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Glioma stem cells promote radioresistance by preferential activation of the DNA damage response

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A Strong Candidate for the Breast and Ovarian Cancer Susceptibility Gene BRCA1

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The resurgence of platinum-based cancer chemotherapy

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In Vivo Activation of the p53 Pathway by Small-Molecule Antagonists of MDM2

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PARP inhibitors in small cell lung cancer: The underlying mechanisms and clinical implications

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Synthesis, spectroscopic characterizations, single crystal X-ray analysis, DFT calculations, in vitro biological evaluation and in silico evaluation studies of thiosemicarbazones based 1,3,4-thiadiazoles

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High Glucose Increases DNA Damage and Elevates the Expression of Multiple DDR Genes

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Establishing a model for assessing DNA damage in murine brain cells as a molecular marker of chemotherapy-associated cognitive impairment

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ZNF365 promotes stalled replication forks recovery to maintain genome stability

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Cell-free Xenopus egg extracts for studying DNA damage response pathways

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Interactions of Mn complexes with DNA: the relevance of therapeutic applications towards cancer treatment

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Gynecologic Cancers: Emerging Novel Strategies for Targeting DNA Repair Deficiency

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Ovarian carcinoma: pathology review with an emphasis in their molecular characteristics

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Selinexor, a selective inhibitor of nuclear export, enhances the anti-tumor activity of olaparib in triple negative breast cancer regardless of BRCA1 mutation status

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Noise-induced bistability in the fate of cancer phenotypic quasispecies: a bit-strings approach

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Centipeda minima extract sensitizes lung cancer cells to DNA-crosslinking agents via targeting Fanconi anemia pathway

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Epigenetically silenced apoptosis-associated tyrosine kinase (AATK) facilitates a decreased expression of Cyclin D1 and WEE1, phosphorylates TP53 and reduces cell proliferation in a kinase-dependent manner

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Critical role of HMGA proteins in cancer cell chemoresistance

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LIMD1 is induced by and required for LMP1 signaling, and protects EBV-transformed cells from DNA damage-induced cell death

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Rational design and characterization of a DNA/HDAC dual-targeting inhibitor containing nitrogen mustard and 2-aminobenzamide moieties

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Pesticides and Bladder Cancer: Mechanisms Leading to Anti-Cancer Drug Chemoresistance and New Chemosensitization Strategies

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Small Molecule Interactions with Biomacromolecules: DNA Binding Interactions of a Manganese(III) Schiff Base Complex with Potential Anticancer Activities

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Discovery of a Meisoindigo-Derived PROTAC as the ATM Degrader: Revolutionizing Colorectal Cancer Therapy via Synthetic Lethality with ATR Inhibitors

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Can a minimal replicating construct be identified as the embodiment of cancer?

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Unraveling DNA damage response-signaling networks through systems approaches

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Just like the rest of evolution in Mother Nature, the evolution of cancers may be driven by natural selection, and not by haphazard mutations

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Increased sensitivity of BRCA defective triple negative breast tumors to plumbagin through induction of DNA Double Strand Breaks (DSB)

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Clinical Pharmacokinetics and Mass Balance of Veliparib in Combination with Temozolomide in Subjects with Nonhematologic Malignancies

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Therapeutic Effect of Quinacrine, an Antiprotozoan Drug, by Selective Suppression of p-CHK1/2 in p53-Negative Malignant Cancers

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Minocycline and cisplatin exert synergistic growth suppression on hepatocellular carcinoma by inducing S phase arrest and apoptosis

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Efficacious cellular codelivery of doxorubicin and EGFP siRNA mediated by the composition of PLGA and PEI protected gold nanoparticles

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How Cancer Cells Resist Chemotherapy: Design and Development of Drugs Targeting Protein-Protein Interactions

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A red-light activatable and mitochondrion-targeting Pt IV complex to overcome drug resistance

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Dual-targeted nanoparticulate drug delivery systems for enhancing triple-negative breast cancer treatment

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An alternative approach of TUNEL assay to specifically characterize DNA fragmentation in cell model systems

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Inter-individual variation in nucleotide excision repair pathway is modulated by non-synonymous polymorphisms in ERCC4 and MBD4 genes

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Current State-of-the-Art Therapy for Advanced Squamous Cell Lung Cancer

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The nuclear expression of poly (ADP-ribose) polymerase-1 (PARP1) in invasive primary breast tumors is associated with chemotherapy sensitivity

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Dual drug loaded vitamin D3 nanoparticle to target drug resistance in cancer

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Dietary flavonoid derivatives enhance chemotherapeutic effect by inhibiting the DNA damage response pathway

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ARF Confers a Context-Dependent Response to Chemotherapy in Muscle-Invasive Bladder Cancer

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MicroRNAs in DNA Damage Response, Carcinogenesis, and Chemoresistance

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CCT128930 induces cell cycle arrest, DNA damage, and autophagy independent of Akt inhibition

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Notch1 inhibition enhances DNA damage induced by cisplatin in cervical cancer

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Targeting of PI3K/AKT signaling and DNA damage response in acute myeloid leukemia: a novel therapeutic strategy to boost chemotherapy response and overcome resistance

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The function of miR-145 in colorectal cancer progression; an updated review on related signaling pathways

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The DNA damage repair-related lncRNAs signature predicts the prognosis and immunotherapy response in gastric cancer

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Hawthorn with “homology of medicine and food”: a review of anticancer effects and mechanisms

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MDC1 promotes ovarian cancer metastasis by inducing epithelial-mesenchymal transition

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Levels of DNA Methylation Vary at CpG Sites across the BRCA1 Promoter, and Differ According to Triple Negative and “BRCA-Like” Status, in Both Blood and Tumour DNA

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Research progress in endogenous H2S‐activatable nanoplatforms for cancer theranostics

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Targeting cancer via ribosome biogenesis: the cachexia perspective

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Bladder cancer: shedding light on the most promising investigational drugs in clinical trials

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Targeted Cancer Therapy Based on Acetylation and Deacetylation of Key Proteins Involved in Double-Strand Break Repair

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DNA Repair and Resistance to Cancer Therapy

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Wilms’ tumor gene WT1 promotes homologous recombination‐mediated DNA damage repair

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5-FU resistance abrogates the amplified cytotoxic effects induced by inhibiting checkpoint kinase 1 in p53-mutated colon cancer cells

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Prognostic implication of HSPA (HSP70) in breast cancer patients treated with neoadjuvant anthracycline-based chemotherapy

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Epithelioid Trophoblastic Tumor Around an Abdominal Cesarean Scar: A Pathologic and Molecular Genetic Analysis

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Programming of Cell Resistance to Genotoxic and Oxidative Stress

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Abrupt transitions to tumor extinction: a phenotypic quasispecies model

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Benzo[a]pyrene promotes progression in tongue squamous cell carcinoma

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Over expression of hRad9 protein correlates with reduced chemosensitivity in breast cancer with administration of neoadjuvant chemotherapy

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Adaptation to chronic exposure to sepantronium bromide (YM155), a prototypical survivin suppressant is due to persistent DNA damage-response in breast cancer cells

Wani, T. H., Surendran, S., Mishra, V. S., Chaturvedi, J., Chowdhury, G., & Chakrabarty, A. (2018) · Oncotarget · doi:10.18632/oncotarget.26096 · Cited by 16

The use of DNA repair genes as prognostic indicators of gastric cancer

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Key genes and drug delivery systems to improve the efficiency of chemotherapy

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Microbial Lipopeptide Supramolecular Self‐Assemblies as a Methuosis‐Like Cell Death Inducer with In Vivo Antitumor Activity

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ACTL6A deficiency induces apoptosis through impairing DNA replication and inhibiting the ATR-Chk1 signaling in glioblastoma cells

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Discovery of novel ataxia telangiectasia mutated (ATM) kinase modulators: Computational simulation, biological evaluation and cancer combinational chemotherapy study

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The oncoprotein BCL6 enables solid tumor cells to evade genotoxic stress

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Pharmacological inhibition of EZH2 combined with DNA‑damaging agents interferes with the DNA damage response in MM cells

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Norcantharidin inhibits the DDR of bladder cancer stem-like cells through cdc6 degradation

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Lactylation-mediated miRNA regulation in cancer therapy resistance

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Deficiency of ligase IV leads to reduced NHEJ, accumulation of DNA damage, and can sensitize cells to cancer therapeutics

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Landscape of homologous recombination deficiency in gastric cancer and clinical implications for first-line chemotherapy

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DNA damage response is hijacked by human papillomaviruses to complete their life cycle

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Differential and Concordant Roles for Poly(ADP-Ribose) Polymerase 1 and Poly(ADP-Ribose) in Regulating WRN and RECQL5 Activities

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Bridging Plant and Human Radiation Response and DNA Repair through an In Silico Approach

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Endostatin sensitizes p53‐deficient non‐small‐cell lung cancer to genotoxic chemotherapy by targeting DNA‐dependent protein kinase catalytic subunit

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CTLA-4 Facilitates DNA Damage–Induced Apoptosis by Interacting With PP2A

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MicroRNA-495: a therapeutic and diagnostic tumor marker

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Radiation therapy for triple-negative breast cancer: from molecular insights to clinical perspectives

Kim, J., Fahmy, V., & Haffty, B. G. (2024) · Expert Review of Anticancer Therapy · doi:10.1080/14737140.2024.2333320 · Cited by 14

Germline determinants of clinical outcome of cutaneous melanoma

Vogelsang, M., Wilson, M. A., & Kirchhoff, T. (2015) · Pigment Cell & Melanoma Research · doi:10.1111/pcmr.12418 · Cited by 14

Emerging treatment options for recurrent ovarian cancer: the potential role of olaparib

Hall, M., & Shaw, H. M. (2013) · OncoTargets and Therapy · doi:10.2147/ott.s30748 · Cited by 14

Improved Efficacy of Acylfulvene in Colon Cancer Cells When Combined with a Nuclear Excision Repair Inhibitor

van Midwoud, P. M., & Sturla, S. J. (2013) · Chemical Research in Toxicology · doi:10.1021/tx400255f · Cited by 14

BRCA1 alterations with additional defects in DNA damage response genes may confer chemoresistance to BRCA‐like breast cancers treated with neoadjuvant chemotherapy

Takada, M., Nagai, S. E., Haruta, M., Sugino, R. P., Tozuka, K., Takei, H., Ohkubo, F., Inoue, K., Kurosumi, M., Miyazaki, M., et al. (2017) · Genes Chromosomes and Cancer · doi:10.1002/gcc.22445 · Cited by 14

Downregulation of ATM and BRCA1 Predicts Poor Outcome in Head and Neck Cancer: Implications for ATM-Targeted Therapy

Wang, Y.-C., Lee, K., Tsai, Y., Lu, H.-H., Chen, S., Hsieh, H., & Lin, C. (2021) · Journal of Personalized Medicine · doi:10.3390/jpm11050389 · Cited by 15

Netrin-1 promoted pancreatic cancer cell proliferation by upregulation of Mdm2

Huang, Q., Hua, H.-W., Jiang, F., Liu, D.-H., & Ding, G. (2014) · Tumor Biology · doi:10.1007/s13277-014-2195-3 · Cited by 14

The G2 checkpoint inhibitor CBP-93872 increases the sensitivity of colorectal and pancreatic cancer cells to chemotherapy

Iwata, T., Uchino, T., Koyama, A., Johmura, Y., Koyama, K., Saito, T., Ishiguro, S., Arikawa, T., Komatsu, S., Miyachi, M., et al. (2017) · PLoS ONE · doi:10.1371/journal.pone.0178221 · Cited by 14

Next generation sequencing identifies novel potential actionable mutations for grade I meningioma treatment.

Pepe, F., Pisapia, P., De, M. D. B., Conticelli, F., Malapelle, U., Troncone, G., & Martı́nez, J. C. (2020) · PubMed · doi:10.14670/hh-18-195 · Cited by 14

Beta galactosidase mediated bio-enzymatically synthesized nano-gold with aggrandized cytotoxic potential against pathogenic bacteria and cancer cells

Ahmed, F., Faisal, S. M., Ahmed, A., & Husain, Q. (2020) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/j.jphotobiol.2020.111923 · Cited by 14

Blockade of integrin signaling reduces chemotherapy-induced premature senescence in collagen cultured bladder cancer cells

Deng, L., Jin, K., Zhou, X., Zhang, Z., Ge, L., Xiong, X., Su, X., Jin, D., Yuan, Q., Zhang, C., et al. (2022) · Precision Clinical Medicine · doi:10.1093/pcmedi/pbac007 · Cited by 14

Biomarkers for chemotherapy and drug resistance in the mismatch repair pathway.

Dong, L., Jiang, H.-Q., Kang, Z.-H., & Guan, M. (2023) · Clinica chimica acta; international journal of clinical chemistry · doi:10.1016/j.cca.2023.117338 · Cited by 12

Loss of TDP-43 function contributes to genomic instability in amyotrophic lateral sclerosis

Fang, M., Deibler, S. K., Nana, A. L., Vatsavayai, S. C., Banday, S., Zhou, Y., Almeida, S., Weiss, A., Brown, R. H., Seeley, W. W., et al. (2023) · Frontiers in Neuroscience · doi:10.3389/fnins.2023.1251228 · Cited by 17

Impaired end joining induces cardiac atrophy in a Hutchinson–Gilford progeria mouse model

Chen, Y., Huang, S., Cui, Z., Sun, X., Tang, Y., Zhang, H., Chen, Z., Jiang, R., Zhang, W., Li, X., et al. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2309200120 · Cited by 15

Therapy-induced secretion of spliceosomal components mediates pro-survival crosstalk between ovarian cancer cells

Shender, V. О., Anufrieva, K. S., Shnaider, P. V., Arapidi, G. P., Pavlyukov, M. S., Ivanova, O. M., Malyants, I. K., Stepanov, G. A., Zhuravlev, E. S., Ziganshin, R., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-49512-6 · Cited by 13

Strategies to Overcome Intrinsic and Acquired Resistance to Chemoradiotherapy in Head and Neck Cancer

de Bakker, T., Maes, A., Dragan, T., Martinive, P., Penninckx, S., & Gestel, D. V. (2024) · Cells · doi:10.3390/cells14010018 · Cited by 18

O-linked N-acetylgalactosamine modification is present on the tumor suppressor p53

Xu, Z., Ku, X., Tomioka, A., Xie, W., Liang, T., Zou, X., Cui, Y., Sato, T., Kaji, H., Narimatsu, H., et al. (2020) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2020.129635 · Cited by 13

MicroRNA-145 Impairs Classical Non-Homologous End-Joining in Response to Ionizing Radiation-Induced DNA Double-Strand Breaks via Targeting DNA-PKcs

Srinivasa, S. M., Hariharasudhan, G., Jun, S., Seo, G., Radhakrishnan, K., Kim, H. H., & Lee, J.-H. (2022) · Cells · doi:10.3390/cells11091509 · Cited by 13

RAD51 potentiates synergistic effects of chemotherapy with PCI-24781 andcis-diamminedichloroplatinum on gastric cancer

He, W. (2014) · World Journal of Gastroenterology · doi:10.3748/wjg.v20.i29.10094 · Cited by 13

The DNA damage inducible lncRNA SCAT7 regulates genomic integrity and topoisomerase 1 turnover in lung adenocarcinoma

Statello, L., Ali, M. M., Reischl, S., Mahale, S. P., Kosalai, S. T., Huarte, M., & Kanduri, C. (2021) · NAR Cancer · doi:10.1093/narcan/zcab002 · Cited by 13

Opportunities for translation: Targeting DNA repair pathways in pancreatic cancer

Maginn, E. N., de Sousa, C. H., Wasan, H. S., & Stronach, E. A. (2014) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2014.04.002 · Cited by 14

Genetic Dissection of Cancer Development, Therapy Response, and Resistance in Mouse Models of Breast CancerPreprint

Annunziato, S., Barazas, M., Rottenberg, S., & Jonkers, J. (2016) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2016.81.030924 · Cited by 12

Comprehensive Analysis of Regulatory Factors and Immune-Associated Patterns to Decipher Common and BRCA1/2 Mutation-Type-Specific Critical Regulation in Breast Cancer

Li, Y., Dong, W., Zhang, P., Zhang, T., Ma, L., Qu, M., Ma, X., Zhou, X., & He, Q. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.750897 · Cited by 13

DNA repair dysregulation from cancer driver to therapeutic target

Curtin, N. J. (2012) · Nature Reviews Cancer · doi:10.1038/nrc3399 · Cited by 1,051

DNA repair and the contribution to chemotherapy resistance

Nesic, K., Parker, P., Swisher, E. M., & Krais, J. J. (2025) · Genome Medicine · doi:10.1186/s13073-025-01488-8 · Cited by 57

Targeting DNA damage response in cancer therapy

Hosoya, N., & Miyagawa, K. (2014) · Cancer Science · doi:10.1111/cas.12366 · Cited by 309

Targeting DNA damage response pathways in cancer

Groelly, F. J., Fawkes, M., Dagg, R. A., Blackford, A. N., & Tarsounas, M. (2022) · Nature reviews. Cancer · doi:10.1038/s41568-022-00535-5 · Cited by 890

Replication Fork Remodeling and Therapy Escape in DNA Damage Response-Deficient Cancers

Liptay, M., Barbosa, J. S., & Rottenberg, S. (2020) · Frontiers in Oncology · doi:10.3389/fonc.2020.00670 · Cited by 30