The Oral Microbiome and Cancer
Open accessAbstract
There is mounting evidence that members of the human microbiome are highly associated with a wide variety of cancer types. Among oral cancers, oral squamous cell carcinoma (OSCC) is the most prevalent and most commonly studied, and it is the most common malignancy of the head and neck worldwide. However, there is a void regarding the role that the oral microbiome may play in OSCC. Previous studies have not consistently found a characteristic oral microbiome composition associated with OSCC. Although a direct causality has not been proven, individual members of the oral microbiome are capable of promoting various tumorigenic functions related to cancer development. Two prominent oral pathogens, Porphyromonas gingivalis, and Fusobacterium nucleatum can promote tumor progression in mice. P. gingivalis infection has been associated with oro-digestive cancer, increased oral cancer invasion, and proliferation of oral cancer stem cells. The microbiome can influence the evolution of the disease by directly interacting with the human body and significantly altering the response and toxicity to various forms of cancer therapy. Recent studies have shown an association of certain phylogenetic groups with the immunotherapy treatment outcomes of certain tumors. On the other side of the coin, recently it has been a resurgence in interest on the potential use of bacteria to cure cancer. These kinds of treatments were used in the late nineteenth and early twentieth centuries as the first line of defense against cancer in some hospitals but later displaced by other types of treatments such as radiotherapy. Currently, organisms such as Salmonella typhimurium and Clostridium spp. have been used for targeted strategies as potential vectors to treat cancer. In this review, we briefly summarize our current knowledge of the role of the oral microbiome, focusing on its bacterial fraction, in cancer in general and in OSCC more precisely, and a brief description of the potential use of bacteria to target tumors.
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Alterations in abundance of oral bacteria have been directly or indirectly linked to onset of cancer, cardiovascular and pulmonary diseases, stroke, diabetes and neurodegeneration.
“Accordingly, alterations in the abundance of oral bacteria have been directly or indirectly linked to the onset of different disorders, such as cancer, cardiovascular and pulmonary diseases, stroke, diabetes and even neurodegeneration [487,488,489,490,491].”
From The Interplay between Gut Microbiota and Parkinson’s Disease: Implications on Diagnosis and Treatment (2022) · cites this paper as [488]
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Varesi, A., Campagnoli, L. I. M., Fahmideh, F., Pierella, E., Romeo, M., Ricevuti, G., Nicoletta, M., Chirumbolo, S., & Pascale, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232012289 · Cited by 88 · see citing works
- Authors
- Irfan, M., Delgado, R. Z. R., & Frias-Lopez, J.
- Affiliations
- University of Florida (US)
- Venue
- Frontiers in Immunology
- Publisher
- Frontiers Media SA
- Published
- 2020-10-23
- Volume
- 11
- Pages
- 591088-591088
- ISSN
- 1664-3224 (ISSN-L)
- PMC
- PMC7645040
- OpenAlex
- W3094268377
- Cited by
- 341
- References
- 230
- Citations by year
- 2026: 51 · 2025: 77 · 2024: 80 · 2023: 56 · 2022: 59 · 2021: 18
- FWCI
- 5.40
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Frontiers in Immunology (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Institute of Dental and Craniofacial Research
- Topics
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Health Sciences › Medicine › Otorhinolaryngology › Head and Neck Cancer Studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Cancer Research and Treatments
- Keywords
- oral microbiota, oral squamous cell carcinoma, Porphyromonas gingivalis, Fusobacterium nucleatum, oral pathogens, tumor progression, cancer stem cells, cancer immunotherapy response, cancer therapy toxicity, bacterial cancer therapy, Salmonella typhimurium, Clostridium, head and neck cancer
- MeSH terms
- Squamous Cell Carcinoma of Head and Neck, Animals, Combined Modality Therapy, Disease Susceptibility, Humans, Mouth Mucosa, Mouth Neoplasms, Neoplasms, Organ Specificity, Treatment Outcome, Disease Management, Host-Pathogen Interactions, Microbiota
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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