Using immunotherapy to boost the abscopal effect
Open accessAbstract
More than 60 years ago, the effect whereby radiotherapy at one site may lead to regression of metastatic cancer at distant sites that are not irradiated was described and called the abscopal effect (from 'ab scopus', that is, away from the target). The abscopal effect has been connected to mechanisms involving the immune system. However, the effect is rare because at the time of treatment, established immune-tolerance mechanisms may hamper the development of sufficiently robust abscopal responses. Today, the growing consensus is that combining radiotherapy with immunotherapy provides an opportunity to boost abscopal response rates, extending the use of radiotherapy to treatment of both local and metastatic disease. In this Opinion article, we review evidence for this growing consensus and highlight emerging limitations to boosting the abscopal effect using immunotherapy. This is followed by a perspective on current and potential cross-disciplinary approaches, including the use of smart materials to address these limitations.
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Radiotherapy in combination with immunotherapy can maximize the antitumor immune response and promote durable disease control.
“In combination with immunotherapy, radiotherapy can maximize the antitumor immune response and promote durable disease control16,17.”
From Gut microbiome diversity is an independent predictor of survival in cervical cancer patients receiving chemoradiation (2021) · cites this paper as [16]
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- Authors
- Ngwa, W., Irabor, O. C., Schoenfeld, J. D., Hesser, J., Demaria, S., & Formenti, S. C.
- Affiliations
- Brigham and Women's Hospital (US)
- Heidelberg University (DE)
- Weill Cornell Medicine (US)
- Corresponding author
- Ngwa, Wilfred
- ORCID
- Venue
- Nature Reviews Cancer
- Published
- 2018-02-16
- Volume
- 18
- Issue
- 5
- Pages
- 313-322
- ISSN
- 1474-175X (ISSN-L)
- 1474-1768
- PMC
- PMC5912991
- OpenAlex
- W2788208686
- Cited by
- 1,260
- References
- 114
- Citations by year
- 2026: 136 · 2025: 160 · 2024: 148 · 2023: 162 · 2022: 168 · 2021: 156 · 2020: 181 · 2019: 103 · 2018: 46
- FWCI
- 12.72
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature reviews. Cancer (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Cancer Institute (R21CA205094, K01CA172478)
- Topics
- Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Radiopharmaceutical Chemistry and Applications
- Keywords
- abscopal effect, radiotherapy, immunotherapy, combination therapy, metastatic cancer, immune tolerance, cancer immunotherapy, smart materials
- MeSH terms
- Animals, Combined Modality Therapy, Dose-Response Relationship, Immunologic, Dose-Response Relationship, Radiation, Drug Carriers, Humans, Immunosuppression Therapy, Immunotherapy, Neoplasms, Radiotherapy, Biomarkers, Tumor, Drug Delivery Systems, Nanoparticles
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