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Cited by 569

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Cancer stem cells in nervous system tumors

Singh, Sheila K, Clarke, Ian D, Hide, Takuichiro, Dirks, Peter B·2004·Oncogene
DOI 10.1038/sj.onc.1207946
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Abstract

Most current research on human brain tumors is focused on the molecular and cellular analysis of the bulk tumor mass. However, evidence in leukemia and more recently in solid tumors such as breast cancer suggests that the tumor cell population is heterogeneous with respect to proliferation and differentiation. Recently, several groups have described the existence of a cancer stem cell population in human brain tumors of different phenotypes from both children and adults. The finding of brain tumor stem cells (BTSCs) has been made by applying the principles for cell culture and analysis of normal neural stem cells (NSCs) to brain tumor cell populations and by identification of cell surface markers that allow for isolation of distinct tumor cell populations that can then be studied in vitro and in vivo. A population of brain tumor cells can be enriched for BTSCs by cell sorting of dissociated suspensions of tumor cells for the NSC marker CD133. These CD133+ cells, which also expressed the NSC marker nestin, but not differentiated neural lineage markers, represent a minority fraction of the entire brain tumor cell population, and exclusively generate clonal tumor spheres in suspension culture and exhibit increased self-renewal capacity. BTSCs can be induced to differentiate in vitro into tumor cells that phenotypically resembled the tumor from the patient. Here, we discuss the evidence for and implications of the discovery of a cancer stem cell in human brain tumors. The identif…

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Crossref · 10.1038/sj.onc.1207946

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  • Glioblastomas arise and are maintained by a population of progenitor cells with stem-like characteristics including self-renewal for unlimited proliferation.

    “It is hypothesized that glioblastomas, like other cancers such as leukemia [51], arise and are maintained by a population of progenitor cells with stem-like characteristics including the ability to self-renew for unlimited proliferation [21], [52], [53].”

    From Reduced Expression of Brain-Enriched microRNAs in Glioblastomas Permits Targeted Regulation of a Cell Death Gene (2011) · cites this paper as [52]

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Metadata

Authors
Singh, S. K., Clarke, I. D., Hide, T., & Dirks, P. B.
Venue
Oncogene
Publisher
Springer Science and Business Media LLC
Published
2004-09-20
Volume
23
Issue
43
Pages
7267-7273
ISSN
  • 0950-9232
  • 1476-5594
DOI
10.1038/sj.onc.1207946
Cited by
569
References
2
Language
en
Licence

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