Therapeutic opportunities within the DNA damage response

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Prevalence of Mismatch Repair Deficiency in Primary Prostate Cancer in a Large Prospective Cohort

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Increased Sensitivity to Ionizing Radiation in a Relevant Subset of Patients with Cancer and Systemic Lupus Erythematosus

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Radiation sensitivity in genetic tumour syndromes and how to test for them

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The leading role of MYC in DNA damage response: exploring opportunities for therapeutic inhibition

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Modulating DNA damage response in uveal melanoma through embryonic stem cell microenvironment

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Inhibition of the ATR-DNAPKcs-RB axis drives G1/S-phase transition and sensitizes triple-negative breast cancer (TNBC) to DNA holliday junctions

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Somatic CpG hypermutation is associated with mismatch repair deficiency in cancer

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Mendelian Randomization Reveals Potential Causal Relationships Between DNA Damage Repair-Related Genes and Inflammatory Bowel Disease

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Cancer Biology and the Principles of Targeted Cancer Drug Discovery

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Landscape of somatic mutated genes and inherited susceptibility genes in gynecological cancer

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Interference with DNA repair after ionizing radiation by a pyrrole-imidazole polyamide

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IDH1 R132H acts as a tumor suppressor in glioma via epigenetic upregulation of the DNA damage responsePreprint

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CK2–HTATSF1–TOPBP1 signaling axis modulates tumor chemotherapy response

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Clinical outcomes of DNA-damaging agents and DNA damage response inhibitors combinations in cancer: a data-driven review

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Decoding cellular stress states for toxicology using single-cell transcriptomics

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Betaine-loaded Foeniculum vulgare@Fe-MOF: A novel approach to combat bleomycin-induced hepatotoxicity in rats

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Molecular Pathogenesis of HPV16‐Associated Cervical Cancer: From Viral Entry to Therapeutic Interventions

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Targeted CRISPR knockout screening identifies known and novel chemogenomic interactions between DNA damaging agents and DNA repair genes

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Molecular associations and clinical significance of core NHEJ pathway genes in renal clear cell carcinoma

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Natural pentacyclic triterpenoid from Pristimerin sensitizes p53-deficient tumor to PARP inhibitor by ubiquitination of Chk1

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LncRNA LINC01664 promotes cancer resistance through facilitating homologous recombination-mediated DNA repair

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Image-Based High Content Screening: Automating the Quantification Process for DNA Damage-Induced Foci

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G2 Phase, Responses to DNA Damage, and Control of Entry Into Mitosis

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Drug Delivery to Primary and Metastatic Brain Tumors: Challenges and Opportunities

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ATP-Linked Chimeric Nucleotide as a Specific Luminescence Reporter of Deoxyuridine Triphosphatase

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Gene–Environment Interactions in Repeat Expansion Diseases: Mechanisms of Environmentally Induced Repeat Instability

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Dynamic structures in DNA damage responses & cancer

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Editorial: Current understanding of genomic and chromosomal instabilities in solid malignancies

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Epigenetic mechanism of therapeutic resistance and potential of epigenetic therapeutics in chemorefractory prostate cancer

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A DNA damage response‐like phenotype defines a third of colon cancers at onset

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cGAS – STING Pathway Activation Enhances Antitumor Effect of Talaporfin Photodynamic Therapy Through ROS Production

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Programmable DNA‐Based Synthetic Organelles as Telomerase Traps for Cell Cycle Regulation in Cancer Cells

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Differential PARP inhibitor responses in BRCA1-deficient and resistant cells in competitive co-culture

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Mutation profile and molecular heterogeneity in mismatch repair deficient endometrial carcinoma

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Non-coding RNAs-mediated regulation of the MAPK pathway in gastric cancer: translational perspectives

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MOKCa-3D database: functional and structural analysis of missense mutations in cancer

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A small molecule disrupts G4–STAT1 interaction and synergizes with olaparib to drive cancer cell death

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Correctly identifying the cells of origin is essential for tailoring treatment and understanding the emergence of cancer stem cells and late metastases

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DNA damage in peripheral blood mononuclear cells in patients with melanoma

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Effect of a personalized intensive dietary intervention on base excision repair (BER) in colorectal cancer patients: Results from a randomized controlled trial

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PALB2 variant status in hematological malignancies – a potential therapeutic target?

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High RPMB predicts poor disease-free survival of male N1 papillary thyroid cancer after adjuvant radioiodine therapy

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Rare variant phasing using paired tumor:normal sequence data

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DNA Damage Response in Quiescent Hematopoietic Stem Cells and Leukemia Stem Cells

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Radiotherapy in Brain Tumors

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Low Plasma Citrate Levels and Specific Transcriptional Signatures Associated with Quiescence of CD34+ Progenitors Predict Azacitidine Therapy Failure in MDS/AML Patients

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Suppressors of Break-Induced Replication in Human Cells

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Imaging and force detection of single deoxyribonucleic acid molecules by atomic force microscopy

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The distinct roles of MSH2 and MLH1 in basal-like breast cancer and immune modulationPreprint

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Mutation characteristics of cancer susceptibility genes in Chinese ovarian cancer patients

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Identification of DNA damage repair-related genes in sepsis using bioinformatics and machine learning: An observational study

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Design and synthesis of 2-amino-4-(trifluoromethyl)pyrimidine derivatives as potential Werner-dependent antiproliferative agents

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mTORC2 Regulates Non-homologous End Joining Through Modulating the Temporal Dynamics of 53BP1

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Efficacy and safety of PARP inhibitors in metastatic breast cancer patients with homologous recombination repair pathway gene mutations: a retrospective multicenter real-world study

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Discovery of GBA-16-24 as a highly potent, selective ATR inhibitor for the treatment of FLT3-mutated acute myeloid leukemia

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Dual Targeting of DNA and EGFR by ZYH005 Induces DNA Damage and Mitotic Catastrophe in Glioblastoma

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B.R.E.A.S.T. Breast canceR Enhanced AI-Supported Therapy: A New Interpretable Proteomics-Driven Machine Learning Framework for Therapy Response Prediction in Breast Cancer

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Chalcones as multitarget modulators in non-small cell lung cancer: mechanistic insights and therapeutic perspectives

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Molecular profiling of a case of advanced pancreatic cancer identifies an active and tolerable combination of targeted therapy with backbone chemotherapy.

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Radiation DNA damage and use in cancer/therapeutics-translation of radiation modifiers

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Prognostic and Predictive Significance of Base Excision Repair in Human Cancers

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DNA Probes for Analysis of the Activity of Key Enzymes of the Base Excision DNA Repair Pathway in Human Cells

Alekseeva, I. V., Кузнецова, А. А., Kladova, O. A., Shender, V. О., Schneider, P. V., Fedorova, O. S., & Kuznetsov, N. A. (2023) · Molecular Biology · doi:10.1134/s0026893323020024 · Cited by 1

DEAD/H‐box helicase 11 is transcriptionally activated by Yin Yang‐1 and accelerates oral squamous cell carcinoma progression

Yang, G., Shi, X., Zhang, M., Wang, K., Tian, X., & Wang, X. (2024) · Cell Biology International · doi:10.1002/cbin.12228 · Cited by 1

The FANCA to FANCZ of DNA interstrand crosslink repair: Lessons from Fanconi anemia

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Interface of DNA Repair and Metabolism

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Development of a CRISPR‐Cas9 Based Luciferase Turn‐On System as Nonhomologous End Joining Pathway Reporter

Wang, Y., Zhao, Y., Su, W., Guo, X., & Li, S. (2021) · ChemBioChem · doi:10.1002/cbic.202100128 · Cited by 1

Comprehensive analysis to identify DNA damage response-related lncRNA pairs as a prognostic and therapeutic biomarker in gastric cancer

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Genetic insights into biological mechanisms governing human ovarian ageing

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Cancer therapies inducing DNA damage

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Low RPMB indicates better disease-free survival of adjuvant radiotherapy after radical surgery in thymoma.

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Identification of RAD17 as a candidate cancer predisposition gene in families with histories of pancreatic and breast cancers

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Mutational signatures in upper tract urothelial carcinoma define etiologically distinct subtypes with prognostic relevancePreprint

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In Reply: DDR Pathway Alteration, Tumor Mutation Burden and Cisplatin Sensitivity in Small Cell Lung Cancer: Difference Detected by Whole-Exome and Targeted-Gene Sequencing

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Loose ends in cancer genome structurePreprint

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Genomic hallmarks of cellular dormancy in cancer and therapeutic implicationsPreprint

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Identification and characterization of novel genes involved in DNA double strand break repair process in the yeast Saccharomyces cerevisiae

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Faculty Opinions recommendation of Genomic and Molecular Landscape of DNA Damage Repair Deficiency across The Cancer Genome Atlas.

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Repression of PRMT activities sensitize homologous recombination-proficient ovarian and breast cancer cells to PARP inhibitor treatmentPreprint

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Characterisation of two deubiquitinating enzymes in the DNA damage response and replication

Stone, H. R. (2015) · University of Birmingham Institutional Research Archive (University of Birmingham)

Analysis and characterization of chemo- and radiation therapy sensitizing strategies in tumours with focus on effects of phenothiazines on DNA damage response signalling

Zielinska-Chomej, K. (2015) · Figshare

MicroRNA involvement in breast cancer susceptibility and progression

Gomes, B. C. (2016) · Portuguese National Funding Agency for Science, Research and Technology (RCAAP Project by FCT)

USP9X controls DNA replication fork stability and the replication stress checkpoint through Claspin

McGarry, E. (2016) · Arrow@dit (Dublin Institute of Technology) · doi:10.13025/17576

A Transcriptional Regulatory Network Model Reveals miR-34a as a Potential Regulator of Proliferation in Cancer Cell Lines

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New Targets to Modulate the DNA Damage Response

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Perspectives for Characterizing Drug Component of Theranostic Products Containing Nanomaterials

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Epigenetikai faktorok hatásának vizsgálata a Huntington-kór patomechanizmusában Drosophila modellben

Varga, J. (2020) · SZTE Repository of Dissertations (University of Szeged) · doi:10.14232/phd.10540

Exploring the Involvement of FoxM1 in CML Cells from DNA Damage Response-Regulatory ProspectivePreprint

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Cancer Precision Drug Discovery Using Big Data and Artificial Intelligence Technologies

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“The replication stress response suppresses mutation rates in mismatch repair deficient budding yeast and human cancers”Preprint

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Prediction and Investigation of Novel Proteins in DNA Double Stranded Break Repair

Hooshyar, M. (2016) · doi:10.22215/etd/2016-11472

Faculty Opinions recommendation of Revisiting the hallmarks of cancer.

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Peer Review #3 of "A signature of tumor DNA repair genes associated with the prognosis of surgically-resected lung adenocarcinoma (v0.1)"

(2020) · PeerJ · doi:10.7287/peerj.10418v0.1/reviews/3

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Total Synthesis and Chemoproteomics Connect Curcusone Diterpenes with Oncogenic Protein BRAT1Preprint

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Peer Review #4 of "A signature of tumor DNA repair genes associated with the prognosis of surgically-resected lung adenocarcinoma (v0.2)"

(2020) · PeerJ · doi:10.7287/peerj.10418v0.2/reviews/4

Peer Review #2 of "A signature of tumor DNA repair genes associated with the prognosis of surgically-resected lung adenocarcinoma (v0.2)"

(2020) · PeerJ · doi:10.7287/peerj.10418v0.2/reviews/2

Pan-Cancer Analysis of Potential Synthetic Lethal Drug Targets Specific to Alterations in DNA Damage Response

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