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Stimulation of Bone Formation in Vitro and in Rodents by Statins

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A Pooled Analysis of Bone Marrow Micrometastasis in Breast Cancer

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Glucocorticoids indirectly decrease colon cancer cell proliferation and invasion via effects on cancer-associated fibroblasts

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An Automatable Hydrogel Culture Platform for Evaluating Efficacy of Antibody‐Based Therapeutics in Overcoming Chemoresistance

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Treatment Strategy for Multiple Myeloma to Improve Immunological Environment and Maintain MRD Negativity

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Immune status for monitoring and treatment of bladder cancer

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In Silico Identification and In Vitro Evaluation of New ABCG2 Transporter Inhibitors as Potential Anticancer Agents

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Human Plasma-Derived 3D Cultures Model Breast Cancer Treatment Responses and Predict Clinically Effective Drug Treatment Concentrations

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Targeting the AKT pathway: Repositioning HIV protease inhibitors as radiosensitizers

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Kinase Inhibition Leads to Hormesis in a Dual Phosphorylation-Dephosphorylation Cycle

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CD157: From Myeloid Cell Differentiation Marker to Therapeutic Target in Acute Myeloid Leukemia

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The bone ecosystem facilitates multiple myeloma relapse and the evolution of heterogeneous drug resistant disease

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ODSEI Chip: An Open 3D Microfluidic Platform for Studying Tumor Spheroid‐Endothelial Interactions

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Role of Microenvironmental Components in Head and Neck Squamous Cell Carcinoma

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Exosomes: A Cutting-Edge Theranostics Tool for Oral Cancer

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IL ‐8 from CD248 ‐expressing cancer‐associated fibroblasts generates cisplatin resistance in non‐small cell lung cancer

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The Role of GDF15 in Regulating the Canonical Pathways of the Tumor Microenvironment in Wild-Type p53 Ovarian Tumor and Its Response to Chemotherapy

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Combined treatment with paclitaxel and suramin prevents the development of metastasis by inhibiting metastatic colonization of circulating tumor cells

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Expression of basic fibroblast growth factor, CD31, and α-smooth muscle actin and esophageal cancer recurrence after definitive chemoradiation

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ICAM-3 endows anticancer drug resistance against microtubule-damaging agents via activation of the ICAM-3-AKT/ERK-CREB-2 pathway and blockage of apoptosis

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In vivo metabolic imaging identifies lipid vulnerability in a preclinical model of Her2+/Neu breast cancer residual disease and recurrence

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CK1δ and CK1ε Signaling Sustains Mitochondrial Metabolism and Cell Survival in Multiple Myeloma

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Integrins as the pivotal regulators of cisplatin response in tumor cells

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Adhesion of ZAP-70+ chronic lymphocytic leukemia cells to stromal cells is enhanced by cytokines and blocked by inhibitors of the PI3-kinase pathway

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Environmentally Sensitive Paramagnetic and Diamagnetic Contrast Agents for Nuclear Magnetic Resonance Imaging and Spectroscopy

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Carcinoma-Associated Fibroblasts Promote Growth of Sox2-Expressing Breast Cancer Cells

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Phosphoinositide-dependent kinase 1 regulates leukemia stem cell maintenance in MLL-AF9-induced murine acute myeloid leukemia

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Putting the brakes on anticancer therapies: suppression of innate immune pathways by tumor-associated myeloid cells

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The importance of the tissue microenvironment in hairy cell leukemia

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Growth factor expression mediates resistance to EGFR inhibitors in head and neck squamous cell carcinomas

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Generation of prostate cancer assembloids modeling the patient-specific tumor microenvironment

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Adaptive cancer therapy: can non-genetic factors become its achilles heel?

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Sample Preparation Methods Following CellSearch Approach Compatible of Single-Cell Whole-Genome Amplification: An Overview

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Ascites volume at the time of primary debulking and overall survival of patients with advanced epithelial ovarian cancer

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FBP1 knockdown decreases ovarian cancer formation and cisplatin resistance through EZH2-mediated H3K27me3

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Engineering tandem CD33xCD146 CAR CIK (cytokine-induced killer) cells to target the acute myeloid leukemia niche

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Integrin Activation Contributes to Lower Cisplatin Sensitivity in MV3 Melanoma Cells by Inducing the Wnt Signalling Pathway

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Numerical investigation of drug transport from blood vessels to tumour tissue using a Tumour-Vasculature-on-a-Chip

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An Immune-Related Signature for Predicting the Prognosis of Lower-Grade Gliomas

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Fibroblasts Influence Metastatic Melanoma Cell Sensitivity to Combined BRAF and MEK Inhibition

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Akt isoforms differentially provide for chemoresistance in prostate cancer

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Gene Expression Signatures Predictive of Bevacizumab/Erlotinib Therapeutic Benefit in Advanced Nonsquamous Non–Small Cell Lung Cancer Patients (SAKK 19/05 trial)

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A Three-dimensional Tissue Culture Model to Study Primary Human Bone Marrow and its Malignancies

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A Dual Fluorescent 3-D Multicellular Coculture of Breast Cancer MCF-7 and Fibroblast NIH-3T3 Cells for High Throughput Cancer Drug Screening

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Sonic Hedgehog Ligand: A Role in Formation of a Mesenchymal Niche in Human Pancreatic Ductal Adenocarcinoma

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Factors Influencing the Delivery Efficiency of Cancer Nanomedicines

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INCB018424 induces apoptotic cell death through the suppression of pJAK1 in human colon cancer cells

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Targeting Cancer-Associated Fibroblasts in Prostate Cancer: Recent Advances and Therapeutic Opportunities

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Ablation of Wnt signaling in bone marrow stromal cells overcomes microenvironment-mediated drug resistance in acute myeloid leukemia

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Ovarian Cancer and Drug Resistance

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Immune Regulation of the Metastatic Process

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The Actin Binding Protein Plastin-3 Is Involved in the Pathogenesis of Acute Myeloid Leukemia

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Sensitization of HT29 colorectal cancer cells to vemurafenib in three‐dimensional collagen cultures

Kikuchi, K., & Hoshino, D. (2019) · Cell Biology International · doi:10.1002/cbin.11262 · Cited by 12

Recapitulating the Cancer Microenvironment Using Bioprinting Technology for Precision Medicine

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Transcriptional Factor Repertoire of Breast Cancer in 3D Cell Culture Models

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Mesenchymal stromal cells confer breast cancer doxorubicin resistance by producing hyaluronan

Liu, Z., Hou, P., Fang, J., Zhu, J., Zha, J., Liu, R., Ding, Y., Zuo, M., Li, P., Cao, L., et al. (2023) · Oncogene · doi:10.1038/s41388-023-02837-w · Cited by 13

Targeting the Pro-Survival Protein MET with Tivantinib (ARQ 197) Inhibits Growth of Multiple Myeloma Cells

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Jagged-1: a new promising factor associated with favorable prognosis in patients with acute myeloid leukemia

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Lung mesenchymal cells function as an inductive microenvironment for human lung cancer propagating cells†

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Bortezomib interferes with adhesion of B cell precursor acute lymphoblastic leukemia cells through SPARC up-regulation in human bone marrow mesenchymal stromal/stem cells

Iwasa, M., Miura, Y., Fujishiro, A., Fujii, S., Sugino, N., Yoshioka, S., Yokota, A., Hishita, T., Hirai, H., Andoh, A., et al. (2017) · International Journal of Hematology · doi:10.1007/s12185-016-2169-x · Cited by 13

AML‑derived mesenchymal stem cells upregulate CTGF expression through the BMP pathway and induce K562‑ADM fusiform transformation and chemoresistance

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How Reciprocal Interactions Between the Tumor Microenvironment and Ion Transport Proteins Drive Cancer Progression

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Theranostic Applications of Tailored Lipid-based Nanoparticles as Drug Delivery Systems for Cancer Treatment

Gupta, C., Yadav, H., Dhanwani, I., & Gulati, S. (2025) · ACS Applied Nano Materials · doi:10.1021/acsanm.5c03503 · Cited by 13

Integrin α6β4 Confers Doxorubicin Resistance in Cancer Cells by Suppressing Caspase-3–Mediated Apoptosis: Involvement of N-Glycans on β4 Integrin Subunit

Kariya, Y., Gu, J., & Kariya, Y. (2023) · Biomolecules · doi:10.3390/biom13121752 · Cited by 12

Single-cell Transcriptomic Analysis Reveals an Immunosuppressive Network Between POSTN CAFs and ACKR1 ECs in TKI-resistant Lung Cancer

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Role of the bone marrow microenvironment in multiple myeloma: Impact of niches on drug resistance mechanisms

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Fc-engineering significantly improves the recruitment of immune effector cells by anti-ICAM-1 antibody MSH-TP15 for myeloma therapy

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Searching for Goldilocks: How Evolution and Ecology Can Help Uncover More Effective Patient-Specific Chemotherapies

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Extracellular Vesicles in the Progression and Therapeutic Resistance of Nasopharyngeal Carcinoma

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Galectin-1 and Galectin-3 in B-Cell Precursor Acute Lymphoblastic Leukemia

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Nanodrugs systems for therapy and diagnosis of esophageal cancer

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An update on molecular biology and drug resistance mechanisms of multiple myeloma

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Where Is PTEN?

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The HOXB13 p.Gly84Glu mutation is not associated with the risk of breast cancer

Akbari, M. R., Kluźniak, W., Rodin, R., Li, S., Wokołorczyk, D., Royer, R., Kashyap, A., Menkiszak, J., Lubiński, J., Narod, S. A., et al. (2012) · Breast Cancer Research and Treatment · doi:10.1007/s10549-012-2295-y · Cited by 12

Identifying anti-cancer drug response related genes using an integrative analysis of transcriptomic and genomic variations with cell line-based drug perturbations

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Creating Chemotherapeutic-Resistant Breast Cancer Cell Lines: Advances and Future Perspectives

Steding, C. E. (2016) · Future Oncology · doi:10.2217/fon-2016-0059 · Cited by 13

The great escape: How metastases of melanoma, and other carcinomas, avoid elimination

Wells, A. H., Clark, A. M., Bradshaw, A. M., Ma, B., & Edington, H. J. D. (2018) · Experimental Biology and Medicine · doi:10.1177/1535370218820287 · Cited by 12

Pluronic block copolymers enhance the anti-myeloma activity of proteasome inhibitors

Hu, H., Petrosyan, A., Osna, N. A., Liu, T., Olou, A. A., Alakhova, D. Y., Singh, P. K., Kabanov, A. V., Faber, E. A., & Bronich, T. K. (2019) · Journal of Controlled Release · doi:10.1016/j.jconrel.2019.05.026 · Cited by 12

An in vitro tumor swamp model of heterogeneous cellular and chemotherapeutic landscapes

Lin, K.-C., Sun, Y. Y., Torga, G., Sherpa, P., Zhao, Y., Qu, J., Amend, S. R., Pienta, K. J., Sturm, J. C., & Austin, R. H. (2020) · Lab on a Chip · doi:10.1039/d0lc00131g · Cited by 12

Advances in experimental approaches for investigating cell aggregate mechanics

Zhang, W., Wang, S., Lin, M., Han, Y., Zhao, G., Lu, T. J., & Xu, F. (2012) · Acta Mechanica Solida Sinica · doi:10.1016/s0894-9166(12)60042-1 · Cited by 12

Exploring and bypassing resistance to targeted therapies in colorectal cancer

Favier, S., Xiong, W., Chalabi-Dchar, M., Chettab, K., Piercey, O., Wu, T., Fenouil, T., Albaret, M.-A., Jordheim, L. P., Diaz, J.-J., et al. (2025) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2025.118741 · Cited by 12

Understanding therapeutic tolerance through a mathematical model of drug-induced resistance

Gevertz, J. L., Greene, J. M., Prosperi, S., Comandante-Lou, N., & Sontag, E. D. (2025) · npj Systems Biology and Applications · doi:10.1038/s41540-025-00511-3 · Cited by 12

Modeling the Bone Marrow Niche in Multiple Myeloma: From 2D Cultures to 3D Systems

Bottaro, A., Nasso, M. E., Stagno, F., Fazio, M., & Allegra, A. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26136229 · Cited by 13

Elucidating the expression and function of Numbl during cell adhesion-mediated drug resistance (CAM-DR) in multiple myeloma (MM)

Huang, Y., Huang, X., Cheng, C., Xu, X., Liu, H. S., Yang, X., Li, Y., Ding, Z., Tang, J., He, S., et al. (2019) · BMC Cancer · doi:10.1186/s12885-019-6446-y · Cited by 11

Chrono-Pharmaceutical Approaches to Optimize Dosing Regimens Based on the Circadian Clock Machinery

Koyanagi, S. (2021) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.b21-00476 · Cited by 11

Immuno-onco-metabolism and Therapeutic Resistance

Mir, M. A., Aisha, S., Nisar, S., Qayoom, H., & Mehraj, U. (2022) · Springer eBooks · doi:10.1007/978-981-16-6226-3_3 · Cited by 11

A novel DDR1 inhibitor enhances the anticancer activity of gemcitabine in pancreatic cancer.

Ko, S., Jung, K. H., Yoon, Y., Han, B. S., Park, M. S., Lee, Y. J., Kim, S. E., Cho, Y. J., Lee, P., Lim, J. H., et al. (2022) · PubMed Central · Cited by 11

Evaluation of the Effect of Fibroblasts on Melanoma Metastasis Using a Biomimetic Co-Culture Model

Wu, M., Yu, E., Ye, K., Huang, Y., Ren, T., Guo, M., Yin, J., Xu, K., & Wei, P. (2023) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.2c01186 · Cited by 11

A comprehensive survey into the role of exosomes in pancreatic cancer; from the origin of cancer to the progress and possibility of diagnosis and treatment

Farahmand, Y., Tehrany, P. M., Nazari, A., Nava, Z. H., Alsaffar, M. F., Yazdani, O., Adili, A., Esbati, R., & Ghafouri, K. (2023) · Pathology - Research and Practice · doi:10.1016/j.prp.2023.154465 · Cited by 11

Electron microscopy imaging and mechanical characterization of T47D multicellular tumor spheroids–Older spheroids reduce interstitial space and become stiffer

Madhavan, M., Jaiswal, D., Karlberg, S., Duggan, A., Almarshad, H. A., Claffey, K. P., & Hoshino, K. (2023) · PLoS ONE · doi:10.1371/journal.pone.0286291 · Cited by 11

TFDP3 confers chemoresistance in minimal residual disease within childhood T-cell acute lymphoblastic leukemia

Chu, M., Yin, K., Dong, Y., Wang, P., Xue, Y., Zhou, P., Wang, Y., & Wang, Y. (2016) · Oncotarget · doi:10.18632/oncotarget.13630 · Cited by 11

Dormancy Stems the Tide of Chemotherapy

Pal, D., Heidenreich, O. T., & Vormoor, J. H. (2016) · Cancer Cell · doi:10.1016/j.ccell.2016.11.014 · Cited by 11

A Computational Model of Tumor Growth and Anakoinosis

Pantziarka, P., Ghibelli, L., & Reichle, A. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00287 · Cited by 11

Transcriptome Analysis Reveals the Immune Infiltration Profiles in Cervical Cancer and Identifies KRT23 as an Immunotherapeutic Target

Li, X., Cheng, Y., Cheng, Y., & Shi, H. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.779356 · Cited by 11

Microenvironment–A Role in Tumour Progression and Prognosis

Muddana, K. (2013) · JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH · doi:10.7860/jcdr/2013/6619.3419 · Cited by 11

Bone marrow myeloid cells in regulation of multiple myeloma progression

Herlihy, S. E., Lin, C., & Nefedova, Y. (2017) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-017-1992-0 · Cited by 11

Aberrant Lipid Metabolic Signatures in Acute Myeloid Leukemia

Singh, P., Murali, R., Shanmugam, S. G., Thomas, S., Scott, J. X., Warrier, S. R., Arfuso, F., Dharmarajan, A., & Gandhirajan, R. K. (2024) · Stem Cells · doi:10.1093/stmcls/sxad095 · Cited by 10

Cell-free ascites from ovarian cancer patients induces Warburg metabolism and cell proliferation through TGFβ-ERK signaling

Szeőcs, D., Vida, B., Petővári, G., Póliska, S., Janka, E. A., Sipos, A., Uray, K., Sebestyén, A. R., Krasznai, Z. T., & Bai, P. (2024) · GeroScience · doi:10.1007/s11357-023-01056-1 · Cited by 10

Applications of smart responsive nanomaterials in the theranostics of gastrointestinal malignancies: Current status and future perspectives

Huang, W., Zhou, J., Liang, Y., Saladin, R. J., Li, L., Kang, L., Hua, C., & Cai, W. (2025) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2025.216641 · Cited by 11

CEMIP2 sensitizes PDAC to chemotherapy through extracellular matrix remodeling by hyaluronan degradation

Yao, N., Fu, Y., Wang, T. Z., Qin, J., Cao, Y., Shi, M., Ma, F., Shen, B., & Jiang, L. (2025) · Cancer Letters · doi:10.1016/j.canlet.2025.217898 · Cited by 11

Research progress of evironment-mediated drug resistance contributed to minimal residual disease

Zhang, T. (2011)

The influence of the tumor microenvironment on drug response and drug resistance

Dalton, W. S. (2008) · Clinical Cancer Research · Cited by 3

Le microenvironnement tumoral et la résistance thérapeutique

Borriello, L., & DeClerck, Y. A. (2014) · médecine/sciences · doi:10.1051/medsci/20143004021 · Cited by 23

The tumor microenvironment is a dominant force in multidrug resistance

Correia, A. L., & Bissell, M. J. (2012) · Drug Resistance Updates · doi:10.1016/j.drup.2012.01.006 · Cited by 455

The mesenchymal tumor microenvironment

Cukierman, E., & Bassi, D. (2012) · Cell Adhesion & Migration · doi:10.4161/cam.20210 · Cited by 45