Cited by 568Cancer-related Molecular PathwaysGenomics and Chromatin DynamicsChromatin Remodeling and Cancer

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The expanding universe of p53 targets

Menendez, Daniel, Inga, Alberto, Resnick, Michael A.·2009·Nature Reviews Cancer

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Abstract

The p53 tumour suppressor is modified through mutation or changes in expression in most cancers, leading to the altered regulation of hundreds of genes that are directly influenced by this sequence-specific transcription factor. Central to the p53 master regulatory network are the target response element (RE) sequences. The extent of p53 transactivation and transcriptional repression is influenced by many factors, including p53 levels, cofactors and the specific RE sequences, all of which contribute to the role that p53 has in the aetiology of cancer. This Review describes the identification and functionality of REs and highlights the inclusion of non-canonical REs that expand the universe of genes and regulation mechanisms in the p53 tumour suppressor network.

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Authors: Menendez, D., Inga, A., & Resnick, M. A.
Affiliations: National Institutes of Health (US)
Corresponding author: Resnick, Michael A.
ORCID: Inga, Alberto
Resnick, Michael A.
Venue: Nature Reviews Cancer
Publisher: Springer Science and Business Media LLC
Published: 2009-10
Volume: 9
Issue: 10
Pages: 724-737
ISSN: 1474-175X (ISSN-L)
1474-1768
DOI: 10.1038/nrc2730
OpenAlex: W2094375196
Cited by: 568
References: 208
Citations by year: 2026: 11 · 2025: 8 · 2024: 11 · 2023: 17 · 2022: 28 · 2021: 18 · 2020: 23 · 2019: 28 · 2018: 31 · 2017: 42 · 2016: 44 · 2015: 44 · 2014: 54 · 2013: 59 · 2012: 56
FWCI: 4.10
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Nature reviews. Cancer (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
National Institute of Environmental Health Sciences (Z01ES065079)
Topics: Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
Keywords: p53, transcriptional regulation, tumour suppressor, p53 target genes, p53 transactivation, transcriptional repression, cancer etiology
MeSH terms: Humans, Mutation, Neoplasms, Gene Expression, Genes, p53, Tumor Suppressor Protein p53, Response Elements

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