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The tumour microenvironment after radiotherapy: mechanisms of resistance and recurrence
Open accessAbstract
Radiotherapy plays a central part in curing cancer. For decades, most research on improving treatment outcomes has focused on modulating radiation-induced biological effects on cancer cells. Recently, we have better understood that components within the tumour microenvironment have pivotal roles in determining treatment outcomes. In this Review, we describe vascular, stromal and immunological changes that are induced in the tumour microenvironment by irradiation and discuss how these changes may promote radioresistance and tumour recurrence. We also highlight how this knowledge is guiding the development of new treatment paradigms in which biologically targeted agents will be combined with radiotherapy.
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“Generation of intratumoral O2 is also feasible to improve the efficacy of radiotherapy by using bioactive albumin-MnO2 nanoparticles [94].”
From Hypoxia Signaling in Cancer: From Basics to Clinical Practice (2021) · cites this paper as [94]
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Metadata
- Authors
- Barker, H. E., Paget, J. T. E., Khan, A. A., & Harrington, K. J.
- Affiliations
- Institute of Cancer Research (GB)
- Corresponding author
- Barker, Holly E.
- Venue
- Nature Reviews Cancer
- Published
- 2015-06-24
- Volume
- 15
- Issue
- 7
- Pages
- 409-425
- ISSN
- 1474-175X (ISSN-L)
- 1474-1768
- PMC
- PMC4896389
- OpenAlex
- W1912124796
- Cited by
- 2,144
- References
- 200
- Citations by year
- 2026: 181 · 2025: 215 · 2024: 246 · 2023: 242 · 2022: 249 · 2021: 256 · 2020: 230 · 2019: 175 · 2018: 161 · 2017: 119 · 2016: 63 · 2015: 7
- FWCI
- 12.40
- Type
- journal article
- Language
- en
- Update notices
- erratum (2015-07-24)
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Nature reviews. Cancer (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Cancer Research UK (C46 ⁄ A10588, C7224/A13407, A13407, 13407)
- National Institute for Health and Care Research (CL-2014-22-003)
- Rosetrees Trust
- Topics
- Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Effects of Radiation Exposure
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Cancer, Hypoxia, and Metabolism
- Keywords
- tumor microenvironment, radioresistance (biology), radiotherapy, tumor stroma, tumor recurrence, vascular changes, immunological changes, combination therapy, molecularly targeted agents
- MeSH terms
- Animals, Fibroblasts, Humans, Immune Tolerance, Neoplasm Recurrence, Local, Neoplasms, Radiation Tolerance, Cell Hypoxia, Transforming Growth Factor beta, Vascular Endothelial Growth Factor A, Tumor Microenvironment
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