Tissue-resident memory features are linked to the magnitude of cytotoxic T cell responses in human lung cancer
Open accessAbstract
Therapies that boost the anti-tumor responses of cytotoxic T lymphocytes (CTLs) have shown promise; however, clinical responses to the immunotherapeutic agents currently available vary considerably, and the molecular basis of this is unclear. We performed transcriptomic profiling of tumor-infiltrating CTLs from treatment-naive patients with lung cancer to define the molecular features associated with the robustness of anti-tumor immune responses. We observed considerable heterogeneity in the expression of molecules associated with activation of the T cell antigen receptor (TCR) and of immunological-checkpoint molecules such as 4-1BB, PD-1 and TIM-3. Tumors with a high density of CTLs showed enrichment for transcripts linked to tissue-resident memory cells (T RM cells), such as CD103, and CTLs from CD103 hi tumors displayed features of enhanced cytotoxicity. A greater density of T RM cells in tumors was predictive of a better survival outcome in lung cancer, and this effect was independent of that conferred by CTL density. Here we define the 'molecular fingerprint' of tumor-infiltrating CTLs and identify potentially new targets for immunotherapy.
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The presence of CD103+CD8+ TILs is a positive prognostic marker in several cancers.
“Further research revealed that the presence of CD103+CD8+ TILs is a positive prognostic marker in several cancers [269-272].”
From Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition) (2021) · cites this paper as [272]
The Results section, “CD103 density is predictive of survival in lung cancer” (page not available), reports better survival and lower mortality in patients with CD103-high lung tumors, including among patients with high CD8+ TIL density. This supports lung cancer as one example, but the paper does not establish the prognostic claim across several cancers; its survival analysis also uses CD103 density rather than directly counting CD103+CD8+ TILs. (LLM, conf=0.84)
Experimental — accuracy not yet measuredA subset of TILs in tumors of NSCLC shares the phenotype of Trm in adjacent lung tissue (expression of CD103, CD69, CXCR6, CD49a).
“A subset of TILs in tumors of NSCLC shares the phenotype of Trm in adjacent lung tissue (expression of CD103, CD69, CXCR6, CD49a) [272, 273].”
From Guidelines for the use of flow cytometry and cell sorting in immunological studies (third edition) (2021) · cites this paper as [272]
The Results section, “TILhi tumors show enrichment for CD8+ TRM cells” (page unavailable), reports CD103+CD8+ TILs co-expressing CD69 and CD49a, and higher CXCR6 transcript expression in TIL-high tumors. These findings support a subset of lung-cancer TILs having tissue-resident-memory features, but the cited passages do not establish that this subset shares its phenotype specifically with TRM cells in adjacent lung tissue. (LLM, conf=0.85)
Experimental — accuracy not yet measured
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Armed and Ready: Transcriptional Regulation of Tissue-Resident Memory CD8 T Cells
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Metabolic programs of T cell tissue residency empower tumour immunity
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Cancer-specific tissue-resident memory T-cells express ZNF683 in colorectal cancer
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- Authors
- Ganesan, A.-P., Clarke, J., Wood, O., Garrido-Martin, E. M., Chee, S. J., Mellows, T., Samaniego-Castruita, D., Singh, D., Seumois, G., Alzetani, A., Woo, E., Friedmann, P. S., King, E. V., Thomas, G. J., Sanchez-Elsner, T., Vijayanand, P., & Ottensmeier, C. H.
- Affiliations
- La Jolla Institute for Immunology (US)
- University of Southampton (GB)
- University Hospital Southampton NHS Foundation Trust (GB)
- Corresponding author
- Vijayanand, Pandurangan
- ORCID
- Venue
- Nature Immunology
- Published
- 2017-06-19
- Volume
- 18
- Issue
- 8
- Pages
- 940-950
- ISSN
- 1529-2908 (ISSN-L)
- 1529-2916
- PMC
- PMC6036910
- OpenAlex
- W2626312449
- Cited by
- 528
- References
- 66
- Citations by year
- 2026: 28 · 2025: 45 · 2024: 51 · 2023: 60 · 2022: 68 · 2021: 85 · 2020: 64 · 2019: 65 · 2018: 52 · 2017: 10
- FWCI
- 23.03
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Nature Immunology (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- ePrints Soton (University of Southampton) (submittedVersion)
- Zenodo (CERN European Organization for Nuclear Research) (submittedVersion)
- Funders
- Cancer Research UK (S_1716, 18158, 18892, 18161, 15951, 20613, 21998, 22795, 23904)
- National Institutes of Health (1s10od016262-01)
- Medical Research Council (MR/P024351/1)
- Topics
- Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Keywords
- lung cancer, tissue-resident memory T cells, CD8+ T cells, cytotoxic T lymphocytes, tumor-infiltrating lymphocytes, CD103, T cell cytotoxicity, PD-1, TIM-3, 4-1BB, T cell receptor stimulation, immune checkpoint, tumor transcriptome, survival prediction, immunotherapy targets
- MeSH terms
- Hepatitis A Virus Cellular Receptor 2, Squamous Cell Carcinoma of Head and Neck, Adenocarcinoma, Adult, Aged, Aged, 80 and over, Carcinoma, Squamous Cell, Female, Head and Neck Neoplasms, Humans, Immunologic Memory, Immunotherapy, Lung Neoplasms, Male, Middle Aged, Prognosis, Receptors, Antigen, T-Cell, T-Lymphocytes, Cytotoxic, Antigens, CD, Survival Rate, Lymphocytes, Tumor-Infiltrating, Gene Expression Profiling, Integrin alpha Chains, Tumor Necrosis Factor Receptor Superfamily, Member 9, Programmed Cell Death 1 Receptor
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