Chip–NMR biosensor for detection and molecular analysis of cells
Open accessAbstract
Rapid and accurate measurement of biomarkers in tissue and fluid samples is a major challenge in medicine. Here we report the development of a new, miniaturized diagnostic magnetic resonance (DMR) system for multiplexed, quantitative and rapid analysis. By using magnetic particles as a proximity sensor to amplify molecular interactions, the handheld DMR system can perform measurements on unprocessed biological samples. We show the capability of the DMR system by using it to detect bacteria with high sensitivity, identify small numbers of cells and analyze them on a molecular level in real time, and measure a series of protein biomarkers in parallel. The DMR technology shows promise as a robust and portable diagnostic device.
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The chip-based DMR system has been tested for detection of cancer biomarkers in serum samples.
“This DMR system has been tested for the detection of cancer biomarkers in serum samples [205].”
From Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications (2019) · cites this paper as [205]
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Iron oxide nanoparticles: Diagnostic, therapeutic and theranostic applications
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- Authors
- Lee, H., Sun, E., Ham, D., & Weissleder, R.
- Affiliations
- Harvard University (US)
- Corresponding author
- Weissleder, Ralph
- Venue
- Nature Medicine
- Published
- 2008-07-06
- Volume
- 14
- Issue
- 8
- Pages
- 869-874
- ISSN
- 1078-8956 (ISSN-L)
- 1546-170X
- PMC
- PMC2729055
- OpenAlex
- W2099680426
- Cited by
- 621
- References
- 3
- Citations by year
- 2026: 6 · 2025: 14 · 2024: 21 · 2023: 24 · 2022: 30 · 2021: 31 · 2020: 33 · 2019: 36 · 2018: 29 · 2017: 44 · 2016: 39 · 2015: 48 · 2014: 42 · 2013: 58 · 2012: 54
- FWCI
- 16.17
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Medicine (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Digital Access to Scholarship at Harvard (DASH) (Harvard University) (submittedVersion, cc-by)
- Funders
- National Institutes of Health (5u54ca119349-05)
- National Heart, Lung, and Blood Institute (U01HL080731)
- National Cancer Institute (U54 CA-119349)
- Topics
- Physical Sciences › Chemistry › Spectroscopy › Advanced NMR Techniques and Applications
- Physical Sciences › Physics and Astronomy › Nuclear and High Energy Physics › NMR spectroscopy and applications
- Physical Sciences › Engineering › Biomedical Engineering › Biosensors and Analytical Detection
- Keywords
- biomarker detection, bacterial detection, cell identification, protein biomarkers, portable diagnostic device, multiplex analysis
- MeSH terms
- Animals, Biotechnology, Equipment Design, Humans, Macrophages, Magnetic Resonance Spectroscopy, Sensitivity and Specificity, Reproducibility of Results, Biosensing Techniques, Biomarkers, Oligonucleotide Array Sequence Analysis, Microchip Analytical Procedures, Microfluidic Analytical Techniques, Mice, Nanoparticles
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