Activating autophagy to potentiate immunogenic chemotherapy and radiation therapy

Repertoires of Autophagy in the Pathogenesis of Ocular Diseases

Li, Y., Jiang, Q. L., Cao, G.-F., Yao, J., & Yan, B. (2015) · Cellular Physiology and Biochemistry · doi:10.1159/000373980 · Cited by 16,351

Cancer Immunoediting: Integrating Immunity’s Roles in Cancer Suppression and Promotion

Schreiber, R. D., Old, L. J., & Smyth, M. J. (2011) · Science · doi:10.1126/science.1203486 · Cited by 6,474

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).

Klionsky, D. J., Abdelmohsen, K., Abe, A., Abedin, M. J., Abeliovich, H., Acevedo Arozena, A., Adachi, H., Adams, C. M., Adams, P. D., Adeli, K., et al. (2016) · Autophagy · doi:10.1080/15548627.2015.1100356 · Cited by 5,894

A role for mitochondria in nlrp3 inflammasome activation

Zhou, R., Yazdi, A. S., Menu, P., & Tschopp, J. (2011) · Nature · doi:10.1038/nature09663 · Cited by 5,602

Induction of the Vitamin D Receptor Attenuates Autophagy Dysfunction-Mediated Cell Death Following Traumatic Brain Injury

Cui, C., Cui, J., Jin, F., Cui, Y., Li, R., Jiang, X., Tian, Y., Wang, R. C., Jiang, P., & Gao, J. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000479571 · Cited by 5,214

Autophagy and Viruses: Adversaries or Allies?

Dong, X., & Levine, B. (2013) · Journal of Innate Immunity · doi:10.1159/000346388 · Cited by 4,444

Bcl-2 Antiapoptotic Proteins Inhibit Beclin 1-Dependent Autophagy

Pattingre, S., Tassa, A., Qu, X., Garuti, R., Liang, X. H., Mizushima, N., Packer, M., Schneider, M. D., & Levine, B. (2005) · Cell · doi:10.1016/j.cell.2005.07.002 · Cited by 3,536

Immunogenic cell death in cancer and infectious disease

Galluzzi, L., Buqué, A., Kepp, O., Zitvogel, L., & Kroemer, G. (2017) · Nature Reviews Immunology · doi:10.1038/nri.2016.107 · Cited by 3,119

The role of autophagy during the early neonatal starvation period

Kuma, A., Hatano, M., Matsui, M., Yamamoto, A., Nakaya, H., Yoshimori, T., Ohsumi, Y., Tokuhisa, T., & Mizushima, N. (2004) · Nature · doi:10.1038/nature03029 · Cited by 2,865

Immune checkpoint targeting in cancer therapy: toward combination strategies with curative potential

Sharma, P., & Allison, J. P. (2015) · Cell · doi:10.1016/j.cell.2015.03.030 · Cited by 2,345

Molecular mechanisms of cell death: recommendations of the nomenclature committee on cell death 2018.

Galluzzi, L., Vitale, I., Aaronson, S. A., Abrams, J. M., Adam, D., Agostinis, P., Alnemri, E. S., Altucci, L., Amelio, I., Andrews, D. W., et al. (2018) · Cell Death & Differentiation · doi:10.1038/s41418-017-0012-4 · Cited by 6,680

Mechanism and medical implications of mammalian autophagy

Dikic, I., & Elazar, Z. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0003-4 · Cited by 2,771

Macrophages and metabolism in the tumor microenvironment

Vitale, I., Manic, G., Coussens, L. M., Kroemer, G., & Galluzzi, L. (2019) · Cell Metabolism · doi:10.1016/j.cmet.2019.06.001 · Cited by 1,837

Molecular definitions of autophagy and related processes

Galluzzi, L., Baehrecke, E. H., Ballabio, A., Boya, P., Bravo‐San Pedro, J. M., Cecconi, F., Choi, A. M., Chu, C. T., Codogno, P., Colombo, M. I., et al. (2017) · The EMBO Journal · doi:10.15252/embj.201796697 · Cited by 1,646

Autophagy in major human diseases

Klionsky, D. J., Petroni, G., Amaravadi, R. K., Baehrecke, E. H., Ballabio, A., Boya, P., Bravo‐San Pedro, J. M., Cadwell, K., Cecconi, F., Choi, A. M. K., et al. (2021) · The EMBO Journal · doi:10.15252/embj.2021108863 · Cited by 1,585

Mitochondrial metabolism and cancer

Porporato, P. E., Filigheddu, N., Pedro, J. M. B., Kroemer, G., & Galluzzi, L. (2017) · Cell Research · doi:10.1038/cr.2017.155 · Cited by 1,323

The Roles of Autophagy in Cancer

Yun, C. W., & Lee, S. H. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19113466 · Cited by 965

Pharmacological modulation of autophagy: therapeutic potential and persisting obstacles

Galluzzi, L., Bravo-San Pedro, J. M., Levine, B., Green, D. R., & Kroemer, G. (2017) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2017.22 · Cited by 842

Advantages of targeting the tumor immune microenvironment over blocking immune checkpoint in cancer immunotherapy

Tang, T., Huang, X., Zhang, G., Hong, Z., Bai, X., & Liang, T. (2021) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-020-00449-4 · Cited by 618

Lactate: A Metabolic Driver in the Tumour Landscape

Ippolito, L., Morandi, A., Giannoni, E., & Chiarugi, P. (2018) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2018.10.011 · Cited by 541

Linking cellular stress responses to systemic homeostasis

Galluzzi, L., Yamazaki, T., & Kroemer, G. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-018-0068-0 · Cited by 556

Lactate and lactylation in cancer

Chen, J., Huang, Z., Chen, Y., Tian, H., Chai, P., Shen, Y., Yao, Y., Xu, S., Ge, S., & Jia, R. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-02082-x · Cited by 545

Engineering of a Nanosized Biocatalyst for Combined Tumor Starvation and Low-Temperature Photothermal Therapy

Zhou, J., Li, M., Hou, Y., Luo, Z., Chen, Q., Cao, H., Huo, R., Xue, C., Sutrisno, L., Hao, L., et al. (2018) · ACS Nano · doi:10.1021/acsnano.8b00309 · Cited by 424

The spectrum of T cell metabolism in health and disease

Bantug, G. R., Galluzzi, L., Kroemer, G., & Hess, C. (2017) · Nature reviews. Immunology · doi:10.1038/nri.2017.99 · Cited by 436

Autophagy and cancer stem cells: molecular mechanisms and therapeutic applications

Nazio, F., Bordi, M., Cianfanelli, V., Locatelli, F., & Cecconi, F. (2019) · Cell Death and Differentiation · doi:10.1038/s41418-019-0292-y · Cited by 395

Mitochondrial DNA drives abscopal responses to radiation that are inhibited by autophagy

Yamazaki, T., Kirchmair, A., Sato, A., Buqué, A., Rybstein, M., Petroni, G., Bloy, N., Finotello, F., Stafford, L., Navarro Manzano, E., et al. (2020) · Nature Immunology · doi:10.1038/s41590-020-0751-0 · Cited by 359

Metal Drugs and the Anticancer Immune Response

Englinger, B., Pirker, C., Heffeter, P., Terenzi, A., Kowol, C. R., Keppler, B. K., & Berger, W. (2019) · Chemical Reviews · doi:10.1021/acs.chemrev.8b00396 · Cited by 355

Metal-based NanoEnhancers for Future Radiotherapy: Radiosensitizing and Synergistic Effects on Tumor Cells

Liu, Y., Zhang, P., Li, F., Jin, X., Li, J., Chen, W., & Li, Q. (2018) · Theranostics · doi:10.7150/thno.22172 · Cited by 335

An ER‐Targeting Iridium(III) Complex That Induces Immunogenic Cell Death in Non‐Small‐Cell Lung Cancer

Wang, L., Guan, R., Xie, L., Liao, X., Xiong, K., Rees, T. W., Chen, Y., Ji, L., & Chao, H. (2020) · Angewandte Chemie International Edition · doi:10.1002/anie.202013987 · Cited by 294

The autophagic network and cancer

Rybstein, M. D., Pedro, J. M. B., Kroemer, G., & Galluzzi, L. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0042-2 · Cited by 294

Trial watch: Immunogenic cell death induction by anticancer chemotherapeutics

Garg, A. D., More, S., Rufo, N., Meçe, O., Sassano, M. L., Agostinis, P., Zitvogel, L., Kroemer, G., & Galluzzi, L. (2017) · OncoImmunology · doi:10.1080/2162402x.2017.1386829 · Cited by 288

The circular RNA ACR attenuates myocardial ischemia/reperfusion injury by suppressing autophagy via modulation of the Pink1/ FAM65B pathway

Zhou, L., Zhai, M., Huang, Y. H., Xu, S., An, T., Wang, Y.-H., Zhang, R., Liu, C.-Y., Dong, Y.-H., Wang, M., et al. (2018) · Cell Death and Differentiation · doi:10.1038/s41418-018-0206-4 · Cited by 253

Salidroside induces apoptosis and protective autophagy in human gastric cancer AGS cells through the PI3K/Akt/mTOR pathway

Li, R., Li, Z., Leng, X., Li, H., Ma, Y., Chen, Y., & Song, F. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2019.109726 · Cited by 250

Radiation-induced tumor immune microenvironments and potential targets for combination therapy

Guo, S., Yao, Y., Tang, Y., Xin, Z., Wu, D., Ni, C., Huang, J., Wei, Q., & Zhang, T. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01462-z · Cited by 290

WNT Signaling in Cancer Immunosurveillance

Galluzzi, L., Spranger, S., Fuchs, E. V., & López‐Soto, A. (2018) · Trends in Cell Biology · doi:10.1016/j.tcb.2018.08.005 · Cited by 245

Trial watch: chemotherapy-induced immunogenic cell death in immuno-oncology

Vanmeerbeek, I., Sprooten, J., Ruysscher, D. D., Tejpar, S., Vandenberghe, P., Fucikova, J. P., Špíšek, R., Zitvogel, L., Kroemer, G., Galluzzi, L., et al. (2020) · OncoImmunology · doi:10.1080/2162402x.2019.1703449 · Cited by 231

Sonodynamic therapy-derived multimodal synergistic cancer therapy

Xu, M., Zhou, L., Zheng, L., Zhou, Q., Liu, K., Mao, Y., & Song, S. (2021) · Cancer Letters · doi:10.1016/j.canlet.2020.10.037 · Cited by 211

Autophagy in stem cells: repair, remodelling and metabolic reprogramming

Boya, P., Codogno, P., & Rodriguez-Muela, N. (2018) · Development · doi:10.1242/dev.146506 · Cited by 197

Photodynamic Therapy and Immunity: An Update

Falk‐Mahapatra, R., & Gollnick, S. O. (2020) · Photochemistry and Photobiology · doi:10.1111/php.13253 · Cited by 201

mTOR-mediated cancer drug resistance suppresses autophagy and generates a druggable metabolic vulnerability

Gremke, N., Polo, P., Dort, A., Schneikert, J., Elmshäuser, S., Brehm, C. U., Klingmüller, U., Schmitt, A., Reinhardt, H. C., Timofeev, O. N., et al. (2020) · Nature Communications · doi:10.1038/s41467-020-18504-7 · Cited by 192

IP3 Receptor-Mediated Calcium Signaling and Its Role in Autophagy in Cancer

Kania, E., Roest, G., Vervliet, T., Parys, J. B., & Bultynck, G. (2017) · Frontiers in Oncology · doi:10.3389/fonc.2017.00140 · Cited by 169

Autophagy and intermittent fasting: the connection for cancer therapy?

Antunes, F., Erustes, A. G., Costa, A. J., Nascimento, A. C., Bincoletto, C., Ureshino, R. P., Pereira, G. J. S., & Smaili, S. S. (2018) · Clinics · doi:10.6061/clinics/2018/e814s · Cited by 179

Targeting oncogene and non-oncogene addiction to inflame the tumour microenvironment

Petroni, G., Buqué, A., Coussens, L. M., & Galluzzi, L. (2022) · Nature Reviews Drug Discovery · doi:10.1038/s41573-022-00415-5 · Cited by 162

Radiotherapy orchestrates natural killer cell dependent antitumor immune responses through CXCL8

Walle, T., Kraske, J. A., Liao, B., Lenoir, B., Timke, C., Halbach, E. V. B. U., Tran, F., Griebel, P., Albrecht, D., Ahmed, A., et al. (2022) · Science Advances · doi:10.1126/sciadv.abh4050 · Cited by 159

Research progress on morphology and mechanism of programmed cell death

Chen, Y., Li, X., Yang, M., & Liu, S. (2024) · Cell Death and Disease · doi:10.1038/s41419-024-06712-8 · Cited by 168

Recent Insights into the Mitochondrial Role in Autophagy and Its Regulation by Oxidative Stress

Agujetas, V. R., de Dios, C., Pinilla, L. L., Marı́, M., Morales, A., & Colell, A. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/3809308 · Cited by 153

Green Synthesis of Silver Nanoparticles Using Annona muricata Extract as an Inducer of Apoptosis in Cancer Cells and Inhibitor for NLRP3 Inflammasome via Enhanced Autophagy

Jabir, M. S., Saleh, Y. M., Sulaiman, G. M., Yaseen, N. Y., Sahib, U. I., Dewir, Y. H., Alwahibi, M. S., & Soliman, D. A. (2021) · Nanomaterials · doi:10.3390/nano11020384 · Cited by 143

Stress-induced cellular responses in immunogenic cell death: Implications for cancer immunotherapy

Radogna, F., & Diederich, M. F. (2018) · Biochemical Pharmacology · doi:10.1016/j.bcp.2018.02.006 · Cited by 146

A novel anti-HER2 anthracycline-based antibody-drug conjugate induces adaptive anti-tumor immunity and potentiates PD-1 blockade in breast cancer

D’Amico, L., Menzel, U., Prummer, M., Müller, P., Buchi, M., Kashyap, A. S., Haessler, U., Yermanos, A., Gébleux, R., Briendl, M., et al. (2019) · Journal for ImmunoTherapy of Cancer · doi:10.1186/s40425-018-0464-1 · Cited by 133

FOXM1 contributes to docetaxel resistance in castration-resistant prostate cancer by inducing AMPK/mTOR-mediated autophagy

Lin, J., Wang, W., Hu, T., Zhu, G., Li, L.-N., Zhang, C.-Y., Xu, Z., Yu, H.-B., Wu, H., & Zhu, J. (2019) · Cancer Letters · doi:10.1016/j.canlet.2019.11.014 · Cited by 136

circHIPK3 promotes oxaliplatin-resistance in colorectal cancer through autophagy by sponging miR-637

Zhang, Y., Li, C., Liu, X., Wang, Y., Zhao, R., Yang, Y., Zheng, X. M., Zhang, Y., & Zhang, X. (2019) · EBioMedicine · doi:10.1016/j.ebiom.2019.09.051 · Cited by 135

NF‐κB targeting for overcoming tumor resistance and normal tissues toxicity

Mortezaee, K., Najafi, M., Farhood, B., Ahmadi, A., Shabeeb, D., & Musa, A. E. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.28504 · Cited by 130

Ivermectin, a potential anticancer drug derived from an antiparasitic drug

Tang, M., Hu, X., Wang, Y., Yao, X., Zhang, W., Yu, C., Cheng, F., Li, J., & Fang, Q. (2020) · Pharmacological Research · doi:10.1016/j.phrs.2020.105207 · Cited by 133

Trial Watch: Immunomodulatory monoclonal antibodies for oncological indications

Buqué, A., Bloy, N., Aranda, F., Castoldi, F., Eggermont, A. M. M., Cremer, I., Fridman, W. H., Fucikova, J. P., Galon, J., Marabelle, A., et al. (2015) · OncoImmunology · doi:10.1080/2162402x.2015.1008814 · Cited by 132

Targeting autophagy in cancer stem cells as an anticancer therapy

Lei, Y., Zhang, D., Yu, J., Dong, H. F., Zhang, J., & Yang, S. (2017) · Cancer Letters · doi:10.1016/j.canlet.2017.02.012 · Cited by 127

Progress of engineered bacteria for tumor therapy

Fan, J., Niu, M., Qin, Y., Sun, Y., & Zhang, X. (2022) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2022.114296 · Cited by 126

Autophagy and Hallmarks of Cancer

Huang, T., Song, X., Yang, Y., Wan, X., Alvarez, A. A., Sastry, N. G., Feng, H., Hu, B., & Cheng, S. (2018) · Critical Reviews™ in Oncogenesis · doi:10.1615/critrevoncog.2018027913 · Cited by 120

Targeting regulated cell death in tumor nanomedicines

Zeng, Q., Ma, X., Song, Y., Chen, Q., Jiao, Q., & Zhou, L. (2021) · Theranostics · doi:10.7150/thno.67932 · Cited by 120

Rapamycin inhibits proliferation and induces autophagy in human neuroblastoma cells

Lin, X., Han, L., Weng, J., Wang, K., & Chen, T. (2018) · Bioscience Reports · doi:10.1042/bsr20181822 · Cited by 110

LncRNA SNHG6 promotes chemoresistance through ULK1-induced autophagy by sponging miR-26a-5p in colorectal cancer cells

Wang, X., Lan, Z., He, J., Lai, Q., Yao, X., Li, Q., Liu, Y., Lai, H., Gu, C.-C., Yan, Q., et al. (2019) · Cancer Cell International · doi:10.1186/s12935-019-0951-6 · Cited by 108

Autophagy: Supporting cellular and organismal homeostasis by self-eating

Eskelinen, E. (2019) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2019.03.010 · Cited by 110

The role of Wnt signaling pathway in tumor metabolic reprogramming

Mo, Y., Wang, Y., Zhang, L., Yang, L., Zhou, M., Li, X., Li, Y., Li, G., Zeng, Z., Xiong, W., et al. (2019) · Journal of Cancer · doi:10.7150/jca.31166 · Cited by 106

Immunogenic stress and death of cancer cells: Contribution of antigenicity vs adjuvanticity to immunosurveillance

Bloy, N., Garcia, P., Laumont, C. M., Pitt, J. M., Sistigu, A., Stoll, G., Yamazaki, T., Bonneil, É., Buqué, A., Humeau, J., et al. (2017) · Immunological Reviews · doi:10.1111/imr.12582 · Cited by 106

Hypoxia-driven intratumor heterogeneity and immune evasion

Terry, S., Engelsen, A. S. T., Buart, S., El‐Sayed, W., Venkatesh, G. H., & Chouaı̈b, S. (2020) · Cancer Letters · doi:10.1016/j.canlet.2020.07.004 · Cited by 102

Biological causes of immunogenic cancer cell death (ICD) and anti-tumor therapy; Combination of Oncolytic virus-based immunotherapy and CAR T-cell therapy for ICD induction

Mardi, A., Shirokova, A. V., Mohammed, R. N., Keshavarz, A., Zekiy, A. O., Thangavelu, L. P., Mohammad, T. A. M., Marofi, F., Shomali, N., Zamani, A., et al. (2022) · Cancer Cell International · doi:10.1186/s12935-022-02585-z · Cited by 102

The Role of Decorin and Biglycan Signaling in Tumorigenesis

Diehl, V., Huber, L. S., Trebicka, J., Wygrecka, M., Iozzo, R. V., & Schaefer, L. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.801801 · Cited by 100

A novel long noncoding RNA SP100-AS1 induces radioresistance of colorectal cancer via sponging miR-622 and stabilizing ATG3

Zhou, Y., Shao, Y., Hu, W., Zhang, J., Shi, Y., Kong, X., & Jiang, J. (2022) · Cell Death and Differentiation · doi:10.1038/s41418-022-01049-1 · Cited by 93

Pyridinium‐Substituted Tetraphenylethylenes Functionalized with Alkyl Chains as Autophagy Modulators for Cancer Therapy

Huang, Y., You, X., Wang, L., Zhang, G., Gui, S., Jin, Y., Zhao, R., & Zhang, D. (2020) · Angewandte Chemie International Edition · doi:10.1002/anie.202001906 · Cited by 93

Inhibiting autophagy flux and DNA repair of tumor cells to boost radiotherapy of orthotopic glioblastoma

Xu, Q., Zhang, H., Liu, H., Han, Y., Qiu, W., & Li, Z. (2021) · Biomaterials · doi:10.1016/j.biomaterials.2021.121287 · Cited by 91

Melatonin transport into mitochondria

Mayo, J. C., Sainz, R. M., González‐Menéndez, P., Hevia, D., & Cernuda‐Cernuda, R. (2017) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-017-2616-8 · Cited by 93

Targeting Autophagy in the Tumor Microenvironment: New Challenges and Opportunities for Regulating Tumor Immunity

Janji, B., Berchem, G., & Chouaı̈b, S. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00887 · Cited by 86

Transformable Nanoparticle‐Enabled Synergistic Elicitation and Promotion of Immunogenic Cell Death for Triple‐Negative Breast Cancer Immunotherapy

Xu, C., Yu, Y., Sun, Y., Kong, L., Yang, C., Hu, M. Y., Yang, T., Zhang, J., Hu, Q., & Zhang, Z. (2019) · Advanced Functional Materials · doi:10.1002/adfm.201905213 · Cited by 84

Circular CPM promotes chemoresistance of gastric cancer via activating PRKAA2‐mediated autophagy

Fang, L., Lv, J., Xuan, Z., Li, B., Li, Z., He, Z., Li, F., Xu, J., Wang, S., Xia, Y., et al. (2022) · Clinical and Translational Medicine · doi:10.1002/ctm2.708 · Cited by 85

Apigenin, by activating p53 and inhibiting STAT3, modulates the balance between pro-apoptotic and pro-survival pathways to induce PEL cell death

Granato, M., Montani, M. S. G., Santarelli, R., D’Orazi, G., Faggioni, A., & Cirone, M. (2017) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-017-0632-z · Cited by 83

HAMdb: a database of human autophagy modulators with specific pathway and disease information

Wang, N.-N., Dong, J., Zhang, L., Ouyang, D., Cheng, Y., Chen, A. F., Lu, A.-P., & Cao, D.-S. (2018) · Journal of Cheminformatics · doi:10.1186/s13321-018-0289-4 · Cited by 83

Autophagy modulation: a prudent approach in cancer treatment?

Bishop, E., & Bradshaw, T. D. (2018) · Cancer Chemotherapy and Pharmacology · doi:10.1007/s00280-018-3669-6 · Cited by 87

Enhancing tumor chemotherapy and overcoming drug resistance through autophagy-mediated intracellular dissolution of zinc oxide nanoparticles

Hu, Y. B., Zhang, H., Dong, L., Xu, M., Zhang, L., Ding, W., Zhang, J., Lin, J., Zhang, Y., Qiu, B., et al. (2019) · Nanoscale · doi:10.1039/c8nr08442d · Cited by 83

Targeting of cancer cell death mechanisms by curcumin: Implications to cancer therapy

Yu, C. H. A., Yang, B., & Najafi, M. (2021) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/bcpt.13648 · Cited by 78

Shikonin induces colorectal carcinoma cells apoptosis and autophagy by targeting galectin-1/JNK signaling axis

Zhang, N., Peng, F., Wang, Y., Li, Y., Wu, F., Wang, X., Cui, Y., Han, B., & He, G. (2019) · International Journal of Biological Sciences · doi:10.7150/ijbs.36955 · Cited by 77

3′-epi-12β-hydroxyfroside, a new cardenolide, induces cytoprotective autophagy via blocking the Hsp90/Akt/mTOR axis in lung cancer cells

Sun, Y., Huang, Y., Huang, F., Mei, W.-L., Liu, Q., Wang, C.-C., Lin, Y., Huang, C., Li, Y., Dai, H., et al. (2018) · Theranostics · doi:10.7150/thno.23304 · Cited by 74

Immune oncology, immune responsiveness and the theory of everything

Turan, T., Kannan, D., Patel, M. R., Barnes, J. M., Tanlimco, S. G., Lu, R. O., Halliwill, K. D., Kongpachith, S., Kline, D. E., Hendrickx, W., et al. (2018) · Journal for ImmunoTherapy of Cancer · doi:10.1186/s40425-018-0355-5 · Cited by 76

Autophagy in natural and therapy-driven anticancer immunosurveillance

Pietrocola, F., Pedro, J. M. B., Galluzzi, L., & Kroemer, G. (2017) · Autophagy · doi:10.1080/15548627.2017.1310356 · Cited by 75

Trial watch: immune checkpoint blockers for cancer therapy

Vanpouille-Box, C., Lhuillier, C., Bezu, L., Aranda, F., Yamazaki, T., Kepp, O., Fucikova, J., Spisek, R., Demaria, S., Formenti, S. C., et al. (2017) · OncoImmunology · doi:10.1080/2162402x.2017.1373237 · Cited by 73

Expression analysis of LC3B and p62 indicates intact activated autophagy is associated with an unfavorable prognosis in colon cancer

Niklaus, M., Adams, O. J., Berezowska, S., Zlobec, I., Graber, F., Slotta‐Huspenina, J., Nitsche, U., Rosenberg, R., Tschan, M. P., & Langer, R. (2017) · Oncotarget · doi:10.18632/oncotarget.17554 · Cited by 72

KLF5 downregulation desensitizes castration-resistant prostate cancer cells to docetaxel by increasing BECN1 expression and inducing cell autophagy

Jia, J., Zhang, H., Shi, Q., Yang, C., Ma, J., Jin, B., Wang, X., He, D., & Guo, P. (2019) · Theranostics · doi:10.7150/thno.33282 · Cited by 71

Astragalus polysaccharide enhanced antitumor effects of Apatinib in gastric cancer AGS cells by inhibiting AKT signalling pathway

Wu, J., Yu, J., Wang, J., Zhang, C., Shang, K., Yao, X., & Cao, B. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.01.140 · Cited by 70

Interaction of Discoidin Domain Receptor 1 with a 14-3-3-Beclin-1-Akt1 Complex Modulates Glioblastoma Therapy Sensitivity

Vehlow, A., Klapproth, E., Jin, S., Hannen, R., Hauswald, M., Bartsch, J. W., Nimsky, C., Temme, A., Leitinger, B., & Cordes, N. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.02.096 · Cited by 70

Potentiating prostate cancer immunotherapy with oncolytic viruses

Lee, P. C., & Gujar, S. A. (2018) · Nature Reviews Urology · doi:10.1038/nrurol.2018.10 · Cited by 70

Circulating Exosomal miR-141-3p and miR-375 in Metastatic Progression of Rectal Cancer

Meltzer, S., Bjørnetrø, T., Lyckander, L. G., Flatmark, K., Dueland, S., Samiappan, R., Johansen, C., Kalanxhi, E., Ree, A. H., & Redalen, K. R. (2019) · Translational Oncology · doi:10.1016/j.tranon.2019.04.014 · Cited by 68

LACTB Regulates PIK3R3 to Promote Autophagy and Inhibit EMT and Proliferation Through the PI3K/AKT/mTOR Signaling Pathway in Colorectal Cancer

Xu, W., Yu, M., Qin, J., Luo, Y., & Zhong, M. (2020) · Cancer Management and Research · doi:10.2147/cmar.s250661 · Cited by 68

Cell death pathologies: targeting death pathways and the immune system for cancer therapy

Pentimalli, F., Grelli, S., Daniele, N. D., Melino, G., & Amelio, I. (2018) · Genes and Immunity · doi:10.1038/s41435-018-0052-x · Cited by 69

Induction of immunogenic cell death in cancer cells by a photoactivated platinum( iv ) prodrug

Novohradský, V., Prachařová, J., Kašpárková, J., Imberti, C., Bridgewater, H. E., Sadler, P. J., & Brabec, V. (2020) · Inorganic Chemistry Frontiers · doi:10.1039/d0qi00991a · Cited by 67

Cell damage produced by magnetic fluid hyperthermia on microglial BV2 cells

Calatayud, M. P., Soler, E., Torres, T. E., González, E. C., Junquera, C., Ibarra, M. R., & Goya, G. F. (2017) · Scientific Reports · doi:10.1038/s41598-017-09059-7 · Cited by 66

Autophagy manipulation as a strategy for efficient anticancer therapies: possible consequences

Cirone, M., Montani, M. S. G., Granato, M., Garufi, A., Faggioni, A., & D’Orazi, G. (2019) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-019-1275-z · Cited by 65

Therapeutic modulation of autophagy: which disease comes first?

Maiuri, M. C., & Kroemer, G. (2019) · Cell Death and Differentiation · doi:10.1038/s41418-019-0290-0 · Cited by 66

Molecular Insights Into Therapeutic Potential of Autophagy Modulation by Natural Products for Cancer Stem Cells

Rahman, M. A., Saha, S. K., Rahman, M. S., Uddin, M. J., Uddin, M. S., Pang, M., Rhim, H., & Cho, S. (2020) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2020.00283 · Cited by 61

Gold nanoparticles impair autophagy flux through shape-dependent endocytosis and lysosomal dysfunction

Zhou, H., Gong, X., Lin, H., Chen, H., Huang, D., Li, D., Shan, H., & Gao, J. (2018) · Journal of Materials Chemistry B · doi:10.1039/c8tb02390e · Cited by 63

The use of African medicinal plants in cancer management

Gaobotse, G., Venkataraman, S., Brown, P. D., Masisi, K., Kwape, T. E., Nkwe, D. O., Rantong, G., & Makhzoum, A. B. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1122388 · Cited by 68

Engineering mitochondrial uncoupler synergistic photodynamic nanoplatform to harness immunostimulatory pro-death autophagy/mitophagy

Sun, Q., Yang, J., Shen, W. H., Lu, H., Hou, X., Liu, Y., Xu, Y., Wu, Q., Xuan, Z., Yang, Y., et al. (2022) · Biomaterials · doi:10.1016/j.biomaterials.2022.121796 · Cited by 61

The role of radiation induced oxidative stress as a regulator of radio-adaptive responses

Sisakht, M., Darabian, M., Mahmoodzadeh, A., Bazı, A., Shafiee, S. M., Mokarram, P., & Khoshdel, Z. (2020) · International Journal of Radiation Biology · doi:10.1080/09553002.2020.1721597 · Cited by 60

Molecular determinants of immunogenic cell death elicited by radiation therapy

Galassi, C., Klapp, V., Yamazaki, T., & Galluzzi, L. (2023) · Immunological Reviews · doi:10.1111/imr.13271 · Cited by 65

Trial Watch: Immunostimulation with recombinant cytokines for cancer therapy

García-Martínez, E., Smith, M. M., Buqué, A., Aranda, F., de la Peña, F. A., Rubio, A. I., Cánovas, M. S., Conesa, M. A. V., Fucikova, J. P., Špíšek, R., et al. (2018) · OncoImmunology · doi:10.1080/2162402x.2018.1433982 · Cited by 56

Redox-responsive nanoassembly restrained myeloid-derived suppressor cells recruitment through autophagy-involved lactate dehydrogenase A silencing for enhanced cancer immunochemotherapy

Xia, C., Li, M., Ran, G., Wang, X., Lu, Z., Li, T., Tang, X., Zhang, Z., & He, Q. (2021) · Journal of Controlled Release · doi:10.1016/j.jconrel.2021.05.034 · Cited by 55

TRPM2-AS promotes cancer cell proliferation through control of TAF15

Li, P., Li, Y., Jin, L., Li, J., & Xu, A. (2019) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/j.biocel.2019.105683 · Cited by 54

Linc-RA1 inhibits autophagy and promotes radioresistance by preventing H2Bub1/USP44 combination in glioma cells

Zheng, J., Wang, B., Zheng, R., Zhang, J., Huang, C., Zheng, R., Huang, Z., Qiu, W., Liu, M., Yang, K., et al. (2020) · Cell Death and Disease · doi:10.1038/s41419-020-02977-x · Cited by 54

Chloroquine supplementation increases the cytotoxic effect of curcumin against Her2/neu overexpressing breast cancer cells in vitro and in vivo in nude mice while counteracts it in immune competent mice

Masuelli, L., Granato, M., Benvenuto, M., Mattera, R., Bernardini, R., Mattei, M., d’Amati, G., D’Orazi, G., Faggioni, A., Bei, R., et al. (2017) · OncoImmunology · doi:10.1080/2162402x.2017.1356151 · Cited by 52

Epigenetic targeting of autophagy for cancer prevention and treatment by natural compounds

Vidoni, C., Ferraresi, A., Secomandi, E., Vallino, L., Dhanasekaran, D. N., & Isidoro, C. (2019) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2019.04.006 · Cited by 54

Novel and Alternative Targets Against Breast Cancer Stemness to Combat Chemoresistance

Sridharan, S., Howard, C. M., Tilley, A. M. C., Subramaniyan, B., Tiwari, A. K., Ruch, R. J., & Raman, D. (2019) · Frontiers in Oncology · doi:10.3389/fonc.2019.01003 · Cited by 54

Autophagy blockade synergistically enhances nanosonosensitizer-enabled sonodynamic cancer nanotherapeutics

Zhou, L., Huo, M., Qian, X., Ding, L., Yu, L., Feng, W., Cui, X., & Chen, Y. (2021) · Journal of Nanobiotechnology · doi:10.1186/s12951-021-00855-y · Cited by 53

The interplay between autophagy and cGAS-STING signaling and its implications for cancer

Schmid, M., Fischer, P., Engl, M., Widder, J., Gruber, S., & Slade, D. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1356369 · Cited by 61

Autophagy inhibition radiosensitizes in vitro, yet reduces radioresponses in vivo due to deficient immunogenic signalling

Ko, A., Kanehisa, A., Martins, I., Senovilla, L., Chargari, C., Dugué, D., Mariño, G., Kepp, O., Michaud, M., Perfettini, J., et al. (2013) · Cell Death and Differentiation · doi:10.1038/cdd.2013.124 · Cited by 212

Autophagy in natural and therapy-driven anticancer immunosurveillance

Pietrocola, F., Pedro, J. M. B., Galluzzi, L., & Kroemer, G. (2017) · Autophagy · doi:10.1080/15548627.2017.1310356 · Cited by 75

Role of Autophagy in Cancer Therapy

Ma, Y. (2016) · Elsevier eBooks · doi:10.1016/b978-0-12-802937-4.00013-2

Abstract 2262: Contribution of autophagy in anticancer immune response induced by chemotherapy

Sukkurwala, A. Q., Michaud, M., Martins, I., & Kroemer, G. (2012) · Cancer Research · doi:10.1158/1538-7445.am2012-2262

R(h)oad to antitumour therapy

Conceicao, V. N. D., Mishra, B. B., & Singh, B. B. (2022) · Clinical and Translational Discovery · doi:10.1002/ctd2.160