The DOI matches its Crossref record; 120 of the 120 references it cites were found in a registry or an index.
Novel roles for Slits and netrins: axon guidance cues as anticancer targets?
Open accessAbstract
Netrin 1 and members of the Slit family and their receptors are deregulated in a large proportion of human cancers, suggesting that they could be tumour suppressor genes or oncogenes. Evidence for and against these functions is discussed, along with recent data that these ligand–receptor pairs could be promising targets for personalized anticancer therapies. Over the past few years, several genes, proteins and signalling pathways that are required for embryogenesis have been shown to regulate tumour development and progression by playing a major part in overriding antitumour safeguard mechanisms. These include axon guidance cues, such as Netrins and Slits. Netrin 1 and members of the Slit family are secreted extracellular matrix proteins that bind to deleted in colorectal cancer (DCC) and UNC5 receptors, and roundabout receptors (Robos), respectively. Their expression is deregulated in a large proportion of human cancers, suggesting that they could be tumour suppressor genes or oncogenes. Moreover, recent data suggest that these ligand–receptor pairs could be promising targets for personalized anticancer therapies.
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2 retracted
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The Molecular Biology of Axon Guidance
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Identification of a Chromosome 18q Gene that Is Altered in Colorectal Cancers
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The netrins define a family of axon outgrowth-promoting proteins homologous to C. elegans UNC-6
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Netrins are diffusible chemotropic factors for commissural axons in the embryonic spinal cord
Kennedy, T. E., Serafini, T., de la Torre, J., & Tessier-Lavigne, M. (1994) · Cell · doi:10.1016/0092-8674(94)90421-9 · Cited by 1,338
Eph receptors and ephrins in cancer: bidirectional signalling and beyond
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Deleted in Colorectal Cancer (DCC) Encodes a Netrin Receptor
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Slit Is the Midline Repellent for the Robo Receptor in Drosophila
Kidd, T., Bland, K. S., & Goodman, C. S. (1999) · Cell · doi:10.1016/s0092-8674(00)80589-9 · Cited by 949
Cited by
Pancreatic cancer genomes reveal aberrations in axon guidance pathway genes
Initiative, A. P. C. G., Biankin, A. V., Waddell, N., Kassahn, K. S., Gingras, M.-C., Muthuswamy, L. B., Johns, A. L., Miller, D. K., Wilson, P. J., Patch, A.-M., et al. (2012) · Nature · doi:10.1038/nature11547 · Cited by 2,058
Apoptosis Deregulation and the Development of Cancer Multi-Drug Resistance
Neophytou, C. M., Trougakos, I. P., Erin, N., & Papageorgis, P. (2021) · Cancers · doi:10.3390/cancers13174363 · Cited by 371
Nerve–Cancer Cell Cross-talk: A Novel Promoter of Tumor Progression
Jobling, P., Pundavela, J., Oliveira, S. M. R., Roselli, S., Walker, M. M., & Hondermarck, H. (2015) · Cancer Research · doi:10.1158/0008-5472.can-14-3180 · Cited by 272
Structural Decoding of the Netrin-1/UNC5 Interaction and its Therapeutical Implications in Cancers
Grandin, M., Meier, M., Delcros, J. G., Nikodemus, D., Reuten, R., Patel, T. R., Goldschneider, D., Orriss, G., Krahn, N., Boussouar, A., et al. (2016) · Cancer Cell · doi:10.1016/j.ccell.2016.01.001 · Cited by 128
Self-citationDependence Receptors and Cancer: Addiction to Trophic Ligands
Gibert, B., & Mehlen, P. (2015) · Cancer Research · doi:10.1158/0008-5472.can-14-3652 · Cited by 73
Self-citation
Metadata
- Authors
- Mehlen, P., Delloye-Bourgeois, C., & Chédotal, A.
- Venue
- Nature Reviews Cancer
- Published
- 2011-02-17
- Volume
- 11
- Issue
- 3
- Pages
- 188-197
- ISSN
- 1474-175X (ISSN-L)
- 1474-1768
- OpenAlex
- W2048888260
- Cited by
- 275
- References
- 120
- FWCI
- 1.18
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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