The DOI matches its Crossref record; 129 of the 129 references it cites were found in a registry or an index.
Diffuse large B-cell lymphoma—treatment approaches in the molecular era
Open accessAbstract
Diffuse large B-cell lymphoma (DLBCL) is an aggressive B-cell non-Hodgkin lymphoma that affects patients of all ages with a wide range of clinical presentations. Although DLBCL is curable even in advanced stages, up to one-third of patients will not achieve cure with initial therapy. In the modern era of rituximab-based therapy as the first-line treatment, the prognoses of patients who require salvage therapy are poor and most will eventually succumb to their disease. Insight into the complex molecular circuitry of DLBCL reveals a diverse range of somatic mutations and aberrant intracellular signalling pathways that characterize distinct molecular subsets of the disease. The next major breakthrough in DLBCL therapy during this 'molecular era' of disease definition will be the identification of combinations of novel agents that target the oncogenic drivers of these subsets. Well-conducted clinical trials, with translational molecular investigations, will be essential to achieve the goal of precision medicine and expand the number of patients with DLBCL who achieve a cure.
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1 retracted
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Cited by
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Role of Bruton’s tyrosine kinase in B cells and malignancies
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Genetics of diffuse large B-cell lymphoma
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Metadata
- Authors
- Roschewski, M., Staudt, L. M., & Wilson, W. H.
- Venue
- Nature Reviews Clinical Oncology
- Published
- 2013-11-12
- Volume
- 11
- Issue
- 1
- Pages
- 12-23
- ISSN
- 1759-4774 (ISSN-L)
- 1759-4782
- OpenAlex
- W2044306036
- Cited by
- 411
- References
- 129
- FWCI
- 4.70
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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