The DOI matches its Crossref record; 173 of the 173 references it cites were found in a registry or an index.
Ras superfamily GEFs and GAPs: validated and tractable targets for cancer therapy?
Open accessAbstract
There is now considerable and increasing evidence for a causal role for aberrant activity of the Ras superfamily of small GTPases in human cancers. These GTPases function as GDP–GTP-regulated binary switches that control many fundamental cellular processes. A common mechanism of GTPase deregulation in cancer is the deregulated expression and/or activity of their regulatory proteins, guanine nucleotide exchange factors (GEFs) that promote formation of the active GTP-bound state and GTPase-activating proteins (GAPs) that return the GTPase to its GDP-bound inactive state. In this Review, we assess the association of GEFs and GAPs with cancer and their druggability for cancer therapeutics.
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Metadata
- Authors
- Vigil, D., Cherfils, J., Rossman, K. L., & Der, C. J.
- Venue
- Nature Reviews Cancer
- Published
- 2010-11-24
- Volume
- 10
- Issue
- 12
- Pages
- 842-857
- ISSN
- 1474-175X (ISSN-L)
- 1474-1768
- OpenAlex
- W2071018921
- Cited by
- 819
- References
- 173
- FWCI
- 2.73
- Type
- journal article
- Language
- en
- Open access
- green
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