Reducing the risk of CVD in patients with periodontitis
Abstract
The association between periodontitis and other chronic diseases, such as cardiovascular disease (CVD) and type 2 diabetes mellitus, could be related to systemic inflammation initiated by a local inflammatory challenge. Oliveira et al. have added lack of oral hygiene, and its link with systemic inflammation, to the spectrum of risk factors for CVD.
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Patients with severe periodontitis have higher blood neutrophil counts and pro-inflammatory mediator levels (IL-1, IL-6, CRP, fibrinogen) compared to healthy controls.
“Patients with severe periodontitis had higher blood neutrophil counts and pro-inflammatory mediator levels (such as IL-1, IL-6, CRP, and fibrinogen) compared to healthy controls [14–17]”
From Effect of non-surgical periodontal therapy on risk markers of cardiovascular disease: a systematic review and meta-analysis (2024) · cites this paper as [15]
Cites
Identification of Periodontal Pathogens in Atheromatous Plaques
Haraszthy, V. I., Zambon, J. J., Trevisan, M., Zeid, M., & Genco, R. J. (2000) · Journal of Periodontology · doi:10.1902/jop.2000.71.10.1554 · Cited by 1,125 · see citing works
Self-citationA systematic review and meta‐analyses on C‐reactive protein in relation to periodontitis
Paraskevas, S., Huizinga, J. D., & Loos, B. G. (2008) · Journal of Clinical Periodontology · doi:10.1111/j.1600-051x.2007.01173.x · Cited by 757 · see citing works
Periodontal Disease and Coronary Heart Disease Incidence: A Systematic Review and Meta-analysis
Humphrey, L. L., Fu, R. F., Buckley, D., Freeman, M., & Helfand, M. (2008) · Journal of General Internal Medicine · doi:10.1007/s11606-008-0787-6 · Cited by 723 · see citing works
Bahekar, A., Singh, S., Saha, S. A., Molnár, J., & Arora, R. (2007) · American Heart Journal · doi:10.1016/j.ahj.2007.06.037 · Cited by 699 · see citing works
Periodontal Disease and Risk of Cerebrovascular Disease
Wu, T., Trevisan, M., Genco, R. J., Dorn, J. P., Falkner, K. L., & Sempos, C. T. (2000) · Archives of Internal Medicine · doi:10.1001/archinte.160.18.2749 · Cited by 495 · see citing works
Self-citationToothbrushing, inflammation, and risk of cardiovascular disease: results from Scottish Health Survey
de Oliveira, C., Watt, R., & Hamer, M. (2010) · BMJ · doi:10.1136/bmj.c2451 · Cited by 365 · see citing works
Friedewald, V. E., Kornman, K. S., Beck, J. D., Genco, R. J., Goldfine, A. B., Libby, P., Offenbacher, S., Ridker, P. M., Dyke, T. E. V., & Roberts, W. C. (2009) · Journal of Periodontology · doi:10.1902/jop.2009.097001 · Cited by 266 · see citing works
Self-citationOffenbacher, S., Beck, J. D., MOSS, K. L., Mendoza, L., Paquette, D. W., Barrow, D. A., Couper, D. J., Stewart, D., Falkner, K. L., Graham, S., et al. (2009) · Journal of Periodontology · doi:10.1902/jop.2009.080007 · Cited by 258 · see citing works
Self-citationRole for Periodontitis in the Progression of Lipid Deposition in an Animal Model
Jain, A. R., Júnior, E. L. B., Serhan, C. N., Stahl, G. L., & Dyke, T. E. V. (2003) · Infection and Immunity · doi:10.1128/iai.71.10.6012-6018.2003 · Cited by 180 · see citing works
Periodontitis May Increase the Risk of Peripheral Arterial Disease
Chen, Y., Umeda, M., Nagasawa, T., Takeuchi, Y., Huang, Y., Inoue, Y., Iwai, T., Izumi, Y., & Ishikawa, I. (2007) · European Journal of Vascular and Endovascular Surgery · doi:10.1016/j.ejvs.2007.08.016 · Cited by 125 · see citing works
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Periodontitis: from microbial immune subversion to systemic inflammation
Hajishengallis, G. (2015) · Nature Reviews Immunology · doi:10.1038/nri3785 · Cited by 3,046 · see citing works
The keystone-pathogen hypothesis
Hajishengallis, G., Darveau, R. P., & Curtis, M. A. (2012) · Nature Reviews Microbiology · doi:10.1038/nrmicro2873 · Cited by 1,790 · see citing works
Local and systemic mechanisms linking periodontal disease and inflammatory comorbidities
Hajishengallis, G., & Chavakis, T. (2021) · Nature Reviews Immunology · doi:10.1038/s41577-020-00488-6 · Cited by 1,871 · see citing works
Hajishengallis, G., Liang, S., Payne, M. A., Hashim, A., Jotwani, R., Eskan, M. A., McIntosh, M. L., Alsam, A., Kirkwood, K. L., Lambris, J. D., et al. (2011) · Cell Host & Microbe · doi:10.1016/j.chom.2011.10.006 · Cited by 1,154 · see citing works
Immunomicrobial pathogenesis of periodontitis: keystones, pathobionts, and host response
Hajishengallis, G. (2014) · Trends in Immunology · doi:10.1016/j.it.2013.09.001 · Cited by 1,150 · see citing works
The cytokine network involved in the host immune response to periodontitis
Pan, W., Wang, Q., & Chen, Q. (2019) · International Journal of Oral Science · doi:10.1038/s41368-019-0064-z · Cited by 709 · see citing works
Optimization of the ligature-induced periodontitis model in mice
Abe, T., & Hajishengallis, G. (2013) · Journal of Immunological Methods · doi:10.1016/j.jim.2013.05.002 · Cited by 550 · see citing works
The leukocyte integrin antagonist Del-1 inhibits IL-17-mediated inflammatory bone loss
Eskan, M. A., Jotwani, R., Abe, T., Chmelar, J., Lim, J.-H., Liang, S., Ciero, P. A., Krauss, J. L., Li, F., Rauner, M., et al. (2012) · Nature Immunology · doi:10.1038/ni.2260 · Cited by 429 · see citing works
Periodontal Disease: The Good, The Bad, and The Unknown
Sedghi, L. M., Bacino, M. S., & Kapila, Y. L. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2021.766944 · Cited by 385 · see citing works
de Molon, R. S., Rossa, C., Thurlings, R. M., Cirelli, J. A., & Koenders, M. I. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20184541 · Cited by 262 · see citing works
Streptococcus Sanguinis Biofilm Formation & Interaction with Oral Pathogens
Zhu, B., Macleod, L. C., Kitten, T. O., & Xu, P. (2018) · Future Microbiology · doi:10.2217/fmb-2018-0043 · Cited by 228 · see citing works
Infection and inflammatory mechanisms
Dyke, T. E. V., & Winkelhoff, A. J. V. (2013) · Journal of Periodontology · doi:10.1902/jop.2013.1340018 · Cited by 221 · see citing works
Helicobacter pylori in human health and disease: Mechanisms for local gastric and systemic effects
Bravo, D., Hoare, A., Soto, C., Valenzuela, M., & Quest, A. F. G. (2018) · World Journal of Gastroenterology · doi:10.3748/wjg.v24.i28.3071 · Cited by 212 · see citing works
Hasturk, H., Abdallah, R., Kantarci, A., Nguyen, D., Giordano, N., Hamilton, J., & Van Dyke, T. E. (2015) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/atvbaha.115.305324 · Cited by 199 · see citing works
Oral infections and cardiovascular disease
Kholy, K. E., Genco, R. J., & Dyke, T. E. V. (2015) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2015.03.001 · Cited by 201 · see citing works
Self-citationPeriodontal diseases and adverse pregnancy outcomes
Komine‐Aizawa, S., Aizawa, S., & Hayakawa, S. (2018) · Journal of obstetrics and gynaecology research · doi:10.1111/jog.13782 · Cited by 172 · see citing works
Oral Dysbiotic Communities and Their Implications in Systemic Diseases
Sudhakara, P., Gupta, A., Bhardwaj, A., & Wilson, A. (2018) · Dental journal · doi:10.3390/dj6020010 · Cited by 150 · see citing works
Applications of nanomaterials in tissue engineering
Zheng, X., Zhang, P., Fu, Z., Meng, S., Dai, L., & Yang, H. (2021) · RSC Advances · doi:10.1039/d1ra01849c · Cited by 171 · see citing works
Infection and inflammatory mechanisms
Dyke, T. E. V., & Winkelhoff, A. J. V. (2013) · Journal Of Clinical Periodontology · doi:10.1111/jcpe.12088 · Cited by 154 · see citing works
The role of probiotic bacteria in managing periodontal disease: a systematic review
Matsubara, V. H., Bandara, N., Ishikawa, K., Mayer, M. P. A., & Samaranayake, L. P. (2016) · Expert Review of Anti-infective Therapy · doi:10.1080/14787210.2016.1194198 · Cited by 147 · see citing works
Distal Consequences of Oral Inflammation
Konkel, J. E., O’Boyle, C., & Krishnan, S. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01403 · Cited by 142 · see citing works
Xin, X., Liu, J., Liu, X., Yu, X., Hou, Y., Xiang, X., Deng, Y., Yang, B., & Yu, W. (2024) · ACS Nano · doi:10.1021/acsnano.3c12580 · Cited by 130 · see citing works
Lundmark, A., Hu, Y. O. O., Huss, M., Johannsen, G., Andersson, A. F., & Yucel‐Lindberg, T. (2019) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2019.00216 · Cited by 128 · see citing works
Maekawa, T., & Hajishengallis, G. (2014) · Journal of Periodontal Research · doi:10.1111/jre.12164 · Cited by 127 · see citing works
Complement and dysbiosis in periodontal disease
Hajishengallis, G., & Lambris, J. D. (2012) · Immunobiology · doi:10.1016/j.imbio.2012.07.007 · Cited by 127 · see citing works
Filifactor alocis – a new emerging periodontal pathogen
Aruni, W., Mishra, A., Dou, Y., Chioma, O. S., Hamilton, B. N., & Fletcher, H. M. (2015) · Microbes and Infection · doi:10.1016/j.micinf.2015.03.011 · Cited by 123 · see citing works
Periodontal disease and periodontal bacteria as triggers for rheumatoid arthritis
Cheng, Z., Meade, J. L., Mankia, K. S., Emery, P., & DeVine, D. (2017) · Best Practice & Research Clinical Rheumatology · doi:10.1016/j.berh.2017.08.001 · Cited by 120 · see citing works
Abe, T., Hosur, K. B., Hajishengallis, E., Reis, E. S., Ricklin, D., Lambris, J. D., & Hajishengallis, G. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1202339 · Cited by 119 · see citing works
Phage–bacteria interaction network in human oral microbiome
Wang, J., Gao, Y., & Zhao, F. (2015) · Environmental Microbiology · doi:10.1111/1462-2920.12923 · Cited by 118 · see citing works
Endogenous modulators of inflammatory cell recruitment
Hajishengallis, G., & Chavakis, T. (2012) · Trends in Immunology · doi:10.1016/j.it.2012.08.003 · Cited by 110 · see citing works
Zhou, M., Gao, S., Zhang, X., Zhang, T., Zhang, T., Tian, T., Li, S., Lin, Y., & Cai, X. (2020) · Bioactive Materials · doi:10.1016/j.bioactmat.2020.11.018 · Cited by 109 · see citing works
Role of Maternal Periodontitis in Preterm Birth
Ren, H., & Du, M. (2017) · Frontiers in Immunology · doi:10.3389/fimmu.2017.00139 · Cited by 97 · see citing works
Chen, W.-P., Chang, S., Tang, C. Y., Liou, M., Tsai, S. J., & Lin, Y.-L. (2018) · BioMed Research International · doi:10.1155/2018/3130607 · Cited by 95 · see citing works
Periodontitis and systemic disease
Winning, L., & Linden, G. J. (2015) · BDJ Team · doi:10.1038/bdjteam.2015.163 · Cited by 93 · see citing works
Qiu, X., Yu, Y., Liu, H., Li, X., Sun, W., Wu, W., Liu, C., & Miao, L. (2021) · Acta Biomaterialia · doi:10.1016/j.actbio.2021.08.009 · Cited by 93 · see citing works
ROS-scavenging biomaterials for periodontitis
Chen, E., Wang, T., Tu, Y., Sun, Z., Ding, Y., Gu, Z., & Xiao, S. (2022) · Journal of Materials Chemistry B · doi:10.1039/d2tb02319a · Cited by 90 · see citing works
Filifactor alocis : The Newly Discovered Kid on the Block with Special Talents
Aruni, W., Chioma, O. S., & Fletcher, H. M. (2014) · Journal of Dental Research · doi:10.1177/0022034514538283 · Cited by 88 · see citing works
Gene expression profiling of periodontitis-affected gingival tissue by spatial transcriptomics
Lundmark, A., Gerasimčik, N., Båge, T., Jemt, A., Mollbrink, A., Salmén, F., Lundeberg, J., & Yucel‐Lindberg, T. (2018) · Scientific Reports · doi:10.1038/s41598-018-27627-3 · Cited by 86 · see citing works
Role of complement in host–microbe homeostasis of the periodontium
Hajishengallis, G., Abe, T., Maekawa, T., Hajishengallis, E., & Lambris, J. D. (2013) · Seminars in Immunology · doi:10.1016/j.smim.2013.04.004 · Cited by 81 · see citing works
Novel Inflammatory Pathways in Periodontitis
Hajishengallis, G., & Sahingur, S. E. (2014) · Advances in Dental Research · doi:10.1177/0022034514526240 · Cited by 81 · see citing works
Mahmoud, M. Y., Steinbach-Rankins, J. M., & Demuth, D. R. (2019) · Journal of Controlled Release · doi:10.1016/j.jconrel.2019.01.036 · Cited by 67 · see citing works
Hajishengallis, G., Li, X., Divaris, K., & Chavakis, T. (2022) · Periodontology 2000 · doi:10.1111/prd.12421 · Cited by 67 · see citing works
An Evidence-Based Update on the Molecular Mechanisms Underlying Periodontal Diseases
Qasim, S. S. B., Alotaibi, D. H., Jasser, R. A., Gul, S. S., & Zafar, M. S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21113829 · Cited by 64 · see citing works
Dashper, S. G., Mitchell, H. L., Seers, C. A., Gladman, S. L., Seemann, T., Bulach, D., Chandry, P. S., Cross, K. J., Cleal, S. M., & Reynolds, E. C. (2017) · Frontiers in Microbiology · doi:10.3389/fmicb.2017.00048 · Cited by 58 · see citing works
Chen, H., Lan, Z., Li, Q., & Li, Y. (2019) · Artificial Cells Nanomedicine and Biotechnology · doi:10.1080/21691401.2019.1620256 · Cited by 56 · see citing works
RetractedEpigenetic biomarkers: a step forward for understanding periodontitis
Lindroth, A. M., & Park, Y. J. (2013) · Journal of Periodontal & Implant Science · doi:10.5051/jpis.2013.43.3.111 · Cited by 54 · see citing works
Deng, Z.-L., Sztajer, H., Jarek, M., Bhuju, S., & Wagner‐Döbler, I. (2018) · Frontiers in Microbiology · doi:10.3389/fmicb.2018.00124 · Cited by 53 · see citing works
Song, L., Yao, J., He, Z., & Xu, B. (2015) · BMC Oral Health · doi:10.1186/s12903-015-0086-7 · Cited by 48 · see citing works
Immunomodulatory Properties of Stem Cells in Periodontitis: Current Status and Future Prospective
Wang, M., Xie, J., Wang, C., Zhong, D., Xie, L., & Fang, H. (2020) · Stem Cells International · doi:10.1155/2020/9836518 · Cited by 48 · see citing works
Jin, S., Zhou, R., Guan, X., Zhou, J., & Liu, J. (2019) · Journal of Periodontal Research · doi:10.1111/jre.12693 · Cited by 47 · see citing works
Aruni, W., Zhang, K., Dou, Y., & Fletcher, H. M. (2014) · Infection and Immunity · doi:10.1128/iai.01727-14 · Cited by 47 · see citing works
Illuminating the oral microbiome and its host interactions: animal models of disease
Hajishengallis, G. (2023) · FEMS Microbiology Reviews · doi:10.1093/femsre/fuad018 · Cited by 46 · see citing works
Inhibition of Ctsk modulates periodontitis with arthritis via downregulation of TLR9 and autophagy
Wei, W., Ren, J., Yin, W., Ding, H., Lu, Q., Tan, L., Deng, S., Liu, J., Yang, Q., Wang, J., et al. (2019) · Cell Proliferation · doi:10.1111/cpr.12722 · Cited by 45 · see citing works
Jiang, J., Xie, J., Zhou, L., Han, W., Ye, J., Hu, D., Xie, W., Qiu, J., Chen, R., & Wang, X. (2023) · Chemical Engineering Journal · doi:10.1016/j.cej.2023.147850 · Cited by 42 · see citing works
Presence of periodontal pathogenic bacteria in blood of patients with coronary artery disease
Corredor, Z., Suárez-Molina, A., Fong, C., Cifuentes-C, L., & Guauque-Olarte, S. (2022) · Scientific Reports · doi:10.1038/s41598-022-05337-1 · Cited by 48 · see citing works
Rajakaruna, G. A., Negi, M., Uchida, K., Sekine, M., Furukawa, A., Ito, T., Kobayashi, D., Suzuki, Y., Akashi, T., Umeda, M., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-27766-7 · Cited by 40 · see citing works
Nemoto, T., & Ohara‐Nemoto, Y. (2020) · Molecular Oral Microbiology · doi:10.1111/omi.12317 · Cited by 41 · see citing works
Nemoto, T., & Ohara‐Nemoto, Y. (2015) · Japanese Dental Science Review · doi:10.1016/j.jdsr.2015.08.002 · Cited by 39 · see citing works
Er:YAG Laser and Cyclosporin A Effect on Cell Cycle Regulation of Human Gingival Fibroblast Cells
Abbaszadeh, H., Peyvandi, A. A., Sadeghi, Y., Safaei, A., Azodi, M. Z., Khoramgah, M. S., & Rezaei–Tavirani, M. (2017) · Journal of lasers in medical sciences · doi:10.15171/jlms.2017.26 · Cited by 39 · see citing works
Porphyromonas gingivalis lipopolysaccharide affects oral epithelial connections via pyroptosis
Li, Y., Li, B., Liu, Y., Wang, H., He, M., Liu, Y., Sun, Y., & Meng, W. (2021) · Journal of Dental Sciences · doi:10.1016/j.jds.2021.01.003 · Cited by 40 · see citing works
Mahmoud, M. Y., Demuth, D. R., & Steinbach-Rankins, J. M. (2018) · Journal of Nanobiotechnology · doi:10.1186/s12951-018-0396-4 · Cited by 38 · see citing works
Development and validation of a predictive model for periodontitis using NHANES 2011–2012 data
Montero, E., Herrera, D., Sanz, M., Dhir, S., Dyke, T. E. V., & Sima, C. (2019) · Journal Of Clinical Periodontology · doi:10.1111/jcpe.13098 · Cited by 38 · see citing works
Svärd, A., Neilands, J., Palm, E., Svensäter, G., Bengtsson, T., & Aili, D. (2020) · ACS Applied Nano Materials · doi:10.1021/acsanm.0c01899 · Cited by 37 · see citing works
Kurgan, Ş., Önder, C., Balcı, N., Fentoğlu, Ö., Eser, F., Balseven, H. M., Serdar, M. A., Tatakis, D. N., & Günhan, M. (2016) · Journal of Periodontal Research · doi:10.1111/jre.12425 · Cited by 36 · see citing works
Tang, M., Wang, G., Li, J., Wang, Y., Peng, C., Chang, X., Guo, J. X., & Gui, S. (2023) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2023.117324 · Cited by 31 · see citing works
Kalia, P., Jain, A., Krishnan, R. R., Demuth, D. R., & Steinbach-Rankins, J. M. (2017) · International Journal of Nanomedicine · doi:10.2147/ijn.s139178 · Cited by 30 · see citing works
Mizutani, K., Mikami, R., Gohda, T., Gotoh, H., Aoyama, N., Matsuura, T., Kido, D., Takeda, K., Izumi, Y., Sasaki, Y., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-78724-1 · Cited by 32 · see citing works
Exploring the Imbalance of Periodontitis Immune System From the Cellular to Molecular Level
He, L., Liu, L., Li, T., Zhuang, D., Dai, J., Wang, B., & Bi, L. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2021.653209 · Cited by 30 · see citing works
Campi, P., Herrera, B. S., de Jesus, F. N., Napolitano, M., Teixeira, S. A., Dantas, A. M., Spolidório, L. C., Akamine, E. H., Mayer, M. P. A., de Carvalho, M. H. C., et al. (2015) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2015.11.022 · Cited by 30 · see citing works
Oral microbiota in aging and diseases
Ren, Y., Chen, M., Wang, Z., & Han, J. J. (2024) · Life Medicine · doi:10.1093/lifemedi/lnae024 · Cited by 30 · see citing works
Mizutani, K., Buranasin, P., Mikami, R., Takeda, K., Kido, D., Watanabe, K., Takemura, S., Nakagawa, K., Kominato, H., Saito, N., et al. (2021) · Antioxidants · doi:10.3390/antiox10081304 · Cited by 29 · see citing works
Wang, L., Zhang, T., Zhang, Z., Wang, Z., Zhou, Y., & Wang, Z. (2021) · BMC Oral Health · doi:10.1186/s12903-021-01788-6 · Cited by 29 · see citing works
Therapeutic Targets for Management of Periodontitis and Diabetes
Sima, C., & Dyke, T. E. V. (2016) · Current Pharmaceutical Design · doi:10.2174/1381612822666160216150338 · Cited by 29 · see citing works
Inhibition of Porphyromonas gingivalis‐induced periodontal bone loss by CXCR4 antagonist treatment
McIntosh, M. L., & Hajishengallis, G. (2012) · Molecular Oral Microbiology · doi:10.1111/j.2041-1014.2012.00657.x · Cited by 28 · see citing works
Balci, N., Cekici, A., Kurgan, Ş., Sahinkaya, S., & Serdar, M. A. (2021) · Journal of Periodontal Research · doi:10.1111/jre.12859 · Cited by 27 · see citing works
Holden, M. S., Black, J., Lewis, A., Boutrin, M., Walemba, E., Sabir, T. S., Boskovic, D. S., Aruni, W., Fletcher, H. M., & Perry, C. C. (2016) · Journal of Nanomaterials · doi:10.1155/2016/9605906 · Cited by 27 · see citing works
Links between oral microbiome and insulin resistance: Involvement of MAP kinase signaling pathway
Chang, Y., Cheng, W., Hsiao, Y.-C., Su, G.-W., Lin, S.-J., Wei, Y., Chou, H., Lin, H.-P. P., Lin, G.-Y., & Chan, H. (2023) · Biochimie · doi:10.1016/j.biochi.2023.06.013 · Cited by 26 · see citing works
Zhou, R., Shen, L., Yang, C., Wang, L., Guo, H., Yang, P., & Song, A. (2018) · Inflammation · doi:10.1007/s10753-018-0751-5 · Cited by 26 · see citing works
Long non‐coding RNA SNHG5 mediates periodontal inflammation through the NF‐κB signalling pathway
Han, Y., Huang, Y., Yang, Q., Jia, L., Zheng, Y., & Li, W. (2022) · Journal Of Clinical Periodontology · doi:10.1111/jcpe.13684 · Cited by 26 · see citing works
Lee, H., Joo, J., Sohn, D. H., Kang, J., Yu, Y., Park, H. R., & Kim, Y. H. (2022) · Journal of Translational Medicine · doi:10.1186/s12967-022-03702-2 · Cited by 26 · see citing works
Malm, S., Jusko, M., Eick, S., Potempa, J., Riesbeck, K., & Blom, A. M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0034852 · Cited by 26 · see citing works
Eivazi, M., Falahi, N., Eivazi, N., Eivazi, M. A., Vaisi‐Raygani, A., & Rezaei, F. (2017) · The Open Dentistry Journal · doi:10.2174/1874210601711010573 · Cited by 26 · see citing works
Балмасова, И. П., Lomakin, Y. A., Babaev, E. A., Tsarev, V. N., Gabibov, A. G., Smirnov, I. V., Knorre, V. D., Ovchinnikova, L. A., Gnuchev, N. V., Khurs, E. N., et al. (2019) · Acta Naturae · doi:10.32607/20758251-2019-11-4-79-87 · Cited by 26 · see citing works
Roles of ubiquitin-specific proteases in inflammatory diseases
Chen, R., Zhang, H., Li, L., Li, J., Xie, J., Weng, J., Tan, H., Liu, Y., Guo, T., & Wang, M. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1258740 · Cited by 25 · see citing works
Mikami, R., Mizutani, K., Gohda, T., Matsuyama, Y., Gotoh, H., Nakagawa, K., Takemura, S., Aoyama, N., Matsuura, T., Kido, D., et al. (2023) · Scientific Reports · doi:10.1038/s41598-023-38959-0 · Cited by 26 · see citing works
Soto, C., Bugueno, I. M., Hoare, A., González, S., Venegas, D., Salinas, D., Melgar-Rodríguez, S. A., Vernal, R., Gamonal, J. A., Quest, A. F. G., et al. (2015) · Journal of Periodontal Research · doi:10.1111/jre.12331 · Cited by 25 · see citing works
Sima, C., Cheng, Q., Rautava, J., Levesque, C. M., Sherman, P. M., & Glogauer, M. (2015) · Journal of Periodontal Research · doi:10.1111/jre.12303 · Cited by 25 · see citing works
Meng, R., Xu, J., Fan, C., Liao, H., Wu, Z., & Zeng, Q. (2024) · BMC Oral Health · doi:10.1186/s12903-024-04433-0 · Cited by 26 · see citing works
Apitherapy and Periodontal Disease: Insights into In Vitro, In Vivo, and Clinical Studies
Kumar, M., Prakash, S., Radha, R., Lorenzo, J. M., Chandran, D., Dhumal, S., Dey, A., Senapathy, M., Rais, N., Singh, S., et al. (2022) · Antioxidants · doi:10.3390/antiox11050823 · Cited by 23 · see citing works
Apolipoprotein E Related Co-Morbidities and Alzheimer’s Disease
Singhrao, S. K., Harding, A., Chukkapalli, S. S., Olsen, I., Kesavalu, L. N., & Crean, S. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad150690 · Cited by 24 · see citing works
Hu, Z., Zhou, Y., Wu, H., Hong, G., Chen, M., Jin, W., Lu, W., Zuo, M., Xie, Z., & Shi, J. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.126060 · Cited by 22 · see citing works
A Roadmap for the Rational Use of Biomarkers in Oral Disease Screening
Cirillo, N. (2024) · Biomolecules · doi:10.3390/biom14070787 · Cited by 22 · see citing works
Ingalagi, P., Bhat, K. G., Kulkarni, R. D., Kotrashetti, V., Kumbar, V. M., & Kugaji, M. S. (2022) · Journal of Oral and Maxillofacial Pathology · doi:10.4103/jomfp.jomfp_163_21 · Cited by 20 · see citing works
Complement-Targeted Therapeutics in Periodontitis
Hajishengallis, G., & Lambris, J. D. (2012) · Advances in experimental medicine and biology · doi:10.1007/978-1-4614-4118-2_13 · Cited by 20 · see citing works
Association of NOD2 Mutations with Aggressive Periodontitis
Sudo, T., Okada, Y., Ozaki, K., Urayama, K., Kanai, M., Kobayashi, H., Gokyu, M., Izumi, Y., & Tanaka, T. (2017) · Journal of Dental Research · doi:10.1177/0022034517715432 · Cited by 20 · see citing works
Nassar, C. A., Bresolin, A. C., Pronsatti, M. M., Pasqualotto, L. N., Jorge, A. S., da Silva, E. A. A., & Nassar, P. O. (2013) · Vascular Health and Risk Management · doi:10.2147/vhrm.s52187 · Cited by 20 · see citing works
Ohara-Nemoto, Y., Shimoyama, Y., Ono, T., Sarwar, M. T., Nakasato, M., Sasaki, M., & Nemoto, T. K. (2022) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2022.101585 · Cited by 18 · see citing works
Polyphenols-based intelligent oral barrier membranes for periodontal bone defect reconstruction
Chen, E., Wang, T., Sun, Z., Gu, Z., Xiao, S., & Ding, Y. (2024) · Regenerative Biomaterials · doi:10.1093/rb/rbae058 · Cited by 18 · see citing works
The investigation of the role of oral-originated Prevotella-induced inflammation in childhood asthma
Yan, T., Bao, Y., Cao, S., Jiang, P., Zhang, Z., Li, L., Kang, Y., & Wu, Q. (2024) · Frontiers in Microbiology · doi:10.3389/fmicb.2024.1400079 · Cited by 17 · see citing works
Alveolar bone loss and periodontal status in a bariatric patient
de Moura‐Grec, P. G., Marsicano, J. A., Rodrigues, L. M., & Peres, S. H. D. C. S. (2011) · European Journal of Gastroenterology & Hepatology · doi:10.1097/meg.0b013e32834bebb3 · Cited by 17 · see citing works
- Authors
- Genco, R. J., & Van Dyke, T. E.
- Affiliations
- University at Buffalo, State University of New York (US)
- Corresponding author
- Genco, Robert J.
- ORCID
- Genco, Robert J.
- Venue
- Nature Reviews Cardiology
- Published
- 2010-09
- Volume
- 7
- Issue
- 9
- Pages
- 479-480
- ISSN
- 1759-5002 (ISSN-L)
- 1759-5010
- OpenAlex
- W2044895821
- Cited by
- 182
- References
- 10
- Citations by year
- 2026: 7 · 2025: 12 · 2024: 18 · 2023: 18 · 2022: 14 · 2021: 15 · 2020: 12 · 2019: 14 · 2018: 15 · 2017: 7 · 2016: 6 · 2015: 14 · 2014: 7 · 2013: 10 · 2012: 9
- FWCI
- 8.53
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Health Sciences › Dentistry › General Dentistry › Dental Research and COVID-19
- Health Sciences › Dentistry › Periodontics › Dental Health and Care Utilization
- Keywords
- periodontitis, cardiovascular disease, systemic inflammation, type 2 diabetes, oral hygiene, cardiovascular risk factors
- MeSH terms
- C-Reactive Protein, Cardiovascular Diseases, Fibrinogen, Humans, Inflammation, Oral Hygiene, Risk Factors, Lipid Metabolism, Chronic Periodontitis
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