A Platform of Synthetic Lethal Gene Interaction Networks Reveals that the GNAQ Uveal Melanoma Oncogene Controls the Hippo Pathway through FAK
Open accessAbstract
Activating mutations in GNAQ/GNA11, encoding Gαq G proteins, are initiating oncogenic events in uveal melanoma (UM). However, there are no effective therapies for UM. Using an integrated bioinformatics pipeline, we found that PTK2, encoding focal adhesion kinase (FAK), represents a candidate synthetic lethal gene with GNAQ activation. We show that Gαq activates FAK through TRIO-RhoA non-canonical Gαq-signaling, and genetic ablation or pharmacological inhibition of FAK inhibits UM growth. Analysis of the FAK-regulated transcriptome demonstrated that GNAQ stimulates YAP through FAK. Dissection of the underlying mechanism revealed that FAK regulates YAP by tyrosine phosphorylation of MOB1, inhibiting core Hippo signaling. Our findings establish FAK as a potential therapeutic target for UM and other Gαq-driven pathophysiologies that involve unrestrained YAP function.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
FAK positively regulates YAP activity through tyrosine phosphorylation of the YAP upstream modulator MOB1, then dissociating the MOB1/LATS complex.
“On the other hand, FAK was reported to positively regulate YAP activity through tyrosine phosphorylation of the YAP upstream modulator MOB1, then dissociating the MOB1/LATS complex.[ 31, 32 ]”
From Focal Adhesion Kinase (FAK) Inhibition Synergizes with KRAS G12C Inhibitors in Treating Cancer through the Regulation of the FAK–YAP Signaling (2021) · cites this paper as [31]
FAK activates and accumulates YAP in cell nucleus through regulation of the MOB1/LATS1/2 complex.
“FAK is known to activate and accumulate YAP in cell nucleus through its regulation of the MOB1/LATS1/2 complex, which is an upstream biomarker of YAP signaling[ 31, 32 ]”
From Focal Adhesion Kinase (FAK) Inhibition Synergizes with KRAS G12C Inhibitors in Treating Cancer through the Regulation of the FAK–YAP Signaling (2021) · cites this paper as [31]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Subramanian, A., Tamayo, P., Mootha, V. K., Mukherjee, S., Ebert, B. L., Gillette, M. A., Paulovich, A., Pomeroy, S. L., Golub, T. R., Lander, E. S., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506580102 · Cited by 53,625 · see citing works
Self-citationIntegrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal
Gao, J., Aksoy, B. A., Dogrusoz, U., Dresdner, G., Gross, B., Sumer, S. O., Sun, Y., Jacobsen, A., Sinha, R., Larsson, E., et al. (2013) · Science Signaling · doi:10.1126/scisignal.2004088 · Cited by 15,160 · see citing works
The Molecular Signatures Database Hallmark Gene Set Collection
Liberzon, A., Birger, C., Thorvaldsdóttir, H., Ghandi, M., Mesirov, J. P., & Tamayo, P. (2015) · Cell Systems · doi:10.1016/j.cels.2015.12.004 · Cited by 13,807 · see citing works
Self-citationThe cancer genome atlas pan-cancer analysis project
The Cancer Genome Atlas Research Network, Weinstein, J. N., Collisson, E. A., Mills, G. B., Shaw, K. R. M., Ozenberger, B. A., Ellrott, K., Shmulevich, I., Sander, C., & Stuart, J. M. (2013) · Nature Genetics · doi:10.1038/ng.2764 · Cited by 9,092 · see citing works
Modeling Survival Data: Extending the Cox Model
Therneau, T. M., & Grambsch, P. M. (2000) · Statistics for Biology and Health · doi:10.1007/978-1-4757-3294-8 · Cited by 8,674 · see citing works
The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity
Barretina, J., Caponigro, G., Stransky, N., Venkatesan, K., Margolin, A. A., Kim, S., Wilson, C. J., Lehár, J., Kryukov, G. V., Sonkin, D., et al. (2012) · Nature · doi:10.1038/nature11003 · Cited by 7,950 · see citing works
Defining a Cancer Dependency Map
Tsherniak, A., Vazquez, F., Montgomery, P. G., Weir, B. A., Kryukov, G., Cowley, G. S., Gill, S., Harrington, W. F., Pantel, S., Krill-Burger, J. M., et al. (2017) · Cell · doi:10.1016/j.cell.2017.06.010 · Cited by 3,276 · see citing works
TEAD mediates YAP-dependent gene induction and growth control
Zhao, B., Ye, X., Yu, J., Li, L., Li, W., Li, S., Yu, J., Lin, J. D., Wang, C.-Y., Chinnaiyan, A. M., et al. (2008) · Genes & Development · doi:10.1101/gad.1664408 · Cited by 2,498 · see citing works
Systematic identification of genomic markers of drug sensitivity in cancer cells
Garnett, M. J., Edelman, E. J., Heidorn, S. J., Greenman, C. D., Dastur, A., Lau, K. W., Greninger, P., Thompson, I. R., Luo, X., Soares, J., et al. (2012) · Nature · doi:10.1038/nature11005 · Cited by 2,456 · see citing works
The Hippo Signaling Pathway in Development and Cancer
Pan, D. (2010) · Developmental Cell · doi:10.1016/j.devcel.2010.09.011 · Cited by 2,274 · see citing works
Hippo pathway in organ size control, tissue homeostasis, and cancer
Yu, F.-X., Zhao, B., & Guan, K.-L. (2015) · Cell · doi:10.1016/j.cell.2015.10.044 · Cited by 2,206 · see citing works
A Landscape of Pharmacogenomic Interactions in Cancer
Iorio, F., Knijnenburg, T. A., Vis, D. J., Bignell, G. R., Menden, M. P., Schubert, M., Aben, N., Gonçalves, E., Barthorpe, S., Lightfoot, H., et al. (2016) · Cell · doi:10.1016/j.cell.2016.06.017 · Cited by 2,090 · see citing works
Armbruster, B. N., Li, X., Pausch, M. H., Herlitze, S., & Roth, B. L. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0700293104 · Cited by 2,046 · see citing works
DrugBank 4.0: shedding new light on drug metabolism
Law, V., Knox, C., Djoumbou-Feunang, Y., Jewison, T., Guo, A. C., Liu, Y., Maciejewski, A., Arndt, D., Wilson, M., Neveu, V., et al. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt1068 · Cited by 1,995 · see citing works
Mechanisms of Hippo pathway regulation
Meng, Z., Moroishi, T., & Guan, K.-L. (2016) · Genes & Development · doi:10.1101/gad.274027.115 · Cited by 1,667 · see citing works
Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi
Raamsdonk, C. D. V., Bezrookove, V., Green, G., Bauer, J. M., Gaugler, L., O’Brien, J. M., Simpson, E. M., Barsh, G. S., & Bastian, B. C. (2008) · Nature · doi:10.1038/nature07586 · Cited by 1,621 · see citing works
Mutations in GNA11 in Uveal Melanoma
Raamsdonk, C. D. V., Griewank, K., Crosby, M. B., Garrido, M. C., Vemula, S. S., Wiesner, T., Obenauf, A. C., Wackernagel, W., Green, G., Bouvier, N., et al. (2010) · New England Journal of Medicine · doi:10.1056/nejmoa1000584 · Cited by 1,481 · see citing works
G-protein-coupled receptors and cancer
Dorsam, R. T., & Gutkind, J. S. (2007) · Nature reviews. Cancer · doi:10.1038/nrc2069 · Cited by 1,399 · see citing works
Self-citationFAK in cancer: mechanistic findings and clinical applications
Sulzmaier, F. J., Jean, C., & Schlaepfer, D. D. (2014) · Nature Reviews Cancer · doi:10.1038/nrc3792 · Cited by 1,381 · see citing works
Self-citationThe emerging roles of YAP and TAZ in cancer
Moroishi, T., Hansen, C. G., & Guan, K. (2015) · Nature reviews. Cancer · doi:10.1038/nrc3876 · Cited by 1,156 · see citing works
Mechanism of Blebbistatin Inhibition of Myosin II
Kovács, M., Tóth, J. S., Hetényi, C., Málnási‐Csizmadia, A., & Sellers, J. R. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m405319200 · Cited by 1,022 · see citing works
Protein kinase C and other diacylglycerol effectors in cancer
Griner, E. M., & Kazanietz, M. G. (2007) · Nature Reviews Cancer · doi:10.1038/nrc2110 · Cited by 978 · see citing works
Integrative Analysis Identifies Four Molecular and Clinical Subsets in Uveal Melanoma
Robertson, A. G., Shih, J., Yau, C. S. F., Gibb, E. A., Oba, J., Mungall, K. L., Hess, J. M., Uzunangelov, V., Walter, V., Danilova, L., et al. (2017) · Cancer Cell · doi:10.1016/j.ccell.2017.07.003 · Cited by 894 · see citing works
Basu, A. B., Bodycombe, N. E., Cheah, J. H., Price, E. V., Liu, K., Schaefer, G. I., Ebright, R. Y., Stewart, M. L., Ito, D., Wang, S. Y., et al. (2013) · Cell · doi:10.1016/j.cell.2013.08.003 · Cited by 820 · see citing works
A gp130–Src–YAP module links inflammation to epithelial regeneration
Taniguchi, K., Wu, L.-W., Grivennikov, S. I., de Jong, P. R., Lian, I., Yu, F.-X., Wang, K., Ho, S. B., Boland, B. S., Chang, J. T., et al. (2015) · Nature · doi:10.1038/nature14228 · Cited by 633 · see citing works
Calcium in tumour metastasis: new roles for known actors
Prevarskaya, N. B., Skryma, R. N., & Шуба, Я. М. (2011) · Nature reviews. Cancer · doi:10.1038/nrc3105 · Cited by 606 · see citing works
Feng, X., Degese, M. S., Iglesias‐Bartolomé, R., Vaque, J. P., Molinolo, A., Rodrigues, M. W., Zaidi, M. R., Ksander, B. R., Merlino, G. T., Sodhi, A., et al. (2014) · Cancer Cell · doi:10.1016/j.ccr.2014.04.016 · Cited by 559 · see citing works
Self-citationThe emerging mutational landscape of G proteins and G-protein-coupled receptors in cancer
O’Hayre, M., Vázquez‐Prado, J., Kufareva, I., Stawiski, E. W., Handel, T. M., Seshagiri, S., & Gutkind, J. S. (2013) · Nature reviews. Cancer · doi:10.1038/nrc3521 · Cited by 559 · see citing works
Self-citationProtein kinase C: poised to signal
Newton, A. C. (2009) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00477.2009 · Cited by 520 · see citing works
The Cyclic AMP PathwayPreprint
Sassone‐Corsi, P. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a011148 · Cited by 519 · see citing works
Mutant Gq/11 Promote Uveal Melanoma Tumorigenesis by Activating YAP
Yu, F., Luo, J., Mo, J., Liu, G., Kim, Y. C., Meng, Z., Zhao, L., Peyman, G. A., Ouyang, H. W., Jiang, W., et al. (2014) · Cancer Cell · doi:10.1016/j.ccr.2014.04.017 · Cited by 464 · see citing works
Mitogenic signaling pathways induced by G protein‐coupled receptors
Rozengurt, E. (2007) · Journal of Cellular Physiology · doi:10.1002/jcp.21246 · Cited by 461 · see citing works
Functional Genomic Landscape of Human Breast Cancer Drivers, Vulnerabilities, and Resistance
Marcotte, R., Sayad, A., Brown, K. R., Sanchez-Garcia, F., Reimand, J., Haider, M., Virtanen, C., Bradner, J. E., Bader, G. D., Mills, G. B., et al. (2016) · Cell · doi:10.1016/j.cell.2015.11.062 · Cited by 439 · see citing works
Effect of Selumetinib vs Chemotherapy on Progression-Free Survival in Uveal Melanoma
Carvajal, R. D., Sosman, J. A., Quevedo, J. F., Milhem, M. M., Joshua, A. M., Kudchadkar, R. R., Linette, G. P., Gajewski, T. F., Lutzky, J., Lawson, D. H., et al. (2014) · JAMA · doi:10.1001/jama.2014.6096 · Cited by 433 · see citing works
Cheung, H. W., Cowley, G. S., Weir, B. A., Boehm, J. S., Rusin, S., Scott, J. A., East, A., Ali, L. D., Lizotte, P. H., Wong, T. C., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1109363108 · Cited by 423 · see citing works
Self-citationCowley, G., Weir, B., Vazquez, F., Tamayo, P., Scott, J. A., Rusin, S., East-Seletsky, A., Ali, L., Gerath, W. F. J., Pantel, S., et al. (2014) · Scientific Data · doi:10.1038/sdata.2014.35 · Cited by 398 · see citing works
Self-citationThe experimental power of FR900359 to study Gq-regulated biological processes
Schrage, R., Schmitz, A.-L., Gaffal, E., Annala, S., Kehraus, S., Wenzel, D., Büllesbach, K. M., Bald, T., Inoue, A., Shinjo, Y., et al. (2015) · Nature Communications · doi:10.1038/ncomms10156 · Cited by 366 · see citing works
Self-citationUse and properties of ROCK-specific inhibitor Y-27632
Narumiya, S., Ishizaki, T., & Ufhata, M. (2000) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(00)25449-9 · Cited by 332 · see citing works
Recurrent activating mutations of G-protein-coupled receptor CYSLTR2 in uveal melanoma
Moore, A. R., Ceraudo, E., Sher, J. J., Guan, Y., Shoushtari, A. N., Chang, M. T., Zhang, J. Q., Walczak, E. G., Kazmi, M. A., Taylor, B. S., et al. (2016) · Nature Genetics · doi:10.1038/ng.3549 · Cited by 313 · see citing works
Essential Gene Profiles in Breast, Pancreatic, and Ovarian Cancer Cells
Marcotte, R., Brown, K. R., Suárez, F., Sayad, A., Karamboulas, K., Krzyzanowski, P. M., Sircoulomb, F., Medrano, M., Fedyshyn, Y., Koh, J. L. Y., et al. (2011) · Cancer Discovery · doi:10.1158/2159-8290.cd-11-0224 · Cited by 297 · see citing works
Muscarinic acetylcholine receptor subtypes as agonist-dependent oncogenes.
Gutkind, J. S., Novotny, E. A., Brann, M. R., & Robbins, K. C. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.11.4703 · Cited by 291 · see citing works
Self-citationCarvajal, R. D., Piperno-Neumann, S., Kapiteijn, E., Chapman, P. B., Frank, S. J., Joshua, A. M., Piulats, J. M., Wolter, P., Cocquyt, V., Chmielowski, B., et al. (2018) · Journal of Clinical Oncology · doi:10.1200/jco.2017.74.1090 · Cited by 272 · see citing works
Cell signalling diversity of the Gqα family of heterotrimeric G proteins
Hubbard, K. B., & Hepler, J. R. (2005) · Cellular Signalling · doi:10.1016/j.cellsig.2005.08.004 · Cited by 266 · see citing works
An FAK-YAP-mTOR Signaling Axis Regulates Stem Cell-Based Tissue Renewal in Mice
Hu, J. K., Du, W. T., Shelton, S. J., Oldham, M. C., DiPersio, C. M., & Klein, O. D. (2017) · Cell stem cell · doi:10.1016/j.stem.2017.03.023 · Cited by 241 · see citing works
Zuidervaart, W., van Nieuwpoort, F. A., Stark, M. S., Dijkman, R., Packer, L., Borgstein, A. M., Pavey, S. J., van der Velden, P., Out, C. J., Jager, M. J., et al. (2005) · British Journal of Cancer · doi:10.1038/sj.bjc.6602598 · Cited by 219 · see citing works
Li, P., Silvis, M. R., Honaker, Y., Lien, W.-H., Arron, S. T., & Vasioukhin, V. (2016) · Genes & Development · doi:10.1101/gad.274951.115 · Cited by 180 · see citing works
FAK controls the mechanical activation of YAP, a transcriptional regulator required for durotaxis
Lachowski, D., Cortes, E., Robinson, B., Rice, A., Rombouts, K., & Del Río Hernández, A. E. (2018) · The FASEB Journal · doi:10.1096/fj.201700721r · Cited by 175 · see citing works
Assembly and activation of the Hippo signalome by FAT1 tumor suppressor
Martin, D., Degese, M. S., Vitale-Cross, L., Iglesias-Bartolome, R., Valera, J. L. C., Wang, Z., Feng, X., Yeerna, H., Vadmal, V., Moroishi, T., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-04590-1 · Cited by 174 · see citing works
Self-citationRasGRP3 Mediates MAPK Pathway Activation in GNAQ Mutant Uveal Melanoma
Chen, X., Wu, Q., Depeille, P., Chen, P., Thornton, S., Kalirai, H., Coupland, S. E., Roose, J. P., & Bastian, B. C. (2017) · Cancer Cell · doi:10.1016/j.ccell.2017.04.002 · Cited by 172 · see citing works
Vaque, J. P., Dorsam, R. T., Feng, X., Iglesias‐Bartolomé, R., Forsthoefel, D. J., Chen, Q., Debant, A., Seeger, M. A., Ksander, B. R., Teramoto, H., et al. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.10.018 · Cited by 163 · see citing works
Self-citationMutated alpha subunit of the Gq protein induces malignant transformation in NIH 3T3 cells.
Kalinec, G. M., Nazarali, A. J., Hermouet, S., Xu, N., & Gutkind, J. S. (1992) · Molecular and Cellular Biology · doi:10.1128/mcb.12.10.4687 · Cited by 162 · see citing works
Self-citationChikumi, H., Fukuhara, S., & Gutkind, J. S. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m108504200 · Cited by 162 · see citing works
Self-citationTreatment of age-related macular degeneration with photodynamic therapy (TAP) study group (2004) · American Journal of Ophthalmology · doi:10.1016/j.ajo.2003.11.059 · Cited by 145 · see citing works
Harnessing synthetic lethality to predict the response to cancer treatment
Lee, J. S., Das, A., Jerby‐Arnon, L., Arafeh, R., Auslander, N., Davidson, M. A., McGarry, L., James, D. T., Amzallag, A., Park, S. G., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-04647-1 · Cited by 120 · see citing works
Self-citationBasile, B., Marsal, J., & DeJong, T. M. (2003) · Tree Physiology · doi:10.1093/treephys/23.10.695 · Cited by 111 · see citing works
VERTEPORFIN THERAPY OF SUBFOVEAL CHOROIDAL NEOVASCULARIZATION IN AGE-RELATED MACULAR DEGENERATION
Groups, T. O. A.-R. M. D. W. P. T. (. A. V. I. P. T. (. S. (2004) · Retina · doi:10.1097/00006982-200402000-00001 · Cited by 94 · see citing works
Marinissen, M. J., Servitja, J., Offermanns, S., Simon, M. I., & Gutkind, J. S. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m305709200 · Cited by 93 · see citing works
Self-citationSignaling by Sensory ReceptorsPreprint
Julius, D. J., & Nathans, J. (2011) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a005991 · Cited by 86 · see citing works
Divergent Signaling Pathways Link Focal Adhesion Kinase to Mitogen-activated Protein Kinase Cascades
Igishi, T., Fukuhara, S., Patel, V., Katz, B., Yamada, K. M., & Gutkind, J. S. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.43.30738 · Cited by 86 · see citing works
Self-citationCross-talk between calcium and protein kinase A in the regulation of cell migration
Howe, A. K. (2011) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2011.05.006 · Cited by 85 · see citing works
Treatment of choroidal melanoma using photodynamic therapy
BARBAZETTO, I. A., Lee, T. C., Rollins, I. S., Chang, S., & Abramson, D. H. (2003) · American Journal of Ophthalmology · doi:10.1016/s0002-9394(02)02222-5 · Cited by 85 · see citing works
FAK activity protects nucleostemin in facilitating breast cancer spheroid and tumor growth
Tancioni, I., Miller, N. L. G., Uryu, S. A., Lawson, C., Jean, C., Chen, X. L., Kleinschmidt, E. G., & Schlaepfer, D. D. (2015) · Breast Cancer Research · doi:10.1186/s13058-015-0551-x · Cited by 72 · see citing works
Self-citationIdentification of H-Ras, RhoA, Rac1 and Cdc42 responsive genes
Teramoto, H., Malek, R. L., Behbahani, B., Castellone, M. D., Lee, N. H., & Gutkind, J. S. (2003) · Oncogene · doi:10.1038/sj.onc.1206364 · Cited by 54 · see citing works
Self-citationGutkind, J. S., & Robbins, K. C. (1992) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(92)92363-3 · Cited by 51 · see citing works
Self-citationFriedman, A. A., Amzallag, A., Pruteanu-Malinici, I., Baniya, S., Cooper, Z. A., Piris, A., Hargreaves, L., Igras, V., Frederick, D. T., Lawrence, D. P., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0140310 · Cited by 45 · see citing works
Ikeda, F., Terajima, H., Shimahara, Y., Kondo, T., & Yamaoka, Y. (2003) · Journal of Surgical Research · doi:10.1016/s0022-4804(02)00081-1 · Cited by 26 · see citing works
Souček, P., & Cihelkova, I. (2006) · PubMed · Cited by 25 · see citing works
Yamaguchi, K., Iglesias‐Bartolomé, R., Wang, Z., Callejas‐Valera, J. L., Amornphimoltham, P., Molinolo, A., Cohen, E. E. W., Califano, J. A., Lippman, S. M., Luo, J., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.7372 · Cited by 22 · see citing works
Self-citationOncotargeting G proteins: The Hippo in the room
Feng, X., Chen, Q., & Gutkind, J. S. (2014) · Oncotarget · doi:10.18632/oncotarget.2815 · Cited by 18 · see citing works
Self-citationBhatt, M., Shah, S. S., & Shivprakash (2010) · Journal of Chromatography B · doi:10.1016/j.jchromb.2010.03.019 · Cited by 18 · see citing works
YAP as oncotarget in uveal melanoma
Yu, F., Zhang, K., & Guan, K. (2014) · Oncoscience · doi:10.18632/oncoscience.57 · Cited by 14 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Jager, M. J., Shields, C. L., Cebulla, C. M., Abdel‐Rahman, M. H., Grossniklaus, H. E., Stern, M., Carvajal, R. D., Belfort, R. N., Jia, R., Shields, J. A., et al. (2020) · Nature Reviews Disease Primers · doi:10.1038/s41572-020-0158-0 · Cited by 836 · see citing works
The present and future of the Cancer Dependency Map
Arafeh, R., Shibue, T., Dempster, J. M., Hahn, W. C., & Vazquez, F. (2025) · Nature Reviews Cancer · doi:10.1038/s41568-024-00763-x · Cited by 454 · see citing works
Targeting FAK in anticancer combination therapies
Dawson, J. C., Serrels, A., Stupack, D. G., Schlaepfer, D. D., & Frame, M. C. (2021) · Nature reviews. Cancer · doi:10.1038/s41568-021-00340-6 · Cited by 397 · see citing works
Self-citationControl of cellular responses to mechanical cues through YAP/TAZ regulation
Dasgupta, I., & McCollum, D. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.rev119.007963 · Cited by 360 · see citing works
The Hippo pathway in cancer: YAP/TAZ and TEAD as therapeutic targets in cancer
Cunningham, R., & Hansen, C. G. (2022) · Clinical Science · doi:10.1042/cs20201474 · Cited by 331 · see citing works
Advances in the clinical management of uveal melanoma
Carvajal, R. D., Sacco, J. J., Jager, M. J., Eschelman, D. J., Bagge, R. O., Harbour, J. W., Chieng, N. D., Patel, S. P., Joshua, A. M., & Piperno-Neumann, S. (2023) · Nature Reviews Clinical Oncology · doi:10.1038/s41571-022-00714-1 · Cited by 289 · see citing works
YAP/TAZ: Drivers of Tumor Growth, Metastasis, and Resistance to Therapy
Thompson, B. J. (2020) · BioEssays · doi:10.1002/bies.201900162 · Cited by 262 · see citing works
Big data in basic and translational cancer research
Jiang, P., Sinha, S., Aldape, K., Hannenhalli, S., Sahinalp, C., & Ruppin, E. (2022) · Nature Reviews Cancer · doi:10.1038/s41568-022-00502-0 · Cited by 254 · see citing works
Self-citationYAP/TAZ as master regulators in cancer: modulation, function and therapeutic approaches
Piccolo, S., Panciera, T., Contessotto, P., & Cordenonsi, M. (2022) · Nature Cancer · doi:10.1038/s43018-022-00473-z · Cited by 250 · see citing works
Wu, V. H., Yeerna, H., Nohata, N., Chiou, J., Harismendy, O., Raimondi, F., Inoue, A., Russell, R. B., Tamayo, P., & Gutkind, J. S. (2019) · Journal of Biological Chemistry · doi:10.1074/jbc.rev119.005601 · Cited by 177 · see citing works
Self-citationXie, W., Wei, X., Kang, H., Jiang, H., Chu, Z., Lin, Y., Hou, Y., & Wei, Q. (2023) · Advanced Science · doi:10.1002/advs.202204594 · Cited by 176 · see citing works
Uchihara, T., Miyake, K., Yonemura, A., Komohara, Y., Itoyama, R., Koiwa, M., Yasuda, T., Arima, K., Harada, K., Eto, K., et al. (2020) · Cancer Research · doi:10.1158/0008-5472.can-19-3803 · Cited by 159 · see citing works
Synthetic lethality-mediated precision oncology via the tumor transcriptome
Lee, J. S., Nair, N. U., Dinstag, G., Chapman, L. M., Chung, Y., Wang, K., Sinha, S., Cha, H., Kim, D., Schperberg, A. V., et al. (2021) · Cell · doi:10.1016/j.cell.2021.03.030 · Cited by 154 · see citing works
Self-citationMolecular profiling of driver events in metastatic uveal melanoma
Karlsson, J. W., Nilsson, L. M., Mitra, S., Alsén, S., Shelke, G. V., Sah, V. R., Forsberg, E. M. V., Stierner, U. K., All‐Eriksson, C., Einarsdottir, B. O., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-15606-0 · Cited by 155 · see citing works
G Protein‐Coupled receptors and heterotrimeric G proteins as cancer drivers
Arang, N., & Gutkind, J. S. (2020) · FEBS Letters · doi:10.1002/1873-3468.14017 · Cited by 147 · see citing works
Self-citationHaderk, F., Chou, Y., Čech, L., Fernández-Méndez, C., Yu, J. X., Olivas, V. R., Meraz, I. M., Rabago, D. B., Kerr, D. L., Gómez, C. F., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-47423-0 · Cited by 106 · see citing works
Self-citationSilva, P., Fernández‐Díaz, D., Bande, M. F., Pardo, M., Loidi, L., & Blanco‐Teijeiro, M. J. (2022) · Cancers · doi:10.3390/cancers14133066 · Cited by 107 · see citing works
Mohanty, A. R., Pharaon, R. R., Nam, A., Salgia, S. K., Kulkarni, P., & Massarelli, E. (2020) · Expert Opinion on Investigational Drugs · doi:10.1080/13543784.2020.1740680 · Cited by 101 · see citing works
Yang, J., Wang, P., Zhang, Y., Zhang, M., Sun, Q., Chen, H., Dong, L., Chu, Z., Xue, B., Hoff, W. D., et al. (2024) · Cell stem cell · doi:10.1016/j.stem.2024.09.016 · Cited by 95 · see citing works
Targeted Therapy of Uveal Melanoma: Recent Failures and New Perspectives
Croce, M., Ferrini, S., Pfeffer, U., & Gangemi, R. M. R. (2019) · Cancers · doi:10.3390/cancers11060846 · Cited by 92 · see citing works
Roles and inhibitors of FAK in cancer: current advances and future directions
Hu, H.-H., Wang, S., Shang, H.-L., Lv, H., Chen, B., Gao, S., & Chen, X. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1274209 · Cited by 91 · see citing works
Rigiracciolo, D. C., Nohata, N., Lappano, R., Cirillo, F., Talia, M., Scordamaglia, D., Gutkind, J. S., & Maggiolini, M. (2020) · Cells · doi:10.3390/cells9041010 · Cited by 88 · see citing works
Self-citationMokhtari, R. B., Ashayeri, N., Baghaie, L., Sambi, M., Satari, K., Baluch, N., Bosykh, D. A., Szewczuk, M. R., & Chakraborty, S. (2023) · Cancers · doi:10.3390/cancers15133468 · Cited by 88 · see citing works
Transcription factors in fibroblast plasticity and CAF heterogeneity
Melchionna, R., Trono, P., Carlo, A. D., Modugno, F. D., & Nisticò, P. (2023) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-023-02934-4 · Cited by 87 · see citing works
Sánchez‐Espino, L. F., Ivars, M., Antoñanzas, J., & Baselga, E. (2023) · The Application of Clinical Genetics · doi:10.2147/tacg.s363685 · Cited by 85 · see citing works
Zhang, B., Zhang, Y., Zhang, J., Liu, P., Jiao, B., Wang, Z., & Ren, R. (2021) · Advanced Science · doi:10.1002/advs.202100250 · Cited by 83 · see citing works
Self-citationEndothelial YAP/TAZ Signaling in Angiogenesis and Tumor Vasculature
Hooglugt, A., van der Stoel, M. M., Boon, R. A., & Huveneers, S. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2020.612802 · Cited by 82 · see citing works
Paradis, J. S., Acosta, M., Saddawi‐Konefka, R., Kishore, A., Lubrano, S., Gomes, F., Arang, N., Tiago, M., Coma, S., Wu, X., et al. (2021) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-20-3363 · Cited by 76 · see citing works
Self-citationHeterotrimeric Gq proteins as therapeutic targets?
Kostenis, E., Pfeil, E. M., & Annala, S. (2020) · Journal of Biological Chemistry · doi:10.1074/jbc.rev119.007061 · Cited by 74 · see citing works
Self-citationRamms, D. J., Raimondi, F., Arang, N., Herberg, F. W., Taylor, S. S., & Gutkind, J. S. (2021) · Pharmacological Reviews · doi:10.1124/pharmrev.120.000269 · Cited by 71 · see citing works
Self-citationFAK, vinculin, and talin control mechanosensitive YAP nuclear localization
Holland, E. N., Fernández, M., Zhou, D. W., O’Neill, E. B., Woodfolk, A. U., Mora‐Boza, A., Fu, J., Schlaepfer, D. D., & Garcı́a, A. J. (2024) · Biomaterials · doi:10.1016/j.biomaterials.2024.122542 · Cited by 71 · see citing works
Self-citationFunctional characterization of uveal melanoma oncogenes
Ma, J., Weng, L., Bastian, B. C., & Chen, X. (2020) · Oncogene · doi:10.1038/s41388-020-01569-5 · Cited by 70 · see citing works
EGFR Regulates the Hippo pathway by promoting the tyrosine phosphorylation of MOB1
Ando, T., Arang, N., Wang, Z., Costea, D. E., Feng, X., Goto, Y., Izumi, H., Gilardi, M., Ando, K., & Gutkind, J. S. (2021) · Communications Biology · doi:10.1038/s42003-021-02744-4 · Cited by 67 · see citing works
Self-citationRodrigues, M. J., de Koning, L., Coupland, S. E., Jochemsen, A. G., Marais, R., Stern, M., Valente, A., Barnhill, R. L., Cassoux, N., Evans, A., et al. (2019) · Cancers · doi:10.3390/cancers11071032 · Cited by 67 · see citing works
Functional and clinical characteristics of focal adhesion kinases in cancer progression
Zhang, Z., Li, J., Jiao, S., Han, G., Zhu, J., & Liu, T. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.1040311 · Cited by 62 · see citing works
STRIPAK directs PP2A activity toward MAP4K4 to promote oncogenic transformation of human cells
Kim, J. W., Berrios, C. J., Kim, M., Schade, A. E., Adelmant, G., Yeerna, H., Damato, E., Iniguez, A. B., Swanson, S. K., Florens, L. A., et al. (2020) · eLife · doi:10.7554/elife.53003 · Cited by 54 · see citing works
Self-citationUveal melanoma: progress in molecular biology and therapeutics
Li, Y., Shi, J., Yang, J., Ge, S., Zhang, J., Jia, R., & Fan, X. (2020) · Therapeutic Advances in Medical Oncology · doi:10.1177/1758835920965852 · Cited by 55 · see citing works
A TAZ-AXL-ABL2 Feed-Forward Signaling Axis Promotes Lung Adenocarcinoma Brain Metastasis
Hoj, J. P., Mayro, B., & Pendergast, A. M. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.11.018 · Cited by 54 · see citing works
VE-Cadherin modulates β-catenin/TCF-4 to enhance Vasculogenic Mimicry
Delgado‐Bellido, D., Zamudio-Martínez, E., Fernández‐Cortés, M., Herrera-Campos, A. B., Olmedo-Pelayo, J., Perez, C. J., Expósito, J., de Álava, E., Amaral, A. T., O’Valle, F., et al. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-05666-7 · Cited by 51 · see citing works
MOB (Mps one Binder) Proteins in the Hippo Pathway and Cancer
Gündoğdu, R., & Hergovich, A. (2019) · Cells · doi:10.3390/cells8060569 · Cited by 51 · see citing works
Focal Adhesion Kinase Fine Tunes Multifaced Signals toward Breast Cancer Progression
Rigiracciolo, D. C., Cirillo, F., Talia, M., Muglia, L., Gutkind, J. S., Maggiolini, M., & Lappano, R. (2021) · Cancers · doi:10.3390/cancers13040645 · Cited by 53 · see citing works
Self-citationComputational methods, databases and tools for synthetic lethality prediction
Wang, J., Zhang, Q., Han, J., Zhao, Y., Zhao, C., Yan, B., Dai, C., Wu, L., Wen, Y., Zhang, Y., et al. (2022) · Briefings in Bioinformatics · doi:10.1093/bib/bbac106 · Cited by 50 · see citing works
Self-citationPathogenesis of Port-Wine Stains: Directions for Future Therapies
Liu, L., Li, X., Zhao, Q., Yang, L., & Jiang, X. L. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232012139 · Cited by 50 · see citing works
Hippo‐Yap/Taz signaling: Complex network interactions and impact in epithelial cell behavior
van Soldt, B. J., & Cardoso, W. V. (2019) · Wiley Interdisciplinary Reviews Developmental Biology · doi:10.1002/wdev.371 · Cited by 50 · see citing works
Goto, Y., Ando, T., Izumi, H., Feng, X., Arang, N., Gilardi, M., Wang, Z., Ando, K., & Gutkind, J. S. (2020) · Oncogene · doi:10.1038/s41388-020-1272-x · Cited by 47 · see citing works
Self-citationLubrano, S., Cervantes‐Villagrana, R. D., Faraji, F., Ramirez, S. I., Sato, K., Adame-Garcia, S. R., Officer, A., Arang, N., Rigiracciolo, D. C., Quiroz, P. Y. A., et al. (2025) · Cancer Cell · doi:10.1016/j.ccell.2025.02.001 · Cited by 49 · see citing works
Self-citationNew Insights on the Nuclear Functions and Targeting of FAK in Cancer
Pomella, S., Cassandri, M., Braghini, M. R., Marampon, F., Alisi, A., & Rota, R. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23041998 · Cited by 46 · see citing works
GPR39 Overexpression in OSCC Promotes YAP-Sustained Malignant Progression
Jiang, Y., Li, T., Wu, Y., Xu, H., Xie, C., Dong, Y., Zhong, L., Wang, Z., Zhao, H., Zhou, Y., et al. (2020) · Journal of Dental Research · doi:10.1177/0022034520915877 · Cited by 44 · see citing works
Self-citationTargeting primary and metastatic uveal melanoma with a G protein inhibitor
Onken, M. D., Makepeace, C. M., Kaltenbronn, K. M., Choi, J., Hernandez-Aya, L. F., Weilbaecher, K. N., Piggott, K., Rao, P. K., Yuede, C. M., Dixon, A. J., et al. (2021) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2021.100403 · Cited by 44 · see citing works
Harnessing the Co-vulnerabilities of Amino Acid-Restricted Cancers
Pathria, G., & Ronai, Z. A. (2021) · Cell Metabolism · doi:10.1016/j.cmet.2020.12.009 · Cited by 42 · see citing works
PARP Inhibition Increases the Response to Chemotherapy in Uveal Melanoma
de Koning, L., Decaudin, D., Botty, R. E., Nicolas, A., Carita, G., Schuller, M., Ouine, B., Cartier, A., Naguez, A., Fleury, J., et al. (2019) · Cancers · doi:10.3390/cancers11060751 · Cited by 41 · see citing works
Zhang, L., Zhao, D., Wang, Y., Zhang, W., Zhang, J., Fan, J., Zhan, Q., & Chen, J. (2020) · Molecular Carcinogenesis · doi:10.1002/mc.23273 · Cited by 38 · see citing works
Emerging Therapeutic Opportunities Based on Current Knowledge of Uveal Melanoma Biology
Vivet-Noguer, R., Tarin, M., Roman‐Roman, S., & Alsafadi, S. (2019) · Cancers · doi:10.3390/cancers11071019 · Cited by 40 · see citing works
LACTB suppresses melanoma progression by attenuating PP1A and YAP interaction
Ma, Y., Wang, L., He, F., Yang, J., Ding, Y., Ge, S., Fan, X., Zhou, Y., Xu, X., & Jia, R. (2021) · Cancer Letters · doi:10.1016/j.canlet.2021.02.022 · Cited by 39 · see citing works
Context-dependent transcriptional regulations of YAP/TAZ in cancer
Guo, Y., Luo, J., Zou, H., Liu, C., Deng, L., & Li, P. (2021) · Cancer Letters · doi:10.1016/j.canlet.2021.12.019 · Cited by 39 · see citing works
Faraji, F., Ramirez, S. I., Quiroz, P. Y. A., Mendez-Molina, A. N., & Gutkind, J. S. (2022) · Cells · doi:10.3390/cells11081370 · Cited by 40 · see citing works
Self-citationWang, H., Song, X., Liao, H., Wang, P., Zhang, Y., Che, L., Zhang, J., Zhou, Y., Cigliano, A., Ament, C. E., et al. (2020) · Hepatology · doi:10.1002/hep.31692 · Cited by 37 · see citing works
Song, G., Zhou, J., Song, R., Liu, D., Yu, W., Xie, W., Ma, Z., Gong, J., Meng, H., Yang, T., et al. (2020) · Stem Cell Research & Therapy · doi:10.1186/s13287-020-01940-z · Cited by 36 · see citing works
Secondary Somatic Mutations in G-Protein-Related Pathways and Mutation Signatures in Uveal Melanoma
Piaggio, F., Tozzo, V., Bernardi, C., Croce, M., Puzone, R., Viaggi, S., Patrone, S., Barla, A., Coviello, D. A., Jager, M. J., et al. (2019) · Cancers · doi:10.3390/cancers11111688 · Cited by 34 · see citing works
Multi-Functional Regulation by YAP/TAZ Signaling Networks in Tumor Progression and Metastasis
Thrash, H. L., & Pendergast, A. M. (2023) · Cancers · doi:10.3390/cancers15194701 · Cited by 33 · see citing works
G protein‐coupled receptors can control the Hippo/YAP pathway through Gq signaling
Zindel, D., Mensat, P., Vol, C., Homayed, Z., Charrier‐Savournin, F., Trinquet, E., Banères, J., Pin, J., Pannequin, J., Roux, T., et al. (2021) · The FASEB Journal · doi:10.1096/fj.202002159r · Cited by 33 · see citing works
The future of targeted kinase inhibitors in melanoma
Caksa, S., Baqai, U., & Aplin, A. E. (2022) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2022.108200 · Cited by 33 · see citing works
FACEts of mechanical regulation in the morphogenesis of craniofacial structures
Du, W. T., Bhojwani, A., & Hu, J. K. (2021) · International Journal of Oral Science · doi:10.1038/s41368-020-00110-4 · Cited by 33 · see citing works
Vergara, I. A., Wilmott, J. S., Long, G. V., & Scolyer, R. A. (2021) · Experimental Dermatology · doi:10.1111/exd.14287 · Cited by 33 · see citing works
MEK inhibition reduced vascular tumor growth and coagulopathy in a mouse model with hyperactive GNAQ
Schrenk, S., Bischoff, L. J., Goines, J., Cai, Y., Vemaraju, S., Odaka, Y., Good, S., Palumbo, J. S., Szabo, S., Reynaud, D., et al. (2023) · Nature Communications · doi:10.1038/s41467-023-37516-7 · Cited by 32 · see citing works
Zheng, C., Liu, H., Zhao, P., Lu, W., Song, S., He, T., Fan, J., Wang, D., Yang, P., Jie, Q., et al. (2023) · Science Translational Medicine · doi:10.1126/scitranslmed.adg3983 · Cited by 29 · see citing works
Lamhamedi-Cherradi, S.-E., Mohiuddin, S., Mishra, D. K., Krishnan, S., Velasco, A. R., Vetter, A. M., Pence, K. A., McCall, D. C., Truong, D. D., Cuglievan, B., et al. (2021) · Cancer Gene Therapy · doi:10.1038/s41417-020-00281-6 · Cited by 30 · see citing works
Genetic Landscape and Emerging Therapies in Uveal Melanoma
Seedor, R. S., Orloff, M. M., & Sato, T. (2021) · Cancers · doi:10.3390/cancers13215503 · Cited by 31 · see citing works
YAP and TAZ: Monocorial and bicorial transcriptional co-activators in human cancers
Sardo, F. L., Canu, V., Maugeri‐Saccà, M., Strano, S., & Blandino, G. (2022) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2022.188756 · Cited by 30 · see citing works
Update on GNA Alterations in Cancer: Implications for Uveal Melanoma Treatment
Larribère, L., & Utikal, J. S. (2020) · Cancers · doi:10.3390/cancers12061524 · Cited by 29 · see citing works
Recent Advances in Molecular and Genetic Research on Uveal Melanoma
Fuentes-Rodriguez, A., Mitchell, A., Guérin, S. L., & Landreville, S. (2024) · Cells · doi:10.3390/cells13121023 · Cited by 28 · see citing works
Targeted degradation of endogenous YAP by nanobody bioPROTAC inhibits tumor progression
Zhou, R., Wang, H., Zhang, G., Liu, Y., Liu, X., Li, Z., Shi, G., Yuan, J., Qu, C., Li, Y., et al. (2025) · Nature Communications · doi:10.1038/s41467-025-64426-7 · Cited by 28 · see citing works
Decaudin, D., Frisch-Dit-Leitz, E., Némati, F., Tarin, M., Naguez, A., Zerara, M., Marande, B., Vivet-Noguer, R., Halilovic, E., Fabre, C., et al. (2020) · European Journal of Cancer · doi:10.1016/j.ejca.2019.12.012 · Cited by 28 · see citing works
Dual roles of FAK in tumor angiogenesis: A review focused on pericyte FAK
Zhang, J., Li, W., Wang, W., Chen, Q., Xu, Z., Deng, M., Zhou, L., & He, G. (2023) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2023.175694 · Cited by 28 · see citing works
Self-citationHammill, A. M., & Boscolo, E. (2024) · Journal of Clinical Investigation · doi:10.1172/jci172842 · Cited by 27 · see citing works
Role of Hippo-YAP1/TAZ pathway and its crosstalk in cardiac biology
Chen, X., Yuan, W., Li, Y., Luo, J., & Hou, N. (2020) · International Journal of Biological Sciences · doi:10.7150/ijbs.47142 · Cited by 27 · see citing works
Targeting Oncogenic Gαq/11 in Uveal Melanoma
Lapadula, D., & Benovic, J. (2021) · Cancers · doi:10.3390/cancers13246195 · Cited by 27 · see citing works
PI3K/Akt/YAP signaling promotes migration and invasion of DLD‑1 colorectal cancer cells
Takeda, T., Yamamoto, Y., Tsubaki, M., Matsuda, T., Kimura, A., Shimo, N., & Nishida, S. (2022) · Oncology Letters · doi:10.3892/ol.2022.13226 · Cited by 27 · see citing works
Trigt, W. K. V., Kelly, K. M., & Hughes, C. C. W. (2022) · Frontiers in Human Neuroscience · doi:10.3389/fnhum.2022.1006027 · Cited by 29 · see citing works
Anbunathan, H., Verstraten, R., Singh, A. D., Harbour, J. W., & Bowcock, A. M. (2019) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-18-3052 · Cited by 26 · see citing works
YAP Activity is Not Associated with Survival of Uveal Melanoma Patients and Cell Lines
Kim, Y. J., Lee, S. C., Kim, S. E., Kim, S. K., Kim, S. K., & Lee, C. S. (2020) · Scientific Reports · doi:10.1038/s41598-020-63391-z · Cited by 25 · see citing works
Arang, N., Lubrano, S., Ceribelli, M., Rigiracciolo, D. C., Saddawi‐Konefka, R., Faraji, F., Ramirez, S. I., Kim, D., Tosto, F. A., Stevenson, E. J., et al. (2023) · Cell Reports Medicine · doi:10.1016/j.xcrm.2023.101244 · Cited by 26 · see citing works
Self-citationMITF deficiency accelerates GNAQ-driven uveal melanoma
Phelps, G. B., Hagen, H. R., Amsterdam, A., & Lees, J. A. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2107006119 · Cited by 24 · see citing works
Jiang, L., Zhou, Y., Tang, S., Yang, D., Zhang, Y., Zhang, J., Yang, F., Zhou, T., Xia, X., Chen, Q., et al. (2024) · International Journal of Oral Science · doi:10.1038/s41368-024-00308-w · Cited by 23 · see citing works
Self-citationSynergic Interactions Between Hepatic Stellate Cells and Uveal Melanoma in Metastatic Growth
Piquet, L., Dewit, L., Schoonjans, N., Millet, M., Bérubé, J., Gerges, P. R. A., Bordeleau, F., & Landreville, S. (2019) · Cancers · doi:10.3390/cancers11081043 · Cited by 23 · see citing works
State-of-the-art in Metastatic Uveal Melanoma Treatment: A 2025 Update
Ziogas, D. C., Foteinou, D., Theocharopoulos, C., Martinos, A., Petsiou, D., Anastasopoulou, A. N., & Gogas, H. J. (2025) · Current Oncology Reports · doi:10.1007/s11912-025-01684-0 · Cited by 22 · see citing works
Development of Combination Strategies for Focal Adhesion Kinase Inhibition in Diffuse Gastric Cancer
Peng, K., Zhang, F., Wang, Y., Sahgal, P., Li, T., Zhou, J. R., Liang, X., Zhang, Y., Sethi, N. S., Liu, T., et al. (2022) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-22-1609 · Cited by 22 · see citing works
New targeted and epigenetic therapeutic strategies for the treatment of uveal melanoma
Wei, A. Z., Maniar, A. B., & Carvajal, R. D. (2022) · Cancer Gene Therapy · doi:10.1038/s41417-022-00443-8 · Cited by 20 · see citing works
Cervantes‐Villagrana, R. D., García‐Jiménez, I., & Vázquez‐Prado, J. (2023) · Cellular Signalling · doi:10.1016/j.cellsig.2023.110749 · Cited by 20 · see citing works
Chen, J., Zhang, J., Zhu, Y., Zhu, Y., Pang, J., Wu, Q., Wang, Y., & Zhan, Q. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-025-02395-5 · Cited by 19 · see citing works
Phan, H. T. N., Kim, N. H., Wei, W., Tall, G. G., & Smrcka, A. V. (2021) · Science Signaling · doi:10.1126/scisignal.abj4243 · Cited by 19 · see citing works
Catalytic site mutations confer multiple states of G protein activation
Hewitt, N., Ma, N., Arang, N., Martin, S. A., Prakash, A., DiBerto, J. F., Knight, K. M., Ghosh, S., Olsen, R. H. J., Roth, B. L., et al. (2023) · Science Signaling · doi:10.1126/scisignal.abq7842 · Cited by 19 · see citing works
Self-citationUveal melanoma: Recent advances in immunotherapy
Sorrentino, F. S., Rosa, F. D., Terlizzi, P. D., Toneatto, G., Gabai, A., Finocchio, L., Salati, C., Spadea, L., & Zeppieri, M. (2024) · World Journal of Clinical Oncology · doi:10.5306/wjco.v15.i1.23 · Cited by 19 · see citing works
Strepkos, D., Markouli, M., Papavassiliou, K. A., Papavassiliou, A. G., & Piperi, C. (2021) · Neuropathology and Applied Neurobiology · doi:10.1111/nan.12762 · Cited by 19 · see citing works
Arang, N., Lubrano, S., Rigiracciolo, D. C., Nachmanson, D., Lippman, S. M., Mali, P., Harismendy, O., & Gutkind, J. S. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.102866 · Cited by 18 · see citing works
Self-citationSun, Q., Liang, R., Li, M., & Zhou, H. (2021) · Journal of Pharmacy and Pharmacology · doi:10.1093/jpp/rgab161 · Cited by 18 · see citing works
Uveal Melanoma: A European Network to Face the Many Challenges of a Rare Cancer
Piperno-Neumann, S., Piulats, J. M., Goebeler, M., Galloway, I., Lugowska, I. A., Becker, J. C., Vihinen, P., Calster, J. V., Hadjistilianou, T., Proença, R. D., et al. (2019) · Cancers · doi:10.3390/cancers11060817 · Cited by 18 · see citing works
G protein-coupled receptors as promising targets in cancer
Almeria, C. V. P., Setiawan, I. M., Siderius, M. H., & Smit, M. J. (2020) · Current Opinion in Endocrine and Metabolic Research · doi:10.1016/j.coemr.2020.10.005 · Cited by 17 · see citing works
Emerging therapeutic strategies for metastatic uveal melanoma: Targeting driver mutations
Liu, X., Run‐hua, Z., Pan, J., Li, Z., Yu, L., & Li, Y. (2024) · Pigment Cell & Melanoma Research · doi:10.1111/pcmr.13161 · Cited by 18 · see citing works
A Review of MicroRNA in Uveal Melanoma
Li, Y. F., Dong, L., Li, Y., & Wei, W. B. (2020) · OncoTargets and Therapy · doi:10.2147/ott.s253946 · Cited by 17 · see citing works
- Authors
- Feng, X., Arang, N., Rigiracciolo, D. C., Lee, J. S., Yeerna, H., Wang, Z., Lubrano, S., Kishore, A., Pachter, J. A., König, G. M., Maggiolini, M., Kostenis, E., Schlaepfer, D. D., Tamayo, P., Chen, Q., Ruppin, E., & Gutkind, J. S.
- Affiliations
- Sichuan University (CN)
- University of California San Diego (US)
- National Institutes of Health (US)
- Verastem (United States) (US)
- University of Bonn (DE)
- University of Calabria (IT)
- Corresponding author
- Lee, Joo Sang
- Chen, Qianming
- Ruppin, Eytan
- Gutkind, J. Silvio
- ORCID
- Venue
- Cancer Cell
- Publisher
- Elsevier BV
- Published
- 2019-03
- Volume
- 35
- Issue
- 3
- Pages
- 457-472.e5
- ISSN
- 1535-6108 (ISSN-L)
- PMC
- PMC6737937
- OpenAlex
- W2911710737
- Cited by
- 237
- References
- 71
- Citations by year
- 2026: 14 · 2025: 22 · 2024: 31 · 2023: 40 · 2022: 36 · 2021: 40 · 2020: 37 · 2019: 17
- FWCI
- 17.21
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cancer Cell (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Archive of Doctoral Theses and Digital Collections (University of Calabria) (submittedVersion)
- Funders
- NIH (R33CA225291, U01CA217885, P30 CA023100, R01HG009285, 10193SC, CA209891, CA102310, T32GM007752)
- DGE (1650112, T32CA067754-22)
- MOE (B14038)
- National Natural Science Foundation (81672677, 81520108009, 81621062)
- AIRC (IG 21322)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Hippo pathway signaling and YAP/TAZ
- Health Sciences › Medicine › Ophthalmology › Ocular Oncology and Treatments
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Kinase Regulation and GTPase Signaling
- Keywords
- uveal melanoma, GNAQ, GNA11, focal adhesion kinase, synthetic lethality, Hippo signaling pathway, YAP, MOB1, tyrosine phosphorylation, therapeutic target
- MeSH terms
- Hippo Signaling Pathway, Uveal Melanoma, Animals, Genes, Lethal, Humans, Melanoma, Neoplasm Transplantation, Phosphorylation, Prognosis, Uveal Neoplasms, Signal Transduction, Survival Analysis, Protein Serine-Threonine Kinases, Computational Biology, GTP-Binding Protein alpha Subunits, Gq-G11, Cell Line, Tumor, Cell Proliferation, Mice, Focal Adhesion Kinase 1
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review