The DOI matches its Crossref record; 143 of the 143 references it cites were found in a registry or an index.
The DREAM complex: master coordinator of cell cycle-dependent gene expression
Open accessAbstract
The dimerization partner, RB-like, E2F and multi-vulval class B (DREAM) complex provides a previously unsuspected unifying role in the cell cycle by directly linking p130, p107, E2F, BMYB and forkhead box protein M1. DREAM mediates gene repression during the G0 phase and coordinates periodic gene expression with peaks during the G1/S and G2/M phases. Perturbations in DREAM complex regulation shift the balance from quiescence towards proliferation and contribute to the increased mitotic gene expression levels that are frequently observed in cancers with a poor prognosis.
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“This is a multi-subunit complex that associates with repressive subunits, which inhibit gene expression during G1/S, and with activating subunits, which stimulate gene expression during G2/M.”
From Regulatory mechanisms that control mitotic kinesins (2015) · cites this paper as [3]
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“Other important transcriptional networks controlling kinesin expression include those genes regulated by the DREAM/MMB (Myb-MuvB) complexes [3].”
From Regulatory mechanisms that control mitotic kinesins (2015) · cites this paper as [3]
Experimental — accuracy not yet measuredIn the citing paper
“The pocket proteins p107 and p130, together with E2F4, are members of the multiprotein repressor complex DREAM that binds cell cycle genes during quiescence.104, 105, 106”
From Census and evaluation of p53 target genes (2017) · cites this paper as [106]
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Retinoblastoma Tumor Suppressor Gene
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Metadata
- Authors
- Sadasivam, S., & DeCaprio, J. A.
- Affiliations
- National Centre for Biological Sciences (IN)
- Brigham and Women's Hospital (US)
- Corresponding author
- DeCaprio, James A.
- Venue
- Nature Reviews Cancer
- Published
- 2013-07-11
- Volume
- 13
- Issue
- 8
- Pages
- 585-595
- ISSN
- 1474-175X (ISSN-L)
- 1474-1768
- PMC
- PMC3986830
- OpenAlex
- W2025718369
- Cited by
- 524
- References
- 142
- Citations by year
- 2026: 29 · 2025: 45 · 2024: 33 · 2023: 49 · 2022: 58 · 2021: 52 · 2020: 42 · 2019: 43 · 2018: 38 · 2017: 41 · 2016: 35 · 2015: 30 · 2014: 23 · 2013: 6
- FWCI
- 3.32
- Type
- journal article
- Language
- en
- Update notices
- erratum (2013-08-23)
- Open access
- green
- europepmc.org
- Locations
- Nature reviews. Cancer (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (R01CA173023, R01CA63113, P01CA050661, R01CA063113)
- Topics
- Health Sciences › Medicine › Oncology › Cancer-related Molecular Pathways
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Chromatin Remodeling and Cancer
- Keywords
- DREAM complex, cell cycle regulation, cell cycle-dependent gene expression, p130, p107, E2F transcription factors, FOXM1, gene repression, G0 quiescence, cell proliferation, tumor progression, cancer prognosis
- MeSH terms
- Cell Cycle, Cell Transformation, Neoplastic, Gene Expression Regulation, Humans, Transcription Factors, Retinoblastoma Protein, Cell Cycle Proteins, Cell Proliferation
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