The expanding universe of p53 targets

Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources

Huang, D. W., Sherman, B. T., & Lempicki, R. A. (2009) · Nature Protocols · doi:10.1038/nprot.2008.211 · Cited by 35,890

WebLogo: A Sequence Logo Generator: Figure 1Preprint

Crooks, G. E., Hon, G. C., Chandonia, J., & Brenner, S. E. (2004) · Genome Research · doi:10.1101/gr.849004 · Cited by 12,418

In Vivo Activation of the p53 Pathway by Small-Molecule Antagonists of MDM2

Vassilev, L. T., Vu, B. T., Graves, B., Carvajal, D., Podlaski, F., Filipovic, Z., Kong, N., Kammlott, U., Lukacs, C., Klein, C., et al. (2004) · Science · doi:10.1126/science.1092472 · Cited by 4,661

Mdm2 promotes the rapid degradation of p53

Haupt, Y., Maya, R., Kazaz, A., & Oren, M. (1997) · Nature · doi:10.1038/387296a0 · Cited by 4,506

Live or let die: the cell's response to p53

Vousden, K. H., & Lü, X. (2002) · Nature reviews. Cancer · doi:10.1038/nrc864 · Cited by 3,231

Blinded by the Light: The Growing Complexity of p53

Vousden, K. H., & Prives, C. (2009) · Cell · doi:10.1016/j.cell.2009.04.037 · Cited by 3,163

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

Kastan, M. B., Zhan, Q., El-Deiry, W. S., Carrier, F., Jacks, T., Walsh, W. V., Plunkett, B. S., Vogelstein, B., & Fornace, A. J. (1992) · Cell · doi:10.1016/0092-8674(92)90593-2 · Cited by 3,047

Activation of p53 Sequence-Specific DNA Binding by Acetylation of the p53 C-Terminal Domain

Gu, W., & Roeder, R. G. (1997) · Cell · doi:10.1016/s0092-8674(00)80521-8 · Cited by 2,559

Definition of a consensus binding site for p53

El-Deiry, W. S., Kern, S. E., Pietenpol, J. A., Kinzler, K. W., & Vogelstein, B. (1992) · Nature Genetics · doi:10.1038/ng0492-45 · Cited by 1,985

Transcriptional control of human p53-regulated genes

Riley, T., Sontag, E., Chen, P., & Levine, A. (2008) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2395 · Cited by 1,921

Nuclear Subdomains and Cancer

Cann, K. L., Huang, S., & Dellaire, G. (2010) · Springer eBooks · doi:10.1007/978-90-481-9899-3_1

REGULATION OF HEDGEHOG SIGNALLING DURING DEVELOPMENT AND CARCINOGENESIS

Fiaschi, M. (2009) · Figshare

Overview of the biochemical and genetic processes in malignant mesothelioma* Panorama dos processos bioquímicos e genéticos presentes no mesotelioma maligno

Vinícius, L., de Assis, M., & Isoldi, M. C. (2014)

UNIVERSIDADE FEDERAL DE GOIÁS PROGRAMA DE PÓS-GRADUAÇÃO EM CIÊNCIAS FARMACÊUTICAS

Zoghaib, I., & Zoghaib, J. (2013)

epidermal carcinoma defines molecular determinants of human cancer malignancy

García‐Escudero, R., Martínez‐Cruz, A. B., Santos, M., Lorz, C., Segrelles, C., Garaulet, G., Sáiz-Ladera, C., Costa, C., Buitrago-Pérez, Á., Dueñas, M., et al. (2010)

REGULATION OF DNA DAMAGE PROCESSING BY COVALENT MODIFICATION OF THYMINE DNA GLYCOSYLASE (Spine title: Regulation of DNA damage processing by thymine DNA glycosylase) (Thesis format: Integrated-Article)

Mohan, R. D. (2010)

Molecular Pathology of Colon and Small Bowel Cancers: Sporadic Type

Rashid, A. (2012) · Molecular pathology library · doi:10.1007/978-1-4614-6015-2_8

Molecular characterization of pluripotency in embryos and embryonic stem cells

Gómez, J. P. (2010) · LA Referencia (Red Federada de Repositorios Institucionales de Publicaciones Científicas)

Phospho-regulation and metastatic potential of Murine Double Minute 2

Batuello, C. N. (2012) · doi:10.7912/c2/1866

cells to staurosporine and camptothecin-induced cell death.

Moela, P. (2013)

Mechanisms of p53-mediated Intrinsic and Extrinsic Tumor Suppression

Selivanova, G., Höglund, P., Piaggio, G., Elena, R., Pereira, T., Wright, A. R., Wadelius, C., & Universitit, U. (2014)

THE P53-NMNAT2 FEEDBACK REGULATORY LOOP: MECHANISMS UNDERLYING P53 ACTIVATION

Pan, L.-Z. (2012) · Library and Archives Canada (Government of Canada)

Università degli Studi di Milano Scuola di Dottorato in Medicina Molecolare

Bòsari, S. (2012)

Helena S. ThurowFernando P. HartwigClarice S. Alho • Deborah S. B. S. SilvaRafael RoeslerAna Lucia Abujamra • Caroline Brunetto de FariasAlgemir Lunardi Brunetto •

Seixas, F. K. (2013)

Comparative Biology of Glioma Stem Cells and Embryonic Neural Stem Cells in Dogs.

Woolard, K. (2010) · NCSU Libraries Repository (North Carolina State University Libraries)

Characterisation of caspase-2 function in the DNA damage response and tumour suppression.

Puccini, J. (2014) · Adelaide Research & Scholarship (AR&S) (University of Adelaide)

The regulation of DNA damage signalling and repair by MOB2

Gündoğdu, R. (2016) · UCL Discovery (University College London)

Death Shapes Life: Characterizing the Role of p63 and p73 During Neural Development and Aging

Dugani, S. (2011) · TSpace (University of Toronto)

The effect of UVA irradiation on the DNA damage response in a human keratinocyte cell line

Eastham, M. (2016) · Lancaster EPrints (Lancaster University)

Panorama dos processos bioquímicos e genéticos presentes no mesotelioma maligno* Overview of the biochemical and genetic processes in malignant mesothelioma

Vinícius, L., de Assis, M., & Isoldi, M. C. (2014)

Neoplasia of the Gastrointestinal Tract

Margalit, O., & DuBois, R. N. (2015) · Wiley eBooks · doi:10.1002/9781118512074.ch31

OPINION Interactions between the tumor suppressor p53 and immune responses

Menéndez, D., Shatz, M., & Resnick, M. A. (2013)

A comprehensive approach for validating p53 binding site predictions

Özyer, T., & Alhajj, R. (2017) · doi:10.1109/icitech.2017.8079957

Breast Cancer Genetics

de Gouvêa, A. C. R. C., & Garber, J. E. (2017) · Springer eBooks · doi:10.1007/978-3-319-48848-6_8

Towards the Investigation of the Effects of Nitration on the Activity of the Human p53 Tumour Suppressor Protein. Nitration of the p53 Tumour Suppressor Protein

Husaini, R. (2014) · Bradford Scholars (University of Bradford)

A different perspective to the tumor microenvironment in periampullary cancers: a neglected ring in tumorogenesis.

Zengin, M. (2018) · Journal of Health Sciences and Medicine · doi:10.32322/jhsm.453541

НЕКОТОРЫЕ АСПЕКТЫ КАНЦЕРОГЕНЕЗА, СВЯЗАННЫЕ С ГЕНЕТИЧЕСКИМИ И ЭПИГЕНЕТИЧЕСКИМИ ФАКТОРАМИ, "Успехи современной биологии"

Vf, M., Шуленина, Л. В., Васильева, И. М., Салеева, Д. В., & Засухина, Г. Д. (2018) · Успехи современной биологии · doi:10.7868/s0042132418050010

Antioxidant Effect of Grape Seed Proanthocyanidin Extract against Potassium Dichromate Induced Oxidative DNA Damage in Small Intestine of Adult Male Albino Rats

El-Noor, M. A., Sarhan, N., & Moustafa, K. A. (2013) · Ain Shams Journal of Forensic Medicine and Clinical Toxicology · doi:10.21608/ajfm.2013.19168

Transcriptional regulation of ARF tumor suppressor

Zeng, Y. (2019) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/tvpm-m937

Genomic Instability: DNA Repair and Cancer

Carlos, A. R. (2019) · Learning materials in biosciences · doi:10.1007/978-3-030-11812-9_5

In Vivo Discoveries in MDM2-Mediated p53 Regulation

Tackmann, N. R. (2019) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/z7ta-7m83

Characterization of NEK10 Tyrosine Kinase Activity in the Cellular Response to DNA Damage

Haider, N. (2018) · TSpace (University of Toronto)

Gastric Metastasis at the First Presentation of Breast Cancer May Mimic Primary Carcinoma: A Case Report and Literature Review

Wang, J. (2020) · Gastroenterology Medicine & Research · doi:10.31031/gmr.2020.05.000609

Individual roles of p53 and NF1 in OPC Competition and Gliomagenesis

Gonzalez, P. P. (2017) · doi:10.18130/v39s69

Avaliação da expressão de genes e miRNAs relacionados aos mecanismos de reparo ao dano do DNA em pacientes com leucemia mieloide crônica ao diagnóstico e na crise blástica

Nardinelli, L. (2020) · Digital Library of Theses and Dissertations (Universidade de São Paulo) · doi:10.11606/t.5.2020.tde-22092021-115923

p53

Menéndez, D., Nguyen, T., Resnick, M. A., & Anderson, C. W. (2017) · Springer eBooks · doi:10.1007/978-3-319-67199-4_57

p53

Menéndez, D., Nguyen, T., Resnick, M. A., & Anderson, C. W. (2016) · Springer eBooks · doi:10.1007/978-1-4614-6438-9_57-1

Faculty Opinions recommendation of Identification of a functional risk variant for pemphigus vulgaris in the ST18 gene.

Yamagami, J. (2018) · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · doi:10.3410/f.726334849.793549763

TP53 mutation–associated and copy number–dependent KDM7A-DT expression affects DNA repair and promotes invasive breast cancer progressionPreprint

Giannakakis, A., Tsifintaris, M., Gouzouasis, V., Tafyllou, C., Ow, G. S., Papp, C., Ivshina, A. V., & Kuznetsov, V. A. (2022) · Research Square · doi:10.21203/rs.3.rs-1896103/v1

TP53mutation–associated and copy number–dependent KDM7A-DT expression affects DNA repair and promotes invasive breast cancer progressionPreprint

Giannakakis, A., Tsifintaris, M., Triantafyllou, C., Gouzouasis, V., Ow, G. S., Aau, M. Y., Papp, C., Ivshina, A. V., & Kuznetsov, V. A. (2022) · Research Square · doi:10.21203/rs.3.rs-1896103/v3

A novel map of human p53 response elements uncovers evidence of selection pressures and variants similar to Li-Fraumeni Syndrome mutationsPreprint

Zhang, P., Brown, K. A., Barnes, D., Kitchen-Smith, I., Sims, D., Flanagan, A. M., Noon, S. D., Loo, P. V., Hargreaves, S., Cross, W., et al. (2022) · medRxiv · doi:10.1101/2022.09.28.22280453

Adipocyte signaling affects thyroid-specific gene expression via down-regulation of TTF-2/FOXE1

Zamboni, M., Strimpakos, G., Poggiogalle, E., Donini, L. M., & Civitareale, D. (2022) · Journal of Molecular Endocrinology · doi:10.1530/jme-22-0129

Diepoxybutane induces the p53‐dependent transactivation of the CCL4 gene that mediates apoptosis in exposed human lymphoblasts

Ewunkem, A. J., Deve, M., Harrison, S. H., & Muganda, P. M. (2023) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.23316

The MDM2 oncoprotein antagonizes Poly(ADP-ribosyl)ation

Giansanti, C. (2023) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-9741

The presence of a G-quadruplex prone sequence upstream of a minimal promoter increases transcriptional activity in the yeast S. cerevisiaePreprint

Kratochvilová, L., Vojsovič, M., Valková, N., Šislerová, L., Rashed, Z. E., Inga, A., Monti, P., & Brázda, V. (2023) · bioRxiv · doi:10.1101/2023.06.23.546269 · Cited by 1

The TP53-Activated E3 Ligase RNF144B Is a Tumour Suppressor That Prevents Genomic InstabilityPreprint

Abad, E., Sandoz, J., Romero, G., Urgel-Solas, J., Borredat, P., Kourtis, S., Ortet, L., Martínez, C. M., Weghorn, D., Sdelci, S., et al. (2023) · SSRN Electronic Journal · doi:10.2139/ssrn.4566343

Effects of moderate - intensity exercise training on cardiac angiogenic capacity and fibrosis in middle-aged and aged rats

Mekrungruangwong, T., Patumraj, S., & Viboolvorakul, S. (2019) · doi:10.58837/chula.the.2019.368

Molecular characterization of FOX factors and Wnt signalling interplay in human cancers

Pizzolato, G. (2023) · Linköping University medical dissertations · doi:10.3384/9789180753364

What can we learn from tumors? Parallels in cell and human behavior

Šmardová, J. (2023) · Masarykova univerzita eBooks · doi:10.5817/cz.muni.m280-0377-2023

Dominant suppressor genes of p53-induced apoptosis in Drosophila melanogasterPreprint

Lukácsovich, T., Szlanka, T., Bálint, É., Szabó, K., Hajdú, I., Molnár, E., Viràgh, E., Lin, Y.-H., Méhi, O., Zvara, Á., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.02.06.579196

Cellular Regulation and Oncogenesis of Primary Tumors in the Central Nervous System

Lemos, L. A. M., Stadler, C., Lemos, I. C., Pardins, J. P., & Sauka, V. B. P. (2024) · Arquivos Brasileiros de Neurocirurgia Brazilian Neurosurgery · doi:10.1055/s-0044-1796653

IN VITRO AND IN SILICO CYTOTOXICITY EVALUATION OF SOME ISATIN MANNICH BASES ON HUMAN MELANOMA CELLS

Isgor, M. M., Küçükgül, A., Karaman, M., Ozgun, D. O., Yanık, T., Gul, H. I., & Bulgurcu, M. (2022) · Journal of Applied Biological Sciences · doi:10.71336/jabs.968

Cognate DNA inhibits p53 aggregation but fails to rescue key hotspot mutants

Steinsaltz, M., Gomes, G.-N. W., & Levine, Z. A. (2026) · Insights in Biochemistry and Molecular Biology · doi:10.1101/2025.07.24.665437

Additional file 3 of Eleven immune-gene pairs signature associated with TP53 predicting the overall survival of gastric cancer: a retrospective analysis of large sample and multicenter from public database

Huo, J., Wu, L., & Zang, Y. (2021) · Figshare · doi:10.6084/m9.figshare.14516540

Identification of MKRN1 as a key modulator of the p53-MDM2 feedback loop

Shimada, T., Noguchi, T., Komatsu, R., Otani, K., Komatsu, T., Suzuki, S., Mitsuya, M., Okubo, T., Ito, R., Yamada, M., et al. (2026) · Cell Death and Differentiation · doi:10.1038/s41418-026-01662-4

Etude des cellules souches et progénitrices mammaires et de leur contribution à la tumorigenèse : rôle des facteurs de transcription Myc et p53

Chiche, A. (2012) · doi:10.70675/67609440zb6dez49d8z872az1256bad88650

Role of p53 in muscle wasting

de Abreu, P. A. (2016) · theses.fr (ABES) · doi:10.70675/a49b7f77z1189z425fz86b8z8ee9f8fa327a

Implication de glycosyltransférases dans la tumorigenèse colorectale : POFUT1 et ST3GAL2

Deschuyter, M. (2021) · doi:10.70675/a7f48b7dz94d5z4817z897bz5677e68073a8

Colorectal Precancerous Lesions: Molecular Mechanisms, Research Tools, and Natural Product‐Based Clinical Translation

Liu, S., Cui, C., Kong, L., Xu, Q., Cheng, H., Zhou, L., & Sun, Y. (2026) · MedComm – Oncology · doi:10.1002/mog2.70067

Preclinical Pharmacokinetics of Erdafitinib, an FGFR Tyrosine Kinase Inhibitor, via LC‐MS/MS in Sprague Dawley Rats

Boggavarapu, R. K., & Chimakurthy, J. (2026) · Rapid Communications in Mass Spectrometry · doi:10.1002/rcm.70116

Opportunities and challenges of dihydrodiol dehydrogenase expression in hepatocellular carcinoma

Kuang, Y., Hu, K., Zhu, H., 林如英, Wang, D., Huang, Y., Yuan, W., chen, J., Sun, Y., & Feng, J. (2026) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2026.105462

Associative memory plays a role in ER-1α positive breast cancers

Lu, D., Hoyos, D., Yao, N., Greenbaum, B. D., Aylon, Y., Oren, M., & Levine, A. J. (2026) · Cell Death and Differentiation · doi:10.1038/s41418-026-01822-6

Proof-of-concept: the TGx-DDI transcriptomic biomarker discriminates radiation-induced DNA damage at the individual-level across dose and dose-rate regimes in human lymphocytes

Chauhan, V., Williams, A., & Yauk, C. L. (2026) · International Journal of Radiation Biology · doi:10.1080/09553002.2026.2704747

Aloe-emodin isolated from Rheum ribes induces cytotoxicity and apoptosis in MCF-7 human breast cancer cells

Erdoğan, M. K., SEVER, A., Gündoğdu, R., & Geçibesler, İ. H. (2026) · International Journal of Secondary Metabolite · doi:10.21448/ijsm.1841301

BindingDB Entry 50047411: Structure-activity relationship study of 4-substituted piperidines at Leu26 moiety of novel p53-hDM2 inhibitors.

BindingDB (2017) · UC San Diego · doi:10.7270/q28s4rtd

The ubiquitin ligase G2E3 modulates cell proliferation, survival and the DNA damage response

Schmidt, F. (2014) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-4625

The p53 Master Regulator and Rules of Engagement with Target Sequences

Inga, A., Jordan, J. J., Menéndez, D., Sanctis, V. D., & Resnick, M. A. (2010) · Elsevier eBooks · doi:10.1016/b978-0-12-374145-5.00265-5

Potentiating the p53 network.

Menéndez, D., Inga, A., & Resnick, M. A. (2010) · PubMed · Cited by 32

Computational identification of tumour suppressor protein p53 target genes

Fong, S. C., Paulin, F., & Thompson, A. M. (2007) · BMC Systems Biology · doi:10.1186/1752-0509-1-s1-p8

Functional evolution of the p53 regulatory network through its target response elements

Jegga, A. G., Inga, A., Menéndez, D., Aronow, B. J., & Resnick, M. A. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0704694105 · Cited by 67

The p53 response element and transcriptional repression

Wang, B., Xiao, Z., Ko, H. L., & Ren, E.-C. (2010) · Cell Cycle · doi:10.4161/cc.9.5.10825 · Cited by 90