The DOI matches its Crossref record; 82 of the 82 references it cites were found in a registry or an index.
The emerging mutational landscape of G proteins and G-protein-coupled receptors in cancer
Open accessAbstract
Aberrant expression and activity of G proteins and G-protein-coupled receptors (GPCRs) are frequently associated with tumorigenesis. Deep sequencing studies show that 4.2% of tumours carry activating mutations in GNAS (encoding Gαs), and that oncogenic activating mutations in genes encoding Gαq family members (GNAQ or GNA11) are present in ∼66% and ∼6% of melanomas arising in the eye and skin, respectively. Furthermore, nearly 20% of human tumours harbour mutations in GPCRs. Many human cancer-associated viruses also express constitutively active viral GPCRs. These studies indicate that G proteins, GPCRs and their linked signalling circuitry represent novel therapeutic targets for cancer prevention and treatment.
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YAP/TAZ at the Roots of Cancer
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Self-citationEstrogen regulates Hippo signaling via GPER in breast cancer
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Metadata
- Authors
- O'Hayre, M., Vázquez-Prado, J., Kufareva, I., Stawiski, E. W., Handel, T. M., Seshagiri, S., & Gutkind, J. S.
- Venue
- Nature Reviews Cancer
- Published
- 2013-05-03
- Volume
- 13
- Issue
- 6
- Pages
- 412-424
- ISSN
- 1474-175X (ISSN-L)
- 1474-1768
- OpenAlex
- W2038709562
- Cited by
- 559
- References
- 82
- FWCI
- 2.93
- Type
- journal article
- Language
- en
- Open access
- bronze
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- O'Hayre, M., Vázquez-Prado, J., Kufareva, I., Stawiski, E. W., Handel, T. M., Seshagiri, S., & Gutkind, J. S. (2013). The emerging mutational landscape of G proteins and G-protein-coupled receptors in cancer. Nature Reviews Cancer. https://doi.org/10.1038/nrc3521
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
