The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Human cancers express mutator phenotypes: origin, consequences and targeting
Open accessAbstract
Recent data on DNA sequencing of human tumours have established that cancer cells contain thousands of mutations. These data support the concept that cancer cells express a mutator phenotype. This Perspective considers the evidence supporting the mutator phenotype hypothesis, the origin and consequences of a mutator phenotype, the implications for personalized medicine and the feasibility of ablating tumours by error catastrophe.
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Wang, Y., Waters, J., Leung, M. L., Unruh, A., Roh, W., Shi, X., Chen, K., Scheet, P., Vattathil, S., Liang, H., et al. (2014) · Nature · doi:10.1038/nature13600 · Cited by 1,029
Evolutionary dynamics of carcinogenesis and why targeted therapy does not work
Gillies, R. J., Verduzco, D., & Gatenby, R. A. (2012) · Nature Reviews Cancer · doi:10.1038/nrc3298 · Cited by 684
APOBEC Enzymes: Mutagenic Fuel for Cancer Evolution and Heterogeneity
Swanton, C., McGranahan, N., Starrett, G. J., & Harris, R. S. (2015) · Cancer Discovery · doi:10.1158/2159-8290.cd-15-0344 · Cited by 488
Genetic heterogeneity and cancer drug resistance
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Metadata
- Authors
- Loeb, L. A.
- Venue
- Nature Reviews Cancer
- Published
- 2011-05-19
- Volume
- 11
- Issue
- 6
- Pages
- 450-457
- ISSN
- 1474-175X (ISSN-L)
- 1474-1768
- OpenAlex
- W2042813882
- Cited by
- 396
- References
- 14
- FWCI
- 1.87
- Type
- journal article
- Language
- en
- Open access
- green
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- Loeb, L. A. (2011). Human cancers express mutator phenotypes: origin, consequences and targeting. Nature Reviews Cancer. https://doi.org/10.1038/nrc3063
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