The DOI matches its Crossref record; 143 of the 143 references it cites were found in a registry or an index.
FAK in cancer: mechanistic findings and clinical applications
Open accessAbstract
Focal adhesion kinase (FAK) is a cytoplasmic protein tyrosine kinase that is overexpressed and activated in several advanced-stage solid cancers. FAK promotes tumour progression and metastasis through effects on cancer cells, as well as stromal cells of the tumour microenvironment. The kinase-dependent and kinase-independent functions of FAK control cell movement, invasion, survival, gene expression and cancer stem cell self-renewal. Small molecule FAK inhibitors decrease tumour growth and metastasis in several preclinical models and have initial clinical activity in patients with limited adverse events. In this Review, we discuss FAK signalling effects on both tumour and stromal cell biology that provide rationale and support for future therapeutic opportunities.
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“Interestingly, multiple previous studies have implicated FAK activation in the development of resistance against various chemotherapy agents through its regulation of the tumor microenvironment.[ 11, 15, 44 ]”
From Focal Adhesion Kinase (FAK) Inhibition Synergizes with KRAS G12C Inhibitors in Treating Cancer through the Regulation of the FAK–YAP Signaling (2021) · cites this paper as [11]
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Cites
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DeNardo, D. G., & Ruffell, B. (2019) · Nature reviews. Immunology · doi:10.1038/s41577-019-0127-6 · Cited by 2,619
Targeting focal adhesion kinase renders pancreatic cancers responsive to checkpoint immunotherapy
Jiang, H., Hegde, S., Knolhoff, B. L., Zhu, Y., Herndon, J. M., Meyer, M. A., Nywening, T. M., Hawkins, W. G., Shapiro, I. M., Weaver, D. T., et al. (2016) · Nature Medicine · doi:10.1038/nm.4123 · Cited by 1,060
Nia, H. T., Munn, L. L., & Jain, R. K. (2020) · Science · doi:10.1126/science.aaz0868 · Cited by 882
The delivery of therapeutic oligonucleotides
Juliano, R. L. (2016) · Nucleic Acids Research · doi:10.1093/nar/gkw236 · Cited by 882
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Metadata
- Authors
- Sulzmaier, F. J., Jean, C., & Schlaepfer, D. D.
- Affiliations
- University of California San Diego (US)
- Corresponding author
- Schlaepfer, David D.
- Venue
- Nature Reviews Cancer
- Published
- 2014-08-07
- Volume
- 14
- Issue
- 9
- Pages
- 598-610
- ISSN
- 1474-175X (ISSN-L)
- 1474-1768
- PMC
- PMC4365862
- OpenAlex
- W2044423100
- Cited by
- 1,381
- References
- 142
- Citations by year
- 2026: 92 · 2025: 85 · 2024: 131 · 2023: 111 · 2022: 147 · 2021: 154 · 2020: 144 · 2019: 122 · 2018: 105 · 2017: 128 · 2016: 91 · 2015: 63 · 2014: 6
- FWCI
- 12.73
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature reviews. Cancer (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- HAL (submittedVersion)
- eScholarship (California Digital Library) (submittedVersion)
- Funders
- American Heart Association
- Verastem Oncology
- National Institutes of Health
- National Cancer Institute (R01CA102310, CA102310, R01CA180769, CA180769, T32CA121938)
- Topics
- Health Sciences › Medicine › Immunology and Allergy › Cell Adhesion Molecules Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular Mechanics and Interactions
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Keywords
- focal adhesion kinase, FAK inhibitors, tumor microenvironment, tumor stromal cells, metastasis, tumor progression, cancer stem cells, cell invasion, cell migration, small molecule inhibitors, clinical development
- MeSH terms
- Animals, Humans, Neoplasm Invasiveness, Neoplasms, Signal Transduction, Stromal Cells, Protein Kinase Inhibitors, Focal Adhesion Kinase 1, Small Molecule Libraries, Molecular Targeted Therapy, Tumor Microenvironment
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