Cited by 4,744Cancer, Hypoxia, and MetabolismMetabolism, Diabetes, and CancerCancer and biochemical research

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Regulation of cancer cell metabolism

Cairns, Rob A., Harris, Isaac S., Mak, Tak W.·2011·Nature Reviews Cancer

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Abstract

Interest in the topic of tumour metabolism has waxed and waned over the past century of cancer research. The early observations of Warburg and his contemporaries established that there are fundamental differences in the central metabolic pathways operating in malignant tissue. However, the initial hypotheses that were based on these observations proved inadequate to explain tumorigenesis, and the oncogene revolution pushed tumour metabolism to the margins of cancer research. In recent years, interest has been renewed as it has become clear that many of the signalling pathways that are affected by genetic mutations and the tumour microenvironment have a profound effect on core metabolism, making this topic once again one of the most intense areas of research in cancer biology.

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Authors: Cairns, R. A., Harris, I. S., & Mak, T. W.
Corresponding author: Mak, Tak W.
ORCID: Cairns, Rob A.
Harris, Isaac S.
Mak, Tak W.
Venue: Nature Reviews Cancer
Publisher: Springer Science and Business Media LLC
Published: 2011-01-24
Volume: 11
Issue: 2
Pages: 85-95
ISSN: 1474-175X (ISSN-L)
1474-1768
DOI: 10.1038/nrc2981
OpenAlex: W2028897202
Semantic Scholar: 9d36b5b10983f1aa90a9d9d5a7bcffe671b38257
Cited by: 4,744
References: 142
Citations by year: 2026: 95 · 2025: 192 · 2024: 234 · 2023: 276 · 2022: 293 · 2021: 418 · 2020: 423 · 2019: 386 · 2018: 386 · 2017: 414 · 2016: 399 · 2015: 387 · 2014: 318 · 2013: 251 · 2012: 192
FWCI: 19.59
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature reviews. Cancer (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cancer and biochemical research
Keywords: cancer metabolism, Warburg effect, redox homeostasis, tumor microenvironment, carcinogenesis, central metabolic pathways
MeSH terms: Cell Transformation, Neoplastic, Humans, Neoplasms, Oxidation-Reduction, Transcription Factors, Signal Transduction, Gene Expression Regulation, Neoplastic, Intracellular Signaling Peptides and Proteins, Gene Regulatory Networks

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