The DOI matches its Crossref record; 90 of the 90 references it cites were found in a registry or an index.
Heterogeneity of epidermal growth factor receptor signalling networks in glioblastoma
Open accessAbstract
As tumours evolve, the daughter cells of the initiating cell often become molecularly heterogeneous and develop different functional properties and therapeutic vulnerabilities. In glioblastoma (GBM), a lethal form of brain cancer, the heterogeneous expression of the epidermal growth factor receptor (EGFR) poses a substantial challenge for the effective use of EGFR-targeted therapies. Understanding the mechanisms that cause EGFR heterogeneity in GBM should provide better insights into how they, and possibly other amplified receptor tyrosine kinases, affect cellular signalling, metabolism and drug resistance.
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Self-citation
Metadata
- Authors
- Furnari, F. B., Cloughesy, T. F., Cavenee, W. K., & Mischel, P. S.
- Venue
- Nature Reviews Cancer
- Published
- 2015-04-09
- Volume
- 15
- Issue
- 5
- Pages
- 302-310
- ISSN
- 1474-175X (ISSN-L)
- 1474-1768
- OpenAlex
- W2034015235
- Cited by
- 381
- References
- 90
- FWCI
- 7.34
- Type
- journal article
- Language
- en
- Open access
- green
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- Furnari, F. B., Cloughesy, T. F., Cavenee, W. K., & Mischel, P. S. (2015). Heterogeneity of epidermal growth factor receptor signalling networks in glioblastoma. Nature Reviews Cancer. https://doi.org/10.1038/nrc3918
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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