Cited by 299Dementia and Cognitive Impairment ResearchNeurological Disease Mechanisms and TreatmentsBlood Pressure and Hypertension Studies

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The relationship between blood pressure and cognitive function

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Novak, Vera, Hajjar, Ihab·2010·Nature Reviews Cardiology

DOI 10.1038/nrcardio.2010.161PMC PMC3328310

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Abstract

The relationship between blood pressure (BP) and cognitive outcomes in elderly adults has implications for global health care. Both hypertension and hypotension affect brain perfusion and worsen cognitive outcomes. The presence of hypertension and other vascular risk factors has been associated with decreased performance in executive function and attention tests. Cerebrovascular reserve has emerged as a potential biomarker for monitoring pressure-perfusion-cognition relationships. A decline in vascular reserve capacity can lead to impaired neurovascular coupling and decreased cognitive ability. Endothelial dysfunction, microvascular disease, and mascrovascular disease in midlife could also have an important role in the manifestations and severity of multiple medical conditions underlying cognitive decline late in life. However, questions remain about the role of antihypertensive therapies for long-term prevention of cognitive decline. In this Review, we address the underlying pathophysiology and the existing evidence supporting the role of vascular factors in late-life cognitive decline.

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Global burden of hypertension: analysis of worldwide data
Kearney, P. M., Whelton, M., Reynolds, K., Muntner, P., Whelton, P. K., & He, J. (2005) · The Lancet · doi:10.1016/s0140-6736(05)17741-1 · Cited by 8,698
Mild cognitive impairment – Beyond controversies, towards a consensus: Report of the International Working Group on Mild Cognitive Impairment.
Winblad, B., Palmer, K., Kivipelto, M., Jelic, V., Fratiglioni, L., Wahlund, L. ‐., Nordberg, A., Bäckman, L., Albert, M., Almkvist, O., et al. (2004) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.2004.01380.x · Cited by 4,946
Silent Brain Infarcts and the Risk of Dementia and Cognitive Decline
Vermeer, S. E., Prins, N. D., den Heijer, T., Hofman, A., Koudstaal, P. J., & Breteler, M. M. B. (2003) · New England Journal of Medicine · doi:10.1056/nejmoa022066 · Cited by 2,313
Cerebral autoregulation dynamics in humans.
Aaslid, R., Lindegaard, K.-F., Sorteberg, W., & NORNES, H. (1989) · Stroke · doi:10.1161/01.str.20.1.45 · Cited by 1,630
Prevention of dementia in randomised double-blind placebo-controlled Systolic Hypertension in Europe (Syst-Eur) trial
Forette, F., Seux, M.-L., Staessen, J. A., Thijs, L., Birkenhäger, W. H., Babarskiene, M.-R., Babeanu, S., Bossini, A., Gil-Extremera, B., Girerd, X., et al. (1998) · The Lancet · doi:10.1016/s0140-6736(98)03086-4 · Cited by 1,441
The Study on Cognition and Prognosis in the Elderly (SCOPE)
Lithell, H., Hansson, L., Skoog, I. G., Elmfeldt, D., Albert Hofman, D., Olofsson, B., Trenkwalder, P., & Zanchetti, A. (2003) · Journal of Hypertension · doi:10.1097/00004872-200305000-00011 · Cited by 1,419
Neurovascular coupling in the normal brain and in hypertension, stroke, and Alzheimer disease
Girouard, H., & Iadecola, C. (2005) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00966.2005 · Cited by 1,311
Consensus statement on the definition of orthostatic hypotension, pure autonomic failure, and multiple system atrophy
The Consensus Committee of the American Autonomic Society and the American Academy of Neurology (1996) · Neurology · doi:10.1212/wnl.46.5.1470 · Cited by 1,247
The age-dependent relation of blood pressure to cognitive function and dementia
Qiu, C., Winblad, B., & Fratiglioni, L. (2005) · The Lancet Neurology · doi:10.1016/s1474-4422(05)70141-1 · Cited by 1,138
Continuous Recording and Control of Ventricular Fluid Pressure in Neurosurgical Practice
Lundberg, N. (1962) · Journal of Neuropathology & Experimental Neurology · doi:10.1097/00005072-196207000-00018 · Cited by 1,093

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Liu, H., Gao, S., Hall, K. S., Unverzagt, F. W., Lane, K. A., Callahan, C. M., & Hendrie, H. C. (2013) · Journal of the American Geriatrics Society · doi:10.1111/jgs.12259 · Cited by 30
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Giordano, N., Tikhonoff, V., Palatini, P., Bascelli, A., Boschetti, G., Lazzari, F. D., Grasselli, C., Martini, B., Caffi, S., Piccoli, A., et al. (2012) · International Journal of Hypertension · doi:10.1155/2012/274851 · Cited by 29
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Cheung, B., Ho, I., Chan, R., Sea, M. M.-M., & Woo, J. (2014) · Advances in food and nutrition research · doi:10.1016/b978-0-12-800270-4.00004-3 · Cited by 31
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Kirschen, G. W., Kéry, R., & Ge, S. (2017) · Brain Plasticity · doi:10.3233/bpl-170055 · Cited by 28
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Aine, C. J., Sanfratello, L., Adair, J. C., Knoefel, J. E., Qualls, C., Lundy, S. L., Caprihan, A., Stone, D., & Stephen, J. M. (2013) · NeuroImage · doi:10.1016/j.neuroimage.2013.09.025 · Cited by 26
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The correlation between cerebral arterial pulsatility and cognitive dysfunction in Alzheimer's disease patients
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Authors: Novak, V., & Hajjar, I.
Affiliations: Beth Israel Deaconess Medical Center (US)
Corresponding author: Novak, Vera
ORCID: Novak, Vera
Hajjar, Ihab
Venue: Nature Reviews Cardiology
Publisher: Springer Science and Business Media LLC
Published: 2010-10-26
Volume: 7
Issue: 12
Pages: 686-698
ISSN: 1759-5002 (ISSN-L)
1759-5010
DOI: 10.1038/nrcardio.2010.161
PMC: PMC3328310
OpenAlex: W2048075564
Cited by: 299
References: 122
Citations by year: 2026: 11 · 2025: 9 · 2024: 9 · 2023: 13 · 2022: 24 · 2021: 15 · 2020: 20 · 2019: 29 · 2018: 15 · 2017: 28 · 2016: 16 · 2015: 19 · 2014: 30 · 2013: 31 · 2012: 20
FWCI: 2.77
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: www.springer.com/tdm (tdm)
Locations: Nature Reviews Cardiology (publishedVersion)
PubMed (publishedVersion)
Europe PMC (PubMed Central) (acceptedVersion)
PubMed Central (acceptedVersion)
Funders: National Institutes of Health
National Institute on Aging (1R01AG028076-A2, R01AG028076, P30AG028717, 1P01AG028717-01A2, K23AG030057)
National Institute of Diabetes and Digestive and Kidney Diseases (R21DK084463)
National Institute of Neurological Disorders and Stroke (R01NS045745)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Blood Pressure and Hypertension Studies
Keywords: blood pressure, cognitive decline, dementia, hypertension, hypotension, cerebral perfusion, cerebrovascular reserve, neurovascular coupling, vascular risk factors, endothelial dysfunction, microangiopathy, macroangiopathy, antihypertensive therapy, executive function, attention, older adults
MeSH terms: Age Factors, Aged, Aged, 80 and over, Antihypertensive Agents, Blood Pressure, Cognition, Cognition Disorders, Female, Humans, Hypertension, Hypotension, Male, Middle Aged, Risk Factors, Risk Assessment

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