Cited by 314Autophagy in Disease and TherapyCancer Immunotherapy and BiomarkersImmunotherapy and Immune Responses

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Activating autophagy to potentiate immunogenic chemotherapy and radiation therapy

Galluzzi, Lorenzo, Bravo-San Pedro, José Manuel, Demaria, Sandra, Formenti, Silvia Chiara, Kroemer, Guido·2017·Nature Reviews Clinical Oncology

DOI 10.1038/nrclinonc.2016.183

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Abstract

Autophagy is fundamental to the maintenance of intracellular homeostasis in virtually all human cells. Accordingly, defective autophagy predisposes healthy cells to undergoing malignant transformation. By contrast, malignant cells are able to harness autophagy to thrive, despite adverse microenvironmental conditions, and to resist therapeutic challenges. Thus, inhibition of autophagy has been proposed as a strategy to kill cancer cells or sensitize them to therapy; however, autophagy is also critical for optimal immune function, and mediates cell-extrinsic homeostatic effects owing to its central role in danger signalling by neoplastic cells responding to immunogenic chemotherapy and/or radiation therapy. In this Perspective, we discuss accumulating preclinical and clinical evidence in support of the all-too-often dismissed possibility that activating autophagy might be a relevant clinical objective that enables an increase in the effectiveness of immunogenic chemotherapy and/or radiation therapy.

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Authors: Galluzzi, L., Bravo-San Pedro, J. M., Demaria, S., Formenti, S. C., & Kroemer, G.
Affiliations: Inserm (FR)
Weill Cornell Medicine (US)
Karolinska University Hospital (SE)
Corresponding author: Galluzzi, Lorenzo
ORCID: Galluzzi, Lorenzo
Demaria, Sandra
Formenti, Silvia Chiara
Kroemer, Guido
Venue: Nature Reviews Clinical Oncology
Publisher: Springer Science and Business Media LLC
Published: 2016-11-15
Volume: 14
Issue: 4
Pages: 247-258
ISSN: 1759-4774 (ISSN-L)
1759-4782
DOI: 10.1038/nrclinonc.2016.183
OpenAlex: W2549172728
Cited by: 314
References: 126
Citations by year: 2026: 14 · 2025: 13 · 2024: 22 · 2023: 36 · 2022: 36 · 2021: 30 · 2020: 43 · 2019: 45 · 2018: 43 · 2017: 30 · 2016: 1
FWCI: 5.34
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
www.springer.com/tdm (vor)
Locations: Nature Reviews Clinical Oncology (publishedVersion)
PubMed (publishedVersion)
Funders: National Cancer Institute (R01CA198533, R01CA161891, R01CA201246)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
Keywords: autophagy, autophagy activation, immunogenic chemotherapy, radiotherapy, cancer immunotherapy, antitumor immunity, autophagy inhibition, tumor microenvironment, tumor immunosuppression
MeSH terms: Autophagy, Clinical Trials as Topic, Forecasting, Humans, Immunotherapy, Neoplasms, Tumor Microenvironment

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Activating autophagy to potentiate immunogenic chemotherapy and radiation therapy

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