., Davison-Versagli, C. A., Leliaert, A. K., Pape, D. J., McCallister, C. M., Zuo, J.-L., Durbin, S., Buchheit, C. L., Zhang, S., & Schafer, Z. T. (2016) · Cell Death and Differentiation · doi:10.1038/cdd.2016.15 · Cited by 72 · see citing works

Autophagy, Oxidative Stress and Cancer Development

Taucher, E., Mykoliuk, I., Fediuk, M., & Smolle‐Jüttner, F. (2022) · Cancers · doi:10.3390/cancers14071637 · Cited by 74 · see citing works

Necroptosis in cancer: An angel or a demon?

Wang, T., Jin, Y., Yang, W., Zhang, L., Jin, X., Liu, X., He, Y., & Li, X. (2017) · Tumor Biology · doi:10.1177/1010428317711539 · Cited by 72 · see citing works

Necroptosis: A Pathogenic Negotiator in Human Diseases

Chaouhan, H. S., Vinod, C., Mahapatra, N., Yu, S., Wang, I., Chen, K., Yu, T., & Li, C. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232112714 · Cited by 68 · see citing works

Architecture in 3D cell culture: An essential feature for in vitro toxicology

Lelièvre, S. A., Kwok, T., & Chittiboyina, S. (2017) · Toxicology in Vitro · doi:10.1016/j.tiv.2017.03.012 · Cited by 69 · see citing works

Anoikis evasion in inflammatory breast cancer cells is mediated by Bim-EL sequestration

Buchheit, C. L., Angarola, B. L., Steiner, A., Weigel, K. J., & Schafer, Z. T. (2015) · Cell Death & Differentiation · doi:10.1038/cdd.2014.209 · Cited by 63 · see citing works

Combined treatment with Metformin and 2-deoxy glucose induces detachment of viable MDA-MB-231 breast cancer cells in vitro

Bizjak, M., Malavašič, P., Dolinar, K., Pohar, J., Pirkmajer, S., & Pavlin, M. (2017) · Scientific Reports · doi:10.1038/s41598-017-01801-5 · Cited by 63 · see citing works

Migration and proliferation of cancer cells in culture are differentially affected by molecular size of modified citrus pectin

do Prado, S. B. R., Shiga, T. M., Harazono, Y., Hogan, V. A., Raz, A., Carpita, N. C., & Fabi, J. P. (2019) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2019.02.010 · Cited by 60 · see citing works

Collagen XVII expression correlates with the invasion and metastasis of colorectal cancer

Moilanen, J. M., Kokkonen, N., Löffek, S., Väyrynen, J. P., Syväniemi, E., Hurskainen, T. L., Mäkinen, M. J., Klintrup, K., Mäkelä, J. T., Sormunen, R. T., et al. (2014) · Human Pathology · doi:10.1016/j.humpath.2014.11.020 · Cited by 55 · see citing works

Loss of anchorage primarily induces non-apoptotic cell death in a human mammary epithelial cell line under atypical focal adhesion kinase signaling

Ishikawa, F., Ushida, K., Mori, K., & Shibanuma, M. (2015) · Cell Death and Disease · doi:10.1038/cddis.2014.583 · Cited by 53 · see citing works

Antioxidant Defenses: A Context-Specific Vulnerability of Cancer Cells

Cockfield, J. A., & Schafer, Z. T. (2019) · Cancers · doi:10.3390/cancers11081208 · Cited by 53 · see citing works

Correlation between the Warburg effect and progression of triple-negative breast cancer

Liu, S., Li, Y., Yuan, M., Song, Q., & Liu, M. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2022.1060495 · Cited by 52 · see citing works

CAF-Secreted IGFBPs Regulate Breast Cancer Cell Anoikis

Weigel, K. J., Jakimenko, A., Conti, B. A., Chapman, S. E., Kaliney, W. J., Leevy, W. M., Champion, M. M., & Schafer, Z. T. (2014) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-14-0090 · Cited by 49 · see citing works

Caspase-8 as a Regulator of Tumor Cell Motility

Graf, R. P., Keller, N., Barbero, S., & Stupack, D. G. (2014) · Current Molecular Medicine · doi:10.2174/1566524014666140128111951 · Cited by 48 · see citing works

Tumour-suppression function of KLF12 through regulation of anoikis

Godin-Heymann, N., Brabetz, S., Murillo, M. M., Saponaro, M., Santos, C. R., Lobley, A., East, P., Chakravarty, P., Matthews, N., Kelly, G. P., et al. (2015) · Oncogene · doi:10.1038/onc.2015.394 · Cited by 47 · see citing works

The Role of Multicellular Aggregation in the Survival of ErbB2-positive Breast Cancer Cells during Extracellular Matrix Detachment

Rayavarapu, R. R., Heiden, B., Pagani, N., Shaw, M. M., Shuff, S., Zhang, S., & Schafer, Z. T. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.612754 · Cited by 42 · see citing works

Unravelling the relationship between macroautophagy and mitochondrial ROS in cancer therapy

Zhao, Y., Qu, T., Wang, P., Li, X., Qiang, J., Xia, Z., Duan, H., Huang, J., & Zhu, L. (2016) · APOPTOSIS · doi:10.1007/s10495-016-1236-3 · Cited by 39 · see citing works

Metabolic Plasticity and Epithelial-Mesenchymal Transition

Thomson, T. M., Balcells, C. D., & Cascante, M. (2019) · Journal of Clinical Medicine · doi:10.3390/jcm8070967 · Cited by 38 · see citing works

Significant Role of Collagen XVII And Integrin β4 in Migration and Invasion of The Less Aggressive Squamous Cell Carcinoma Cells

Moilanen, J. M., Löffek, S., Kokkonen, N., Salo, S., Väyrynen, J. P., Hurskainen, T. L., Manninen, A., Riihilä, P., Heljäsvaara, R., Franzke, C.-W., et al. (2017) · Scientific Reports · doi:10.1038/srep45057 · Cited by 38 · see citing works

Protein disulfide isomerases in the endoplasmic reticulum promote anchorage-independent growth of breast cancer cells

Wise, R., Duhachek-Muggy, S., Qi, Y., Žółkiewski, M., & Żółkiewska, A. (2016) · Breast Cancer Research and Treatment · doi:10.1007/s10549-016-3820-1 · Cited by 38 · see citing works

Intrinsic and Tumor Microenvironment-Induced Metabolism Adaptations of T Cells and Impact on Their Differentiation and Function

Kouidhi, S., Noman, M. Z., Kiéda, C., Elgaaïed, A. B., & Chouaı̈b, S. (2016) · Frontiers in Immunology · doi:10.3389/fimmu.2016.00114 · Cited by 36 · see citing works

Soluble ECM promotes organotypic formation in lung alveolar model

Valdoz, J. C., Franks, N. A., Cribbs, C. G., Jacobs, D. J., Dodson, E. L., Knight, C. J., Poulson, P. D., Garfield, S. R., Johnson, B. C., Hemeyer, B. M., et al. (2022) · Biomaterials · doi:10.1016/j.biomaterials.2022.121464 · Cited by 37 · see citing works

The Alternative Splicing of Cytoplasmic Polyadenylation Element Binding Protein 2 Drives Anoikis Resistance and the Metastasis of Triple Negative Breast Cancer

Johnson, R. M., Vu, N., Griffin, B. P., Gentry, A. E., Archer, K. J., Chalfant, C. E., & Park, M. A. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.671206 · Cited by 34 · see citing works

Network-based proteomic approaches reveal the neurodegenerative, neuroprotective and pain-related mechanisms involved after retrograde axonal damage

Casas, C., Isus, L., Herrando‐Grabulosa, M., Mancuso, F. M., Borràs, E., Sabidó, E., Forés, J., & Aloy, P. (2015) · Scientific Reports · doi:10.1038/srep09185 · Cited by 32 · see citing works

Disialoganglioside GD3-synthase over expression inhibits survival and angiogenesis of pancreatic cancer cells through cell cycle arrest at S-phase and disruption of integrin-β1-mediated anchorage

Mandal, C., Sarkar, S., Chatterjee, U., Schwartz‐Albiez, R., & Mandal, C. (2014) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2014.05.015 · Cited by 32 · see citing works

Iron affects the sphere-forming ability of ovarian cancer cells in non-adherent culture conditions

Battaglia, A. M., Sacco, A., Vecchio, E., Scicchitano, S., Petriaggi, L., Giorgio, E., Bulotta, S., Levi, S., Faniello, M. C., Biamonte, F., et al. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1272667 · Cited by 31 · see citing works

Astrocyte elevated gene 1 (AEG‐1) promotes anoikis resistance and metastasis by inducing autophagy in hepatocellular carcinoma

Zhu, H., Liu, L., Deng, H., Li, Z., Sheng, J., He, X., Tian, D., & Li, P. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.29377 · Cited by 31 · see citing works

Necroptosis in Cholangiocarcinoma

Sarcognato, S., de Jong, I. E. M., Fabris, L., Cadamuro, M., & Guido, M. (2020) · Cells · doi:10.3390/cells9040982 · Cited by 30 · see citing works

The Interplay between Cell-Extracellular Matrix Interaction and Mitochondria Dynamics in Cancer

Yanes, B., & Rainero, E. (2022) · Cancers · doi:10.3390/cancers14061433 · Cited by 30 · see citing works

A gene expression-based comparison of cell adhesion to extracellular matrix and RGD-terminated monolayers

Sobers, C. J., Wood, S. E., & Mrksich, M. (2015) · Biomaterials · doi:10.1016/j.biomaterials.2015.02.045 · Cited by 29 · see citing works

Focal adhesion kinase dependent activation of the PI3 kinase pathway by the functional soluble form of neurotensin receptor-3 in HT29 cells

Massa, F., Devader, C., Béraud-Dufour, S., Brau, F., Coppola, T., & Mazella, J. (2013) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2013.01.020 · Cited by 29 · see citing works

Anoikis in phenotypic reprogramming of the prostate tumor microenvironment

Nepali, P. R., & Kyprianou, N. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1160267 · Cited by 27 · see citing works

Nitro aspirin (NCX4040) induces apoptosis in PC3 metastatic prostate cancer cells via hydrogen peroxide (H2O2)-mediated oxidative stress

Chinnapaka, S., Zheng, G., Chen, A., & Munirathinam, G. (2019) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2019.08.025 · Cited by 27 · see citing works

Focal Adhesion Kinase-Dependent Role of the Soluble Form of Neurotensin Receptor-3/Sortilin in Colorectal Cancer Cell Dissociation

Béraud-Dufour, S., Devader, C., Massa, F., Roulot, M., Coppola, T., & Mazella, J. (2016) · International Journal of Molecular Sciences · doi:10.3390/ijms17111860 · Cited by 27 · see citing works

Reprogramming of iron metabolism confers ferroptosis resistance in ECM-detached cells

He, J., Abikoye, A. M., McLaughlin, B. P., Middleton, R. S., Sheldon, R. D., Jones, R. G., & Schafer, Z. T. (2023) · iScience · doi:10.1016/j.isci.2023.106827 · Cited by 25 · see citing works

Kindlin-1 protects cells from oxidative damage through activation of ERK signalling

Emmert, H., Patel, H., & Brunton, V. G. (2017) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2017.05.013 · Cited by 25 · see citing works

SOX2, a stemness gene, induces progression of NSCLC A549 cells toward anchorage-independent growth and chemoresistance to vinblastine

Choe, C., Kim, H., Min, S., Park, S., Seo, J., & Roh, S. (2018) · OncoTargets and Therapy · doi:10.2147/ott.s175810 · Cited by 22 · see citing works

Mitochondrial Metabolism in Pancreatic Ductal Adenocarcinoma: From Mechanism-Based Perspectives to Therapy

Padinharayil, H., Rai, V., & George, A. (2023) · Cancers · doi:10.3390/cancers15041070 · Cited by 24 · see citing works

Clinical Significance of Receptor-Interacting Protein 3 and Parkin, Essential Molecules for Necroptosis, in Breast Cancer

Won, K. Y., Min, S. Y., Song, J.-Y., Lim, S.-J., & Han, S. (2021) · Journal of Breast Cancer · doi:10.4048/jbc.2021.24.e12 · Cited by 17 · see citing works

Prognostic Utility of FBLN2 Expression in Patients With Urothelial Carcinoma

Li, W., Chan, T., Huang, S. K., Wu, W., Ke, H., Liang, P., Wei, Y., Shiue, Y., & Li, C. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.570340 · Cited by 16 · see citing works

Gene expression profiling for targeted cancer treatment

Yuryev, A. (2014) · Expert Opinion on Drug Discovery · doi:10.1517/17460441.2015.971007 · Cited by 15 · see citing works

Deciphering Mechanisms of Action of Sortilin/Neurotensin Receptor-3 in the Proliferation Regulation of Colorectal and Other Cancers

Mazella, J. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231911888 · Cited by 14 · see citing works

Apoptosis and Other Alternate Mechanisms of Cell Death

Kumar, R., Pate, S. K., Reddy, B. V. R., Bhatt, M., Karthik, K., Gandham, R. K., Mali, Y. S., & Dhama, K. (2015) · Asian Journal of Animal and Veterinary Advances · doi:10.3923/ajava.2015.646.668 · Cited by 14 · see citing works

Survival of detached cancer cells is regulated by movement of intracellular Na+,K+-ATPase

Fujii, T., Shimizu, T., Katoh, M., Nagamori, S., Koizumi, K., Fukuoka, J., Tabuchi, Y., Sawaguchi, A., Okumura, T., Shibuya, K., et al. (2021) · iScience · doi:10.1016/j.isci.2021.102412 · Cited by 14 · see citing works

Metabolic profiling of attached and detached metformin and 2-deoxy-D-glucose treated breast cancer cells reveals adaptive changes in metabolome of detached cells

Repas, J., Zügner, E., Gole, B., Bizjak, M., Potočnik, U., Magnes, C., & Pavlin, M. (2021) · Scientific Reports · doi:10.1038/s41598-021-98642-0 · Cited by 14 · see citing works

Mindin serves as a tumour suppressor gene during colon cancer progression through MAPK/ERK signalling pathway in mice

Cheng, X., Huo, Y., Fan, Y., Xiao, C., Ouyang, X., Liang, L., Lin, Y., Wu, J., Ren, J., & Guleng, B. (2020) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.15332 · Cited by 11 · see citing works

Identification and Assessment of Necroptosis-Related Genes in Clinical Prognosis and Immune Cells in Diffuse Large B-Cell Lymphoma

Zhang, Q., Zhu, Z., Guan, J., & Zheng, C. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.904614 · Cited by 11 · see citing works

β-Integrin mediates LPS-induced coelomocyte apoptosis in sea cucumber Apostichopus japonicus via the integrin/FAK/caspase-3 signaling pathway

Wang, Z., Li, C., Xing, R., Shao, Y., Zhao, X., Zhang, W., & Guo, M. Z. (2018) · Developmental & Comparative Immunology · doi:10.1016/j.dci.2018.10.004 · Cited by 10 · see citing works

The peptide mimicking small extracellular loop domain of CD82 inhibits tumor cell migration, adhesion and induces apoptosis by inhibiting integrin mediated signaling

Luan, M., He, X., Huang, X., Zhang, Q., & Ma, K. (2018) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2018.06.139 · Cited by 10 · see citing works

Antiproliferative and antioxidant properties of protein-free and protein-bound phenolics isolated from purple rice (Oryza sativa L.)

Xiong, S., Chen, M., Pei, X., Yin, J., Oliveira, H., Mateus, N. F. D. C. B., Ye, S., Wu, M., Zhang, R., & He, J. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.139340 · Cited by 9 · see citing works

Oncogenic signaling inhibits c-FLIPL expression and its non-apoptotic function during ECM-detachment

Tsegaye, M. A., He, J., McGeehan, K., Murphy, I. M., Nemera, M. T., & Schafer, Z. T. (2021) · Scientific Reports · doi:10.1038/s41598-021-97715-4 · Cited by 9 · see citing works

In vitro and in vivo effects of short hairpin RNA targeting integrin-linked kinase in prostate cancer cells

Yuan, Y., Xiao, Y., Li, Q., Liu, Z., Zhang, X., Qin, C., Xie, J., Wang, X., & Xu, T. (2013) · Molecular Medicine Reports · doi:10.3892/mmr.2013.1532 · Cited by 9 · see citing works

Construction of the miRNA-mRNA regulatory network and analysis of hub genes in oral squamous cell carcinoma

Cui, Z., Song, Q., Chen, Y., & Yang, K. (2022) · Biomedical Papers · doi:10.5507/bp.2022.001 · Cited by 8 · see citing works

Understanding ROS-Induced DNA Damage for Therapeutics

Moin, I., Mittal, D., & Verma, A. K. (2022) · Springer eBooks · doi:10.1007/978-981-15-9411-3_53 · Cited by 8 · see citing works

Recombinant disintegrin targets α(v) β(3) integrin and leads to mediator production

Ribeiro, L. C., Massimino, L. C., Durante, A. C., Tansini, A., Urbaczek, A. C., Selistre-de-Araújo, H. S., & Carlos, I. Z. (2013) · Cell Adhesion & Migration · doi:10.4161/cam.27698 · Cited by 7 · see citing works

Kallistatin Inhibits Anoikis Resistance and Metastasis of Ectopic Endometrium Cells by Modulating MnSOD and Caspase 3 Signaling

Mao, Y., Qiao, J., Chen, S., Zhou, X., Wang, Z., Cai, S., Li, L., & Luo, Y. (2021) · Reproductive Sciences · doi:10.1007/s43032-020-00421-1 · Cited by 7 · see citing works

3D Hydrogel Culture System Recapitulates Key Tuberculosis Phenotypes and Demonstrates Pyrazinamide Efficacy

Gupta, V. K., Vaishnavi, V. V., Arrieta‐Ortiz, M. L., Abhirami, P. S., Jyothsna, K. M., Jeyasankar, S., Raghunathan, V., Baliga, N. S., & Agarwal, R. (2024) · Advanced Healthcare Materials · doi:10.1002/adhm.202304299 · Cited by 5 · see citing works

Molecular profiling of epigenetic landscape of cancer cells during extracellular matrix detachment

Khan, M. I., Zamzami, M. A., Ahmad, A., & Choudhry, H. (2021) · Scientific Reports · doi:10.1038/s41598-021-82431-w · Cited by 6 · see citing works

A novel necroptosis-related long noncoding RNA model for predicting clinical features, immune characteristics, and therapeutic response in clear cell renal cell carcinoma

Zhang, L., Chen, Y., Hu, W., Wu, B., Ye, L., Wang, D., & Bai, T. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1230267 · Cited by 5 · see citing works

The Importance of the Extracellular Matrix in HPV-Associated Diseases

Sampaio, J., Ferreira, J. D. A., de Souza, A. C. S., Bicho, M., & Bicho, M. C. (2021) · IntechOpen eBooks · doi:10.5772/intechopen.99907 · Cited by 5 · see citing works

Ras-ling with new therapeutic targets for metastasis

Mason, J. A., & Schafer, Z. T. (2017) · Small GTPases · doi:10.1080/21541248.2017.1310650 · Cited by 4 · see citing works

Cellular mechanometabolism: stimuli and implications

Ortiz, I., Lopez, S., Kondapaneni, R. V., Hernández, J. A., Boone, K., & Reinhart‐King, C. A. (2026) · EMBO Reports · doi:10.1038/s44319-026-00795-4 · Cited by 3 · see citing works

Role of Autophagy in Regulation Survival or Death of Cancer Cells

Fu, L., & Liu, B. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802936-7.00011-8 · Cited by 3 · see citing works

ROS, Cancer, Stem Cells

George, S., & Abrahamse, H. (2022) · Springer eBooks · doi:10.1007/978-981-15-9411-3_127 · Cited by 3 · see citing works

Understanding ROS Induced DNA Damage for Therapeutics

Moin, I., Mittal, D., & Verma, A. K. (2021) · Springer eBooks · doi:10.1007/978-981-15-4501-6_53-1 · Cited by 2 · see citing works

Inhibition of β2-adrenergic receptor regulates necroptosis in prostate cancer cell

Wu, S., Li, M., Chen, F., Zeng, Y., & Chen, X. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e31865 · Cited by 2 · see citing works

The roles of collagens in cancer

Willumsen, N., Nissen, N. I., & Karsdal, M. A. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-817068-7.00034-3 · Cited by 2 · see citing works

The Constituents and Potential Targets of the Extracellular Matrix:Implications for Carcinogenesis and Cancer Treatment

Weber, C. E. (2013) · Journal of Carcinogenesis & Mutagenesis · doi:10.4172/2157-2518.s13-006 · Cited by 2 · see citing works

Role of Autophagy in Cancer Development via Mitochondrial Reactive Oxygen Species

Liu, B., & He, G. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802937-4.00012-0 · Cited by 2 · see citing works

Cellular Plasticity in Matrix-attached and -Detached Cells: Implications in Metastasis

Ranganathan, S., Kumar, S., Mohanty, S. S., Jolly, M. K., & Rangarajan, A. (2020) · Journal of the Indian Institute of Science · doi:10.1007/s41745-020-00179-0 · Cited by 2 · see citing works

Grainyhead-like 2 Reverses the Metabolic Changes Induced by the Oncogenic Epithelialmesenchymal Transition: Effects on Anoikis

Farris, J. C. (2016) · doi:10.33915/etd.5579 · Cited by 2 · see citing works

ChipNMR: Hyperpolarized NMR for non-invasive metabolic flux analysis in perfused microfluidic chipsPreprint

Mathiassen, T. B. W., Sanchez-Heredia, J. D., Wang, K.-C., Haupt, C. R., Karlsson, M. G., Jönsson, A., Dufva, M., Thuenauer, R., & Jensen, P. R. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.05.20.654798 · Cited by 2 · see citing works

ChipNMR: Hyperpolarized NMR for Noninvasive Metabolic Flux Analysis in Perfused Microfluidic Chips

Mathiassen, T. B. W., Sanchez-Heredia, J. D., Wang, K.-C., Haupt, C. R., Karlsson, M. G., Jönsson, A., Dufva, M., Thuenauer, R., & Jensen, P. R. (2026) · Analytical Chemistry · doi:10.1021/acs.analchem.5c04058 · Cited by 1 · see citing works

Cancer Metastasis, ROS/Redox Signaling, and PCD Resistance/Redox Metabolism

Bansal, M. P. (2023) · Springer eBooks · doi:10.1007/978-981-99-7342-2_5 · Cited by 1 · see citing works

Clinical significance of novel identified high‐frequency tumor‐specific peptides associated signature in predicting disease status of gastric cancer patients

Li, B., Geng, H., Li, Z., Peng, B., Wang, J., Yin, X., Li, N., Shi, J., Zhao, M., Li, C., et al. (2021) · BioFactors · doi:10.1002/biof.1778 · Cited by 1 · see citing works

Proteomic and Transcriptomic Profiling Identifies Mediators of Anchorage-Independent Growth and Roles of Inhibitor of Differentiation Proteins in Invasive Lobular Breast CancerPreprint

Tasdemir, N., Ding, K., Levine, K. M., Du, T., Bossart, E. A., Lee, A. V., Davidson, N. E., & Oesterreich, S. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/543132 · Cited by 1 · see citing works

Metabolism during ECM Detachment: Achilles Heel of Cancer Cells?

Mason, J. A., Hagel, K. R., Hawk, M. A., & Schafer, Z. T. (2017) · Trends in Cancer · doi:10.1016/j.trecan.2017.04.009 · Cited by 78 · see citing works

Metabolic Contributions to Anoikis-Resistance in Metastatic Dissemination

Boese, A. C., & Kang, S. (2021) · Springer eBooks · doi:10.1007/978-3-030-73856-3_1

Cancer cell survival during detachment from the ECM: multiple barriers to tumour progression

Buchheit, C. L., Weigel, K. J., & Schafer, Z. T. (2014) · Nature Reviews Cancer · doi:10.1038/nrc3789 · Cited by 367 · see citing works

Extracellular Matrix Regulation of Metabolism and Implications for TumorigenesisPreprint

Grassian, A. R., Coloff, J. L., & Brugge, J. S. (2011) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2011.76.010967 · Cited by 75 · see citing works

Investigating Molecular Mechanisms That Promote Survival or Death in ECM-detached Cancer Cells

Cockfield, J. A. (2021) · Figshare · doi:10.7274/70795715p9f