Cited by 524Cancer-related Molecular PathwaysGenomics and Chromatin DynamicsChromatin Remodeling and Cancer

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The DREAM complex: master coordinator of cell cycle-dependent gene expression

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Sadasivam, Subhashini, DeCaprio, James A.·2013·Nature Reviews Cancer

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Abstract

The dimerization partner, RB-like, E2F and multi-vulval class B (DREAM) complex provides a previously unsuspected unifying role in the cell cycle by directly linking p130, p107, E2F, BMYB and forkhead box protein M1. DREAM mediates gene repression during the G0 phase and coordinates periodic gene expression with peaks during the G1/S and G2/M phases. Perturbations in DREAM complex regulation shift the balance from quiescence towards proliferation and contribute to the increased mitotic gene expression levels that are frequently observed in cancers with a poor prognosis.

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Authors: Sadasivam, S., & DeCaprio, J. A.
Affiliations: National Centre for Biological Sciences (IN)
Brigham and Women's Hospital (US)
Corresponding author: DeCaprio, James A.
ORCID: Sadasivam, Subhashini
DeCaprio, James A.
Venue: Nature Reviews Cancer
Publisher: Springer Science and Business Media LLC
Published: 2013-07-11
Volume: 13
Issue: 8
Pages: 585-595
ISSN: 1474-175X (ISSN-L)
1474-1768
DOI: 10.1038/nrc3556
PMC: PMC3986830
OpenAlex: W2025718369
Cited by: 524
References: 142
Citations by year: 2026: 29 · 2025: 45 · 2024: 33 · 2023: 49 · 2022: 58 · 2021: 52 · 2020: 42 · 2019: 43 · 2018: 38 · 2017: 41 · 2016: 35 · 2015: 30 · 2014: 23 · 2013: 6
FWCI: 3.32
Type: journal article
Language: en
Update notices: erratum (2013-08-23)
Open access: green
europepmc.org
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature reviews. Cancer (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Cancer Institute (R01CA173023, R01CA63113, P01CA050661, R01CA063113)
Topics: Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
Keywords: DREAM complex, cell cycle regulation, cell cycle-dependent gene expression, p130, p107, E2F transcription factors, FOXM1, gene repression, G0 quiescence, cell proliferation, tumor progression, cancer prognosis
MeSH terms: Cell Cycle, Cell Transformation, Neoplastic, Gene Expression Regulation, Humans, Transcription Factors, Retinoblastoma Protein, Cell Cycle Proteins, Cell Proliferation

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The DREAM complex: master coordinator of cell cycle-dependent gene expression

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