The DREAM complex: master coordinator of cell cycle-dependent gene expression

Molecular portraits of human breast tumours

Perou, C., Sørlie, T., Eisen, M., van de Rijn, M., Jeffrey, S., Rees, C. A., Pollack, J., Ross, D., Johnsen, H., Akslen, L., et al. (2000) · Nature · doi:10.1038/35021093 · Cited by 16,551

Integrated genomic analyses of ovarian carcinoma

Perou, C. M. (2019) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/hvp3-wg08 · Cited by 7,927

A Multigene Assay to Predict Recurrence of Tamoxifen-Treated, Node-Negative Breast Cancer

Paik, S., Shak, S., Tang, G., Kim, C., Baker, J. B., Cronin, M. T., Baehner, F. L., Walker, M. G., Watson, D., Park, T., et al. (2004) · New England Journal of Medicine · doi:10.1056/nejmoa041588 · Cited by 6,321

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

Serrano, M., Lin, A. W., McCurrach, M. E., Beach, D., & Lowe, S. W. (1997) · Cell · doi:10.1016/s0092-8674(00)81902-9 · Cited by 5,218

Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control

Zhao, B., Wei, X., Li, W., Udan, R. S., Yang, Q., Kim, J., Xie, J., Ikenoue, T., Yu, J., Li, L., et al. (2007) · Genes & Development · doi:10.1101/gad.1602907 · Cited by 3,092

The Hippo Signaling Pathway Coordinately Regulates Cell Proliferation and Apoptosis by Inactivating Yorkie, the Drosophila Homolog of YAP

Huang, J., Wu, S., Barrera, J. A., Matthews, K. A., & Pan, D. (2005) · Cell · doi:10.1016/j.cell.2005.06.007 · Cited by 1,917

The Hippo pathway and human cancer

Harvey, K. F., Zhang, X., & Thomas, D. M. (2013) · Nature reviews. Cancer · doi:10.1038/nrc3458 · Cited by 1,867

Identification of Genes Periodically Expressed in the Human Cell Cycle and Their Expression in Tumors

Whitfield, M. L., Sherlock, G., Saldanha, A. J., Murray, J. I., Ball, C. A., Alexander, K. E., Matese, J. C., Perou, C. M., Hurt, M. M., Brown, P. O., et al. (2002) · Molecular Biology of the Cell · doi:10.1091/mbc.02-02-0030 · Cited by 1,527

A coordinated phosphorylation by Lats and CK1 regulates YAP stability through SCF β-TRCP

Zhao, B., Li, L., Tumaneng, K., Wang, C.-Y., & Guan, K.-L. (2010) · Genes & Development · doi:10.1101/gad.1843810 · Cited by 1,418

A signature of chromosomal instability inferred from gene expression profiles predicts clinical outcome in multiple human cancers

Carter, S. L., Eklund, A. C., Kohane, I. S., Harris, L. N., & Szállási, Z. (2006) · Nature Genetics · doi:10.1038/ng1861 · Cited by 1,199

Senescence in tumours: evidence from mice and humans

Collado, M., & Serrano, M. (2010) · Nature Reviews Cancer · doi:10.1038/nrc2772 · Cited by 1,124

The Hippo Signaling Pathway Components Lats and Yap Pattern Tead4 Activity to Distinguish Mouse Trophectoderm from Inner Cell Mass

Nishioka, N., Inoue, K., Adachi, K., Kiyonari, H., Ota, M., Ralston, A., Yabuta, N., Hirahara, S., Stephenson, R. O., Ogonuki, N., et al. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.02.003 · Cited by 1,120

Large-scale meta-analysis of cancer microarray data identifies common transcriptional profiles of neoplastic transformation and progression

Rhodes, D. R., Yu, J., Sundaram, S. K., Deshpande, N., Varambally, R., Ghosh, D., Barrette, T. R., Pandey, A., & Chinnaiyan, A. M. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0401994101 · Cited by 1,018

FoxM1 is required for execution of the mitotic programme and chromosome stability

Laoukili, J., Kooistra, M. R. H., Brás, A., Kauw, J. J. W., Kerkhoven, R. M., Morrison, A. J., Clevers, H. C., & Medema, R. H. (2005) · Nature Cell Biology · doi:10.1038/ncb1217 · Cited by 808

Tumor Suppressor LATS1 Is a Negative Regulator of Oncogene YAP

Hao, Y., Chun, A., Cheung, K. J., Rashidi, B., & Yang, X. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m709037200 · Cited by 802

The novel ATM-related protein TRRAP is an essential cofactor for the c-Myc and E2F oncoproteins

McMahon, S. B., Van Buskirk, H. A., Dugan, K. A., Copeland, T. D., & Cole, M. D. (1998) · Cell · doi:10.1016/s0092-8674(00)81479-8 · Cited by 693

Common markers of proliferation

Whitfield, M. L., George, L. K., Grant, G. D., & Perou, C. M. (2006) · Nature Reviews Cancer · doi:10.1038/nrc1802 · Cited by 650

Forkhead box M1 regulates the transcriptional network of genes essential for mitotic progression and genes encoding the SCF (Skp2-Cks1) ubiquitin ligase

Wang, I.-C., Chen, Y.-J., Hughes, D., Petrovic, V., Major, M. L., Park, H. J., Tan, Y., Ackerson, T., & Costa, R. H. (2005) · Molecular and Cellular Biology · doi:10.1128/mcb.25.24.10875-10894.2005 · Cited by 627

Analysis of promoter binding by the E2F and pRB families in vivo: distinct E2F proteins mediate activation and repression

Takahashi, Y., Rayman, J. B., & Dynlacht, B. D. (2000) · Genes & Development · doi:10.1101/gad.14.7.804 · Cited by 621

The v-myb oncogene product binds to and activates the promyelocyte-specific mim-1 gene

Ness, S. A., Marknell, Å., & Graf, T. (1989) · Cell · doi:10.1016/0092-8674(89)90767-8 · Cited by 453

pRB and p107/p130 are required for the regulated expression of different sets of E2F responsive genes

Hurford, R. K., Cobrinik, D., Lee, M. H., & Dyson, N. (1997) · Genes & Development · doi:10.1101/gad.11.11.1447 · Cited by 431

The let-23 gene necessary for Caenorhabditis elegans vulval induction encodes a tyrosine kinase of the EGF receptor subfamily

Aroian, R. V., Koga, M., Mendel, J., Ohshima, Y., & Sternberg, P. W. (1990) · Nature · doi:10.1038/348693a0 · Cited by 416

Caenorhabditis elegans ras gene let-60 acts as a switch in the pathway of vulval induction

Beitel, G. J., Clark, S. G., & Horvitz, H. (1990) · Nature · doi:10.1038/348503a0 · Cited by 414

Endogenous Purification Reveals GREB1 as a Key Estrogen Receptor Regulatory Factor

Mohammed, H., D’Santos, C., Serandour, A. A., Ali, H. R., Brown, G. D., Atkins, A., Rueda, O. M., Holmes, K. A., Theodorou, V., Robinson, J. L. L., et al. (2013) · Cell Reports · doi:10.1016/j.celrep.2013.01.010 · Cited by 400

Evolutionarily Conserved Multisubunit RBL2/p130 and E2F4 Protein Complex Represses Human Cell Cycle-Dependent Genes in Quiescence

Litovchick, L., Sadasivam, S., Florens, L., Zhu, X., Swanson, S. K., Velmurugan, S., Chen, R., Washburn, M. P., Liu, X. S., & DeCaprio, J. A. (2007) · Molecular Cell · doi:10.1016/j.molcel.2007.04.015 · Cited by 396

let-60, a gene that specifies cell fates during C. elegans vulval induction, encodes a ras protein

Han, M., & Sternberg, P. W. (1990) · Cell · doi:10.1016/0092-8674(90)90495-z · Cited by 394

Dissecting the Unique Role of the Retinoblastoma Tumor Suppressor during Cellular Senescence

Chicas, A., Wang, X., Zhang, C., McCurrach, M., Zhao, Z., Mert, O., Dickins, R. A., Narita, M., Zhang, M., & Lowe, S. W. (2010) · Cancer Cell · doi:10.1016/j.ccr.2010.01.023 · Cited by 388

A human B‐cell interactome identifies MYB and FOXM1 as master regulators of proliferation in germinal centers

Lefèbvre, C., Rajbhandari, P., Alvarez, M. J., Bandaru, P., Lim, W. K., Sato, M., Wang, K., Sumazin, P., Kustagi, M., Bisikirska, B. C., et al. (2010) · Molecular Systems Biology · doi:10.1038/msb.2010.31 · Cited by 374

Plk1-dependent phosphorylation of FoxM1 regulates a transcriptional programme required for mitotic progression

Fu, Z., Malureanu, L. A., Huang, J., Wang, W., Li, H., van Deursen, J. M., Tindall, D. J., & Chen, J. (2008) · Nature Cell Biology · doi:10.1038/ncb1767 · Cited by 357

The Forkhead Box m1 Transcription Factor Stimulates the Proliferation of Tumor Cells during Development of Lung Cancer

Kim, I., Ackerson, T. J., Ramakrishna, S., Tretiakova, M., Wang, I., Kalin, T. V., Major, M. L., Gusarova, G. A., Yoder, H. M., Costa, R. H., et al. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-3003 · Cited by 338

Herpes viral cyclin/Cdk6 complexes evade inhibition by CDK inhibitor proteins

Swanton, C., Mann, D. J., Fleckenstein, B., Neipel, F., Peters, G. G., & Jones, N. (1997) · Nature · doi:10.1038/36606 · Cited by 334

A genetic pathway for the specification of the vulval cell lineages of Caenorhabditis elegans

Ferguson, E. L., Sternberg, P. W., & Horvitz, H. R. (1987) · Nature · doi:10.1038/326259a0 · Cited by 334

The MuvB complex sequentially recruits B-Myb and FoxM1 to promote mitotic gene expressionPreprint

Sadasivam, S., Duan, S., & DeCaprio, J. A. (2012) · Genes & Development · doi:10.1101/gad.181933.111 · Cited by 323

DYRK family of protein kinases: evolutionary relationships, biochemical properties, and functional roles

Aranda, S., Laguna, A., & de la Luna, S. (2011) · The FASEB Journal · doi:10.1096/fj.10-165837 · Cited by 320

E2Fs link the control of G1/S and G2/M transcription

Zhu, W., Giangrande, P. H., & Nevins, J. R. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600459 · Cited by 319

FoxM1B Is Overexpressed in Human Glioblastomas and Critically Regulates the Tumorigenicity of Glioma Cells

Liu, M., Dai, B., Kang, S.-H., Ban, K., Huang, F.-J., Lang, F. F., Aldape, K., Xie, T., Pelloski, C. E., Xie, K., et al. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-2912 · Cited by 314

Genome-scale RNAi profiling of cell division in human tissue culture cells

Kittler, R., Pelletier, L., Heninger, A., Slabicki, M. M., Theis, M., Mirosław, Ł., Poser, I., Lawo, S., Grabner, H., Kozak, K., et al. (2007) · Nature Cell Biology · doi:10.1038/ncb1659 · Cited by 303

E2F4 and E2F5 Play an Essential Role in Pocket Protein–Mediated G1 Control

Gaubatz, S., Lindeman, G. J., Ishida, S., Jakoi, L., Nevins, J. R., Livingston, D. M., & Rempel, R. E. (2000) · Molecular Cell · doi:10.1016/s1097-2765(00)00071-x · Cited by 302

Relationship Between Tumor Gene Expression and Recurrence in Four Independent Studies of Patients With Stage II/III Colon Cancer Treated With Surgery Alone or Surgery Plus Adjuvant Fluorouracil Plus Leucovorin

O’Connell, M. J., Lavery, I. C., Yothers, G., Paik, S., Clark-Langone, K. M., Lopatin, M., Watson, D., Baehner, F. L., Shak, S., Baker, J. B., et al. (2010) · Journal of Clinical Oncology · doi:10.1200/jco.2010.28.9538 · Cited by 302

DYRK1A protein kinase promotes quiescence and senescence through DREAM complex assembly

Litovchick, L., Florens, L. A., Swanson, S. K., Washburn, M. P., & DeCaprio, J. A. (2011) · Genes & Development · doi:10.1101/gad.2034211 · Cited by 302

Native E2F/RBF Complexes Contain Myb-Interacting Proteins and Repress Transcription of Developmentally Controlled E2F Target Genes

Korenjak, M., Taylor‐Harding, B., Binné, U. K., Satterlee, J. S., Nolan-Stevaux, O., Aasland, R., White‐Cooper, H., Dyson, N. J., & Brehm, A. (2004) · Cell · doi:10.1016/j.cell.2004.09.034 · Cited by 285

Senescence-associated heterochromatin foci are dispensable for cellular senescence, occur in a cell type- and insult-dependent manner and follow expression of p16ink4a

Kosar, M., Bartkova, J., Hubackova, S., Hodny, Z., Lukas, J., & Bartek, J. (2011) · Cell Cycle · doi:10.4161/cc.10.3.14707 · Cited by 283

Increased Levels of the FoxM1 Transcription Factor Accelerate Development and Progression of Prostate Carcinomas in both TRAMP and LADY Transgenic Mice

Kalin, T. V., Wang, I., Ackerson, T. J., Major, M. L., Detrisac, C. J., Kalinichenko, V. V., Lyubimov, A. V., & Costa, R. H. (2006) · Cancer Research · doi:10.1158/0008-5472.can-05-3138 · Cited by 272

The multivulva phenotype of certain Caenorhabditis elegans mutants results from defects in two functionally redundant pathways.

Ferguson, E. L., & Horvitz, H. R. (1989) · Genetics · doi:10.1093/genetics/123.1.109 · Cited by 262

The pRb-related protein p130 is regulated by phosphorylation-dependent proteolysis via the protein–ubiquitin ligase SCFSkp2Preprint

Tedesco, D., Lukas, J., & Reed, S. I. (2002) · Genes & Development · doi:10.1101/gad.1011202 · Cited by 261

Identification of a Drosophila Myb-E2F2/RBF transcriptional repressor complexPreprint

Lewis, P. W., Beall, E. L., Fleischer, T. C., Georlette, D., Link, A. J., & Botchan, M. R. (2004) · Genes & Development · doi:10.1101/gad.1255204 · Cited by 259

Introduction to the E2F Family: Protein Structure and Gene Regulation

Slansky, J. E., & Farnham, P. (1996) · Current topics in microbiology and immunology · doi:10.1007/978-3-642-79910-5_1 · Cited by 245

The winged-helix transcription factor Trident is expressed in cycling cells

Korver, W., Roose, J. P., & Clevers, H. C. (1997) · Nucleic Acids Research · doi:10.1093/nar/25.9.1715 · Cited by 240

Cell cycle-dependent and cell cycle-independent control of transcription by theDrosophilaE2F/RB pathwayPreprint

Dimova, D. K., Nolan-Stevaux, O., Frolov, M. V., & Dyson, N. J. (2003) · Genes & Development · doi:10.1101/gad.1116703 · Cited by 235

The Forkhead Transcription Factor FOXM1 Controls Cell Cycle-Dependent Gene Expression through an Atypical Chromatin Binding Mechanism

Chen, X. X., Müller, G. A., Quaas, M., Fischer, M., Han, N., Stutchbury, B., Sharrocks, A. D., & Engeland, K. (2012) · Molecular and Cellular Biology · doi:10.1128/mcb.00881-12 · Cited by 228

Role for a Drosophila Myb-containing protein complex in site-specific DNA replication

Beall, E. L., Manak, J. R., Zhou, S., Bell, M., Lipsick, J. S., & Botchan, M. R. (2002) · Nature · doi:10.1038/nature01228 · Cited by 223

Cloning and Characterization of Mouse E2F8, a Novel Mammalian E2F Family Member Capable of Blocking Cellular Proliferation

Maiti, B., Li, J., de Bruin, A., Gordon, F., Timmers, C. D., Opavský, R., Patil, K., Tuttle, J., Cleghorn, W. M., & Leone, G. W. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m501410200 · Cited by 194

Characterization of E2F8, a novel E2F-like cell-cycle regulated repressor of E2F-activated transcription

Christensen, J. M. (2005) · Nucleic Acids Research · doi:10.1093/nar/gki855 · Cited by 191

YAP, TAZ, and Yorkie: a conserved family of signal-responsive transcriptional coregulators in animal development and human diseaseThis paper is one of a selection of papers published in this Special Issue, entitled CSBMCB’s 51st Annual Meeting – Epigenetics and Chromatin Dynamics, and has undergone the Journal’s usual peer review process.

Wang, K., Degerny, C., Xu, M., & Yang, X.-J. (2009) · Biochemistry and Cell Biology · doi:10.1139/o08-114 · Cited by 180

LINC, a Human Complex That is Related to pRB-Containing Complexes in Invertebrates Regulates the Expression of G2/M Genes

Schmit, F., Korenjak, M., Mannefeld, M., Schmitt, K., Franke, C., von Eyss, B., Gagrica, S., Hanel, F., Brehm, A., & Gaubatz, S. (2007) · Cell Cycle · doi:10.4161/cc.6.15.4512 · Cited by 179

Degradation of p27Kip cdk inhibitor triggered by Kaposi's sarcoma virus cyclin–cdk6 complex

Ellis, M. A., Chew, Y. P., Fallis, L., Freddersdorf, S., Boshoff, C., Weiss, R. A., Lü, X., & Mittnacht, S. (1999) · The EMBO Journal · doi:10.1093/emboj/18.3.644 · Cited by 178

dpl-1 DP and efl-1 E2F Act with lin-35 Rb to Antagonize Ras Signaling in C. elegans Vulval Development

Ceol, C. J., & Horvitz, H. R. (2001) · Molecular Cell · doi:10.1016/s1097-2765(01)00194-0 · Cited by 178

A zebrafish bmyb mutation causes genome instability and increased cancer susceptibility

Shepard, J. L., Amatruda, J. F., Stern, H. M., Subramanian, A., Finkelstein, D., Ziai, J. M., Finley, K. R., Pfaff, K. L., Hersey, C., Zhou, Y., et al. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0506583102 · Cited by 164

Activation of FoxM1 during G2 Requires Cyclin A/Cdk-Dependent Relief of Autorepression by the FoxM1 N-Terminal Domain

Laoukili, J., Álvarez‐Fernández, M., Meijer, L. A. T., Stahl, M., Mohammed, S., Kleij, L., Heck, A. J. R., & Medema, R. H. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.01710-07 · Cited by 164

Canonical and atypical E2Fs regulate the mammalian endocycle

Chen, H.-Z., Ouseph, M. M., Li, J., Pécot, T., Chokshi, V., Kent, L., Bae, S., Byrne, M., Duran, C., Comstock, G., et al. (2012) · Nature Cell Biology · doi:10.1038/ncb2595 · Cited by 161

Structure of the FoxM1 DNA-recognition domain bound to a promoter sequence

Littler, D. R., Álvarez‐Fernández, M., Stein, A., Hibbert, R. G., Heidebrecht, T., Aloy, P., Medema, R. H., & Anastassis Perrakis, A. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq194 · Cited by 157

E2F7, a novel target, is up-regulated by p53 and mediates DNA damage-dependent transcriptional repression

Carvajal, L. A., Hamard, P.-J., Tonnessen, C., & Manfredi, J. J. (2012) · Genes & Development · doi:10.1101/gad.184911.111 · Cited by 151

Some C. elegans class B synthetic multivulva proteins encode a conserved LIN-35 Rb-containing complex distinct from a NuRD-like complex

Harrison, M. M., Ceol, C. J., Lu, X., & Horvitz, H. R. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0608461103 · Cited by 142

Genomic profiling and expression studies reveal both positive and negative activities for the Drosophila Myb–MuvB/dREAM complex in proliferating cellsPreprint

Georlette, D., Ahn, S., MacAlpine, D. M., Cheung, E. J., Lewis, P. W., Beall, E. L., Bell, S. P., Speed, T. P., Manak, J. R., & Botchan, M. R. (2007) · Genes & Development · doi:10.1101/gad.1600107 · Cited by 141

B-MYB, a transcription factor implicated in regulating cell cycle, apoptosis and cancer

Sala, A. (2005) · European Journal of Cancer · doi:10.1016/j.ejca.2005.08.004 · Cited by 140

A New Class of C. elegans synMuv Genes Implicates a Tip60/NuA4-like HAT Complex as a Negative Regulator of Ras Signaling

Ceol, C. J., & Horvitz, H. R. (2004) · Developmental Cell · doi:10.1016/s1534-5807(04)00065-6 · Cited by 137

Biological Functions of the Genes in the Mammaprint Breast Cancer Profile Reflect the Hallmarks of Cancer

Tian, S., Roepman, P., Veer, L. J. V., Bernards, R., Snoo, F. D., & Glas, A. M. (2010) · Biomarker Insights · doi:10.4137/bmi.s6184 · Cited by 137

Uncoupling of S phase and mitosis in cardiomyocytes and hepatocytes lacking the winged-helix transcription factor Trident

Korver, W., Schilham, M. W., Moerer, P., van den Hoff, M. J. B., Dam, K. V., Lamers, W. H., Medema, R. H., & Clevers, H. C. (1998) · Current Biology · doi:10.1016/s0960-9822(07)00563-5 · Cited by 135

Proteolytic Control of the Oncoprotein Transcription Factor Myc

Thomas, L. R., & Tansey, W. P. (2011) · Advances in cancer research · doi:10.1016/b978-0-12-386469-7.00004-9 · Cited by 132

The atypical E2F family member E2F7 couples the p53 and RB pathways during cellular senescencePreprint

Aksoy, O., Chicas, A., Zeng, T., Zhao, Z., McCurrach, M. E., Wang, X., & Lowe, S. W. (2012) · Genes & Development · doi:10.1101/gad.196238.112 · Cited by 130

A kinase shRNA screen links LATS2 and the pRB tumor suppressorPreprint

Tschöp, K., Conery, A. R., Litovchick, L., DeCaprio, J. A., Settleman, J. E., Harlow, E., & Dyson, N. J. (2011) · Genes & Development · doi:10.1101/gad.2000211 · Cited by 129

Subunit Composition Determines E2F DNA-Binding Site Specificity

Tao, Y., Kassatly, R. F., Cress, W. D., & Horowitz, J. M. (1997) · Molecular and Cellular Biology · doi:10.1128/mcb.17.12.6994 · Cited by 129

Integrated genomic analyses of ovarian carcinoma

The Cancer Genome Atlas Research Network (2011) · Nature · doi:10.1038/nature10166 · Cited by 129

E2F-8: an E2F family member with a similar organization of DNA-binding domains to E2F-7

Logan, N. A., Graham, A., Zhao, X., Fisher, R., Maiti, B., Leone, G. W., & Thangue, N. B. L. (2005) · Oncogene · doi:10.1038/sj.onc.1208703 · Cited by 125

E2F7 represses a network of oscillating cell cycle genes to control S-phase progression

Westendorp, B., Mokry, M., Groot Koerkamp, M. J. A., Holstege, F. C. P., Cuppen, E., & de Bruin, A. (2012) · Nucleic Acids Research · doi:10.1093/nar/gkr1203 · Cited by 125

FoxM1 is a downstream target and marker of HER2 overexpression in breast cancer

Lam (2009) · International Journal of Oncology · doi:10.3892/ijo_00000313 · Cited by 124

The central role of CDE/CHR promoter elements in the regulation of cell cycle‐dependent gene transcription

Müller, G. A., & Engeland, K. (2009) · FEBS Journal · doi:10.1111/j.1742-4658.2009.07508.x · Cited by 123

The human synMuv‐like protein LIN‐9 is required for transcription of G2/M genes and for entry into mitosis

Osterloh, L., von Eyß, B., Schmit, F., Rein, L., Hübner, D., Samans, B., Hauser, S., & Gaubatz, S. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601478 · Cited by 123

A role for E2F6 in distinguishing G1/S- and G2/M-specific transcriptionPreprint

Giangrande, P. H., Zhu, W., Schlisio, S., Sun, X., Mori, S., Gaubatz, S., & Nevins, J. R. (2004) · Genes & Development · doi:10.1101/gad.1239304 · Cited by 121

Anaphase-Promoting Complex/Cyclosome-Cdh1-Mediated Proteolysis of the Forkhead Box M1 Transcription Factor Is Critical for Regulated Entry into S Phase

Park, H. J., Costa, R. H., Lau, L. F., Tyner, A. L., & Raychaudhuri, P. (2008) · Molecular and Cellular Biology · doi:10.1128/mcb.00387-08 · Cited by 118

Mammalian Mip/LIN-9 interacts with either the p107, p130/E2F4 repressor complex or B-Myb in a cell cycle-phase-dependent context distinct from the Drosophila dREAM complex

Pilkinton, M. A., Sandoval, R., & Colamonici, O. R. (2007) · Oncogene · doi:10.1038/sj.onc.1210562 · Cited by 115

Phosphorylation and activation of B-Myb by cyclin A–Cdk2

Ziebold, U., Bartsch, O., Marais, R., Ferrari, S. M., & Klempnauer, K. (1997) · Current Biology · doi:10.1016/s0960-9822(06)00121-7 · Cited by 113

Distinct mechanisms act in concert to mediate cell cycle arrest

Toettcher, J. E., Loewer, A., Ostheimer, G. J., Yaffe, M. B., Tidor, B., & Lahav, G. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0806196106 · Cited by 112

The CHR promoter element controls cell cycle-dependent gene transcription and binds the DREAM and MMB complexes

Müller, G. A., Quaas, M., Schümann, M., Krause, E., Padi, M., Fischer, M., Litovchick, L., DeCaprio, J. A., & Engeland, K. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkr793 · Cited by 110

p53 can repress transcription of cell cycle genes through a p21WAF1/CIP1-dependent switch from MMB to DREAM protein complex binding at CHR promoter elements

Quaas, M., Müller, G. A., & Engeland, K. (2012) · Cell Cycle · doi:10.4161/cc.22917 · Cited by 107

LIN54 is an essential core subunit of the DREAM/LINC complex that binds to the cdc2 promoter in a sequence‐specific manner

Schmit, F., Cremer, S., & Gaubatz, S. (2009) · FEBS Journal · doi:10.1111/j.1742-4658.2009.07261.x · Cited by 105

Activation of human B-MYB by cyclins

Sala, A., Kundu, M., Casella, I., Engelhard, A., Calabretta, B., Grasso, L., Paggi, M. G., Giordano, A., Watson, R. J., Khalili, K., et al. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.2.532 · Cited by 104

Cell cycle regulation by the B-Myb transcription factor

Joaquin, M., & Watson, R. J. (2003) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-003-3037-4 · Cited by 102

DNA binding activity and transcriptional activator function of the human B-myb protein compared with c-MYB.

Mizuguchi, G., Nakagoshi, H., Nagase, T., Nomura, N., Date, T., Ueno, Y., & Ishii, S. (1990) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)38844-1 · Cited by 101

Discovery of tMAC: a Drosophila testis-specific meiotic arrest complex paralogous to Myb–Muv BPreprint

Beall, E. L., Lewis, P. W., Bell, M., Rocha, M., Jones, D. L., & Botchan, M. R. (2007) · Genes & Development · doi:10.1101/gad.1516607 · Cited by 99

In vitro and in vivo analysis of B-Myb in basal-like breast cancer

Thorner, A. R., Hoadley, K. A., Parker, J. S., Winkel, S., Millikan, R. C., & Perou, C. M. (2008) · Oncogene · doi:10.1038/onc.2008.430 · Cited by 98

synMuv B proteins antagonize germline fate in the intestine and ensure C. elegans survival

Petrella, L. N., Wang, W., Spike, C. A., Rechtsteiner, A., Reinke, V., & Strome, S. (2011) · Development · doi:10.1242/dev.059501 · Cited by 92

A Lin-9 complex is recruited by B-Myb to activate transcription of G2/M genes in undifferentiated embryonal carcinoma cells

Knight, A. S., Notaridou, M., & Watson, R. J. (2009) · Oncogene · doi:10.1038/onc.2009.22 · Cited by 90

Binding of FoxM1 to G2/M gene promoters is dependent upon B-Myb

Down, C. F., Millour, J., Lam, E. W. ‐., & Watson, R. J. (2012) · Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms · doi:10.1016/j.bbagrm.2012.03.008 · Cited by 87

Chorion Gene Amplification in Drosophila: A Model for Metazoan Origins of DNA Replication and S-Phase Control

Calvi, B. R., & Spradling, A. C. (1999) · Methods · doi:10.1006/meth.1999.0799 · Cited by 86

B-MYB Is Required for Recovery from the DNA Damage–Induced G2 Checkpoint in p53 Mutant Cells

Mannefeld, M., Klassen, E., & Gaubatz, S. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-4156 · Cited by 82

The cell-cycle regulated transcription factor B-Myb is phosphorylated by Cyclin A/Cdk2 at sites that enhance its transactivation properties

Saville, M. K., & Watson, R. J. (1998) · Oncogene · doi:10.1038/sj.onc.1202503 · Cited by 81

Myb proteins: angels and demons in normal and transformed cells

Zhou, Y. E. (2010) · Frontiers in bioscience · doi:10.2741/3738 · Cited by 80

Dm-myb mutant lethality in Drosophila is dependent upon mip130: positive and negative regulation of DNA replicationPreprint

Beall, E. L., Bell, M., Georlette, D., & Botchan, M. R. (2004) · Genes & Development · doi:10.1101/gad.1206604 · Cited by 80

Characterization and cell cycle-regulated expression of mouse B-myb.

Lam, E. W. ‐., Robinson, C. E., & Rj, W. (1992) · PubMed · Cited by 80

Degradation of B-Myb by ubiquitin-mediated proteolysis: involvement of the Cdc34-SCFp45Skp2 pathway

Charrasse, S., Carena, I., Brondani, V., Klempnauer, K.-H., & Ferrari, S. M. (2000) · Oncogene · doi:10.1038/sj.onc.1203618 · Cited by 79

B-Myb function can be markedly enhanced by cyclin A-dependent kinase and protein truncation

Lane, S., Farlie, P. G., & Watson, R. (1997) · Oncogene · doi:10.1038/sj.onc.1201086 · Cited by 79

Aberrant Activation of ERK/FOXM1 Signaling Cascade Triggers the Cell Migration/Invasion in Ovarian Cancer Cells

Lok, G. T. M., Chan, D. W., Liu, V. W. S., Hui, W. W. Y., Leung, T. H. Y., Yao, K., & Ngan, H. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023790 · Cited by 77

Epigenetic regulation of gene expression by Drosophila Myb and E2F2–RBF via the Myb–MuvB/dREAM complexPreprint

Wen, H., Andrejka, L., Ashton, J., Karess, R. E., & Lipsick, J. S. (2008) · Genes & Development · doi:10.1101/gad.1626308 · Cited by 77

Drosophila myb is required for the G2/M transition and maintenance of diploidyPreprint

Katzen, A. L., Jackson, J., Harmon, B., Fung, S.-M., Ramsay, G. M., & Bishop, J. M. (1998) · Genes & Development · doi:10.1101/gad.12.6.831 · Cited by 71

Mutation of the Drosophila homologue of the Myb protooncogene causes genomic instability

Manak, J. R., Mitiku, N., & Lipsick, J. S. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.122231599 · Cited by 68

Lin9, a Subunit of the Mammalian DREAM Complex, Is Essential for Embryonic Development, for Survival of Adult Mice, and for Tumor Suppression

Reichert, N., Wurster, S., Ulrich, T., Schmitt, K., Hauser, S., Probst, L., Götz, R., Ceteci, F., Moll, R., Rapp, U. R., et al. (2010) · Molecular and Cellular Biology · doi:10.1128/mcb.00028-10 · Cited by 68

Myb controls G2/M progression by inducing cyclin B expression in the Drosophila eye imaginal disc

Okada, M., Akimaru, H., Hou, D., Takahashi, T., & Ishii, S. (2002) · The EMBO Journal · doi:10.1093/emboj/21.4.675 · Cited by 66

p55, the Drosophila Ortholog of RbAp46/RbAp48, Is Required for the Repression of dE2F2/RBF-Regulated Genes

Taylor‐Harding, B., Binné, U. K., Korenjak, M., Brehm, A., & Dyson, N. J. (2004) · Molecular and Cellular Biology · doi:10.1128/mcb.24.20.9124-9136.2004 · Cited by 65

Inhibition of oncogenic transformation by mammalian Lin‐9, a pRB‐associated protein

Gagrica, S., Hauser, S., Kolfschoten, I., Osterloh, L., Agami, R., & Gaubatz, S. (2004) · The EMBO Journal · doi:10.1038/sj.emboj.7600470 · Cited by 63

Functional Evolution of the Vertebrate Myb Gene Family

Davidson, C. J., Tirouvanziam, R. M., Herzenberg, L. A., & Lipsick, J. S. (2004) · Genetics · doi:10.1534/genetics.104.034132 · Cited by 58

Epigenetic regulation of olfactory receptor gene expression by the Myb–MuvB/dREAM complexPreprint

Sim, C. K., Perry, S., Tharadra, S. K., Lipsick, J. S., & Ray, A. (2012) · Genes & Development · doi:10.1101/gad.201665.112 · Cited by 57

B-Myb is Critical for Proper DNA Duplication During an Unperturbed S Phase in Mouse Embryonic Stem Cells

Lorvellec, M., Dumon, S., Maya‐Mendoza, A., Jackson, D. A., Frampton, J., & García, P. (2010) · Stem Cells · doi:10.1002/stem.496 · Cited by 56

The cerberus-related gene, Cerr1, is not essential for mouse head formation

Shawlot, W., Deng, J. M., Wakamiya, M., & Behringer, R. R. (2000) · genesis · doi:10.1002/(sici)1526-968x(200004)26:4 · Cited by 56

Mip/LIN-9 Regulates the Expression of B-Myb and the Induction of Cyclin A, Cyclin B, and CDK1

Pilkinton, M. A., Sandoval, R., Song, J., Ness, S. A., & Colamonici, O. R. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m609924200 · Cited by 55

Disruption of repressive p130–DREAM complexes by human papillomavirus 16 E6/E7 oncoproteins is required for cell-cycle progression in cervical cancer cells

Rashid, N. N., Yusof, R., & Watson, R. J. (2011) · Journal of General Virology · doi:10.1099/vir.0.035352-0 · Cited by 55

B-myb rescues ras-induced premature senescence, which requires its transactivation domain

Masselink, H., Vastenhouw, N. L., & Bernards, R. (2001) · Cancer Letters · doi:10.1016/s0304-3835(01)00631-0 · Cited by 54

The C. elegans gene lin-9,which acts in an Rb-related pathway, is required for gonadal sheath cell development and encodes a novel protein

Beitel, G. J., Lambie, E. J., & Horvitz, H. R. (2000) · Gene · doi:10.1016/s0378-1119(00)00296-1 · Cited by 52

Mutations inDrosophila myblead to centrosome amplification and genomic instability

Fung, S.-M., Ramsay, G. M., & Katzen, A. L. (2002) · Development · doi:10.1242/dev.129.2.347 · Cited by 52

Phosphorylation of B-Myb Regulates Its Transactivation Potential and DNA Binding

Johnson, T. K., Schweppe, R. E., Septer, J., & Lewis, R. E. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.51.36741 · Cited by 52

Deletion of the long arm of chromosome 20 [del(20)(q11)] in myeloid disorders

Testa, J., Kinnealey, A., Rowley, J., Golde, D. W., & Potter, D. (1978) · Blood · doi:10.1182/blood.v52.5.868.868 · Cited by 51

The Winged-Helix Transcription Factor Trident is Expressed in Actively Dividing Lymphocytes

Korver, W., Roose, J. P., Wilson, A., & Clevers, H. C. (1997) · Immunobiology · doi:10.1016/s0171-2985(97)80036-8 · Cited by 51

New Genes That Interact With lin-35 Rb to Negatively Regulate the let-60 ras Pathway in Caenorhabditis elegans

Thomas, J. H., Ceol, C. J., Schwartz, H. T., & Horvitz, H. R. (2003) · Genetics · doi:10.1093/genetics/164.1.135 · Cited by 48

The FOXM1-PLK1 axis is commonly upregulated in oesophageal adenocarcinoma

Dibb, M. J., Han, N., Choudhury, J., Hayes, S. J., Valentine, H. R., West, C., Ang, Y. S., & Sharrocks, A. D. (2012) · British Journal of Cancer · doi:10.1038/bjc.2012.424 · Cited by 45

LIN-61, One of TwoCaenorhabditis elegansMalignant-Brain-Tumor-Repeat-Containing Proteins, Acts With the DRM and NuRD-Like Protein Complexes in Vulval Development but Not in Certain Other Biological Processes

Harrison, M. M., Lu, X., & Horvitz, H. R. (2007) · Genetics · doi:10.1534/genetics.106.069633 · Cited by 44

Ovarian cancer cells, not normal cells, are damaged by Mirk/Dyrk1B kinase inhibition

Hu, J., Deng, H., & Friedman, E. (2012) · International Journal of Cancer · doi:10.1002/ijc.27917 · Cited by 42

The B-MYB Transcriptional Network Guides Cell Cycle Progression and Fate Decisions to Sustain Self-Renewal and the Identity of Pluripotent Stem Cells

Zhan, M., Riordon, D. R., Yan, B., Tarasova, Y. S., Bruweleit, S., Tarasov, K. V., Li, R. A., Wersto, R. P., & Boheler, K. R. (2012) · PLoS ONE · doi:10.1371/journal.pone.0042350 · Cited by 40

B-Myb, a repressed trans -activating protein

Ansieau, S., Kowenz‐Leutz, E., Dechend, R., & Leutz, A. (1997) · Journal of Molecular Medicine · doi:10.1007/s001090050170 · Cited by 31

Duplication and maintenance of the Myb genes of vertebrate animals

Davidson, C. J., Guthrie, E. E., & Lipsick, J. S. (2012) · Biology Open · doi:10.1242/bio.20123152 · Cited by 31

MYBL2 haploinsufficiency increases susceptibility to age-related haematopoietic neoplasia

Clarke, M. L., Dumon, S., Ward, C., Jäger, R., Freeman, S. D., Dawood, B. B., Sheriff, L., Lorvellec, M., Královics, R., Frampton, J., et al. (2012) · Leukemia · doi:10.1038/leu.2012.241 · Cited by 30

A B-myb Promoter Corepressor Site Facilitatesin Vivo Occupation of the Adjacent E2F Site by p107·E2F and p130·E2F Complexes

Catchpole, S., Tavner, F. J., Cam, L. L., Sardet, C., & Watson, R. J. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m202960200 · Cited by 22

LIN54 harboring a mutation in CHC domain is localized to the cytoplasm and inhibits cell cycle progression

Matsuo, T., Kuramoto, H., Kumazaki, T., Mitsui, Y., & Takahashi, T. (2012) · Cell Cycle · doi:10.4161/cc.21569 · Cited by 21

B-Myb overcomes a p107-mediated cell proliferation block by interacting with an N-terminal domain of p107

Joaquin, M., Bessa, M. J., Saville, M. K., & Watson, R. J. (2002) · Oncogene · doi:10.1038/sj.onc.1206001 · Cited by 21

Morphology, cytogenetics, and survival in myelodysplasia with del(20q) or ider(20q): a multicenter study

Mullier, F., Daliphard, S., Garand, R., Dekeyser, M., Cornet, Y., Luquet, I., Talmant, P., Richebourg, S., Jamar, M., Dogné, J.-M., et al. (2011) · Annals of Hematology · doi:10.1007/s00277-011-1286-0 · Cited by 20

Deletion of the p107/p130-binding domain of Mip130/LIN-9 bypasses the requirement for CDK4 activity for the dissociation of Mip130/LIN-9 from p107/p130-E2F4 complex

Sandoval, R., Pilkinton, M. A., & Colamonici, O. R. (2009) · Experimental Cell Research · doi:10.1016/j.yexcr.2009.07.014 · Cited by 18

The dREAM/Myb–MuvB complex and Grim are key regulators of the programmed death of neural precursor cells at the Drosophila posterior wing margin

Rovani, M. K., Brachmann, C. B., Ramsay, G. M., & Katzen, A. L. (2012) · Developmental Biology · doi:10.1016/j.ydbio.2012.08.022 · Cited by 16

Generation of a conditional allele of the B‐myb gene

García, P., Berlanga, O., Watson, R., & Frampton, J. (2005) · genesis · doi:10.1002/gene.20170 · Cited by 15

A mutant allele of BARA/LIN-9 rescues the cdk4−/− phenotype by releasing the repression on E2F-regulated genes

Sandoval, R., Xue, J., Tian, X., Barrett, K., Pilkinton, M. A., Ucker, D. S., Raychaudhuri, P., Kineman, R. D., Luque, R. M., Baida, G. E., et al. (2006) · Experimental Cell Research · doi:10.1016/j.yexcr.2006.04.002 · Cited by 13

Tissue-specific Gene Targeting by the Multiprotein Mammalian DREAM Complex

Flowers, S. J., Beck, G. R., & Morán, E. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.c111.255091 · Cited by 12

Drosophila Lin-52 Acts in Opposition to Repressive Components of the Myb-MuvB/dREAM Complex

Lewis, P. W., Sahoo, D., Geng, C., Bell, M., Lipsick, J. S., & Botchan, M. R. (2012) · Molecular and Cellular Biology · doi:10.1128/mcb.00432-12 · Cited by 10

Interaction of E2F–Rb family members with corepressors binding to the adjacent E2F site

Nakajima, Y., Yamada, S., Kamata, N., & Ikeda, M. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.10.130 · Cited by 5

Chromosome-Biased Binding and Gene Regulation by the Caenorhabditis elegans DRM Complex

Tabuchi, T. M., Deplancke, B., Osato, N., Zhu, L. J., Barrasa, M. I., Harrison, M. M., Horvitz, H. R., Walhout, A. J. M., & Hagstrom, K. (2011) · PLoS Genetics · doi:10.1371/journal.pgen.1002074 · Cited by 4

The history and future of targeting cyclin-dependent kinases in cancer therapy

Asghar, U., Witkiewicz, A. K., Turner, N. C., & Knudsen, E. S. (2015) · Nature Reviews Drug Discovery · doi:10.1038/nrd4504 · Cited by 1,767

Mechanisms of Cellular Senescence: Cell Cycle Arrest and Senescence Associated Secretory Phenotype

Kumari, R., & Jat, P. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.645593 · Cited by 1,622

Cell cycle regulation: p53-p21-RB signaling

Engeland, K. (2022) · Cell Death and Differentiation · doi:10.1038/s41418-022-00988-z · Cited by 1,367

The multiple mechanisms that regulate p53 activity and cell fate

Hafner, A., Bulyk, M. L., Jambhekar, A., & Lahav, G. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-019-0110-x · Cited by 1,129

Census and evaluation of p53 target genes

Fischer, M. (2017) · Oncogene · doi:10.1038/onc.2016.502 · Cited by 971

Mechanistic Insights Into DREAM and RB Control of the Cell Cycle

Schade, A. E. (2019) · Digital Access to Scholarship at Harvard (DASH) (Harvard University) · Cited by 1

DREAM On: Cell Cycle Control in Development and Disease

Walston, H. C., Iness, A. N., & Litovchick, L. (2021) · Annual Review of Genetics · doi:10.1146/annurev-genet-071819-103836 · Cited by 51

Cyclin D–CDK4 relieves cooperative repression of proliferation and cell cycle gene expression by DREAM and RB

Schade, A. E., Oser, M. G., Nicholson, H. E., & DeCaprio, J. A. (2019) · Oncogene · doi:10.1038/s41388-019-0767-9 · Cited by 73

DREAMs in Cancer Cell Quiescence and Beyond

Kim, M. (2023) · Pan American Health Care Exchanges · doi:10.1109/gmepe/pahce58559.2023.10226473

A Dual Role for the dREAM/MMB Complex in the Regulation of Differentiation-Specific E2F/RB Target Genes

Lee, H., Ragusano, L., Martinez, A., Gill, J., & Dimova, D. K. (2012) · Molecular and Cellular Biology · doi:10.1128/mcb.06314-11 · Cited by 18