FAK in cancer: mechanistic findings and clinical applications

Comprehensive molecular portraits of human breast tumours

The Cancer Genome Atlas Network (2012) · Nature · doi:10.1038/nature11412 · Cited by 12,129

The protein kinase complement of the human genome

Manning, G., Whyte, D. B., Martinez, R., Hunter, T., & Sudarsanam, S. (2002) · Science · doi:10.1126/science.1075762 · Cited by 8,145

Integrated genomic analyses of ovarian carcinoma

Perou, C. M. (2019) · Carolina Digital Repository (University of North Carolina at Chapel Hill) · doi:10.17615/hvp3-wg08 · Cited by 7,927

Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling

Levental, K. R., Yu, H., Kass, L., Lakins, J. N., Egeblad, M., Erler, J. T., Fong, S. F. T., Csiszar, K., Giaccia, A., Weninger, W., et al. (2009) · Cell · doi:10.1016/j.cell.2009.10.027 · Cited by 4,101

Focal adhesion kinase: in command and control of cell motility

Mitra, S. K., Hanson, D. A., & Schlaepfer, D. D. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1549 · Cited by 2,657

Focal adhesion kinase: the first ten years

Parsons, J. T. (2003) · Journal of Cell Science · doi:10.1242/jcs.00373 · Cited by 1,389

The role of focal-adhesion kinase in cancer — a new therapeutic opportunity

McLean, G. W., Carragher, N. O., Avizienyte, E., EVANS, J., Brunton, V. G., & Frame, M. C. (2005) · Nature reviews. Cancer · doi:10.1038/nrc1647 · Cited by 1,049

E-cadherin–integrin crosstalk in cancer invasion and metastasis

Canel, M., Serrels, A., Frame, M. C., & Brunton, V. G. (2013) · Journal of Cell Science · doi:10.1242/jcs.100115 · Cited by 651

Cellular functions of FAK kinases: insight into molecular mechanisms and novel functions

Schaller, M. D. (2010) · Journal of Cell Science · doi:10.1242/jcs.045112 · Cited by 613

Signal transduction by focal adhesion kinase in cancer

Zhao, J., & Guan, J. (2009) · Cancer and Metastasis Reviews · doi:10.1007/s10555-008-9165-4 · Cited by 608

Structural Basis for the Autoinhibition of Focal Adhesion Kinase

Lietha, D., Cai, X., Ceccarelli, D. F. J., Li, Y., Schaller, M. D., & Eck, M. J. (2007) · Cell · doi:10.1016/j.cell.2007.05.041 · Cited by 510

Nuclear FAK Promotes Cell Proliferation and Survival through FERM-Enhanced p53 Degradation

Lim, S., Chen, X. L., Lim, Y., Hanson, D. A., Vo, T.-T. T., Howerton, K., Larocque, N., Fisher, S. J., Schlaepfer, D. D., & Ilić, D. (2008) · Molecular Cell · doi:10.1016/j.molcel.2007.11.031 · Cited by 502

Cellular Characterization of a Novel Focal Adhesion Kinase Inhibitor

Slack‐Davis, J. K., Martin, K. H., Tilghman, R. W., Iwanicki, M., Ung, E. J., Autry, C. L., Luzzio, M. J., Cooper, B. A., Kath, J. C., Roberts, W. G., et al. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m606695200 · Cited by 486

The FERM domain: organizing the structure and function of FAK

Frame, M. C., Patel, H., Serrels, B., Lietha, D., & Eck, M. J. (2010) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2996 · Cited by 387

Antitumor Activity and Pharmacology of a Selective Focal Adhesion Kinase Inhibitor, PF-562,271

Roberts, W. G., Ung, E. J., Whalen, P. M., Cooper, B. A., Hulford, C. A., Autry, C., Richter, D., Emerson, E., Lin, J., Kath, J. C., et al. (2008) · Cancer Research · doi:10.1158/0008-5472.can-07-5155 · Cited by 381

Src-induced de-regulation of E-cadherin in colon cancer cells requires integrin signalling

Avizienyte, E., Wyke, A. W., Jones, R. J., McLean, G. W., Westhoff, M., Brunton, V. G., & Frame, M. C. (2002) · Nature Cell Biology · doi:10.1038/ncb829 · Cited by 376

Integrin β 1 -focal adhesion kinase signaling directs the proliferation of metastatic cancer cells disseminated in the lungs

Shibue, T., & Weinberg, R. A. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0904227106 · Cited by 365

VEGF-Induced Vascular Permeability Is Mediated by FAK

Chen, X. L., Nam, J., Jean, C., Lawson, C., Walsh, C. T., Goka, E. T., Lim, S., Tomar, A., Tancioni, I., Uryu, S. A., et al. (2012) · Developmental Cell · doi:10.1016/j.devcel.2011.11.002 · Cited by 355

A genome-wide association study identifies susceptibility loci for ovarian cancer at 2q31 and 8q24

Goode, E. L., Cancer), T. A. C. S. (., The Australian Ovarian Cancer Study Group, Chenevix‐Trench, G., Song, H., Ramus, S. J., Notaridou, M., Lawrenson, K., Widschwendter, M., Vierkant, R. A., et al. (2010) · Nature Genetics · doi:10.1038/ng.668 · Cited by 341

Conditional knockout of focal adhesion kinase in endothelial cells reveals its role in angiogenesis and vascular development in late embryogenesis

Shen, T., Park, A. Y. J., Alcaraz, A., Peng, X., Jang, I. K., Koni, P. A., Flavell, R. A., Gu, H., & Guan, J. (2005) · The Journal of Cell Biology · doi:10.1083/jcb.200411155 · Cited by 304

Mechanisms that link the oncogenic epithelial–mesenchymal transition to suppression of anoikis

Frisch, S. M., Schaller, M. D., & Cieply, B. W. (2013) · Journal of Cell Science · doi:10.1242/jcs.120907 · Cited by 295

Adrenergic modulation of focal adhesion kinase protects human ovarian cancer cells from anoikis

Sood, A. K., Armaiz-Pena, G. N., Halder, J., Nick, A. M., Stone, R. L., Hu, W., Carroll, A. R., Spannuth, W. A., Deavers, M. T., Allen, J. K., et al. (2010) · Journal of Clinical Investigation · doi:10.1172/jci40802 · Cited by 283

Ras- and PI3K-dependent breast tumorigenesis in mice and humans requires focal adhesion kinase signaling

Pylayeva, Y., Gillen, K. M., Gerald, W. L., Beggs, H. E., Reichardt, L. F., & Giancotti, F. G. (2009) · Journal of Clinical Investigation · doi:10.1172/jci37160 · Cited by 271

Focal adhesion kinase controls actin assembly via a FERM-mediated interaction with the Arp2/3 complex

Serrels, B., Serrels, A., Brunton, V. G., Holt, M., McLean, G. W., Gray, C. H., Jones, G. E., & Frame, M. C. (2007) · Nature Cell Biology · doi:10.1038/ncb1626 · Cited by 269

FAK alters invadopodia and focal adhesion composition and dynamics to regulate breast cancer invasion

Chan, K. T., Cortesio, C. L., & Huttenlocher, A. (2009) · The Journal of Cell Biology · doi:10.1083/jcb.200809110 · Cited by 258

Focal adhesion kinase modulates tension signaling to control actin and focal adhesion dynamics

Schöber, M., Raghavan, S., Nikolova, M., Polak, L., Pasolli, H. A., Beggs, H. E., Reichardt, L. F., & Fuchs, E. V. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200608010 · Cited by 253

Merlin Deficiency Predicts FAK Inhibitor Sensitivity: A Synthetic Lethal Relationship

Shapiro, I. M., Kolev, V. N., Vidal, C. M., Kadariya, Y., Ring, J. E., Wright, Q. G., Weaver, D. T., Menges, C. W., Padval, M. V., McClatchey, A. I., et al. (2014) · Science Translational Medicine · doi:10.1126/scitranslmed.3008639 · Cited by 253

Endothelial FAK is essential for vascular network stability, cell survival, and lamellipodial formation

Braren, R., Hu, H., Kim, Y. H., Beggs, H. E., Reichardt, L. F., & Wang, R. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200506184 · Cited by 244

Safety, Pharmacokinetic, and Pharmacodynamic Phase I Dose-Escalation Trial of PF-00562271, an Inhibitor of Focal Adhesion Kinase, in Advanced Solid Tumors

Infante, J. R., Camidge, D. R., Mileshkin, L., Chen, E. X., Hicks, R. J., Rischin, D., Fingert, H. J., Pierce, K. J., Xu, H., Roberts, W. G., et al. (2012) · Journal of Clinical Oncology · doi:10.1200/jco.2011.38.9346 · Cited by 244

TGFβ-induced EMT requires focal adhesion kinase (FAK) signaling

Cicchini, C., Laudadio, I., Citarella, F., Corazzari, M., Steindler, C., Conigliaro, A., Fantoni, A., Amicone, L., & Tripodi, M. (2007) · Experimental Cell Research · doi:10.1016/j.yexcr.2007.09.005 · Cited by 240

FAK promotes recruitment of talin to nascent adhesions to control cell motility

Lawson, C., Lim, S., Uryu, S. A., Chen, X. L., Calderwood, D., & Schlaepfer, D. D. (2012) · The Journal of Cell Biology · doi:10.1083/jcb.201108078 · Cited by 237

Invasive matrix degradation at focal adhesions occurs via protease recruitment by a FAK–p130Cas complex

Wang, Y., & McNiven, M. A. (2012) · The Journal of Cell Biology · doi:10.1083/jcb.201105153 · Cited by 235

Inhibition of Focal Adhesion Kinase by PF-562,271 Inhibits the Growth and Metastasis of Pancreatic Cancer Concomitant with Altering the Tumor Microenvironment

Stokes, J. B., Adair, S. J., Slack‐Davis, J. K., Walters, D. M., Tilghman, R. W., Hershey, E. D., Lowrey, B. T., Thomas, K. S., Bouton, A. H., Hwang, R. F., et al. (2011) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-11-0261 · Cited by 233

The Outgrowth of Micrometastases Is Enabled by the Formation of Filopodium-like Protrusions

Shibue, T., Brooks, M. W., Inan, M. F., Reinhardt, F., & Weinberg, R. A. (2012) · Cancer Discovery · doi:10.1158/2159-8290.cd-11-0239 · Cited by 225

Specific deletion of focal adhesion kinase suppresses tumor formation and blocks malignant progressionPreprint

McLean, G. W., Komiyama, N. H., Serrels, B., Asano, H., Reynolds, L. E., Conti, F. J. A., Hodivala‐Dilke, K., METZGER, D., Chambon, P., Grant, S. G. N., et al. (2004) · Genes & Development · doi:10.1101/gad.316304 · Cited by 223

A FAK-Cas-Rac-Lamellipodin Signaling Module Transduces Extracellular Matrix Stiffness into Mechanosensitive Cell Cycling

Bae, Y., Mui, K. L., Hsu, B. Y., Liu, S., Cretu, A., Razinia, Z., Xu, T., Puré, E., & Assoian, R. K. (2014) · Science Signaling · doi:10.1126/scisignal.2004838 · Cited by 222

β1 Integrin/FAK/cortactin signaling is essential for human head and neck cancer resistance to radiotherapy

Eke, I., Deuse, Y., Hehlgans, S., Gurtner, K., Krause, M., Baumann, M. A., Shevchenko, A., Sandfort, V., & Cordes, N. (2012) · Journal of Clinical Investigation · doi:10.1172/jci61350 · Cited by 220

Mammary Epithelial-Specific Ablation of the Focal Adhesion Kinase Suppresses Mammary Tumorigenesis by Affecting Mammary Cancer Stem/Progenitor Cells

Luo, M., Fan, H., Nagy, T., Wei, H., Wang, C., Liu, S., Wicha, M. S., & Guan, J. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-3078 · Cited by 216

PyK2 and FAK connections to p190Rho guanine nucleotide exchange factor regulate RhoA activity, focal adhesion formation, and cell motility

Lim, Y., Lim, S., Tomar, A., Gardel, M. L., Bernard‐Trifilo, J. A., Chen, X. L., Uryu, S. A., Cañete-Soler, R., Zhai, J., Lin, H., et al. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200708194 · Cited by 215

The dual kinase complex FAK-Src as a promising therapeutic target in cancer

Bolós, V. (2010) · OncoTargets and Therapy · doi:10.2147/ott.s6909 · Cited by 210

Therapeutic Efficacy of a Novel Focal Adhesion Kinase Inhibitor TAE226 in Ovarian Carcinoma

Halder, J., Lin, Y. G., Merritt, W. M., Spannuth, W. A., Nick, A. M., Honda, T., Kamat, A. A., Han, L. Y., Kim, T. J., Lü, C., et al. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-2667 · Cited by 207

Role of Focal Adhesion Kinase in Regulating YB–1–Mediated Paclitaxel Resistance in Ovarian Cancer

Kang, Y., Hu, W., Ivan, C., Dalton, H. J., Miyake, T. M., Pecot, C. V., Zand, B., Liu, T., Huang, J., Jennings, N. B., et al. (2013) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djt210 · Cited by 206

Endothelial focal adhesion kinase mediates cancer cell homing to discrete regions of the lungs via E-selectin up-regulation

Hiratsuka, S., Goel, S., Kamoun, W. S., Maru, Y., Fukumura, D., Duda, D. G., & Jain, R. K. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1100446108 · Cited by 196

Mammary epithelial-specific disruption of the focal adhesion kinase blocks mammary tumor progression

Lahlou, H., Sanguin‐Gendreau, V., Zuo, D., Cardiff, R. D., McLean, G. W., Frame, M. C., & Muller, W. J. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0710091104 · Cited by 196

MicroRNA-7 Inhibits Epithelial-to-Mesenchymal Transition and Metastasis of Breast Cancer Cells via Targeting FAK Expression

Kong, X., Li, G., Yuan, Y., He, Y., Wu, X., Zhang, W., Wu, Z., Chen, T., Wu, W., Lobie, P. E., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0041523 · Cited by 195

Focal Adhesion Kinase Is Required for Intestinal Regeneration and Tumorigenesis Downstream of Wnt/c-Myc Signaling

Ashton, G. H. S., Morton, J. P., Myant, K., Phesse, T. J., Ridgway, R. A., Marsh, V. L., Wilkins, J. A., Athineos, D., Muncan, V., Kemp, R., et al. (2010) · Developmental Cell · doi:10.1016/j.devcel.2010.07.015 · Cited by 195

Inhibition of focal adhesion kinase prevents experimental lung fibrosis and myofibroblast formation

Lagares, D., Busnadiego, Ó., García-Fernández, R. A., Kapoor, M., Liu, S., Carter, D. E., Abraham, D., Shiwen, X., Carreira, P. E., Fontaine, B. A., et al. (2011) · Arthritis & Rheumatism · doi:10.1002/art.33482 · Cited by 194

Distinct biophysical mechanisms of focal adhesion kinase mechanoactivation by different extracellular matrix proteins

Seong, J., Tajik, A., Sun, J., Guan, J., Humphries, M. J., Craig, S. E., Shekaran, A., Garcı́a, A. J., Lu, S., Lin, M. Z., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1307405110 · Cited by 194

A novel low‐molecular weight inhibitor of focal adhesion kinase, TAE226, inhibits glioma growth

Shi, Q., Hjelmeland, A. B., Keir, S. T., Song, L., Wickman, S., Jackson, D., Ohmori, O., Bigner, D. D., Friedman, H. S., & Rich, J. N. (2007) · Molecular Carcinogenesis · doi:10.1002/mc.20297 · Cited by 192

Gene Alterations Identified by Expression Profiling in Tumor-Associated Endothelial Cells from Invasive Ovarian Carcinoma

Lü, C., Bonome, T., Li, Y., Kamat, A. A., Han, L. Y., Schmandt, R. E., Coleman, R. L., Gershenson, D. M., Jaffe, R. B., Birrer, M. J., et al. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-3700 · Cited by 186

Inhibition of endothelial FAK activity prevents tumor metastasis by enhancing barrier function

Jean, C., Chen, X. L., Nam, J., Tancioni, I., Uryu, S. A., Lawson, C., Ward, K. K., Walsh, C. T., Miller, N. L. G., Ghassemian, M., et al. (2014) · The Journal of Cell Biology · doi:10.1083/jcb.201307067 · Cited by 185

Spatial and Temporal Regulation of Focal Adhesion Kinase Activity in Living Cells

Cai, X., Lietha, D., Ceccarelli, D. F. J., Karginov, A. V., Rajfur, Z., Jacobson, K., Hahn, K. M., Eck, M. J., & Schaller, M. D. (2007) · Molecular and Cellular Biology · doi:10.1128/mcb.01324-07 · Cited by 183

Regulation of lamellipodial persistence, adhesion turnover, and motility in macrophages by focal adhesion kinase

Owen, K. A., Pixley, F. J., Thomas, K. S., Vicente‐Manzanares, M., Ray, B. J., Horwitz, A. F., Parsons, J. T., Beggs, H. E., Stanley, E. R., & Bouton, A. H. (2007) · The Journal of Cell Biology · doi:10.1083/jcb.200708093 · Cited by 178

Sonic hedgehog signaling pathway induces cell migration and invasion through focal adhesion kinase/AKT signaling-mediated activation of matrix metalloproteinase (MMP)-2 and MMP-9 in liver cancer

Chen, J., Huang, X., Wang, Q., Huang, J., Zhang, L., Chen, X., Lei, J., & Cheng, Z. (2012) · Carcinogenesis · doi:10.1093/carcin/bgs274 · Cited by 172

Regulation of Focal Adhesion Kinase by Its Amino-Terminal Domain through an Autoinhibitory Interaction

Cooper, L. A., Shen, T., & Guan, J. (2003) · Molecular and Cellular Biology · doi:10.1128/mcb.23.22.8030-8041.2003 · Cited by 170

FAK promotes recruitment of talin to nascent adhesions to control cell motility

Lawson, C., Lim, S., Uryu, S. A., Chen, X. L., Calderwood, D., & Schlaepfer, D. D. (2012) · The Journal of Cell Biology · doi:10.1083/jcb.2011080781963c · Cited by 170

PND-1186 FAK inhibitor selectively promotes tumor cell apoptosis in three-dimensional environments

Tanjoni, I., Walsh, C. T., Uryu, S. A., Tomar, A., Nam, J., Mielgo, A., Lim, S., Liang, C., Koenig, M., Patel, N., et al. (2010) · Cancer Biology & Therapy · doi:10.4161/cbt.9.10.11434 · Cited by 167

Therapeutic targeting of the focal adhesion complex prevents oncogenic TGF-β signaling and metastasis

Wendt, M. K., & Schiemann, W. P. (2009) · Breast Cancer Research · doi:10.1186/bcr2360 · Cited by 164

Endothelial-cell FAK targeting sensitizes tumours to DNA-damaging therapy

Tavora, B., Reynolds, L. E., Batista, S., Demircioglu, F., Fernandez, I., Lechertier, T., Lees, D. M., Wong, P.-P., Alexopoulou, A., Elia, G., et al. (2014) · Nature · doi:10.1038/nature13541 · Cited by 163

Intrinsic FAK activity and Y925 phosphorylation facilitate an angiogenic switch in tumors

Mitra, S. K., Mikolon, D., Molina, J. E., Hsia, D. A., Hanson, D. A., Chi, A., Lim, S.-T., Bernard‐Trifilo, J. A., Ilić, D., Stupack, D. G., et al. (2006) · Oncogene · doi:10.1038/sj.onc.1209588 · Cited by 160

Loss of Ikaros DNA-binding function confers integrin-dependent survival on pre-B cells and progression to acute lymphoblastic leukemia

Joshi, I., Yoshida, T., Jena, N., Qi, X., Zhang, J., Etten, R. A. V., & Georgopoulos, K. (2014) · Nature Immunology · doi:10.1038/ni.2821 · Cited by 158

Compensatory role for Pyk2 during angiogenesis in adult mice lacking endothelial cell FAK

Weis, S. M., Lim, S., Lutu-Fuga, K. M., Barnes, L. A., Chen, X. L., Göthert, J. R., Shen, T., Guan, J., Schlaepfer, D. D., & Cheresh, D. A. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200710038 · Cited by 158

Endothelial FAK is required for tumour angiogenesis

Tavora, B., Batista, S., Reynolds, L. E., Jadeja, S., Robinson, S. D., Kostourou, V., Hart, I. R., Fruttiger, M., Parsons, M., & Hodivala‐Dilke, K. (2010) · EMBO Molecular Medicine · doi:10.1002/emmm.201000106 · Cited by 154

Phosphatidylinositol 4,5-bisphosphate triggers activation of focal adhesion kinase by inducing clustering and conformational changes

Goñi, G., Epifano, C., Boskovic, J., Camacho‐Artacho, M., Zhou, J., Bronowska, A. K., Martín, M. T., Eck, M. J., Kremer, L., Gräter, F., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1317022111 · Cited by 148

FAK dimerization controls its kinase‐dependent functions at focal adhesions

Brami‐Cherrier, K., Gervasi, N., Arsenieva, D., Walkiewicz, K. W., Boutterin, M., Ortega, Á., Leonard, P. G., Seantier, B., Gasmi, L., Bouceba, T., et al. (2014) · The EMBO Journal · doi:10.1002/embj.201386399 · Cited by 145

Quantitative In vivo Imaging of the Effects of Inhibiting Integrin Signaling via Src and FAK on Cancer Cell Movement: Effects on E-cadherin Dynamics

Canel, M., Serrels, A., Miller, D., Timpson, P., Serrels, B., Frame, M. C., & Brunton, V. G. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-1454 · Cited by 144

Mammary Epithelial-Specific Disruption of Focal Adhesion Kinase Retards Tumor Formation and Metastasis in a Transgenic Mouse Model of Human Breast Cancer

Provenzano, P. P., Inman, D. R., Eliceiri, K. W., Beggs, H. E., & Keely, P. J. (2008) · American Journal Of Pathology · doi:10.2353/ajpath.2008.080308 · Cited by 137

Caspase-8 Association with the Focal Adhesion Complex Promotes Tumor Cell Migration and Metastasis

Barbero, S., Mielgo, A., Torres, V. A., Teitz, T., Shields, D. J., Mikolon, D., Bogyo, M. S., Barilà, D., Lahti, J. M., Schlaepfer, D. D., et al. (2009) · Cancer Research · doi:10.1158/0008-5472.can-08-3937 · Cited by 137

Integrated genomic analyses of ovarian carcinoma

The Cancer Genome Atlas Research Network (2011) · Nature · doi:10.1038/nature10166 · Cited by 129

Oral delivery of PND-1186 FAK inhibitor decreases tumor growth and spontaneous breast to lung metastasis in pre-clinical models

Walsh, C. T., Tanjoni, I., Uryu, S. A., Tomar, A., Nam, J., Luo, H., Phillips, A., Patel, N., Kwok, C., McMahon, G., et al. (2010) · Cancer Biology & Therapy · doi:10.4161/cbt.9.10.11433 · Cited by 126

An AMPK-Independent Signaling Pathway Downstream of the LKB1 Tumor Suppressor Controls Snail1 and Metastatic Potential

Goodwin, J. M., Svensson, R. U., Lou, H. J., Winslow, M. M., Turk, B. E., & Shaw, R. J. (2014) · Molecular Cell · doi:10.1016/j.molcel.2014.06.021 · Cited by 123

Tumor-Secreted LOXL2 Activates Fibroblasts through FAK Signaling

Barker, H. E., Bird, D., Lang, G., & Erler, J. T. (2013) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-13-0033-t · Cited by 119

Knock-in Mutation Reveals an Essential Role for Focal Adhesion Kinase Activity in Blood Vessel Morphogenesis and Cell Motility-Polarity but Not Cell Proliferation

Lim, S., Chen, X. L., Tomar, A., Miller, N. L. G., Yoo, J., & Schlaepfer, D. D. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.129999 · Cited by 118

Role of kinase-independent and -dependent functions of FAK in endothelial cell survival and barrier function during embryonic development

Zhao, X., Peng, X., Sun, S., Park, A. Y. J., & Guan, J. (2010) · The Journal of Cell Biology · doi:10.1083/jcb.200912094 · Cited by 118

Overexpression of Focal Adhesion Kinase in Head and Neck Squamous Cell Carcinoma Is Independent of fak Gene Copy Number

Canel, M., Secades, P., Rodrigo, J. P., Cabanillas, R., Herrero, A., Suarez, C. M., & Chiara, M. (2006) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-05-1583 · Cited by 116

Focal Adhesion Kinase: Targeting Adhesion Signaling Pathways for Therapeutic Intervention

Parsons, J. T., Slack‐Davis, J. K., Tilghman, R. W., & Roberts, W. G. (2008) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-07-2220 · Cited by 115

RHOA-FAK is a required signaling axis for the maintenance of KRAS-driven lung adenocarcinomas

Konstantinidou, G., Ramadori, G., Torti, F., Kangasniemi, K., Ramirez, R. E., Cai, Y., Behrens, C., Dellinger, M. T., Brekken, R. A., Wistuba, I. I., et al. (2013) · Cancer Discovery · doi:10.1158/2159-8290.cd-12-0388 · Cited by 114

Nuclear-localized focal adhesion kinase regulates inflammatory VCAM-1 expression

Lim, S., Miller, N. L. G., Chen, X. L., Tancioni, I., Walsh, C. T., Lawson, C., Uryu, S. A., Weis, S. M., Cheresh, D. A., & Schlaepfer, D. D. (2012) · The Journal of Cell Biology · doi:10.1083/jcb.201109067 · Cited by 114

Regulation of heterochromatin remodelling and myogenin expression during muscle differentiation by FAK interaction with MBD2

Luo, S.-W., Zhang, C., Zhang, B., Kim, C., Qiu, Y.-Z., Du, Q., Mei, L., & Xiong, W. (2009) · The EMBO Journal · doi:10.1038/emboj.2009.178 · Cited by 110

Inhibition of focal adhesion kinase (FAK) activity prevents anchorage-independent ovarian carcinoma cell growth and tumor progression

Ward, K. K., Tancioni, I., Lawson, C., Miller, N. L. G., Jean, C., Chen, X. L., Uryu, S. A., Kim, J., Tarin, D., Stupack, D. G., et al. (2012) · Clinical & Experimental Metastasis · doi:10.1007/s10585-012-9562-5 · Cited by 109

Crystal Structures of the FAK Kinase in Complex with TAE226 and Related Bis-Anilino Pyrimidine Inhibitors Reveal a Helical DFG Conformation

Lietha, D., & Eck, M. J. (2008) · PLoS ONE · doi:10.1371/journal.pone.0003800 · Cited by 108

Intrinsic focal adhesion kinase activity controls orthotopic breast carcinoma metastasis via the regulation of urokinase plasminogen activator expression in a syngeneic tumor model

Mitra, S. K., Lim, S.-T., Chi, A., & Schlaepfer, D. D. (2006) · Oncogene · doi:10.1038/sj.onc.1209482 · Cited by 103

A small molecule focal adhesion kinase (FAK) inhibitor, targeting Y397 site: 1-(2-hydroxyethyl) -3, 5, 7-triaza-1-azoniatricyclo [3.3.1.13,7]decane; bromide effectively inhibits FAK autophosphorylation activity and decreases cancer cell viability, clonogenicity and tumor growth in vivo

Golubovskaya, V., Figel, S. A., Ho, B. T., Johnson, C. P., Yemma, M., Huang, G., Zheng, M., Nyberg, C., Magis, A. T., Ostrov, D. A., et al. (2012) · Carcinogenesis · doi:10.1093/carcin/bgs120 · Cited by 103

Focal Adhesion Kinase Versus p53: Apoptosis or Survival?

Cance, W. G., & Golubovskaya, V. (2008) · Science Signaling · doi:10.1126/stke.120pe22 · Cited by 99

Disrupting the Scaffold to Improve Focal Adhesion Kinase–Targeted Cancer Therapeutics

Cance, W. G., Kurenova, E., Marlowe, T. A., & Golubovskaya, V. (2013) · Science Signaling · doi:10.1126/scisignal.2004021 · Cited by 98

Ovarian cancer ascites protects from TRAIL-induced cell death through αvβ5 integrin-mediated focal adhesion kinase and Akt activation

Lane, D. A., Goncharenko-Khaider, N., Rancourt, C., & Piché, A. (2010) · Oncogene · doi:10.1038/onc.2010.107 · Cited by 97

pH sensing by FAK-His58 regulates focal adhesion remodeling

Choi, C., Webb, B. A., Chimenti, M. S., Jacobson, M. P., & Barber, D. L. (2013) · The Journal of Cell Biology · doi:10.1083/jcb.201302131 · Cited by 96

FAK‐dependent regulation of myofibroblast differentiation

Greenberg, R. S., Bernstein, A. M., Benezra, M., Gelman, I. H., Taliana, L., & Masur, S. K. (2006) · The FASEB Journal · doi:10.1096/fj.05-4838fje · Cited by 95

Roles of focal adhesion kinase (FAK) in megakaryopoiesis and platelet function: studies using a megakaryocyte lineage–specific FAK knockout

Hitchcock, I. S., Fox, N. E., Prévost, N., Sear, K., Shattil, S. J., & Kaushansky, K. (2007) · Blood · doi:10.1182/blood-2007-05-089680 · Cited by 94

Therapeutic potential and limitations of new FAK inhibitors in the treatment of cancer

Schultze, A., & Fiedler, W. (2010) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.2010.489548 · Cited by 94

FAK Regulates Intestinal Epithelial Cell Survival and Proliferation during Mucosal Wound Healing

Owen, K. A., Abshire, M. Y., Tilghman, R. W., Casanova, J. E., & Bouton, A. H. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023123 · Cited by 94

Focal adhesion kinase inhibitors are potent anti‐angiogenic agents

Cabrita, M. A., Jones, L., Quizi, J. L., Sabourin, L. A., McKay, B. C., & Addison, C. (2011) · Molecular Oncology · doi:10.1016/j.molonc.2011.10.004 · Cited by 86

Function of Focal Adhesion Kinase Scaffolding to Mediate Endophilin A2 Phosphorylation Promotes Epithelial-Mesenchymal Transition and Mammary Cancer Stem Cell Activities in Vivo

Fan, H., Zhao, X., Sun, S., Luo, M., & Guan, J. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.420497 · Cited by 84

Organization and post-transcriptional processing of focal adhesion kinase gene

Corsi, J.-M., Rouer, É., Girault, J., & Enslen, H. (2006) · BMC Genomics · doi:10.1186/1471-2164-7-198 · Cited by 82

Pyk2 Inhibition of p53 as an Adaptive and Intrinsic Mechanism Facilitating Cell Proliferation and Survival

Lim, S., Miller, N. L. G., Nam, J., Chen, X. L., Lim, Y., & Schlaepfer, D. D. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.064212 · Cited by 80

Fragment-Based Discovery of New Highly Substituted 1H-Pyrrolo[2,3-b]- and 3H-Imidazolo[4,5-b]-Pyridines as Focal Adhesion Kinase Inhibitors

Heinrich, T., Seenisamy, J., Emmanuvel, L., Kulkarni, S. S., Bomke, J., Rohdich, F., Greiner, H. E., Esdar, C., Krier, M., Grädler, U., et al. (2013) · Journal of Medicinal Chemistry · doi:10.1021/jm3016014 · Cited by 79

Loss of Scar/WAVE Complex Promotes N-WASP- and FAK-Dependent Invasion

Tang, H., Li, A., Bi, J., Veltman, D. M., Zech, T., Spence, H. J., Yu, X., Timpson, P., Insall, R. H., Frame, M. C., et al. (2012) · Current Biology · doi:10.1016/j.cub.2012.11.059 · Cited by 77

Nanog Increases Focal Adhesion Kinase (FAK) Promoter Activity and Expression and Directly Binds to FAK Protein to Be Phosphorylated

Ho, B., Olson, G., Figel, S. A., Gelman, I. H., Cance, W. G., & Golubovskaya, V. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.322883 · Cited by 76

Argonaute2 promotes tumor metastasis by way of up-regulating focal adhesion kinase expression in hepatocellular carcinoma

Cheng, N., Li, Y., & Han, Z. (2012) · Hepatology · doi:10.1002/hep.26202 · Cited by 71

Mammary Epithelial-specific Deletion of the Focal Adhesion Kinase Gene Leads to Severe Lobulo-Alveolar Hypoplasia and Secretory Immaturity of the Murine Mammary Gland

Nagy, T., Wei, H., Shen, T., Xu, P., Liang, C.-C., Gan, B., & Guan, J. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m705403200 · Cited by 71

Sunitinib and PF-562,271 (FAK/Pyk2 inhibitor) effectively block growth and recovery of human hepatocellular carcinoma in a rat xenograft model

Bagi, C. M., Christensen, J. G., Cohen, D. P., Roberts, W. G., Wilkie, D. P., Swanson, T. A., Tuthill, T. A., & Andresen, C. J. (2009) · Cancer Biology & Therapy · doi:10.4161/cbt.8.9.8246 · Cited by 70

miRNA Expression Profiling in Migrating Glioblastoma Cells: Regulation of Cell Migration and Invasion by miR-23b via Targeting of Pyk2

Loftus, J. C., Ross, J. T. D., Paquette, K., Paulino, V. M., Nasser, S., Yang, Z., Kloss, J. M., Kim, S., Berens, M. E., & Tran, N. L. (2012) · PLoS ONE · doi:10.1371/journal.pone.0039818 · Cited by 67

IGFBP2/FAK Pathway Is Causally Associated with Dasatinib Resistance in Non–Small Cell Lung Cancer Cells

Lu, H., Wang, L., Gao, W. X., Meng, J., Dai, B., Wu, S., Minna, J. D., Roth, J. A., Hofstetter, W. L., Swisher, S. G., et al. (2013) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-13-0233 · Cited by 64

Cortactin as a Target for FAK in the Regulation of Focal Adhesion Dynamics

Tomar, A., Lawson, C., Ghassemian, M., & Schlaepfer, D. D. (2012) · PLoS ONE · doi:10.1371/journal.pone.0044041 · Cited by 63

Compensatory Function of Pyk2 Protein in the Promotion of Focal Adhesion Kinase (FAK)-null Mammary Cancer Stem Cell Tumorigenicity and Metastatic Activity

Fan, H., & Guan, J. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.200717 · Cited by 63

KLF8 and FAK cooperatively enrich the active MMP14 on the cell surface required for the metastatic progression of breast cancer

Lu, H., Hu, L., Yu, L., Wang, X., Urvalek, A. M., Li, T., Shen, C., Mukherjee, D., Lahiri, S. K., Wason, M. S., et al. (2013) · Oncogene · doi:10.1038/onc.2013.247 · Cited by 63

Protein tyrosine kinase 6 protects cells from anoikis by directly phosphorylating focal adhesion kinase and activating AKT

Zheng, Y., Gierut, J. J., Wang, Z., Miao, J., Asara, J. M., & Tyner, A. L. (2012) · Oncogene · doi:10.1038/onc.2012.427 · Cited by 63

Focal Adhesion Kinase (FAK) Binds RET Kinase via Its FERM Domain, Priming a Direct and Reciprocal RET-FAK Transactivation Mechanism

Plaza-Menacho, I., Morandi, A., Mologni, L., Boender, P. J., Gambacorti-Passerini, C. B., Magee, A. I., Hofstra, R. M. W., Knowles, P. P., McDonald, N. Q., & Isacke, C. M. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.168500 · Cited by 63

Conditional Deletion of the Focal Adhesion Kinase FAK Alters Remodeling of the Blood–Brain Barrier in Glioma

Lee, J., Borboa, A. K., Chun, H. B., Baird, A., & Eliceiri, B. P. (2010) · Cancer Research · doi:10.1158/0008-5472.can-10-2740 · Cited by 63

Endothelial FAK as a therapeutic target in disease

Infusino, G., & Jacobson, J. R. (2011) · Microvascular Research · doi:10.1016/j.mvr.2011.09.011 · Cited by 62

Conditional deletion of FAK in mice endothelium disrupts lung vascular barrier function due to destabilization of RhoA and Rac1 activities

Schmidt, T. T., Tauseef, M., Yue, L., Bonini, M. G., Göthert, J. R., Shen, T., Guan, J., Predescu, S. A., Sadikot, R. T., & Mehta, D. (2013) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00094.2013 · Cited by 61

Snail1 controls epithelial–mesenchymal lineage commitment in focal adhesion kinase–null embryonic cells

Li, X.-Y., Zhou, X., Rowe, R. G., Hu, Y., Schlaepfer, D. D., Ilić, D., Dressler, G. R., Park, A., Guan, J., & Weiss, S. J. (2011) · The Journal of Cell Biology · doi:10.1083/jcb.201105103 · Cited by 61

p190RhoGEF (Rgnef) Promotes Colon Carcinoma Tumor Progression via Interaction with Focal Adhesion Kinase

Yu, H., Nam, J., Miller, N. L. G., Tanjoni, I., Walsh, C. T., Shi, L., Kim, L., Chen, X. L., Tomar, A., Lim, S., et al. (2011) · Cancer Research · doi:10.1158/0008-5472.can-10-2894 · Cited by 61

Disruption of focal adhesion kinase and p53 interaction with small molecule compound R2 reactivated p53 and blocked tumor growth

Golubovskaya, V., Ho, B., Zheng, M., Magis, A. T., Ostrov, D. A., Morrison, C., & Cance, W. G. (2013) · BMC Cancer · doi:10.1186/1471-2407-13-342 · Cited by 60

Mitsugumin 53 (MG53) Ligase Ubiquitinates Focal Adhesion Kinase during Skeletal Myogenesis

Nguyen, N. T. B., Yi, J.-S., Park, H., Lee, J.-S., & Ko, Y.-G. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.525154 · Cited by 60

Structure-based discovery of cellular-active allosteric inhibitors of FAK

Tomita, N., Hayashi, Y., Suzuki, S., Oomori, Y., Aramaki, Y., Matsushita, Y., Iwatani, M., Iwata, H., Okabe, A., Awazu, Y., et al. (2013) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2013.01.047 · Cited by 59

Distinct FAK Activities Determine Progenitor and Mammary Stem Cell Characteristics

Luo, M., Zhao, X., Chen, S., Liu, S., Wicha, M. S., & Guan, J. (2013) · Cancer Research · doi:10.1158/0008-5472.can-13-1351 · Cited by 59

FAK Inhibition Disrupts a β5 Integrin Signaling Axis Controlling Anchorage-Independent Ovarian Carcinoma Growth

Tancioni, I., Uryu, S. A., Sulzmaier, F. J., Shah, N. R., Lawson, C., Miller, N. L. G., Jean, C., Chen, X. L., Ward, K. K., & Schlaepfer, D. D. (2014) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-13-1063 · Cited by 58

High-Throughput Tyrosine Kinase Activity Profiling Identifies FAK as a Candidate Therapeutic Target in Ewing Sarcoma

Crompton, B. D., Carlton, A. L., Thorner, A. R., Christie, A. L., Du, J., Calicchio, M. L., Rivera, M. N., Fleming, M. D., Kohl, N. E., Kung, A. L., et al. (2013) · Cancer Research · doi:10.1158/0008-5472.can-12-1944 · Cited by 58

The role of focal adhesion kinase catalytic activity on the proliferation and migration of squamous cell carcinoma cells

Serrels, A., McLeod, K., Canel, M., Kinnaird, A., Graham, K., Frame, M. C., & Brunton, V. G. (2011) · International Journal of Cancer · doi:10.1002/ijc.26351 · Cited by 54

Analyses of merlin/NF2 connection to FAK inhibitor responsiveness in serous ovarian cancer

Shah, N. R., Tancioni, I., Ward, K. K., Lawson, C., Chen, X. L., Jean, C., Sulzmaier, F. J., Uryu, S. A., Miller, N. L. G., Connolly, D. C., et al. (2014) · Gynecologic Oncology · doi:10.1016/j.ygyno.2014.04.044 · Cited by 54

Autophosphorylation-independent and -dependent Functions of Focal Adhesion Kinase during Development

Corsi, J.-M., Houbron, C., Billuart, P., Brunet, I., Bouvrée, K., Eichmann, A., Girault, J., & Enslen, H. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.067280 · Cited by 52

Tetraspan TM4SF5-dependent direct activation of FAK and metastatic potential of hepatocarcinoma cells

Jung, O., Choi, S., Jang, S., Lee, S.-A., Lim, S., Choi, Y.-J., Kim, H., Kim, D., Kwak, T., Kim, H., et al. (2012) · Journal of Cell Science · doi:10.1242/jcs.100586 · Cited by 51

Proline-rich tyrosine kinase 2 and its phosphorylated form pY881 are novel prognostic markers for non-small-cell lung cancer progression and patients’ overall survival

Kuang, B.-H., Zhang, M.-Q., Xu, L.-H., Hu, L.-J., Wang, H.-B., Zhao, W.-F., Du, Y., & Zhang, X. (2013) · British Journal of Cancer · doi:10.1038/bjc.2013.439 · Cited by 50

FAK-heterozygous mice display enhanced tumour angiogenesis

Kostourou, V., Lechertier, T., Reynolds, L. E., Lees, D. M., Baker, M., Jones, D. T., Tavora, B., Ramjaun, A. R., Birdsey, G. M., Robinson, S. D., et al. (2013) · Nature Communications · doi:10.1038/ncomms3020 · Cited by 49

Focal Adhesion Kinase Regulates Pathogen-Killing Capability and Life Span of Neutrophils via Mediating Both Adhesion-Dependent and -Independent Cellular Signals

Kasorn, A., Alcaide, P., Jia, Y., Subramanian, K. K., Sarraj, B., Li, Y., Loison, F., Hattori, H., Silberstein, L. E., Luscinskas, F. W., et al. (2009) · The Journal of Immunology · doi:10.4049/jimmunol.0802984 · Cited by 48

Differential requirement for focal adhesion kinase signaling in cancer progression in the transgenic adenocarcinoma of mouse prostate model

Slack‐Davis, J. K., Hershey, E. D., Theodorescu, D., Frierson, H. F., & Parsons, J. T. (2009) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-09-0262 · Cited by 48

Crystal structures of free and ligand-bound focal adhesion targeting domain of Pyk2

Lulo, J. E., Yuzawa, S., & Schlessinger, J. (2009) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2009.04.011 · Cited by 43

Visualizing and Manipulating Focal Adhesion Kinase Regulation in Live Cells

Ritt, M., Guan, J. L., & Sivaramakrishnan, S. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.421164 · Cited by 41

Proteomic Profiling of Endothelial Invasion Revealed Receptor for Activated C Kinase 1 (RACK1) Complexed with Vimentin to Regulate Focal Adhesion Kinase (FAK)

Dave, J. M., Kang, H., Abbey, C. A., Maxwell, S. A., & Bayless, K. J. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.512467 · Cited by 40

Phosphorylation of focal adhesion kinase on tyrosine 194 by Met leads to its activation through relief of autoinhibition

Th, C., Pc, C., Cl, C., & Hc, C. (2010) · Oncogene · doi:10.1038/onc.2010.398 · Cited by 39

Essential role for focal adhesion kinase in regulating stress hematopoiesis

Vemula, S., Ramdas, B., Hanneman, P., Martin, J., Beggs, H. E., & Kapur, R. (2010) · Blood · doi:10.1182/blood-2010-01-262790 · Cited by 34

Rgnef (p190RhoGEF) Knockout Inhibits RhoA Activity, Focal Adhesion Establishment, and Cell Motility Downstream of Integrins

Miller, N. L. G., Lawson, C., Chen, X. L., Lim, S., & Schlaepfer, D. D. (2012) · PLoS ONE · doi:10.1371/journal.pone.0037830 · Cited by 33

Targeting Vascular Cell Migration as a Strategy for Blocking Angiogenesis: The Central Role of Focal Adhesion Protein Tyrosine Kinase Family

Angelucci, A., & Bologna, M. (2007) · Current Pharmaceutical Design · doi:10.2174/138161207781039643 · Cited by 31

FAK Deletion Promotes p53-Mediated Induction of p21, DNA-Damage Responses and Radio-Resistance in Advanced Squamous Cancer Cells

Graham, K., Moran‐Jones, K., Sansom, O. J., Brunton, V. G., & Frame, M. C. (2011) · PLoS ONE · doi:10.1371/journal.pone.0027806 · Cited by 31

A non-canonical role for Rgnef (p190RhoGEF) in promoting integrin-stimulated focal adhesion kinase activation

Miller, N. L. G., Lawson, C., Kleinschmidt, E. G., Tancioni, I., Uryu, S. A., & Schlaepfer, D. D. (2013) · Journal of Cell Science · doi:10.1242/jcs.135509 · Cited by 30

Loss of Focal Adhesion Kinase Enhances Endothelial Barrier Function and Increases Focal Adhesions

Arnold, K. M., Goeckeler, Z. M., & Wysolmerski, R. B. (2013) · Microcirculation · doi:10.1111/micc.12063 · Cited by 28

Critical features of FAK-expressing AML bone marrow microenvironment through leukemia stem cell hijacking of mesenchymal stromal cells

Despeaux, M., Labat, E., Gadelorge, M., Prade, N., Bertrand‐Michel, J., Demur, C., Récher, C., Bonnevialle, P., Payrastre, B., Bourin, P., et al. (2011) · Leukemia · doi:10.1038/leu.2011.145 · Cited by 26

Somatic mutational analysis of FAK in breast cancer: A novel gain-of-function mutation due to deletion of exon 33

Fang, X., Liu, X., Yao, L., Chen, C.-Q., Gu, Z., Ni, P., Zheng, X., & Fan, Q. (2013) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2013.11.134 · Cited by 25

Requirement of PEA3 for Transcriptional Activation of FAK Gene in Tumor Metastasis

Li, S., Huang, X., Zhang, D., Huang, Q., Pei, G., Wang, L., Jiang, W., Hu, Q., Tan, R. X., & Hua, Z. (2013) · PLoS ONE · doi:10.1371/journal.pone.0079336 · Cited by 22

Fak depletion in both hematopoietic and nonhematopoietic niche cells leads to hematopoietic stem cell expansion

Lu, J., Sun, Y., Nombela‐Arrieta, C., Du, K., Park, S., Chai, L., Walkley, C. R., Luo, H. R., & Silberstein, L. E. (2011) · Experimental Hematology · doi:10.1016/j.exphem.2011.11.010 · Cited by 22

An aberrant spliced transcript of focal adhesion kinase is exclusively expressed in human breast cancer

Yao, L., Li, K., Peng, W., Lin, Q., Li, S., Hu, X., Zheng, X., & Shao, Z. (2014) · Journal of Translational Medicine · doi:10.1186/1479-5876-12-136 · Cited by 21

Off‐targets effects underlie the inhibitory effect of FAK inhibitors on platelet activation: studies using Fak‐deficient mice

Roh, M. E., Cosgrove, M. E., Gorski, K., & Hitchcock, I. S. (2013) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.12343 · Cited by 13

Macrophages as regulators of tumour immunity and immunotherapy

DeNardo, D. G., & Ruffell, B. (2019) · Nature reviews. Immunology · doi:10.1038/s41577-019-0127-6 · Cited by 2,619

Targeting focal adhesion kinase renders pancreatic cancers responsive to checkpoint immunotherapy

Jiang, H., Hegde, S., Knolhoff, B. L., Zhu, Y., Herndon, J. M., Meyer, M. A., Nywening, T. M., Hawkins, W. G., Shapiro, I. M., Weaver, D. T., et al. (2016) · Nature Medicine · doi:10.1038/nm.4123 · Cited by 1,060

Physical traits of cancer

Nia, H. T., Munn, L. L., & Jain, R. K. (2020) · Science · doi:10.1126/science.aaz0868 · Cited by 882

The delivery of therapeutic oligonucleotides

Juliano, R. L. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw236 · Cited by 882

FAP Promotes Immunosuppression by Cancer-Associated Fibroblasts in the Tumor Microenvironment via STAT3–CCL2 Signaling

Yang, X., Lin, Y., Shi, Y., Li, B., Liu, W., Yin, W., Dang, Y., Chu, Y., Fan, J., & He, R. (2016) · Cancer Research · doi:10.1158/0008-5472.can-15-2973 · Cited by 748

Understanding the Roles of FAK in Cancer

Yoon, H., Dehart, J. P., Murphy, J. M., & Lim, S. (2014) · Journal of Histochemistry & Cytochemistry · doi:10.1369/0022155414561498 · Cited by 228

Emerging Roles of Focal Adhesion Kinase in Cancer

Tai, Y.-L., Chen, L., & Shen, T. (2015) · BioMed Research International · doi:10.1155/2015/690690 · Cited by 233

Targeting focal adhesion kinase in cancer cells and the tumor microenvironment

Murphy, J. M., Rodriguez, Y. A. R., Jeong, K., Ahn, E.-Y. E., & Lim, S. (2020) · Experimental & Molecular Medicine · doi:10.1038/s12276-020-0447-4 · Cited by 226

Prospects of focal adhesion kinase inhibitors as a cancer therapy in preclinical and early phase study

Gao, J., Cheng, J., Xie, W., Zhang, P., Liu, X., Wang, Z., & Zhang, B. (2024) · Expert Opinion on Investigational Drugs · doi:10.1080/13543784.2024.2348068 · Cited by 14

Focal adhesion kinase—An emerging viable target in cancer and development of focal adhesion kinase inhibitors

Chauhan, A., & Khan, T. A. (2020) · Chemical Biology & Drug Design · doi:10.1111/cbdd.13808 · Cited by 52