The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Reducing the risk of CVD in patients with periodontitis
Abstract
The association between periodontitis and other chronic diseases, such as cardiovascular disease (CVD) and type 2 diabetes mellitus, could be related to systemic inflammation initiated by a local inflammatory challenge. Oliveira et al. have added lack of oral hygiene, and its link with systemic inflammation, to the spectrum of risk factors for CVD.
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In the citing paper
“Patients with severe periodontitis had higher blood neutrophil counts and pro-inflammatory mediator levels (such as IL-1, IL-6, CRP, and fibrinogen) compared to healthy controls [14–17]”
From Effect of non-surgical periodontal therapy on risk markers of cardiovascular disease: a systematic review and meta-analysis (2024) · cites this paper as [15]
Citations
Cites
Identification of Periodontal Pathogens in Atheromatous Plaques
Haraszthy, V. I., Zambon, J. J., Trevisan, M., Zeid, M., & Genco, R. J. (2000) · Journal of Periodontology · doi:10.1902/jop.2000.71.10.1554 · Cited by 1,140
Self-citationA systematic review and meta‐analyses on C‐reactive protein in relation to periodontitis
Paraskevas, S., Huizinga, J. D., & Loos, B. G. (2008) · Journal of Clinical Periodontology · doi:10.1111/j.1600-051x.2007.01173.x · Cited by 757
Periodontal Disease and Coronary Heart Disease Incidence: A Systematic Review and Meta-analysis
Humphrey, L. L., Fu, R. F., Buckley, D., Freeman, M., & Helfand, M. (2008) · Journal of General Internal Medicine · doi:10.1007/s11606-008-0787-6 · Cited by 749
Bahekar, A., Singh, S., Saha, S. A., Molnár, J., & Arora, R. (2007) · American Heart Journal · doi:10.1016/j.ahj.2007.06.037 · Cited by 699
Periodontal Disease and Risk of Cerebrovascular Disease
Wu, T., Trevisan, M., Genco, R. J., Dorn, J. P., Falkner, K. L., & Sempos, C. T. (2000) · Archives of Internal Medicine · doi:10.1001/archinte.160.18.2749 · Cited by 495
Self-citationToothbrushing, inflammation, and risk of cardiovascular disease: results from Scottish Health Survey
de Oliveira, C., Watt, R., & Hamer, M. (2010) · BMJ · doi:10.1136/bmj.c2451 · Cited by 365
Friedewald, V. E., Kornman, K. S., Beck, J. D., Genco, R. J., Goldfine, A. B., Libby, P., Offenbacher, S., Ridker, P. M., Dyke, T. E. V., & Roberts, W. C. (2009) · Journal of Periodontology · doi:10.1902/jop.2009.097001 · Cited by 273
Self-citationOffenbacher, S., Beck, J. D., MOSS, K. L., Mendoza, L., Paquette, D. W., Barrow, D. A., Couper, D. J., Stewart, D., Falkner, K. L., Graham, S., et al. (2009) · Journal of Periodontology · doi:10.1902/jop.2009.080007 · Cited by 262
Self-citationRole for Periodontitis in the Progression of Lipid Deposition in an Animal Model
Jain, A. R., Júnior, E. L. B., Serhan, C. N., Stahl, G. L., & Dyke, T. E. V. (2003) · Infection and Immunity · doi:10.1128/iai.71.10.6012-6018.2003 · Cited by 180
Periodontitis May Increase the Risk of Peripheral Arterial Disease
Chen, Y., Umeda, M., Nagasawa, T., Takeuchi, Y., Huang, Y., Inoue, Y., Iwai, T., Izumi, Y., & Ishikawa, I. (2007) · European Journal of Vascular and Endovascular Surgery · doi:10.1016/j.ejvs.2007.08.016 · Cited by 125
Cited by
Sorted by citations
Periodontitis: from microbial immune subversion to systemic inflammation
Hajishengallis, G. (2015) · Nature Reviews Immunology · doi:10.1038/nri3785 · Cited by 3,046
The keystone-pathogen hypothesis
Hajishengallis, G., Darveau, R. P., & Curtis, M. A. (2012) · Nature Reviews Microbiology · doi:10.1038/nrmicro2873 · Cited by 1,790
Local and systemic mechanisms linking periodontal disease and inflammatory comorbidities
Hajishengallis, G., & Chavakis, T. (2021) · Nature Reviews Immunology · doi:10.1038/s41577-020-00488-6 · Cited by 1,871
Hajishengallis, G., Liang, S., Payne, M. A., Hashim, A., Jotwani, R., Eskan, M. A., McIntosh, M. L., Alsam, A., Kirkwood, K. L., Lambris, J. D., et al. (2011) · Cell Host & Microbe · doi:10.1016/j.chom.2011.10.006 · Cited by 1,154
Immunomicrobial pathogenesis of periodontitis: keystones, pathobionts, and host response
Hajishengallis, G. (2014) · Trends in Immunology · doi:10.1016/j.it.2013.09.001 · Cited by 1,150
Metadata
- Authors
- Genco, R. J., & Van Dyke, T. E.
- Affiliations
- University at Buffalo, State University of New York (US)
- Corresponding author
- Genco, Robert J.
- ORCID
- Genco, Robert J.
- Venue
- Nature Reviews Cardiology
- Published
- 2010-09
- Volume
- 7
- Issue
- 9
- Pages
- 479-480
- ISSN
- 1759-5002 (ISSN-L)
- 1759-5010
- OpenAlex
- W2044895821
- Cited by
- 182
- References
- 10
- Citations by year
- 2026: 7 · 2025: 12 · 2024: 18 · 2023: 18 · 2022: 14 · 2021: 15 · 2020: 12 · 2019: 14 · 2018: 15 · 2017: 7 · 2016: 6 · 2015: 14 · 2014: 7 · 2013: 10 · 2012: 9
- FWCI
- 8.53
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Cardiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Dentistry › Periodontics › Oral microbiology and periodontitis research
- Health Sciences › Dentistry › General Dentistry › Dental Research and COVID-19
- Health Sciences › Dentistry › General Dentistry › Dental Health and Care Utilization
- Keywords
- periodontitis, cardiovascular disease, systemic inflammation, type 2 diabetes, oral hygiene, cardiovascular risk factors
- MeSH terms
- C-Reactive Protein, Cardiovascular Diseases, Fibrinogen, Humans, Inflammation, Oral Hygiene, Risk Factors, Lipid Metabolism, Chronic Periodontitis
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