The DOI matches its Crossref record; 35 of the 35 references it cites were found in a registry or an index.
Paths to stemness: building the ultimate antitumour T cell
Open accessAbstract
Stem cells are defined by the ability to self-renew and to generate differentiated progeny, qualities that are maintained by evolutionarily conserved pathways that can lead to cancer when deregulated. There is now evidence that these stem cell-like attributes and signalling pathways are also shared among subsets of mature memory T lymphocytes. We discuss how using stem cell-like T cells can overcome the limitations of current adoptive T cell therapies, including inefficient T cell engraftment, persistence and ability to mediate prolonged immune attack. Conferring stemness to antitumour T cells might unleash the full potential of cellular therapies.
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Direct conversion of fibroblasts to functional neurons by defined factors
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A human memory T cell subset with stem cell–like properties
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Self-citationEffector and memory T-cell differentiation: implications for vaccine development
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Lineage relationship and protective immunity of memory CD8 T cell subsets
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Cited by
Metabolic Pathways in Immune Cell Activation and Quiescence
Pearce, E. L., & Pearce, E. J. (2013) · Immunity · doi:10.1016/j.immuni.2013.04.005 · Cited by 1,692
Dunbar, C. E., High, K. A., Joung, J. K., Kohn, D. B., Ozawa, K., & Sadelain, M. (2018) · Science · doi:10.1126/science.aan4672 · Cited by 1,410
Long-term outcomes following CAR T cell therapy: what we know so far
Cappell, K. M., & Kochenderfer, J. N. (2023) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-023-00754-1 · Cited by 1,382
Inhibiting glycolytic metabolism enhances CD8+ T cell memory and antitumor function
Sukumar, M., Liu, J., Ji, Y., Subramanian, M., Crompton, J. G., Yu, Z., Roychoudhuri, R., Palmer, D. C., Muranski, P., Karoly, E. D., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci69589 · Cited by 952
Self-citationHuman memory T cells: generation, compartmentalization and homeostasis
Farber, D. L., Yudanin, N. A., & Restifo, N. P. (2014) · Nature Reviews Immunology · doi:10.1038/nri3567 · Cited by 897
Self-citation
Metadata
- Authors
- Gattinoni, L., Klebanoff, C. A., & Restifo, N. P.
- Venue
- Nature Reviews Cancer
- Published
- 2012-09-21
- Volume
- 12
- Issue
- 10
- Pages
- 671-684
- ISSN
- 1474-175X (ISSN-L)
- 1474-1768
- OpenAlex
- W2030099809
- Cited by
- 599
- References
- 35
- FWCI
- 2.10
- Type
- journal article
- Language
- en
- Open access
- green
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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