The DOI matches its Crossref record; 262 of the 262 references it cites were found in a registry or an index.
Unravelling the complexity of metastasis — molecular understanding and targeted therapies
Open accessAbstract
Despite recognizing the devastating consequences of metastasis, we are not yet able to effectively treat cancer that has spread to vital organs. The inherent complexity of genomic alterations in late-stage cancers, coupled with numerous heterotypic interactions that occur between tumour and stromal cells, represent fundamental challenges in our quest to understand and control metastatic disease. The incorporation of genomic and other systems level approaches, as well as technological breakthroughs in imaging and animal modelling, have galvanized the effort to overcome gaps in our understanding of metastasis. Future research carries with it the potential to translate the wealth of new knowledge and conceptual advances into effective targeted therapies.
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Citations
Cites
2 retracted
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Cited by
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Cancer cells induce metastasis-supporting neutrophil extracellular DNA traps
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Metadata
- Authors
- Sethi, N., & Kang, Y.
- Venue
- Nature Reviews Cancer
- Published
- 2011-09-23
- Volume
- 11
- Issue
- 10
- Pages
- 735-748
- ISSN
- 1474-175X (ISSN-L)
- 1474-1768
- OpenAlex
- W1976992968
- Cited by
- 397
- References
- 262
- FWCI
- 3.51
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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