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Cited by 422

The DOI matches its Crossref record; 86 of the 86 references it cites were found in a registry or an index.

Breathing new life into immunotherapy: review of melanoma, lung and kidney cancer

Open access
Drake, Charles G., Lipson, Evan J., Brahmer, Julie R.·2014·Nature Reviews Clinical Oncology

Abstract

Previously, clinical approaches to using the immune system against cancer focused on vaccines that intended to specifically initiate or amplify a host response against evolving tumours. Although vaccine approaches have had some clinical success, most cancer vaccines fail to induce objective tumour shrinkage in patients. More-recent approaches have centred on a series of molecules known as immune checkpoints—whose natural function is to restrain or dampen a potentially over-exuberant response. Blocking immune checkpoint molecules with monoclonal antibodies has emerged as a viable clinical strategy that mediates tumour shrinkage in several cancer types. In addition to being part of the current treatment armamentarium for metastatic melanoma, immune checkpoint blockade is currently undergoing phase III testing in several cancer types.

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Registry

Crossref · 10.1038/nrclinonc.2013.208

Cites

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Citations

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Metadata

Authors
Drake, C. G., Lipson, E. J., & Brahmer, J. R.
Venue
Nature Reviews Clinical Oncology
Published
2013-11-19
Volume
11
Issue
1
Pages
24-37
ISSN
  • 1759-4774 (ISSN-L)
  • 1759-4782
OpenAlex
W2135885240
Cited by
422
References
86
FWCI
4.59
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Breathing new life into immunotherapy: review of melanoma, lung and kidney cancer. https://app.cochat.ai/papers/10.1038/nrclinonc.2013.208
The paper
Drake, C. G., Lipson, E. J., & Brahmer, J. R. (2014). Breathing new life into immunotherapy: review of melanoma, lung and kidney cancer. Nature Reviews Clinical Oncology. https://doi.org/10.1038/nrclinonc.2013.208

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.