Student or educator? Sign up with your school email and get 6 months of Pro free.
Cited by 1,014

The DOI matches its Crossref record; 182 of the 182 references it cites were found in a registry or an index.

Ceramide-orchestrated signalling in cancer cells

Morad, Samy A. F., Cabot, Myles C.·2013·Nature Reviews Cancer

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1038/nrc3398

Cites

182 of 182 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 182 references

Research works printed but not linked: 31

  1. Senchenkov, A., Litvak, D. A. & Cabot, M. C. Targeting ceramide metabolism-a strategy for overcoming drug resistance. J. Natl Cancer Inst. 93, 347–357 (2001). · doi:10.1093/jnci/93.5.347
  2. Bornancin, F. Ceramide kinase: the first decade. Cell. Signal. 23, 999–1008 (2011). · doi:10.1016/j.cellsig.2010.11.012
  3. Liu, X. et al. Acid ceramidase inhibition: a novel target for cancer therapy. Front. Biosci. 13, 2293–2298 (2008). · doi:10.2741/2843
  4. Kolesnick, R., Altieri, D. & Fuks, Z. A. CERTain role for ceramide in taxane-induced cell death. Cancer Cell 11, 473–475 (2007). · doi:10.1016/j.ccr.2007.05.003
  5. Schaefer, J. T., Barthlen, W. & Schweizer, P. Ceramide induces apoptosis in neuroblastoma cell cultures resistant to CD95 (Fas/APO-1)-mediated apoptosis. J. Pediatr. Surg. 35, 473–479 (2000). · doi:10.1016/s0022-3468(00)90217-3
  6. Wagenknecht, B., Roth, W., Gulbins, E., Wolburg, H. & Weller, M. C2-ceramide signaling in glioma cells: synergistic enhancement of CD95-mediated, caspase-dependent apoptosis. Cell Death Differ. 8, 595–602 (2001). · doi:10.1038/sj.cdd.4400848
  7. Zhang, Y., Yoshida, T. & Zhang, B. TRAIL induces endocytosis of its death receptors in MDA-MB-231 breast cancer cells. Cancer Biol. Ther. 8, 917–922 (2009). · doi:10.4161/cbt.8.10.8141
  8. Colell, A., Morales, A., Fernandez-Checa, J. C. & Garcia-Ruiz, C. Ceramide generated by acidic sphingomyelinase contributes to tumor necrosis factor-α-mediated apoptosis in human colon HT-29 cells through glycosphingolipids formation. Possible role of ganglioside GD3. FEBS Lett. 526, 135–141 (2002). · doi:10.1016/s0014-5793(02)03140-x
  9. Kuroki, J. et al. Cell-permeable ceramide inhibits the growth of B lymphoma Raji cells lacking TNF-α-receptors by inducing G0/G1 arrest but not apoptosis: a new model for dissecting cell-cycle arrest and apoptosis. Leukemia 10, 1950–1958 (1996).
  10. Karasavvas, N. & Zakeri, Z. Relationships of apoptotic signaling mediated by ceramide and TNF-α in U937 cells. Cell Death Differ. 6, 115–123 (1999). · doi:10.1038/sj.cdd.4400482
  11. Goswami, R., Kilkus, J., Scurlock, B. & Dawson, G. CrmA protects against apoptosis and ceramide formation in PC12 cells. Neurochem. Res. 27, 735–741 (2002). · doi:10.1023/a:1020292504535
  12. Yoon, G. et al. Ceramide increases Fas-mediated apoptosis in glioblastoma cells through FLIP down-regulation. J. Neurooncol 60, 135–141 (2002). · doi:10.1023/a:1020604705831
  13. Zhou, X. D. et al. Overexpression of cellular FLICE-inhibitory protein (FLIP) in gastric adenocarcinoma. Clin. Sci. 106, 397–405 (2004). · doi:10.1042/cs20030238
  14. Sumitomo, M. et al. Protein kinase Cδ amplifies ceramide formation via mitochondrial signaling in prostate cancer cells. J. Clin. Invest. 109, 827–836 (2002). · doi:10.1172/jci0214146
  15. Jiang, Y. et al. Combinatorial therapies improve the therapeutic efficacy of nanoliposomal ceramide for pancreatic cancer. Cancer Biol. Ther. 12, 574–585 (2011). · doi:10.4161/cbt.12.7.15971
  16. Peralta, E. R. & Edinger, A. L. Ceramide-induced starvation triggers homeostatic autophagy. Autophagy 5, 407–409 (2009). · doi:10.4161/auto.5.3.7809
  17. Park, M. A. et al. Regulation of autophagy by ceramide-CD95-PERK signaling. Autophagy 4, 929–931 (2008). This paper reports ceramide–CD95–PERK signalling as a novel pathway involved in autophagy. · doi:10.4161/auto.6732
  18. Wang, H., Maurer, B. J., Reynolds, C. P. & Cabot, M. C. N-(4-hydroxyphenyl)retinamide elevates ceramide in neuroblastoma cell lines by coordinate activation of serine palmitoyltransferase and ceramide synthase. Cancer Res. 61, 5102–5105 (2001).
  19. Maurer, B. J., Metelitsa, L. S., Seeger, R. C., Cabot, M. C. & Reynolds, C. P. Increase of ceramide and induction of mixed apoptosis/necrosis by N-(4-hydroxyphenyl)- retinamide in neuroblastoma cell lines. J. Natl Cancer Inst. 91, 1138–1146 (1999). · doi:10.1093/jnci/91.13.1138
  20. Turner, L. S. et al. Autophagy is increased in prostate cancer cells overexpressing acid ceramidase and enhances resistance to C6 ceramide. Prostate Cancer Prostat. Dis. 14, 30–37 (2011). · doi:10.1038/pcan.2010.47
  21. Kim, W. H., Kang, K. H., Kim, M. Y. & Choi, K. H. Induction of p53-independent p21 during ceramide-induced G1 arrest in human hepatocarcinoma cells. Biochem. Cell Biol. 78, 127–135 (2000). · doi:10.1139/o00-016
  22. Zhu, X. F., Liu, Z. C., Xie, B. F., Feng, G. K. & Zeng, Y. X. Ceramide induces cell cycle arrest and upregulates p27kip in nasopharyngeal carcinoma cells. Cancer Lett. 193, 149–154 (2003). · doi:10.1016/s0304-3835(03)00050-8
  23. Ahn, E. H. & Schroeder, J. J. Induction of apoptosis by sphingosine, sphinganine, and C2-ceramide in human colon cancer cells, but not by C2-dihydroceramide. Anticancer Res. 30, 2881–2884 (2010).
  24. Tsaur, I. et al. The cdk1-cyclin B complex is involved in everolimus triggered resistance in the PC3 prostate cancer cell line. Cancer Lett. 313, 84–90 (2011). · doi:10.1016/j.canlet.2011.08.026
  25. Zwart, W. et al. Resistance to antiestrogen arzoxifene is mediated by overexpression of cyclin D1. Mol. Endocrinol. 23, 1335–1345 (2009). · DOI
  26. Obama, K., Kanai, M., Kawai, Y., Fukushima, M. & Takabayashi, A. Role of retinoblastoma protein and E2F-1 transcription factor in the acquisition of 5-fluorouracil resistance by colon cancer cells. Int. J. Oncol. 21, 309–314 (2002).
  27. Barth, B. M., Cabot, M. C. & Kester, M. Ceramide-based therapeutics for the treatment of cancer. Anticancer Agents Med. Chem. 11, 911–919 (2011). · doi:10.2174/187152011797655177
  28. Kummar, S. et al. Phase I trial of fenretinide lym-x-sorb oral powder in adults with solid tumors and lymphomas. Anticancer Res. 31, 961–966 (2011).
  29. Morad, S. A. F. et al. Tamoxifen enhances chemotherapeutic efficacy of C6− ceramide and increases induction of apoptosis in human colorectal cancer cells by upregulation of MAPK signaling pathway and down-regulation of inhibitor of apoptosis protein, survivin. FASEB J. 26, 993.1 (2012).
  30. Ling, L. U., Lin, H., Tan, K. B. & Chiu, G. N. The role of protein kinase C in the synergistic interaction of safingol and irinotecan in colon cancer cells. Int. J. Oncol. 35, 1463–1471 (2009).
  31. Ling, L. U., Tan, K. B. & Chiu, G. N. Role of reactive oxygen species in the synergistic cytotoxicity of safingol-based combination regimens with conventional chemotherapeutics. Oncol. Lett. 2, 905–910 (2011).

Cited by

See all 1,014

Metadata

Authors
Morad, S. A. F., & Cabot, M. C.
Venue
Nature Reviews Cancer
Published
2012-12-13
Volume
13
Issue
1
Pages
51-65
ISSN
  • 1474-175X (ISSN-L)
  • 1474-1768
OpenAlex
W2069412624
Cited by
1,014
References
182
FWCI
4.41
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: Ceramide-orchestrated signalling in cancer cells. https://app.cochat.ai/papers/10.1038/nrc3398
The paper
Morad, S. A. F., & Cabot, M. C. (2013). Ceramide-orchestrated signalling in cancer cells. Nature Reviews Cancer. https://doi.org/10.1038/nrc3398

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.